Cross-coupling reactions have developed widely and provided a powerful means to synthesize a variety of compounds in each chemical field. The compounds which have C--H bonds are widespread in fossil fuels, chemical ra...Cross-coupling reactions have developed widely and provided a powerful means to synthesize a variety of compounds in each chemical field. The compounds which have C--H bonds are widespread in fossil fuels, chemical raw materials, biologically active molecules, etc. Using these readily- available substances as substrates is high atom- and step-economy for cross-coupling reactions. Over the past decades, our research group focused on finding and developing new strategies for C--H functionalization. Compared with classical C--H activation methods, for example, C--H bonds are depro- tonated by strong base or converted into C--M bonds, oxidation-induced C--H functionalization would be another pathway for C--H bond activation. This perspective shows a brief introduction of our recent works in this oxidation-induced C--H functionalization. We categorized this approach of these C--H bond activations by the key intermediates, radical cations, radicals and cations.展开更多
Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed ...Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner.展开更多
What is the most favorite and original chemistry developed in your research group?Oxidative Cross-Coupling-The chemistry between two"nucleophiles".How do you get into this specific field?Could you please sha...What is the most favorite and original chemistry developed in your research group?Oxidative Cross-Coupling-The chemistry between two"nucleophiles".How do you get into this specific field?Could you please share some experiences with our readers?My first contact with palladium chemistry was the halopalladation of acetylene in 1998.Then I worked on palladium enolate and found it could initiate a transmetalation reaction.Until 2006,I found that desyl chloride(a halogenated hydrocarbon)showed different reactivity with orga no metallic reagents due to the halophilic and oxyphilic properties,thus we achieved the cross-coupling between two orga no metallic reagents.展开更多
基金This work was supported by the National Natural Science Foundation of China （21390402, 21520102003） and the Hubei Province Natural Science Foundation of China （2017CFA010）. The Program of Introducing Talents of Discipline to Universities of China （111 Program） is also appreciated. Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday.
文摘Cross-coupling reactions have developed widely and provided a powerful means to synthesize a variety of compounds in each chemical field. The compounds which have C--H bonds are widespread in fossil fuels, chemical raw materials, biologically active molecules, etc. Using these readily- available substances as substrates is high atom- and step-economy for cross-coupling reactions. Over the past decades, our research group focused on finding and developing new strategies for C--H functionalization. Compared with classical C--H activation methods, for example, C--H bonds are depro- tonated by strong base or converted into C--M bonds, oxidation-induced C--H functionalization would be another pathway for C--H bond activation. This perspective shows a brief introduction of our recent works in this oxidation-induced C--H functionalization. We categorized this approach of these C--H bond activations by the key intermediates, radical cations, radicals and cations.
基金supported by the National Natural Science Foundation of China (21390402, 21520102003, 21702150)the National Basic Research Program of China (2012CB725302)+1 种基金the CAS Interdisciplinary Innovation Team and the Hubei Province Natural Science Foundation of China (2017CFA010)China Postdoctoral Science Foundation (BX201600114, 2016M602340)
文摘Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner.
基金This work was supported by the National Natural Science Foundation of China(No.22031008)the Science Foundation of Wuhan(No.2020010601012192).
文摘What is the most favorite and original chemistry developed in your research group?Oxidative Cross-Coupling-The chemistry between two"nucleophiles".How do you get into this specific field?Could you please share some experiences with our readers?My first contact with palladium chemistry was the halopalladation of acetylene in 1998.Then I worked on palladium enolate and found it could initiate a transmetalation reaction.Until 2006,I found that desyl chloride(a halogenated hydrocarbon)showed different reactivity with orga no metallic reagents due to the halophilic and oxyphilic properties,thus we achieved the cross-coupling between two orga no metallic reagents.
