A catalytic asymmetric hydroxylative dearomatization reaction has been disclosed,and the products can smoothly transform into spiroannulation adducts by simply treated with a base under mild conditions.Novel in-situ g...A catalytic asymmetric hydroxylative dearomatization reaction has been disclosed,and the products can smoothly transform into spiroannulation adducts by simply treated with a base under mild conditions.Novel in-situ generated magnesium catalytic methods are developed by application of combinational ligands.Related concise transformaitons of the spiroannulation adducts have been carried out.展开更多
A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder r...A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction.展开更多
基金the financial support from the National Natural Science Foundation of China (Nos. 21901092, 21807053)Innovation Fund for Medical Sciences (No. 2019-12M-5-074)+2 种基金Program for Chang-jiang Scholars and Innovative Research Team in University (PCSIRT) (No. IRT_15R27)the Funds for Fundamental Research Creative Groups of Gansu Province (No. 20JR5RA310)the Fundamental Research Funds for the Central Universities (Nos. lzujbky2020-49, 2021-kb21)
文摘A catalytic asymmetric hydroxylative dearomatization reaction has been disclosed,and the products can smoothly transform into spiroannulation adducts by simply treated with a base under mild conditions.Novel in-situ generated magnesium catalytic methods are developed by application of combinational ligands.Related concise transformaitons of the spiroannulation adducts have been carried out.
基金the financial support provided by the National Science Foundation of China(No.81273387)
文摘A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction.
