Background Research data regarding the correlation between elevated oxidised low-density lipoprotein(oxLDL)cholesterol concentrations and unfavourable clinical outcomes in individuals experiencing minor acute ischaemi...Background Research data regarding the correlation between elevated oxidised low-density lipoprotein(oxLDL)cholesterol concentrations and unfavourable clinical outcomes in individuals experiencing minor acute ischaemic cerebrovascular events or transient ischaemic attack(TIA)with presumed atherosclerotic aetiology are still limited.Methods This investigation incorporated a cohort of 5814 participants derived from the Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis clinical trial.The core laboratory conducted blinded measurements of baseline plasma oxLDL concentrations.Multivariable Cox regression analyses were employed to assess the correlations between oxLDL levels and adverse clinical events.The principal endpoint for efficacy assessment was defined as the occurrence of stroke within a 90-day follow-up period.Additional secondary endpoints encompassed composite vascular events during the same observation window.The main safety endpoint assessed was the occurrence of bleeding events of moderate to severe intensity.Results The final analytical cohort comprised 5814 patients included in the final analysis.The mean age was 63.7±9.6 years,and 36.0%were female.The average concentration of circulating oxLDL was 36.62μg/dL.Elevated oxLDL concentrations demonstrated a potential correlation with heightened stroke risk(T3 vs T1:HR 1.39,95%CI 1.04 to 1.85),ischaemic stroke(T3 vs T1:HR 1.31,95%CI 0.98 to 1.76)and composite vascular events(T3 vs T1:HR 1.36,95%CI 1.02 to 1.81)within 90 days.An increased concentration of oxLDL demonstrated a significant association with elevated susceptibility to moderate and severe haemorrhagic events(T3 vs T1:HR 3.61,95%CI 1.26 to 10.34)within 90 days.Conclusion Increased concentrations of oxLDL demonstrated an independent correlation with both stroke recurrence and the occurrence of moderate-to severe haemorrhagic events in individuals presenting with acute minor ischaemic stroke or TIA at elevated risk,accompanied by intracranial or extracranial atherosclerotic lesions.展开更多
The objective of this work was to investigate the interfacial adsorption properties and lipid oxidation of oil-in-water(O/W)emulsions prepared by 2,2′-azobis(2-amidinopropane)dihydrochloride(AAPH)oxidised whey protei...The objective of this work was to investigate the interfacial adsorption properties and lipid oxidation of oil-in-water(O/W)emulsions prepared by 2,2′-azobis(2-amidinopropane)dihydrochloride(AAPH)oxidised whey protein isolate(WPI)with different oxidation degrees.The results indicated that as the AAPH concentration increased,the degree of oxidation of WPI also increased significantly,as confirmed by the higher protein carbonyl and N′-formyl-L-kynurenine levels.AAPH interacted with WPI mainly through hydrogen bonding and hydrophobic interactions.Higher AAPH concentration changed the structure of WPI,which verified by the results of intrinsic tryptophan fluorescence,circular dichroism spectra and SDS-PAGE.Moreover,the ζ-potential and adsorbed proteins of O/W emulsions prepared by oxidised-WPI decreased with increasing degree of protein oxidation,but the droplet size of O/W emulsions increased.In addition,higher oxidation degrees of oxidised-WPI promoted lipid oxidation of O/W emulsions,reflected by an increase in lipid hydroperoxide and malondialdehyde levels.These findings indicated that oxidised WPI could lead to quality deterioration of O/W emulsions,especially for those with a higher degree of oxidation.展开更多
Highly concentrated hydrogen peroxide has been widely used as a rocket mono-propellant and oxidiser since 1940＇s. Although the relevant specialist literature concerning HTP is relatively extensive, one can still find...Highly concentrated hydrogen peroxide has been widely used as a rocket mono-propellant and oxidiser since 1940＇s. Although the relevant specialist literature concerning HTP is relatively extensive, one can still find many myths about highly concentrated hydrogen peroxide, especially concerning safety aspects about its preparation by different techniques, handling or further utilisation. Such ambiguities can result in rather apprehensive approach towards preparing, utilising or even handling of HTP in relevant industry or research fields. The paper contains modern approach to laboratory preparation of highly concentrated solutions of hydrogen peroxide of HTP class （concentration 98%＋） that is intended for propulsive （rocket） applications. Authors, who have gained extensive experience in the field of HTP preparation, handling and utilisation, concisely explain facts and disprove some common myths concerning HTP. Additionally, advantages and possible application of 98%＋ solutions of HTP in various propulsive systems such as small satellites are described. The attention is also paid to the possibility of replacing currently used toxic and corrosive rocket propellants, such as hydrazine and its derivatives, RFNA （red fuming nitric acid）, MON （mixed oxides of nitrogen） or NTO （dinitrogen tetroxide）, by 98%＋ HTP. The potential of the medium as green and easy to handle propellant that can act both, as monopropellant or strong liquid oxidiser with hypergolic capability, is outlined briefly as well.展开更多
Herein,we report a shape-dependent intramolecular electronic communication in neutral and oxidised complexes of dinickel(Ⅱ)and dicopper(Ⅱ)porphyrin dimers.Upon careful manipulation of the reaction conditions,nano-si...Herein,we report a shape-dependent intramolecular electronic communication in neutral and oxidised complexes of dinickel(Ⅱ)and dicopper(Ⅱ)porphyrin dimers.Upon careful manipulation of the reaction conditions,nano-sized molecules having different shapes,namely‘linear’,‘cofacially sloping’,and‘clamshell bucket’,were synthesized by varying the concentration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ).Detailed structural,spectroscopic(UV-vis-NIR,NMR,EPR,ESI-MS),VT magnetic study,and extensive computational investigation have been exploited to investigate long-range electronic communication.The varying shapes and extent of conjugation of the porphyrin dimers are responsible for several prominent attributes,including colours,polarity,π-conjugation,intensity of NIR absorption bands and narrow HOMO–LUMO gaps,etc.Notably,the addition of carbonyl moieties at the methine bridge in‘clamshell bucket’facilitates stronger electronic communication through it.Upon stepwise oxidations,highly stable mono-cation radical and di-cation diradicals were isolated that exhibited long-range charge/radical delocalization via the bridge to produce strong NIR bands.The spin-density plots for the neutral,1e^(−),and 2e^(−)oxidised complexes demonstrate the crucial role of metal ions,the bridge,and their shapes in long-range electronic communication.π-Conjugation between two macrocycles in the 2e^(−)-oxidised complexes is better in the linear‘butterfly-like’molecule,followed by curved‘cofacially sloping’and carbonyl-inserted‘clamshell bucket’,while nickel(Ⅱ)dominates over copper(Ⅱ)motifs.Notably,the distinct signatures of the triplet state in the EPR spectra were observed due to the magnetic interaction between the two Cu(Ⅱ)centres in the 2e^(−)-oxidised complexes.The carbonyl group acts as a goodπ-mediator in the oxidised complex fascinating through-space intramolecular communication between the two rings.展开更多
Through successive one-electron reduction processes,a coordinatively unsaturated thiolate-bridged CoIICoII complex[Cp*Co(μ-SEt)_(2)CoCp*](1)was facilely generated in high yield.In the presence of O_(2),complex 1 can ...Through successive one-electron reduction processes,a coordinatively unsaturated thiolate-bridged CoIICoII complex[Cp*Co(μ-SEt)_(2)CoCp*](1)was facilely generated in high yield.In the presence of O_(2),complex 1 can smoothly take up CO_(2),and then install it at the Co_(2)S_(2)scaffold in the form of a carbonate bridge to give complex[Cp*Co(μ-SEt)_(2)(μ–η^(1):η^(1)-CO_(3))CoCp*](2).展开更多
基金supported by the Capital’s Funds for Health Improvement and Research(2024-1-2043)National Natural Science Foundation of China(No.82425101,No.82101358)+3 种基金Beijing Nova Program(20230484336)Capital's Funds for Health Improvement and Research(2022-2-2045)the National Key R&D Program of China(No.2022YFF1501500,2022YFF1501501,2022YFF1501502,2022YFF1501503,2022YFF1501504,2022YFF1501505,2017YFC1307900,2017YFC1307905)Beijing Laboratory of Oral Health(PXM2021_014226_000041).
文摘Background Research data regarding the correlation between elevated oxidised low-density lipoprotein(oxLDL)cholesterol concentrations and unfavourable clinical outcomes in individuals experiencing minor acute ischaemic cerebrovascular events or transient ischaemic attack(TIA)with presumed atherosclerotic aetiology are still limited.Methods This investigation incorporated a cohort of 5814 participants derived from the Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis clinical trial.The core laboratory conducted blinded measurements of baseline plasma oxLDL concentrations.Multivariable Cox regression analyses were employed to assess the correlations between oxLDL levels and adverse clinical events.The principal endpoint for efficacy assessment was defined as the occurrence of stroke within a 90-day follow-up period.Additional secondary endpoints encompassed composite vascular events during the same observation window.The main safety endpoint assessed was the occurrence of bleeding events of moderate to severe intensity.Results The final analytical cohort comprised 5814 patients included in the final analysis.The mean age was 63.7±9.6 years,and 36.0%were female.The average concentration of circulating oxLDL was 36.62μg/dL.Elevated oxLDL concentrations demonstrated a potential correlation with heightened stroke risk(T3 vs T1:HR 1.39,95%CI 1.04 to 1.85),ischaemic stroke(T3 vs T1:HR 1.31,95%CI 0.98 to 1.76)and composite vascular events(T3 vs T1:HR 1.36,95%CI 1.02 to 1.81)within 90 days.An increased concentration of oxLDL demonstrated a significant association with elevated susceptibility to moderate and severe haemorrhagic events(T3 vs T1:HR 3.61,95%CI 1.26 to 10.34)within 90 days.Conclusion Increased concentrations of oxLDL demonstrated an independent correlation with both stroke recurrence and the occurrence of moderate-to severe haemorrhagic events in individuals presenting with acute minor ischaemic stroke or TIA at elevated risk,accompanied by intracranial or extracranial atherosclerotic lesions.
基金supported by Natural Science Funds for Distinguished Young Scholars of Heilongjiang Province(Grant No.JQ2021C003)National Natural Science Foundation of China(Grant No.32172233)Youth Leading Talent Support Program of Northeast Agricultural University(Grant No.NEAU2023QNLJ-014).
文摘The objective of this work was to investigate the interfacial adsorption properties and lipid oxidation of oil-in-water(O/W)emulsions prepared by 2,2′-azobis(2-amidinopropane)dihydrochloride(AAPH)oxidised whey protein isolate(WPI)with different oxidation degrees.The results indicated that as the AAPH concentration increased,the degree of oxidation of WPI also increased significantly,as confirmed by the higher protein carbonyl and N′-formyl-L-kynurenine levels.AAPH interacted with WPI mainly through hydrogen bonding and hydrophobic interactions.Higher AAPH concentration changed the structure of WPI,which verified by the results of intrinsic tryptophan fluorescence,circular dichroism spectra and SDS-PAGE.Moreover,the ζ-potential and adsorbed proteins of O/W emulsions prepared by oxidised-WPI decreased with increasing degree of protein oxidation,but the droplet size of O/W emulsions increased.In addition,higher oxidation degrees of oxidised-WPI promoted lipid oxidation of O/W emulsions,reflected by an increase in lipid hydroperoxide and malondialdehyde levels.These findings indicated that oxidised WPI could lead to quality deterioration of O/W emulsions,especially for those with a higher degree of oxidation.
文摘Highly concentrated hydrogen peroxide has been widely used as a rocket mono-propellant and oxidiser since 1940＇s. Although the relevant specialist literature concerning HTP is relatively extensive, one can still find many myths about highly concentrated hydrogen peroxide, especially concerning safety aspects about its preparation by different techniques, handling or further utilisation. Such ambiguities can result in rather apprehensive approach towards preparing, utilising or even handling of HTP in relevant industry or research fields. The paper contains modern approach to laboratory preparation of highly concentrated solutions of hydrogen peroxide of HTP class （concentration 98%＋） that is intended for propulsive （rocket） applications. Authors, who have gained extensive experience in the field of HTP preparation, handling and utilisation, concisely explain facts and disprove some common myths concerning HTP. Additionally, advantages and possible application of 98%＋ solutions of HTP in various propulsive systems such as small satellites are described. The attention is also paid to the possibility of replacing currently used toxic and corrosive rocket propellants, such as hydrazine and its derivatives, RFNA （red fuming nitric acid）, MON （mixed oxides of nitrogen） or NTO （dinitrogen tetroxide）, by 98%＋ HTP. The potential of the medium as green and easy to handle propellant that can act both, as monopropellant or strong liquid oxidiser with hypergolic capability, is outlined briefly as well.
基金the Science and Engineering Research Board(SERB),India,SERB-STAR and CSIR,New Delhi,for financial support.SJS thank UGC for financial support.
文摘Herein,we report a shape-dependent intramolecular electronic communication in neutral and oxidised complexes of dinickel(Ⅱ)and dicopper(Ⅱ)porphyrin dimers.Upon careful manipulation of the reaction conditions,nano-sized molecules having different shapes,namely‘linear’,‘cofacially sloping’,and‘clamshell bucket’,were synthesized by varying the concentration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ).Detailed structural,spectroscopic(UV-vis-NIR,NMR,EPR,ESI-MS),VT magnetic study,and extensive computational investigation have been exploited to investigate long-range electronic communication.The varying shapes and extent of conjugation of the porphyrin dimers are responsible for several prominent attributes,including colours,polarity,π-conjugation,intensity of NIR absorption bands and narrow HOMO–LUMO gaps,etc.Notably,the addition of carbonyl moieties at the methine bridge in‘clamshell bucket’facilitates stronger electronic communication through it.Upon stepwise oxidations,highly stable mono-cation radical and di-cation diradicals were isolated that exhibited long-range charge/radical delocalization via the bridge to produce strong NIR bands.The spin-density plots for the neutral,1e^(−),and 2e^(−)oxidised complexes demonstrate the crucial role of metal ions,the bridge,and their shapes in long-range electronic communication.π-Conjugation between two macrocycles in the 2e^(−)-oxidised complexes is better in the linear‘butterfly-like’molecule,followed by curved‘cofacially sloping’and carbonyl-inserted‘clamshell bucket’,while nickel(Ⅱ)dominates over copper(Ⅱ)motifs.Notably,the distinct signatures of the triplet state in the EPR spectra were observed due to the magnetic interaction between the two Cu(Ⅱ)centres in the 2e^(−)-oxidised complexes.The carbonyl group acts as a goodπ-mediator in the oxidised complex fascinating through-space intramolecular communication between the two rings.
基金supported by the National Natural Science Foundation of China(No.21690064,21571026,and 21231003)the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT13008)the“111”project of the Ministry of Education of China.
文摘Through successive one-electron reduction processes,a coordinatively unsaturated thiolate-bridged CoIICoII complex[Cp*Co(μ-SEt)_(2)CoCp*](1)was facilely generated in high yield.In the presence of O_(2),complex 1 can smoothly take up CO_(2),and then install it at the Co_(2)S_(2)scaffold in the form of a carbonate bridge to give complex[Cp*Co(μ-SEt)_(2)(μ–η^(1):η^(1)-CO_(3))CoCp*](2).
