After a reivew of basic concepts in multiple criteria optimization, the paper presents a characterization of noncooperative equilibria in multiple criteria games in normal form either by weighted sums or by. order-con...After a reivew of basic concepts in multiple criteria optimization, the paper presents a characterization of noncooperative equilibria in multiple criteria games in normal form either by weighted sums or by. order-consistent achievement scalarizing functions, for convex and nonconvex cases. Possible applications of multiple criteria games and such characterizations of their equilibria are indicated. The analysis of multiple criteria games might be especially useful when studying reasons of possible conflict escalation processes and ways of preventing them.展开更多
This work proposes an innovative approach to evaluate the functional characteristics of a heterogeneous underwater wireless acoustic sensor network(UWASN)using a stochastic model and the network connectivity criterion...This work proposes an innovative approach to evaluate the functional characteristics of a heterogeneous underwater wireless acoustic sensor network(UWASN)using a stochastic model and the network connectivity criterion.The connectivity criterion is probabilistic and considers inherently distinct groups of parameters:technical parameters that determine the network function at specific levels of the communication stack and physical parameters that describe the environment in the water area.The proposed approach enables researchers to evaluate the network characteristics in terms of energy efficiency and reliability while considering specific network and environmental parameters.Moreover,this approach is a simple and convenient tool for analyzing the effectiveness of protocols in various open systems interconnection model levels.It is possible to assess the potential capabilities of any protocol and include it in the proposed model.This work presents the results of modeling the critical characteristics of heterogeneous three-dimensional UWASNs of different scales consisting of stationary sensors and a wave glider as a mobile gateway,using specific protocols as examples.Several alternative routes for the wave glider are considered to optimize the network’s functional capabilities.Optimal trajectories of the wave glider’s movement have been determined in terms of ensuring the efficiency and reliability of the hybrid UWASN at various scales.In the context of the problem,an evaluation of different reference node placement was to ensure message transmission to a mobile gateway.The best location of reference nodes has been found.展开更多
A design approach is presented in this paper for underactuation in robotic finger mechanisms. The characters of underactuated finger mechanisms are introduced as based on linkage and spring systems. The feature of sel...A design approach is presented in this paper for underactuation in robotic finger mechanisms. The characters of underactuated finger mechanisms are introduced as based on linkage and spring systems. The feature of self-adaptive enveloping grasp by underactuated finger mechanisms is discussed with feasible in grasping unknown objects. The design problem of robotic fingers is analyzed by looking at many aspects for an optimal functionality. Design problems and requirements for underactuated mechanisms are formulated as related to human-like robotic fingers. In particular, characteristics of finger mechanisms are analyzed and optimality criteria are summarized with the aim to formulate a general design algorithm. A general multi-objective optimization design approach is applied as based on a suitable optimization problem by using suitable expressions of optimality criteria. An example is illustrated as an improvement of finger mechanism in Laboratory of Robotics and Mechatronics （LARM） Hand. Results of design outputs and grasp simulations are reported with the aim to show the practical feasibility of the proposed concepts and computations.展开更多
Axial overlap(AO)and percent pitch(PP)are considered as key position configuration parameters that affect the tandem cascade performance.The objective of the current study is to investigate the optimal design criteria...Axial overlap(AO)and percent pitch(PP)are considered as key position configuration parameters that affect the tandem cascade performance.The objective of the current study is to investigate the optimal design criteria for these two parameters in tandem cascades of subsonic highly-loaded two-dimensional compressors.Before that,the influence mechanisms of AO and PP are explored separately.Research results show that higher PP is beneficial for decreasing rear blade(RB)load,but an invalidity of gap flow occurs when it approaches 1.The change in AO has an influence on the adverse pressure gradient of the front blade(FB),and it also affects the gap flow strength and FB wake development.Then,the optimal design criteria for AO and PP are obtained in a large design space,which clarifies the matching relationship of the two parameters at different operating conditions.The best global range of AO is about-0.05 to 0.05 while PP is between 0.85 to 0.92,and PP should be smaller to avoid performance degradation as AO increases.According to the fault tolerance in practical applications,PP should be closer to the lower bound to ensure that the deterioration boundary is wide enough.展开更多
Donor selection determines the occurrence of acute graft-versus-host-disease(aGVHD)following allogeneic hematopoietic stem cell transplantation(allo-HSCT).To optimize the current clinical donor selection criteria and ...Donor selection determines the occurrence of acute graft-versus-host-disease(aGVHD)following allogeneic hematopoietic stem cell transplantation(allo-HSCT).To optimize the current clinical donor selection criteria and identify putative donor lymphocyte subsets associated with better recipient outcomes,we analyzed the peripheral CD4^(+)and CD8^(+)subsets in 80 granulocyte colonystimulating factor(G-CSF)mobilized donors and examined the aGVHD incidence of the corresponding 80 haploidentical and identical allo-HSCT recipients.The G-CSF-induced expansion of subsets varied among donors.We discovered a novel PD-1^(+)CD8^(+)CD45RA^(+)CCR7^(+)T lymphocyte subset in suitable donors that was significantly correlated with lower incidence of aGVHD and post-transplant anti-infection.The anti-aGVHD activity of this subset was confirmed in a validation cohort(n=30).Single-cell RNA sequencing revealed that this T cell subset exhibited transcriptomic features of stem cell-like memory T cell(TSCM)with both Treg and Teff activities which indicated its dual functions in aGVHD inhibition and graft-versus-leukemia(GVL)effect.Intriguingly,upon G-CSF mobilization,the donor PD-1^(+)CD8^(+)TSCM-like regulatory cells increased the PD-1 expression in a BCL6-dependent manner.Next,we showed that the mouse counterpart of this subset(PD-1^(+)CD8^(+)CD44^(-)CD62L^(+))ameliorated aGVHD,and confirmed the existence of this subset in clinical recipients.In summary,we,for the first time,identified a novel donor peripheral T cell subset suppressing aGVHD while promoting the immune reconstitution of recipients.It may serve as an indicator for optimal haploidentical and identical donor selection.Importantly,the dual Treg and Teff function of these T cells makes it a promising treatment for not only aGVHD but also auto-immune diseases.展开更多
Convex cones are closely related to preference relations and play an important role in optimization.Corresponding to any convex cone,a binary relation can be defined,but the reverse is not true.Therefore,many binary r...Convex cones are closely related to preference relations and play an important role in optimization.Corresponding to any convex cone,a binary relation can be defined,but the reverse is not true.Therefore,many binary relations are discarded in the optimization.This paper is an attempt to define or prove the prerequisites for using convex coradiant sets(coradiants for simplicity)instead of convex cones so that more binary relations can be used in optimization and nonlinear analysis.展开更多
文摘After a reivew of basic concepts in multiple criteria optimization, the paper presents a characterization of noncooperative equilibria in multiple criteria games in normal form either by weighted sums or by. order-consistent achievement scalarizing functions, for convex and nonconvex cases. Possible applications of multiple criteria games and such characterizations of their equilibria are indicated. The analysis of multiple criteria games might be especially useful when studying reasons of possible conflict escalation processes and ways of preventing them.
基金partially funded by the Ministry of Science and Higher Education of the Russian Federation as a part of World-class Research Center Program:Advanced Digital Technologies(contract No.075-15-2022-312 dated 20 April 2022).
文摘This work proposes an innovative approach to evaluate the functional characteristics of a heterogeneous underwater wireless acoustic sensor network(UWASN)using a stochastic model and the network connectivity criterion.The connectivity criterion is probabilistic and considers inherently distinct groups of parameters:technical parameters that determine the network function at specific levels of the communication stack and physical parameters that describe the environment in the water area.The proposed approach enables researchers to evaluate the network characteristics in terms of energy efficiency and reliability while considering specific network and environmental parameters.Moreover,this approach is a simple and convenient tool for analyzing the effectiveness of protocols in various open systems interconnection model levels.It is possible to assess the potential capabilities of any protocol and include it in the proposed model.This work presents the results of modeling the critical characteristics of heterogeneous three-dimensional UWASNs of different scales consisting of stationary sensors and a wave glider as a mobile gateway,using specific protocols as examples.Several alternative routes for the wave glider are considered to optimize the network’s functional capabilities.Optimal trajectories of the wave glider’s movement have been determined in terms of ensuring the efficiency and reliability of the hybrid UWASN at various scales.In the context of the problem,an evaluation of different reference node placement was to ensure message transmission to a mobile gateway.The best location of reference nodes has been found.
基金supported by Key International S&T Cooperation Project (Grant No. 2008DFA81280)Part of this work has been developed within the project No.27 of the Italy-China program 2006–2009+1 种基金A joined study of first author at Laboratory of Robotics and Mechatronics (LARM) during 2007–2008 has been supported by state scholarship program of China Scholarship Council (CSC)Innovation Foundation of Beijing University of Aeronautics and Astronautics (BUAA) for PhD Graduates
文摘A design approach is presented in this paper for underactuation in robotic finger mechanisms. The characters of underactuated finger mechanisms are introduced as based on linkage and spring systems. The feature of self-adaptive enveloping grasp by underactuated finger mechanisms is discussed with feasible in grasping unknown objects. The design problem of robotic fingers is analyzed by looking at many aspects for an optimal functionality. Design problems and requirements for underactuated mechanisms are formulated as related to human-like robotic fingers. In particular, characteristics of finger mechanisms are analyzed and optimality criteria are summarized with the aim to formulate a general design algorithm. A general multi-objective optimization design approach is applied as based on a suitable optimization problem by using suitable expressions of optimality criteria. An example is illustrated as an improvement of finger mechanism in Laboratory of Robotics and Mechatronics （LARM） Hand. Results of design outputs and grasp simulations are reported with the aim to show the practical feasibility of the proposed concepts and computations.
基金supported by the National Natural Science Foundation of China(Grant numbers 52106057,92152301)the Fundamental Research Funds for the Central Universities(Grant number D5000210483)+2 种基金the Foundation of State Level Key Laboratory of Airfoil and Cascade Aerodynamics(Grant numbers D5150210006,D5050220008)the 111 Project(No.B17037)the Key Laboratory of Flow Visualization and Measurement Techniques,AVIC Aerodynamics Research Institute(D5110220177).
文摘Axial overlap(AO)and percent pitch(PP)are considered as key position configuration parameters that affect the tandem cascade performance.The objective of the current study is to investigate the optimal design criteria for these two parameters in tandem cascades of subsonic highly-loaded two-dimensional compressors.Before that,the influence mechanisms of AO and PP are explored separately.Research results show that higher PP is beneficial for decreasing rear blade(RB)load,but an invalidity of gap flow occurs when it approaches 1.The change in AO has an influence on the adverse pressure gradient of the front blade(FB),and it also affects the gap flow strength and FB wake development.Then,the optimal design criteria for AO and PP are obtained in a large design space,which clarifies the matching relationship of the two parameters at different operating conditions.The best global range of AO is about-0.05 to 0.05 while PP is between 0.85 to 0.92,and PP should be smaller to avoid performance degradation as AO increases.According to the fault tolerance in practical applications,PP should be closer to the lower bound to ensure that the deterioration boundary is wide enough.
基金supported by grants from the National Key Research and Development Program of China(2017YFA0104500)the Program for Scientific and Technological Innovation from the Science and Technology Commission of Shanghai Municipality(22490760400)+1 种基金the National Natural Science Foundation of China(Grant No.82071856,81671579,81930004)Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(2060302).
文摘Donor selection determines the occurrence of acute graft-versus-host-disease(aGVHD)following allogeneic hematopoietic stem cell transplantation(allo-HSCT).To optimize the current clinical donor selection criteria and identify putative donor lymphocyte subsets associated with better recipient outcomes,we analyzed the peripheral CD4^(+)and CD8^(+)subsets in 80 granulocyte colonystimulating factor(G-CSF)mobilized donors and examined the aGVHD incidence of the corresponding 80 haploidentical and identical allo-HSCT recipients.The G-CSF-induced expansion of subsets varied among donors.We discovered a novel PD-1^(+)CD8^(+)CD45RA^(+)CCR7^(+)T lymphocyte subset in suitable donors that was significantly correlated with lower incidence of aGVHD and post-transplant anti-infection.The anti-aGVHD activity of this subset was confirmed in a validation cohort(n=30).Single-cell RNA sequencing revealed that this T cell subset exhibited transcriptomic features of stem cell-like memory T cell(TSCM)with both Treg and Teff activities which indicated its dual functions in aGVHD inhibition and graft-versus-leukemia(GVL)effect.Intriguingly,upon G-CSF mobilization,the donor PD-1^(+)CD8^(+)TSCM-like regulatory cells increased the PD-1 expression in a BCL6-dependent manner.Next,we showed that the mouse counterpart of this subset(PD-1^(+)CD8^(+)CD44^(-)CD62L^(+))ameliorated aGVHD,and confirmed the existence of this subset in clinical recipients.In summary,we,for the first time,identified a novel donor peripheral T cell subset suppressing aGVHD while promoting the immune reconstitution of recipients.It may serve as an indicator for optimal haploidentical and identical donor selection.Importantly,the dual Treg and Teff function of these T cells makes it a promising treatment for not only aGVHD but also auto-immune diseases.
文摘Convex cones are closely related to preference relations and play an important role in optimization.Corresponding to any convex cone,a binary relation can be defined,but the reverse is not true.Therefore,many binary relations are discarded in the optimization.This paper is an attempt to define or prove the prerequisites for using convex coradiant sets(coradiants for simplicity)instead of convex cones so that more binary relations can be used in optimization and nonlinear analysis.
