In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded s...In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping sheets.At the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded sheets.In this work,the bulging process of the tailor-welded overlapping sheets was taken as the research object.Aluminum alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental verification.The results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming quality.When increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.展开更多
To meet the intelligent detection needs of underwater defects in large hydropower stations,the hydrodynamic performance of a bionic streamlined remotely operated vehicle containing a thruster protective net structure ...To meet the intelligent detection needs of underwater defects in large hydropower stations,the hydrodynamic performance of a bionic streamlined remotely operated vehicle containing a thruster protective net structure is numerically simulated via computational fluid dynamics and overlapping mesh technology.The results show that the entity model generates greater hydrodynamic force during steady motion,whereas the square net model experiences greater force and moment during unsteady motion.The lateral and vertical force coefficients of the entity model are 4.32 and 3.13 times greater than those of the square net model in the oblique towing test simulation.The square net model also offers better static and dynamic stability,with a 24.5%increase in dynamic stability,achieving the highest lift-to-drag ratio at attack angles of 6°∼8°.This research provides valuable insights for designing and controlling underwater defect detection vehicles for large hydropower stations.展开更多
Effectively handling imbalanced datasets remains a fundamental challenge in computational modeling and machine learning,particularly when class overlap significantly deteriorates classification performance.Traditional...Effectively handling imbalanced datasets remains a fundamental challenge in computational modeling and machine learning,particularly when class overlap significantly deteriorates classification performance.Traditional oversampling methods often generate synthetic samples without considering density variations,leading to redundant or misleading instances that exacerbate class overlap in high-density regions.To address these limitations,we propose Wasserstein Generative Adversarial Network Variational Density Estimation WGAN-VDE,a computationally efficient density-aware adversarial resampling framework that enhances minority class representation while strategically reducing class overlap.The originality of WGAN-VDE lies in its density-aware sample refinement,ensuring that synthetic samples are positioned in underrepresented regions,thereby improving class distinctiveness.By applying structured feature representation,targeted sample generation,and density-based selection mechanisms strategies,the proposed framework ensures the generation of well-separated and diverse synthetic samples,improving class separability and reducing redundancy.The experimental evaluation on 20 benchmark datasets demonstrates that this approach outperforms 11 state-of-the-art rebalancing techniques,achieving superior results in F1-score,Accuracy,G-Mean,and AUC metrics.These results establish the proposed method as an effective and robust computational approach,suitable for diverse engineering and scientific applications involving imbalanced data classification and computational modeling.展开更多
Due to the network planning of subways and their surrounding structures,increasingly more overlapping shields with a small curve radius have been constructed. A newly constructed upper tunnel partly overlaps a lower o...Due to the network planning of subways and their surrounding structures,increasingly more overlapping shields with a small curve radius have been constructed. A newly constructed upper tunnel partly overlaps a lower one, leading to the extremely complex uplift of the lower tunnel caused by the construction of a new tunnel. Based on the shield-driven project that runs from the Qinghe Xiaoyingqiao Station to the Qinghe Station in Beijing, which adopts the reinforcement measures of interlayer soil grouting and steel supports on site, in this study, the uplift pattern of the lower tunnel and the stress characteristics of steel supports were investigated through numerical simulations and on-site monitoring.The study results show that among all tunnel segments, the first segment of the shield witnesses a maximum uplift displacement that increases with the horizontal space between tunnels. On using either interlayer soil grouting or steel-ring bracing reinforcement, the uplift of the tunnel lining exceeds the control value;by contrast,when these two measures are jointly applied, the uplift of the tunnel lining does not exceed a maximum value of 4.87 mm, which can satisfy the requirements of deformation control. Under these two joint measures, the soil strength between two stacked shield tunnels can be enhanced and the uplift deformation can be restricted with the interlayer soil grouting. Also, the segmental deformation and overall stability of the existing tunnel can be controlled with the temporary steel supports.The deformation of circumferential supports and segments is closely related to each other, and the segmental uplift is controlled by H-shaped steel supports. With the increase in the horizontal space between twin shields, the effect of the construction would gradually weaken, accompanied by a gradual reduction of the stresses of steel supports. These findings provide a valuable reference for the engineering design and safe construction of overlapping shield tunnels with a small curve radius.展开更多
Since the new curriculum reform,labor education has gradually shed its marginalized position in the“five educations,”and the labor curriculum has become an independent course officially separated from comprehensive ...Since the new curriculum reform,labor education has gradually shed its marginalized position in the“five educations,”and the labor curriculum has become an independent course officially separated from comprehensive practical activity courses.Exploring the practical path of labor curriculum in compulsory education in China has become the primary task of labor education in China.Based on the practical situation of labor curriculum in compulsory education in China,drawing on the theory of overlapping influence domains,and from the perspective of collaborative education among family,school,and community,this paper proposes a curriculum practical path of“school-led”family-school-community collaboration and a curriculum practical path guided by“student-centered”sentiment,in order to provide references for the practice of labor curriculum in compulsory education in China.展开更多
For addressing impulse noise in images, this paper proposes a denoising algorithm for non-convex impulse noise images based on the l_(0) norm fidelity term. Since the total variation of the l_(0) norm has a better den...For addressing impulse noise in images, this paper proposes a denoising algorithm for non-convex impulse noise images based on the l_(0) norm fidelity term. Since the total variation of the l_(0) norm has a better denoising effect on the pulse noise, it is chosen as the model fidelity term, and the overlapping group sparse term combined with non-convex higher term is used as the regularization term of the model to protect the image edge texture and suppress the staircase effect. At the same time, the alternating direction method of multipliers, the majorization–minimization method and the mathematical program with equilibrium constraints were used to solve the model. Experimental results show that the proposed model can effectively suppress the staircase effect in smooth regions, protect the image edge details, and perform better in terms of the peak signal-to-noise ratio and the structural similarity index measure.展开更多
BACKGROUND Gastro-esophageal reflux disease(GERD)may affect the upper digestive tract;up to 20%of population in Western nations are affected by GERD.Antacids,histamine H2-receptor antagonists,and Proton Pump Inhibitor...BACKGROUND Gastro-esophageal reflux disease(GERD)may affect the upper digestive tract;up to 20%of population in Western nations are affected by GERD.Antacids,histamine H2-receptor antagonists,and Proton Pump Inhibitors(PPIs)are considered the referring medications for GERD.Nevertheless,PPIs must be managed carefully because their use,especially chronic,could be linked with some adverse effects.An effective and safe alternative pharmacological tool for GERD is needed.After the identification of potentially new medications to flank PPIs,it is mandatory to revise and improve good clinical practices even through a consensus process.AIM To optimize diagnosis and treatment guidelines for GERD through a consensus based on Delphi method.METHODS The availability of clinical studies describing the action of the multicomponent/multitarget medication Nux vomica-Heel,subject of the consensus,is the basic prerequisite for the consensus itself.A modified Delphi process was used to reach a consensus among a panel of Italian GERD specialists on the overlapping approach PPIs/Nux vomica-Heel as a new intervention model for the management of GERD.The Voting Consensus group was composed of 49 Italian Medical Doctors with different specializations:Gastroenterology,otolaryngology,geriatrics,and general medicine.A scientific committee analyzed the literature,determined areas that required investigation(in agreement with the multiple-choice questionnaire results),and identified two topics of interest:(1)GERD disease;and(2)GERD treatment.Statements for each of these topics were then formulated and validated.The Delphi process involved two rounds of questioning submitted to the panel experts using an online platform.RESULTS According to their routinary GERD practice and current clinical evidence,the panel members provided feedback to each questionnaire statement.The experts evaluated 15 statements and reached consensus on all 15.The statements regarding the GERD disease showed high levels of agreement,with consensus ranging from 70%to 92%.The statements regarding the GERD treatment also showed very high levels of agreement,with consensus ranging from 90%to 100%.This Delphi process was able to reach consensus among physicians in relevant aspects of GERD management,such as the adoption of a new approach to treat patients with GERD based on the overlapping between PPIs and Nux vomica-Heel.The consensus was unanimous among the physicians with different specializations,underlying the uniqueness of the agreement reached to identify in the overlapping approach between PPIs and Nux vomica-Heel a new intervention model for GERD management.The results support that an effective approach to deprescribe PPIs through a progressive decalage timetable(reducing PPIs administration to as-needed use),should be considered.CONCLUSION Nux vomica-Heel appears to be a valid opportunity for GERD treatment to favor the deprescription of PPIs and to maintain low disease activity together with the symptomatology remission.展开更多
The large-scale multi-objective optimization algorithm(LSMOA),based on the grouping of decision variables,is an advanced method for handling high-dimensional decision variables.However,in practical problems,the intera...The large-scale multi-objective optimization algorithm(LSMOA),based on the grouping of decision variables,is an advanced method for handling high-dimensional decision variables.However,in practical problems,the interaction among decision variables is intricate,leading to large group sizes and suboptimal optimization effects;hence a large-scale multi-objective optimization algorithm based on weighted overlapping grouping of decision variables(MOEAWOD)is proposed in this paper.Initially,the decision variables are perturbed and categorized into convergence and diversity variables;subsequently,the convergence variables are subdivided into groups based on the interactions among different decision variables.If the size of a group surpasses the set threshold,that group undergoes a process of weighting and overlapping grouping.Specifically,the interaction strength is evaluated based on the interaction frequency and number of objectives among various decision variables.The decision variable with the highest interaction in the group is identified and disregarded,and the remaining variables are then reclassified into subgroups.Finally,the decision variable with the strongest interaction is added to each subgroup.MOEAWOD minimizes the interactivity between different groups and maximizes the interactivity of decision variables within groups,which contributed to the optimized direction of convergence and diversity exploration with different groups.MOEAWOD was subjected to testing on 18 benchmark large-scale optimization problems,and the experimental results demonstrate the effectiveness of our methods.Compared with the other algorithms,our method is still at an advantage.展开更多
BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been v...BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since then.Nocardia is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales order.Conventional methods for diagnosis of NTM are inefficient.Metagenomic next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare species.Most NTM and Nocardia infections occur in immunocompromised patients with atypical clinical symptoms.There are no previous reports of infection by M.canariasense and Nocardia farcinica(N.farcinica),especially in immunocompetent patients.This case report describes an immunocompetent 52-year-old woman who had overlapping infections of M.canariasense,N.farcinica,and Candida parapsilosis(C.parapsilosis)based on mNGS.CASE SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 wk.She received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain persisted.We collected samples of a lung lesion and alveolar lavage fluid for mNGS.The lung tissue was positive for M.canariasense,N.farcinica,and C.parapsilosis,and the alveolar lavage fluid was positive for M.canariasense.The diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the patient.CONCLUSION Etiological diagnosis is critical for patients with infectious diseases.mNGS can identify rare and novel pathogens,and does not require a priori knowledge.展开更多
The influences of strength coefficient K, work hardening exponent n and thickness t of the overlapping sheet on bulging process are analyzed based on hardening material model. Also, bulging experiments are carried out...The influences of strength coefficient K, work hardening exponent n and thickness t of the overlapping sheet on bulging process are analyzed based on hardening material model. Also, bulging experiments are carried out by taking the aluminum alloy LF21 as formed sheet metal, and selecting overlapping sheet with different thicknesses and material properties, by which accuracy of the above analysis result is verified in the aspects of geometric shape, thickness distribution and limit bulging height. The results show that higher strength coefficient K, larger work hardening exponent n and proper thickness of the overlapping sheet are helpful to improve the formability and forming uniformity of formed sheet metal.展开更多
The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield...The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield tunneling remains inadequate.The analytical solution for calculating the deformation of the ground and existing tunnel induced by overlapped curved shield tunneling is derived by the Mirror theory,Mindlin solution and Euler-Bernoulli-Pasternak model,subsequently validated through both finite element simulation and field monitoring.It is determined that the overcutting plays a crucial role in the ground settlement resulting from curved shield tunneling compared to straight shield tunneling.The longitudinal settlement distribution can be categorized into five areas,with the area near the tunnel surface experiencing the most dramatic settlement changes.The deformation of the existing tunnel varies most significantly with turning radius compared to tunnel clearance and grouting pressure,especially when the turning radius is less than 30 times the tunnel diameter.The tunnel crown exhibits larger displacement than the tunnel bottom,resulting in a distinctive‘vertical egg'shape.Furthermore,an optimized overcutting mode is proposed,involving precise control of the extension speed and angular velocity of the overcutting cutter,which effectively mitigates ground deformation,ensuring the protection of the existing tunnel during the construction.展开更多
With the large-scale integration of renewable energy sources into the grid,distribution networks are increasingly challenged by issues related to renewable energy accommodation and the mainte-nance of power quality st...With the large-scale integration of renewable energy sources into the grid,distribution networks are increasingly challenged by issues related to renewable energy accommodation and the mainte-nance of power quality stability.To address the challenge that existing partitioning methods are inad-equate for the planning and operation needs of active distribution networks under frequently changing power flow conditions,a three-stage dynamic partitioning approach is proposed based on an im-proved sand cat swarm optimization(ISCSO)algorithm.Firstly,a comprehensive dynamic partitio-ning index is developed by integrating both structural and functional metrics,including modularity,voltage regulation capability,and regional renewable energy accommodation capacity.Secondly,to overcome the limitations of the conventional sand cat swarm optimization,namely its weak global ex-ploration ability and tendency to fall into local optima in the later optimization stages,chaotic map-ping is employed to initialize a uniformly distributed population.A nonlinear sensitivity mechanism is introduced to balance global exploration and local exploitation,alongside the design of a particle encoding and position updating scheme tailored for dynamic partitioning.Furthermore,a‘state re-tention-local adjustment-global reconstruction’partitioning structure is developed.To avoid unnec-essary partition changes under minor source-load fluctuations,the concept of overlapping nodes is introduced,enabling fine-tuned adjustments under such conditions.Finally,two experimental sce-narios are designed to validate the proposed method.Simulation results demonstrate strong electrical coupling performance and show that the method enhances voltage regulation and renewable energy integration capabilities across regions.展开更多
It has recently become evident that the de novo emergence of genes is widespread and documented for a variety of organisms.De novo genes frequently emerge in proximity to existing genes,forming gene overlaps.Here,we p...It has recently become evident that the de novo emergence of genes is widespread and documented for a variety of organisms.De novo genes frequently emerge in proximity to existing genes,forming gene overlaps.Here,we present an analysis of the evolutionary history of a putative de novo gene,lawc,which overlaps with the conserved Trf2 gene,which encodes a general transcription factor in Drosophila melanogaster.We demonstrate that lawc emerged approximately 68 million years ago in the 5'-untranslated region(UTR)of Trf2 and displays an extensive spatiotemporal expression pattern.One of the most remarkable features of the lawc evolutionary history is that its emergence was facilitated by the engagement of Drosophilidae-specific short,highly conserved regions located in Trf2 introns.This represents a unique example of putative de novo gene birth involving conserved DNA regions localized in introns of conserved genes.The observed lawc expression pattern may be due to the overlap of lawc with the 5'-UTR of Trf2.This study not only enriches our understanding of gene evolution but also highlights the complex interplay between genetic conservation and innovation.展开更多
Medical image analysis based on deep learning has become an important technical requirement in the field of smart healthcare.In view of the difficulties in collaborative modeling of local details and global features i...Medical image analysis based on deep learning has become an important technical requirement in the field of smart healthcare.In view of the difficulties in collaborative modeling of local details and global features in multimodal image analysis of ophthalmology,as well as the existence of information redundancy in cross-modal data fusion,this paper proposes amultimodal fusion framework based on cross-modal collaboration and weighted attention mechanism.In terms of feature extraction,the framework collaboratively extracts local fine-grained features and global structural dependencies through a parallel dual-branch architecture,overcoming the limitations of traditional single-modality models in capturing either local or global information;in terms of fusion strategy,the framework innovatively designs a cross-modal dynamic fusion strategy,combining overlappingmulti-head self-attention modules with a bidirectional feature alignment mechanism,addressing the bottlenecks of low feature interaction efficiency and excessive attention fusion computations in traditional parallel fusion,and further introduces cross-domain local integration technology,which enhances the representation ability of the lesion area through pixel-level feature recalibration and optimizes the diagnostic robustness of complex cases.Experiments show that the framework exhibits excellent feature expression and generalization performance in cross-domain scenarios of ophthalmic medical images and natural images,providing a high-precision,low-redundancy fusion paradigm for multimodal medical image analysis,and promoting the upgrade of intelligent diagnosis and treatment fromsingle-modal static analysis to dynamic decision-making.展开更多
BACKGROUND Autoimmune liver diseases,including primary biliary cholangitis(PBC),autoi-mmune hepatitis(AIH),and their overlap syndrome(OS),involve immune-mediated liver injury,with OS occurring in 1.2%-25%of PBC patien...BACKGROUND Autoimmune liver diseases,including primary biliary cholangitis(PBC),autoi-mmune hepatitis(AIH),and their overlap syndrome(OS),involve immune-mediated liver injury,with OS occurring in 1.2%-25%of PBC patients.OS carries a higher risk of cirrhosis,hepatocellular carcinoma,and reduced survival.While its pathogenesis remains unclear,gut microbiota dysbiosis and serum metabolite alterations may play key roles.This study uses 16S rRNA sequencing and liquid chromatography-mass spec-trometry(LC-MS)metabolomics to compare gut microbiota and serum metabolites among PBC,AIH,and OS patients,and explores their associations with liver function.AIM To differentiate OS from PBC and AIH based on gut microbiota,serum metabolites,and liver function.METHODS Gut microbiota profiles were analyzed using 16S rRNA sequencing,while untargeted serum metabolomics was conducted via LC-MS.Comparative analyses were performed to identify differences in microbial composition and serum metabolite levels among PBC,AIH,and OS groups.Correlation analyses and network visualization tech-niques were applied to elucidate the interactions among liver function parameters,gut microbiota,and serum metabolites in OS patients.RESULTS Compared to patients with PBC or AIH,OS patients demonstrated significantly reduced microbial diversity and richness.Notable taxonomic shifts included decreased abundances of Firmicutes,Bacteroidetes,and Actinobacteria,alongside increased levels of Proteobacteria and Verrucomicrobia.Distinct serum metabolites,such as pentadecanoic acid and aminoimidazole carboxamide ribonucleotide,were identified in OS patients.Correlation analysis revealed that aspartate aminotransferase(AST)levels were negatively associated with the bacterial genus Fusicatenibacter and the metabolite L-Tyrosine.A microbial-metabolite network diagram further confirmed a strong association between Fusicatenibacter and L-Tyrosine in OS patients.CONCLUSION OS patients show decreased gut microbiota diversity and unique serum metabolites.Multi-omics linked AST,Fusicatenibacter,and L-Tyrosine,revealing OS mechanisms and diagnostic potential.展开更多
To address the challenges of fault line identification and low detection accuracy of wave head in Fault Location(FL)research of distribution networks with complex topologies,this paper proposes an FL method of Multi-B...To address the challenges of fault line identification and low detection accuracy of wave head in Fault Location(FL)research of distribution networks with complex topologies,this paper proposes an FL method of Multi-Branch distribution line based on Maximal Overlap Discrete Wavelet Transform(MODWT)combined with the improved Teager Energy Operator(TEO).Firstly,the current and voltage Traveling Wave(TW)signals at the head of each line are extracted,and the fault-induced components are obtained to determine the fault line by analyzing the polarity of the mutation amount of fault voltage and current TWs.Subsequently,the fault discrimination mark is calculated based on the fault-induced line-mode current and the zero-mode voltage,with the fault type determined by comparing each mark’s value against the fault discrimination table,transforming the FL problem in complex topology into a single-line FL problem.Finally,the fault voltage TW is extracted fromthe fault line,and the wave head detection method based on MODWT combined with improved TEO is used to precisely identify the arrival instants of both the first TW wave head and its first reflection at each line terminal,and then the FL result is calculated by applying the double-ended TW ranging formula that removes the influence of wave velocity.Simulation results demonstrate that the proposed method accurately identifies the fault line and types of faults occurring and maintains the ranging accuracy within 0.5%under various fault scenarios.展开更多
The transformation of natural habitats into human-modified landscapes has far-reaching consequences for species distribution and abundance.As species adapt to these changing environments,shifts in distribution pattern...The transformation of natural habitats into human-modified landscapes has far-reaching consequences for species distribution and abundance.As species adapt to these changing environments,shifts in distribution patterns,niche dynamics,and interspecies interactions may occur,impacting biodiversity at multiple levels and potentially leading to ecosystem imbalances.This study aims to assess the impact of variations in vegetation composition and human disturbance on the distribution of sympatric breeding birds and to determine the extent of niche overlap or differentiation among these species.We conducted field surveys and collected data on bird distribution,vegetation composition,and level of human disturbance in eastern Inner Mongolian grasslands.We focused on the six most frequently co-occurring breeding birds,representing a mix of sparrows,larks,and corvids.Generalized Additive Models revealed varying responses of species occurrence along habitat gradients.Species like the Eurasian Skylark(Alauda arvensis),Mongolian Lark(Melanocorypha mongolica),and Asian Shorttoed Lark(Calandrella cheleensis),increased in larger and more connected habitats,while others,like the Tree Sparrow(Passer montanus),Eurasian Magpie(Pica pica),and Barn Swallow(Hirundo rustica),adapted to more fragmented habitats.Niche analysis indicated habitat generalists tended to occupy larger niches than grassland specialists.Substantial niche overlap was also found among the six co-occurring bird species.Conservation efforts should consider the specific needs of specialist species and strive to maintain or restore critical grassland habitats.Additionally,promoting sustainable agricultural practices that balance the needs of birds and human activities can contribute to the coexistence of generalist and specialist bird species in modified landscapes.展开更多
基金Funded by the National Natural Science Foundation of China(Nos.52075347,51575364)and the Natural Science Foundation of Liaoning Provincial(No.2022-MS-295)。
文摘In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping sheets.At the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded sheets.In this work,the bulging process of the tailor-welded overlapping sheets was taken as the research object.Aluminum alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental verification.The results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming quality.When increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.
基金supported by the National Key R&D Program of China(Grant No.2022YFB4703401).
文摘To meet the intelligent detection needs of underwater defects in large hydropower stations,the hydrodynamic performance of a bionic streamlined remotely operated vehicle containing a thruster protective net structure is numerically simulated via computational fluid dynamics and overlapping mesh technology.The results show that the entity model generates greater hydrodynamic force during steady motion,whereas the square net model experiences greater force and moment during unsteady motion.The lateral and vertical force coefficients of the entity model are 4.32 and 3.13 times greater than those of the square net model in the oblique towing test simulation.The square net model also offers better static and dynamic stability,with a 24.5%increase in dynamic stability,achieving the highest lift-to-drag ratio at attack angles of 6°∼8°.This research provides valuable insights for designing and controlling underwater defect detection vehicles for large hydropower stations.
基金supported by Ongoing Research Funding Program(ORF-2025-488)King Saud University,Riyadh,Saudi Arabia.
文摘Effectively handling imbalanced datasets remains a fundamental challenge in computational modeling and machine learning,particularly when class overlap significantly deteriorates classification performance.Traditional oversampling methods often generate synthetic samples without considering density variations,leading to redundant or misleading instances that exacerbate class overlap in high-density regions.To address these limitations,we propose Wasserstein Generative Adversarial Network Variational Density Estimation WGAN-VDE,a computationally efficient density-aware adversarial resampling framework that enhances minority class representation while strategically reducing class overlap.The originality of WGAN-VDE lies in its density-aware sample refinement,ensuring that synthetic samples are positioned in underrepresented regions,thereby improving class distinctiveness.By applying structured feature representation,targeted sample generation,and density-based selection mechanisms strategies,the proposed framework ensures the generation of well-separated and diverse synthetic samples,improving class separability and reducing redundancy.The experimental evaluation on 20 benchmark datasets demonstrates that this approach outperforms 11 state-of-the-art rebalancing techniques,achieving superior results in F1-score,Accuracy,G-Mean,and AUC metrics.These results establish the proposed method as an effective and robust computational approach,suitable for diverse engineering and scientific applications involving imbalanced data classification and computational modeling.
基金National Natural Science Foundation of China,Grant/Award Number:52168059Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region,Grant/Award Number:NJYT23103Fundamental Research Funds in Universities of Inner Mongolia Autonomous Region,Grant/Award Number:2023QNJS159。
文摘Due to the network planning of subways and their surrounding structures,increasingly more overlapping shields with a small curve radius have been constructed. A newly constructed upper tunnel partly overlaps a lower one, leading to the extremely complex uplift of the lower tunnel caused by the construction of a new tunnel. Based on the shield-driven project that runs from the Qinghe Xiaoyingqiao Station to the Qinghe Station in Beijing, which adopts the reinforcement measures of interlayer soil grouting and steel supports on site, in this study, the uplift pattern of the lower tunnel and the stress characteristics of steel supports were investigated through numerical simulations and on-site monitoring.The study results show that among all tunnel segments, the first segment of the shield witnesses a maximum uplift displacement that increases with the horizontal space between tunnels. On using either interlayer soil grouting or steel-ring bracing reinforcement, the uplift of the tunnel lining exceeds the control value;by contrast,when these two measures are jointly applied, the uplift of the tunnel lining does not exceed a maximum value of 4.87 mm, which can satisfy the requirements of deformation control. Under these two joint measures, the soil strength between two stacked shield tunnels can be enhanced and the uplift deformation can be restricted with the interlayer soil grouting. Also, the segmental deformation and overall stability of the existing tunnel can be controlled with the temporary steel supports.The deformation of circumferential supports and segments is closely related to each other, and the segmental uplift is controlled by H-shaped steel supports. With the increase in the horizontal space between twin shields, the effect of the construction would gradually weaken, accompanied by a gradual reduction of the stresses of steel supports. These findings provide a valuable reference for the engineering design and safe construction of overlapping shield tunnels with a small curve radius.
文摘Since the new curriculum reform,labor education has gradually shed its marginalized position in the“five educations,”and the labor curriculum has become an independent course officially separated from comprehensive practical activity courses.Exploring the practical path of labor curriculum in compulsory education in China has become the primary task of labor education in China.Based on the practical situation of labor curriculum in compulsory education in China,drawing on the theory of overlapping influence domains,and from the perspective of collaborative education among family,school,and community,this paper proposes a curriculum practical path of“school-led”family-school-community collaboration and a curriculum practical path guided by“student-centered”sentiment,in order to provide references for the practice of labor curriculum in compulsory education in China.
基金funded by National Nature Science Foundation of China,grant number 61302188。
文摘For addressing impulse noise in images, this paper proposes a denoising algorithm for non-convex impulse noise images based on the l_(0) norm fidelity term. Since the total variation of the l_(0) norm has a better denoising effect on the pulse noise, it is chosen as the model fidelity term, and the overlapping group sparse term combined with non-convex higher term is used as the regularization term of the model to protect the image edge texture and suppress the staircase effect. At the same time, the alternating direction method of multipliers, the majorization–minimization method and the mathematical program with equilibrium constraints were used to solve the model. Experimental results show that the proposed model can effectively suppress the staircase effect in smooth regions, protect the image edge details, and perform better in terms of the peak signal-to-noise ratio and the structural similarity index measure.
文摘BACKGROUND Gastro-esophageal reflux disease(GERD)may affect the upper digestive tract;up to 20%of population in Western nations are affected by GERD.Antacids,histamine H2-receptor antagonists,and Proton Pump Inhibitors(PPIs)are considered the referring medications for GERD.Nevertheless,PPIs must be managed carefully because their use,especially chronic,could be linked with some adverse effects.An effective and safe alternative pharmacological tool for GERD is needed.After the identification of potentially new medications to flank PPIs,it is mandatory to revise and improve good clinical practices even through a consensus process.AIM To optimize diagnosis and treatment guidelines for GERD through a consensus based on Delphi method.METHODS The availability of clinical studies describing the action of the multicomponent/multitarget medication Nux vomica-Heel,subject of the consensus,is the basic prerequisite for the consensus itself.A modified Delphi process was used to reach a consensus among a panel of Italian GERD specialists on the overlapping approach PPIs/Nux vomica-Heel as a new intervention model for the management of GERD.The Voting Consensus group was composed of 49 Italian Medical Doctors with different specializations:Gastroenterology,otolaryngology,geriatrics,and general medicine.A scientific committee analyzed the literature,determined areas that required investigation(in agreement with the multiple-choice questionnaire results),and identified two topics of interest:(1)GERD disease;and(2)GERD treatment.Statements for each of these topics were then formulated and validated.The Delphi process involved two rounds of questioning submitted to the panel experts using an online platform.RESULTS According to their routinary GERD practice and current clinical evidence,the panel members provided feedback to each questionnaire statement.The experts evaluated 15 statements and reached consensus on all 15.The statements regarding the GERD disease showed high levels of agreement,with consensus ranging from 70%to 92%.The statements regarding the GERD treatment also showed very high levels of agreement,with consensus ranging from 90%to 100%.This Delphi process was able to reach consensus among physicians in relevant aspects of GERD management,such as the adoption of a new approach to treat patients with GERD based on the overlapping between PPIs and Nux vomica-Heel.The consensus was unanimous among the physicians with different specializations,underlying the uniqueness of the agreement reached to identify in the overlapping approach between PPIs and Nux vomica-Heel a new intervention model for GERD management.The results support that an effective approach to deprescribe PPIs through a progressive decalage timetable(reducing PPIs administration to as-needed use),should be considered.CONCLUSION Nux vomica-Heel appears to be a valid opportunity for GERD treatment to favor the deprescription of PPIs and to maintain low disease activity together with the symptomatology remission.
基金supported in part by the Central Government Guides Local Science and TechnologyDevelopment Funds(Grant No.YDZJSX2021A038)in part by theNational Natural Science Foundation of China under(Grant No.61806138)in part by the China University Industry-University-Research Collaborative Innovation Fund(Future Network Innovation Research and Application Project)(Grant 2021FNA04014).
文摘The large-scale multi-objective optimization algorithm(LSMOA),based on the grouping of decision variables,is an advanced method for handling high-dimensional decision variables.However,in practical problems,the interaction among decision variables is intricate,leading to large group sizes and suboptimal optimization effects;hence a large-scale multi-objective optimization algorithm based on weighted overlapping grouping of decision variables(MOEAWOD)is proposed in this paper.Initially,the decision variables are perturbed and categorized into convergence and diversity variables;subsequently,the convergence variables are subdivided into groups based on the interactions among different decision variables.If the size of a group surpasses the set threshold,that group undergoes a process of weighting and overlapping grouping.Specifically,the interaction strength is evaluated based on the interaction frequency and number of objectives among various decision variables.The decision variable with the highest interaction in the group is identified and disregarded,and the remaining variables are then reclassified into subgroups.Finally,the decision variable with the strongest interaction is added to each subgroup.MOEAWOD minimizes the interactivity between different groups and maximizes the interactivity of decision variables within groups,which contributed to the optimized direction of convergence and diversity exploration with different groups.MOEAWOD was subjected to testing on 18 benchmark large-scale optimization problems,and the experimental results demonstrate the effectiveness of our methods.Compared with the other algorithms,our method is still at an advantage.
基金Supported by The Guangxi TCM Suitable Technology Development and Promotion Project,No.GZSY20-20.
文摘BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since then.Nocardia is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales order.Conventional methods for diagnosis of NTM are inefficient.Metagenomic next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare species.Most NTM and Nocardia infections occur in immunocompromised patients with atypical clinical symptoms.There are no previous reports of infection by M.canariasense and Nocardia farcinica(N.farcinica),especially in immunocompetent patients.This case report describes an immunocompetent 52-year-old woman who had overlapping infections of M.canariasense,N.farcinica,and Candida parapsilosis(C.parapsilosis)based on mNGS.CASE SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 wk.She received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain persisted.We collected samples of a lung lesion and alveolar lavage fluid for mNGS.The lung tissue was positive for M.canariasense,N.farcinica,and C.parapsilosis,and the alveolar lavage fluid was positive for M.canariasense.The diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the patient.CONCLUSION Etiological diagnosis is critical for patients with infectious diseases.mNGS can identify rare and novel pathogens,and does not require a priori knowledge.
基金Project(51205260)supported by the National Natural Science Foundation of ChinaProject(L2012046)supported by the Liaoning Provincial Committee of Education,China
文摘The influences of strength coefficient K, work hardening exponent n and thickness t of the overlapping sheet on bulging process are analyzed based on hardening material model. Also, bulging experiments are carried out by taking the aluminum alloy LF21 as formed sheet metal, and selecting overlapping sheet with different thicknesses and material properties, by which accuracy of the above analysis result is verified in the aspects of geometric shape, thickness distribution and limit bulging height. The results show that higher strength coefficient K, larger work hardening exponent n and proper thickness of the overlapping sheet are helpful to improve the formability and forming uniformity of formed sheet metal.
基金financially supported by the National Natural Science Foundation of China(Grant No.52078334)the National Key Research and Development Program of China(Grant No.2017YFC0805402)the Tianjin Research Innovation Project for Postgraduate Students(Grant No.2021YJSB141).
文摘The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield tunneling remains inadequate.The analytical solution for calculating the deformation of the ground and existing tunnel induced by overlapped curved shield tunneling is derived by the Mirror theory,Mindlin solution and Euler-Bernoulli-Pasternak model,subsequently validated through both finite element simulation and field monitoring.It is determined that the overcutting plays a crucial role in the ground settlement resulting from curved shield tunneling compared to straight shield tunneling.The longitudinal settlement distribution can be categorized into five areas,with the area near the tunnel surface experiencing the most dramatic settlement changes.The deformation of the existing tunnel varies most significantly with turning radius compared to tunnel clearance and grouting pressure,especially when the turning radius is less than 30 times the tunnel diameter.The tunnel crown exhibits larger displacement than the tunnel bottom,resulting in a distinctive‘vertical egg'shape.Furthermore,an optimized overcutting mode is proposed,involving precise control of the extension speed and angular velocity of the overcutting cutter,which effectively mitigates ground deformation,ensuring the protection of the existing tunnel during the construction.
基金Supported by the Technology Project of State Grid Corporation Headquarters(No.5100-202322029A-1-1-ZN)the 2024 Youth Science Foun-dation Project(No.62303006).
文摘With the large-scale integration of renewable energy sources into the grid,distribution networks are increasingly challenged by issues related to renewable energy accommodation and the mainte-nance of power quality stability.To address the challenge that existing partitioning methods are inad-equate for the planning and operation needs of active distribution networks under frequently changing power flow conditions,a three-stage dynamic partitioning approach is proposed based on an im-proved sand cat swarm optimization(ISCSO)algorithm.Firstly,a comprehensive dynamic partitio-ning index is developed by integrating both structural and functional metrics,including modularity,voltage regulation capability,and regional renewable energy accommodation capacity.Secondly,to overcome the limitations of the conventional sand cat swarm optimization,namely its weak global ex-ploration ability and tendency to fall into local optima in the later optimization stages,chaotic map-ping is employed to initialize a uniformly distributed population.A nonlinear sensitivity mechanism is introduced to balance global exploration and local exploitation,alongside the design of a particle encoding and position updating scheme tailored for dynamic partitioning.Furthermore,a‘state re-tention-local adjustment-global reconstruction’partitioning structure is developed.To avoid unnec-essary partition changes under minor source-load fluctuations,the concept of overlapping nodes is introduced,enabling fine-tuned adjustments under such conditions.Finally,two experimental sce-narios are designed to validate the proposed method.Simulation results demonstrate strong electrical coupling performance and show that the method enhances voltage regulation and renewable energy integration capabilities across regions.
基金funded by a grant from the Russian Science Foundation № 24-24-00354
文摘It has recently become evident that the de novo emergence of genes is widespread and documented for a variety of organisms.De novo genes frequently emerge in proximity to existing genes,forming gene overlaps.Here,we present an analysis of the evolutionary history of a putative de novo gene,lawc,which overlaps with the conserved Trf2 gene,which encodes a general transcription factor in Drosophila melanogaster.We demonstrate that lawc emerged approximately 68 million years ago in the 5'-untranslated region(UTR)of Trf2 and displays an extensive spatiotemporal expression pattern.One of the most remarkable features of the lawc evolutionary history is that its emergence was facilitated by the engagement of Drosophilidae-specific short,highly conserved regions located in Trf2 introns.This represents a unique example of putative de novo gene birth involving conserved DNA regions localized in introns of conserved genes.The observed lawc expression pattern may be due to the overlap of lawc with the 5'-UTR of Trf2.This study not only enriches our understanding of gene evolution but also highlights the complex interplay between genetic conservation and innovation.
基金funded by the Ongoing Research Funding Program(ORF-2025-102),King Saud University,Riyadh,Saudi Arabiaby the Science and Technology Research Programof Chongqing Municipal Education Commission(Grant No.KJQN202400813)by the Graduate Research Innovation Project(Grant Nos.yjscxx2025-269-193 and CYS25618).
文摘Medical image analysis based on deep learning has become an important technical requirement in the field of smart healthcare.In view of the difficulties in collaborative modeling of local details and global features in multimodal image analysis of ophthalmology,as well as the existence of information redundancy in cross-modal data fusion,this paper proposes amultimodal fusion framework based on cross-modal collaboration and weighted attention mechanism.In terms of feature extraction,the framework collaboratively extracts local fine-grained features and global structural dependencies through a parallel dual-branch architecture,overcoming the limitations of traditional single-modality models in capturing either local or global information;in terms of fusion strategy,the framework innovatively designs a cross-modal dynamic fusion strategy,combining overlappingmulti-head self-attention modules with a bidirectional feature alignment mechanism,addressing the bottlenecks of low feature interaction efficiency and excessive attention fusion computations in traditional parallel fusion,and further introduces cross-domain local integration technology,which enhances the representation ability of the lesion area through pixel-level feature recalibration and optimizes the diagnostic robustness of complex cases.Experiments show that the framework exhibits excellent feature expression and generalization performance in cross-domain scenarios of ophthalmic medical images and natural images,providing a high-precision,low-redundancy fusion paradigm for multimodal medical image analysis,and promoting the upgrade of intelligent diagnosis and treatment fromsingle-modal static analysis to dynamic decision-making.
基金Supported by WBE Liver Foundation,No.WBE20220182022 Young and Middle-aged Talents Incubation Project(Youth Innovation)of Beijing Youan Hospital,Capital Medical University,No.BJYAYY-YN-2022-092023 Young and Middle-aged Talents Incubation Project(Youth Innovation)of Beijing Youan Hospital,Capital Medical University,No.BJYAYYYN2023-14.
文摘BACKGROUND Autoimmune liver diseases,including primary biliary cholangitis(PBC),autoi-mmune hepatitis(AIH),and their overlap syndrome(OS),involve immune-mediated liver injury,with OS occurring in 1.2%-25%of PBC patients.OS carries a higher risk of cirrhosis,hepatocellular carcinoma,and reduced survival.While its pathogenesis remains unclear,gut microbiota dysbiosis and serum metabolite alterations may play key roles.This study uses 16S rRNA sequencing and liquid chromatography-mass spec-trometry(LC-MS)metabolomics to compare gut microbiota and serum metabolites among PBC,AIH,and OS patients,and explores their associations with liver function.AIM To differentiate OS from PBC and AIH based on gut microbiota,serum metabolites,and liver function.METHODS Gut microbiota profiles were analyzed using 16S rRNA sequencing,while untargeted serum metabolomics was conducted via LC-MS.Comparative analyses were performed to identify differences in microbial composition and serum metabolite levels among PBC,AIH,and OS groups.Correlation analyses and network visualization tech-niques were applied to elucidate the interactions among liver function parameters,gut microbiota,and serum metabolites in OS patients.RESULTS Compared to patients with PBC or AIH,OS patients demonstrated significantly reduced microbial diversity and richness.Notable taxonomic shifts included decreased abundances of Firmicutes,Bacteroidetes,and Actinobacteria,alongside increased levels of Proteobacteria and Verrucomicrobia.Distinct serum metabolites,such as pentadecanoic acid and aminoimidazole carboxamide ribonucleotide,were identified in OS patients.Correlation analysis revealed that aspartate aminotransferase(AST)levels were negatively associated with the bacterial genus Fusicatenibacter and the metabolite L-Tyrosine.A microbial-metabolite network diagram further confirmed a strong association between Fusicatenibacter and L-Tyrosine in OS patients.CONCLUSION OS patients show decreased gut microbiota diversity and unique serum metabolites.Multi-omics linked AST,Fusicatenibacter,and L-Tyrosine,revealing OS mechanisms and diagnostic potential.
基金funded by the project of Guizhou Power Grid Co.,Ltd.Guiyang Power Supply Bureau(No.GZKJXM20232317).
文摘To address the challenges of fault line identification and low detection accuracy of wave head in Fault Location(FL)research of distribution networks with complex topologies,this paper proposes an FL method of Multi-Branch distribution line based on Maximal Overlap Discrete Wavelet Transform(MODWT)combined with the improved Teager Energy Operator(TEO).Firstly,the current and voltage Traveling Wave(TW)signals at the head of each line are extracted,and the fault-induced components are obtained to determine the fault line by analyzing the polarity of the mutation amount of fault voltage and current TWs.Subsequently,the fault discrimination mark is calculated based on the fault-induced line-mode current and the zero-mode voltage,with the fault type determined by comparing each mark’s value against the fault discrimination table,transforming the FL problem in complex topology into a single-line FL problem.Finally,the fault voltage TW is extracted fromthe fault line,and the wave head detection method based on MODWT combined with improved TEO is used to precisely identify the arrival instants of both the first TW wave head and its first reflection at each line terminal,and then the FL result is calculated by applying the double-ended TW ranging formula that removes the influence of wave velocity.Simulation results demonstrate that the proposed method accurately identifies the fault line and types of faults occurring and maintains the ranging accuracy within 0.5%under various fault scenarios.
基金supported by the National Natural Science Foundation of China (No.32201304)the Fundamental Research Funds for the Central Universities (No.2412022QD026)。
文摘The transformation of natural habitats into human-modified landscapes has far-reaching consequences for species distribution and abundance.As species adapt to these changing environments,shifts in distribution patterns,niche dynamics,and interspecies interactions may occur,impacting biodiversity at multiple levels and potentially leading to ecosystem imbalances.This study aims to assess the impact of variations in vegetation composition and human disturbance on the distribution of sympatric breeding birds and to determine the extent of niche overlap or differentiation among these species.We conducted field surveys and collected data on bird distribution,vegetation composition,and level of human disturbance in eastern Inner Mongolian grasslands.We focused on the six most frequently co-occurring breeding birds,representing a mix of sparrows,larks,and corvids.Generalized Additive Models revealed varying responses of species occurrence along habitat gradients.Species like the Eurasian Skylark(Alauda arvensis),Mongolian Lark(Melanocorypha mongolica),and Asian Shorttoed Lark(Calandrella cheleensis),increased in larger and more connected habitats,while others,like the Tree Sparrow(Passer montanus),Eurasian Magpie(Pica pica),and Barn Swallow(Hirundo rustica),adapted to more fragmented habitats.Niche analysis indicated habitat generalists tended to occupy larger niches than grassland specialists.Substantial niche overlap was also found among the six co-occurring bird species.Conservation efforts should consider the specific needs of specialist species and strive to maintain or restore critical grassland habitats.Additionally,promoting sustainable agricultural practices that balance the needs of birds and human activities can contribute to the coexistence of generalist and specialist bird species in modified landscapes.
