FOXP3-engineered CAR-T cells represent a novel therapeutic approach that redefines metabolic adaptability in solid tumors.In a recent article on cell metabolism,Niu et al.demonstrated that cytoplasmic FOXP3 reprograms...FOXP3-engineered CAR-T cells represent a novel therapeutic approach that redefines metabolic adaptability in solid tumors.In a recent article on cell metabolism,Niu et al.demonstrated that cytoplasmic FOXP3 reprograms CAR-T cell metabolism by engaging Drp1 and promoting mitochondrial fusion and fatty acid oxidation,which results in enhanced persistence and tumor clearance without triggering immunosuppressive activity.展开更多
文摘FOXP3-engineered CAR-T cells represent a novel therapeutic approach that redefines metabolic adaptability in solid tumors.In a recent article on cell metabolism,Niu et al.demonstrated that cytoplasmic FOXP3 reprograms CAR-T cell metabolism by engaging Drp1 and promoting mitochondrial fusion and fatty acid oxidation,which results in enhanced persistence and tumor clearance without triggering immunosuppressive activity.
