[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alc...[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.展开更多
Background:The assessment of Fontan circuit’sflow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions(2Dflow),while recently,a single volumetric 4D-flow MRI acquisition is emerging as a ...Background:The assessment of Fontan circuit’sflow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions(2Dflow),while recently,a single volumetric 4D-flow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart diseases.Purpose:To compare 2D and 4D-flow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential dis-agreement.Methods:39 patients after Fontan palliation(23 males,age 22±11 years)who underwent cardiac MRI with 2D and 4D-flow MRI acquisition were included in the study.In all patients,bloodflow quantification in the Fontan circuit and aorta by 2Dflow and by 4Dflow MRI acquisition blinding to the 2D results was per-formed.The agreement between 2D and 4D-flow MRI was calculated as the intraclass correlation coefficient(ICC).The mean absolute differences between 4D and 2Dflows were analyzed using linear regression models.Results:4D-flow MRI acquisition time was slightly lower than 2D(7.6±1.8 min vs.9.4±3.3 min,p=0.03).Flow was slightly predominant in the right pulmonary artery(58%of total pulmonaryflow).Conduit/tunnel-pul-monary arteriesflow accounted for 60%of the Fontan circuit.Agreement between 2D and 4D was overall good-to-excellent from ICC:0.81795%CI:0.637–0.907 to 0.93295%CI:0.866–0.965.There was no significant influ-ence of evaluated parameters on the agreement on 4D and 2Dflow.Conclusions:4D-flow MRI represents a valid tool in Fontan’sflow quantification.Further larger studies are needed to confirm our results and to evaluate the impact of advanced 4D-flow MRI parameters on the prognostic stratification in patients after Fontan palliation.展开更多
OWS(OGC Web Service)为空间数据共享提供了可行的方法,但如何在浩瀚的互联网上快速、准确地查询到符合用户需要的OWS是一件比较困难的事情。在对Web搜索方法进行深入理解的基础上,提出一种基于全文检索搜索引擎搭建OWS索引服务的思路,...OWS(OGC Web Service)为空间数据共享提供了可行的方法,但如何在浩瀚的互联网上快速、准确地查询到符合用户需要的OWS是一件比较困难的事情。在对Web搜索方法进行深入理解的基础上,提出一种基于全文检索搜索引擎搭建OWS索引服务的思路,并采用Google实现了OWS索引服务中心的原型系统,该系统可以为互联网用户提供OWS搜索服务。展开更多
Coal mine belt fire develops very rapidly and is difficult to control. If not suppressed quickly, a belt fire could easily lead to airflow disorder and undermine the ventilation system. However, belt fire can be preve...Coal mine belt fire develops very rapidly and is difficult to control. If not suppressed quickly, a belt fire could easily lead to airflow disorder and undermine the ventilation system. However, belt fire can be prevented effectively by establishing fire airflow control system. In this work, the 5th belt roadway of Kongzhuang coal mine was taken as the object of investigation, where geometrical models of this roadway were established firstly. Then, based on mathematical model of fire smoke flow, the CO volume fraction, smoke density distribution, air temperature and pollutant velocity vector in the roadway before and after taking airflow control measures were simulated by using Fluent software. It can be known from the simulation that with the normal ventilation status in 5th belt roadway, the countercurrent of smoke does not happen when a fire occurs; the roadway's section is almost filled with CO at 10 m downstream from the fire source, and with air velocity getting stable gradually, the CO concentration reaches about 15 %. After taking airflow control measures, the effect range of temperature field which are harmful to the miners decreases from 69 m to 30 m; and the distance of the roadway fully filled with CO is 5 m farther than that before taking measures. Finally, according to the numerical simulation results and the actual condition of the belt roadway, the warning and automatic remote airflow control system with short-circuit method for the 5th belt roadway was designed to guarantee the safety production.展开更多
The two-stage hybridflow shop problem under setup times is addressed in this paper.This problem is NP-Hard.on the other hand,the studied problem is modeling different real-life applications especially in manufacturing...The two-stage hybridflow shop problem under setup times is addressed in this paper.This problem is NP-Hard.on the other hand,the studied problem is modeling different real-life applications especially in manufacturing and high performance-computing.Tackling this kind of problem requires the development of adapted algorithms.In this context,a metaheuristic using the genetic algorithm and three heuristics are proposed in this paper.These approximate solutions are using the optimal solution of the parallel machines under release and delivery times.Indeed,these solutions are iterative procedures focusing each time on a particular stage where a parallel machines problem is called to be solved.The general solution is then a concatenation of all the solutions in each stage.In addition,three lower bounds based on the relaxation method are provided.These lower bounds present a means to evaluate the efficiency of the developed algorithms throughout the measurement of the relative gap.An experimental result is discussed to evaluate the performance of the developed algorithms.In total,8960 instances are implemented and tested to show the results given by the proposed lower bounds and heuristics.Several indicators are given to compare between algorithms.The results illustrated in this paper show the performance of the developed algorithms in terms of gap and running time.展开更多
Demand Response(DR)is one of the most cost-effective and unfailing techniques used by utilities for consumer load shifting.This research paper presents different DR programs in deregulated environments.The description...Demand Response(DR)is one of the most cost-effective and unfailing techniques used by utilities for consumer load shifting.This research paper presents different DR programs in deregulated environments.The description and the classification of DR along with their potential benefits and associated cost components are presented.In addition,most DR measurement indices and their evaluation are also highlighted.Initially,the economic load model incorporated thermal,wind,and energy storage by considering the elasticity market price from its calculated locational marginal pricing(LMP).The various DR programs like direct load control,critical peak pricing,real-time pricing,time of use,and capacity market programs are considered during this study.The effect of demand response in electricity prices is highlighted using a simulated study on IEEE 30 bus system.Simulation is done by the Shuffled Frog Leap Algorithm(SFLA).Comprehensive performance comparison on voltage deviations,losses,and cost with and without considering DR is also presented in this paper.展开更多
随着网络技术的不断成熟,许多新技术成功地运用到GIS系统的客户端数据展现当中,而最引人注目的技术就是A-JAX;另一方面,开放地理信息系统联盟(OGC)开发了一系列基于Web服务技术的地理空间数据互操作协议OGC Web Services(OWS),其中的Web...随着网络技术的不断成熟,许多新技术成功地运用到GIS系统的客户端数据展现当中,而最引人注目的技术就是A-JAX;另一方面,开放地理信息系统联盟(OGC)开发了一系列基于Web服务技术的地理空间数据互操作协议OGC Web Services(OWS),其中的Web Map Services(WMS)已经广泛地应用于GIS领域。本文首先对于AJAX技术和OWS规范进行基础性的阐述,之后将详细介绍一个结合AJAX技术和OWS规范构造的GIS系统—ACT-GIS。展开更多
Background： To explore the relationship between the heart-type fatty acid binding protein（H-FABP） gene and intramuscular fat（IMF）, a polymorphism of the second exon of the H-FABP gene was investigated in 60 Three...Background： To explore the relationship between the heart-type fatty acid binding protein（H-FABP） gene and intramuscular fat（IMF）, a polymorphism of the second exon of the H-FABP gene was investigated in 60 Three-yellow chickens（TYCs） and 60 Hetian-black chickens（HTBCs）.Results： The IMF contents of the cardiac, chest and leg muscles in HTBC were increased compared with TYC. Both TYC and HTBC populations exhibited Hardy-Weinberg Equilibrium（HWE） according to the χ2test. Three variations of the two birds were detected, namely, G939 A, G982 A and C1014 T. HTBCs with the TT genotypes exhibit increased IMF content in the chest muscles compared with the TC genotype. Thus, the G982 A site could be considered a genetic marker for selecting increased IMF content in the chest muscles of HTBC. The correlation coefficients revealed that H-FABP m RNA expression was negatively correlated with the IMF content in the cardiac, chest and leg muscles of HTBC and in the cardiac and chest muscles of TYC. The relative m RNA expression of H-FABP was reduced in the cardiac and leg muscles of HTBC compared with TYC, but this difference was not observed at the protein level, as assessed by Western blot analysis.Conclusions： These findings offer essential data that can be useful in the breeding program of HTBC and future research exploring the role of H-FABP in IMF deposition and regulation in chickens.展开更多
基金Supported by National Natural Science Foundation of China(31100987)Project of Shandong University of Technology(4040-306018)Young Teacher Development Plan of Shandong University of Technology~~
文摘[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.
基金The Institutional Review Board and Regional Committee(CEAVNO)approved the study(Study No.13756 approved in September 2018).
文摘Background:The assessment of Fontan circuit’sflow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions(2Dflow),while recently,a single volumetric 4D-flow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart diseases.Purpose:To compare 2D and 4D-flow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential dis-agreement.Methods:39 patients after Fontan palliation(23 males,age 22±11 years)who underwent cardiac MRI with 2D and 4D-flow MRI acquisition were included in the study.In all patients,bloodflow quantification in the Fontan circuit and aorta by 2Dflow and by 4Dflow MRI acquisition blinding to the 2D results was per-formed.The agreement between 2D and 4D-flow MRI was calculated as the intraclass correlation coefficient(ICC).The mean absolute differences between 4D and 2Dflows were analyzed using linear regression models.Results:4D-flow MRI acquisition time was slightly lower than 2D(7.6±1.8 min vs.9.4±3.3 min,p=0.03).Flow was slightly predominant in the right pulmonary artery(58%of total pulmonaryflow).Conduit/tunnel-pul-monary arteriesflow accounted for 60%of the Fontan circuit.Agreement between 2D and 4D was overall good-to-excellent from ICC:0.81795%CI:0.637–0.907 to 0.93295%CI:0.866–0.965.There was no significant influ-ence of evaluated parameters on the agreement on 4D and 2Dflow.Conclusions:4D-flow MRI represents a valid tool in Fontan’sflow quantification.Further larger studies are needed to confirm our results and to evaluate the impact of advanced 4D-flow MRI parameters on the prognostic stratification in patients after Fontan palliation.
文摘OWS(OGC Web Service)为空间数据共享提供了可行的方法,但如何在浩瀚的互联网上快速、准确地查询到符合用户需要的OWS是一件比较困难的事情。在对Web搜索方法进行深入理解的基础上,提出一种基于全文检索搜索引擎搭建OWS索引服务的思路,并采用Google实现了OWS索引服务中心的原型系统,该系统可以为互联网用户提供OWS搜索服务。
基金Project supported by Joint Innovative Center for Safe and Effective Mining Technology and Equipment of Coal Resources of Shandong Province,ChinaProject supported by Taishan Scholar Program of Shandong Province,China+2 种基金Project(2014JQJH106)supported by Shandong University of Science and Technology Research Fund,ChinaProject(LAK2012-1)supported by Science and Technology Development Program of Safety Production of Shandong Province,ChinaProject(2012ZHTD06)supported by Science Research Innovative Group of College of Mining and Safety Engineering of Shandong University of Science and Technology,China
文摘Coal mine belt fire develops very rapidly and is difficult to control. If not suppressed quickly, a belt fire could easily lead to airflow disorder and undermine the ventilation system. However, belt fire can be prevented effectively by establishing fire airflow control system. In this work, the 5th belt roadway of Kongzhuang coal mine was taken as the object of investigation, where geometrical models of this roadway were established firstly. Then, based on mathematical model of fire smoke flow, the CO volume fraction, smoke density distribution, air temperature and pollutant velocity vector in the roadway before and after taking airflow control measures were simulated by using Fluent software. It can be known from the simulation that with the normal ventilation status in 5th belt roadway, the countercurrent of smoke does not happen when a fire occurs; the roadway's section is almost filled with CO at 10 m downstream from the fire source, and with air velocity getting stable gradually, the CO concentration reaches about 15 %. After taking airflow control measures, the effect range of temperature field which are harmful to the miners decreases from 69 m to 30 m; and the distance of the roadway fully filled with CO is 5 m farther than that before taking measures. Finally, according to the numerical simulation results and the actual condition of the belt roadway, the warning and automatic remote airflow control system with short-circuit method for the 5th belt roadway was designed to guarantee the safety production.
基金The authors would like to thank the Deanship of Scientific Research at Majmaah University for supporting this work under Project Number No.1439-19.
文摘The two-stage hybridflow shop problem under setup times is addressed in this paper.This problem is NP-Hard.on the other hand,the studied problem is modeling different real-life applications especially in manufacturing and high performance-computing.Tackling this kind of problem requires the development of adapted algorithms.In this context,a metaheuristic using the genetic algorithm and three heuristics are proposed in this paper.These approximate solutions are using the optimal solution of the parallel machines under release and delivery times.Indeed,these solutions are iterative procedures focusing each time on a particular stage where a parallel machines problem is called to be solved.The general solution is then a concatenation of all the solutions in each stage.In addition,three lower bounds based on the relaxation method are provided.These lower bounds present a means to evaluate the efficiency of the developed algorithms throughout the measurement of the relative gap.An experimental result is discussed to evaluate the performance of the developed algorithms.In total,8960 instances are implemented and tested to show the results given by the proposed lower bounds and heuristics.Several indicators are given to compare between algorithms.The results illustrated in this paper show the performance of the developed algorithms in terms of gap and running time.
文摘Demand Response(DR)is one of the most cost-effective and unfailing techniques used by utilities for consumer load shifting.This research paper presents different DR programs in deregulated environments.The description and the classification of DR along with their potential benefits and associated cost components are presented.In addition,most DR measurement indices and their evaluation are also highlighted.Initially,the economic load model incorporated thermal,wind,and energy storage by considering the elasticity market price from its calculated locational marginal pricing(LMP).The various DR programs like direct load control,critical peak pricing,real-time pricing,time of use,and capacity market programs are considered during this study.The effect of demand response in electricity prices is highlighted using a simulated study on IEEE 30 bus system.Simulation is done by the Shuffled Frog Leap Algorithm(SFLA).Comprehensive performance comparison on voltage deviations,losses,and cost with and without considering DR is also presented in this paper.
文摘随着网络技术的不断成熟,许多新技术成功地运用到GIS系统的客户端数据展现当中,而最引人注目的技术就是A-JAX;另一方面,开放地理信息系统联盟(OGC)开发了一系列基于Web服务技术的地理空间数据互操作协议OGC Web Services(OWS),其中的Web Map Services(WMS)已经广泛地应用于GIS领域。本文首先对于AJAX技术和OWS规范进行基础性的阐述,之后将详细介绍一个结合AJAX技术和OWS规范构造的GIS系统—ACT-GIS。
基金supported by the National Natural Science Foundation of China(Project No.31160521)Tarim University Principal Fund(Project No.TDZKGG201504)the project of Key Laboratory of Tarim Animal Husbandry Science and Technology,Xinjiang Production&Construction Group(Project No.HS201302)
文摘Background： To explore the relationship between the heart-type fatty acid binding protein（H-FABP） gene and intramuscular fat（IMF）, a polymorphism of the second exon of the H-FABP gene was investigated in 60 Three-yellow chickens（TYCs） and 60 Hetian-black chickens（HTBCs）.Results： The IMF contents of the cardiac, chest and leg muscles in HTBC were increased compared with TYC. Both TYC and HTBC populations exhibited Hardy-Weinberg Equilibrium（HWE） according to the χ2test. Three variations of the two birds were detected, namely, G939 A, G982 A and C1014 T. HTBCs with the TT genotypes exhibit increased IMF content in the chest muscles compared with the TC genotype. Thus, the G982 A site could be considered a genetic marker for selecting increased IMF content in the chest muscles of HTBC. The correlation coefficients revealed that H-FABP m RNA expression was negatively correlated with the IMF content in the cardiac, chest and leg muscles of HTBC and in the cardiac and chest muscles of TYC. The relative m RNA expression of H-FABP was reduced in the cardiac and leg muscles of HTBC compared with TYC, but this difference was not observed at the protein level, as assessed by Western blot analysis.Conclusions： These findings offer essential data that can be useful in the breeding program of HTBC and future research exploring the role of H-FABP in IMF deposition and regulation in chickens.
