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基于RhoA/ROCK通路探讨沙库巴曲缬沙坦治疗慢性心力衰竭的作用机制
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作者 孙丽娜 张艳华 《淮海医药》 2026年第1期92-95,共4页
目的:基于Rho蛋白A/Rho相关蛋白激(RhoA/ROCK)通路探讨沙库巴曲缬沙坦治疗慢性心力衰竭(CHF)的作用机制。方法:选取郑州市中心医院2022年6月—2024年1月收治的116例CHF患者开展前瞻性研究,采用数字抽签法随机分为常规组(58例)和试验组(5... 目的:基于Rho蛋白A/Rho相关蛋白激(RhoA/ROCK)通路探讨沙库巴曲缬沙坦治疗慢性心力衰竭(CHF)的作用机制。方法:选取郑州市中心医院2022年6月—2024年1月收治的116例CHF患者开展前瞻性研究,采用数字抽签法随机分为常规组(58例)和试验组(58例),常规组予以常规药物治疗,试验组采用沙库巴曲缬沙坦辅助常规药物治疗,比较2组心脏超声指标[左室射血分数(LVEF)、心排血量(CO)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)]、心室重构生化指标[基质外金属蛋白酶2(MMP2)、基质外金属蛋白酶9(MMP9)、氨基末端B型利钠肽前体(NT-proBNP)、半乳糖凝集素-3(Gal-3)]及RhoA、ROCK的mRNA相对表达量(RhoA mRNA、ROCK mRNA),Pearson法分析RhoA、ROCK与CHF患者心脏超声指标及心室重构生化指标的相关性。结果:治疗后,试验组LVEF、CO高于常规组,LVEDV、LVESV低于常规组,MMP2、MMP9、NT-proBNP、Gal-3低于常规组,差异均有统计学意义(P<0.05)。试验组RhoA mRNA、ROCK mRNA[(0.58±0.13)、(0.66±0.13)]均低于常规组[(1.02±0.44)、(1.25±0.39)],差异有统计学意义(P<0.05)。经Pearson相关性系数检验,RhoA mRNA与LVEF、CO呈负相关,与LVEDV、LVESV、MMP2、MMP9、NT-proBNP、Gal-3呈正相关(r=-0.252,-0.254,0.353,0.350,0.354,0.352,0.351,0.355;P<0.05);ROCK mRNA与LVEF、CO呈负相关,与LVEDV、LVESV、MMP2、MMP9、NT-proBNP、Gal-3正相关(r=-0.261,-0.258,0.356,0.352,0.354,0.355,0.357,0.356;P<0.05)。结论:过表达RhoA、ROCK可加重CHF患者病情并引起心室重构,应用沙库巴曲缬沙坦辅助治疗可通过抑制RhoA/ROCK通路信号而逆转患者心室重构。 展开更多
关键词 慢性心力衰竭 沙库巴曲缬沙坦 心室重构 rho蛋白A/rho相关蛋白激
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Multi-Neighborhood Enhanced Harris Hawks Optimization for Efficient Allocation of Hybrid Renewable Energy System with Cost and Emission Reduction
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作者 Elaine Yi-Ling Wu 《Computer Modeling in Engineering & Sciences》 2025年第4期1185-1214,共30页
Hybrid renewable energy systems(HRES)offer cost-effectiveness,low-emission power solutions,and reduced dependence on fossil fuels.However,the renewable energy allocation problem remains challenging due to complex syst... Hybrid renewable energy systems(HRES)offer cost-effectiveness,low-emission power solutions,and reduced dependence on fossil fuels.However,the renewable energy allocation problem remains challenging due to complex system interactions and multiple operational constraints.This study develops a novel Multi-Neighborhood Enhanced Harris Hawks Optimization(MNEHHO)algorithm to address the allocation of HRES components.The proposed approach integrates key technical parameters,including charge-discharge efficiency,storage device configurations,and renewable energy fraction.We formulate a comprehensive mathematical model that simultaneously minimizes levelized energy costs and pollutant emissions while maintaining system reliability.The MNEHHO algorithm employs multiple neighborhood structures to enhance solution diversity and exploration capabilities.The model’s effectiveness is validated through case studies across four distinct institutional energy demand profiles.Results demonstrate that our approach successfully generates practically feasible HRES configurations while achieving significant reductions in costs and emissions compared to conventional methods.The enhanced search mechanisms of MNEHHO show superior performance in avoiding local optima and achieving consistent solutions.Experimental results demonstrate concrete improvements in solution quality(up to 46% improvement in objective value)and computational efficiency(average coefficient of variance of 24%-27%)across diverse institutional settings.This confirms the robustness and scalability of our method under various operational scenarios,providing a reliable framework for solving renewable energy allocation problems. 展开更多
关键词 Hybrid renewable energy system multi-neighborhood enhanced Harris Hawks optimization costemission optimization renewable energy allocation problem reliability
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Rho GTP酶激活蛋白9在肾透明细胞癌中的表达及临床意义的生物信息学分析
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作者 王佳龙 殷桂草 李一帆 《临床肿瘤学杂志》 2026年第1期25-31,共7页
目的 探讨Rho GTP酶激活蛋白9(ARHGAP9)在肾透明细胞癌(KIRC)中的表达、临床预后价值及与免疫细胞浸润的相关性。方法 基于癌症基因组图谱计划数据库及临床样本验证,比较ARHGAP9在KIRC肿瘤组织与正常组织中的表达差异。通过分层分析,探... 目的 探讨Rho GTP酶激活蛋白9(ARHGAP9)在肾透明细胞癌(KIRC)中的表达、临床预后价值及与免疫细胞浸润的相关性。方法 基于癌症基因组图谱计划数据库及临床样本验证,比较ARHGAP9在KIRC肿瘤组织与正常组织中的表达差异。通过分层分析,探讨ARHGAP9表达水平及其DNA启动子甲基化状态与患者临床病理特征的关系。利用检索相互作用的基因/蛋白质的搜索工具平台构建ARHGAP9的蛋白互作网络,并对互作基因进行京都基因与基因组百科全书通路富集分析。进一步应用肿瘤免疫评估资源数据库算法,评估ARHGAP9表达与肿瘤微环境中免疫细胞浸润水平的关联。结合Cox比例风险回归模型,评估ARHGAP9表达及关键免疫细胞浸润对KIRC患者预后的独立预测价值。结果 ARHGAP9在多种肿瘤中差异表达并与患者预后相关(P<0.05)。ARHGAP9的mRNA和蛋白表达水平在KIRC中上调(P<0.05)。KIRC中ARHGAP9的mRNA和蛋白表达以及DNA启动子的甲基化水平与组织学分级、TNM分期和淋巴结分期有关(P<0.05)。功能富集分析结果表明,ARHGAP9参与调节鞘脂信号通路、环磷酸腺苷信号通路、Ras信号通路以及Wnt信号通路。ARHGAP9的表达与CD4^(+)T细胞、CD8^(+)T细胞、中性粒细胞、树突状细胞、B细胞和巨噬细胞的浸润水平相关(P<0.05)。单因素和多因素Cox回归分析显示,ARHGAP9高表达是KIRC患者预后的独立危险因素。结论 ARHGAP9在KIRC中高表达并与不良预后相关,可能作为KIRC患者预后的可靠生物标志物和治疗的潜在靶点。 展开更多
关键词 肾透明细胞癌 rho GTP酶激活蛋白9 临床意义 预后 免疫浸润
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An Adaptive Cubic Regularisation Algorithm Based on Affine Scaling Methods for Constrained Optimization
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作者 PEI Yonggang WANG Jingyi 《应用数学》 北大核心 2026年第1期258-277,共20页
In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the op... In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported. 展开更多
关键词 Constrained optimization Adaptive cubic regularisation Affine scaling Global convergence
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RhoA/ROCK信号转导通路在原发性膝关节骨性关节炎滑膜组织中的表达及意义
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作者 杨天翔 王怡 +5 位作者 刘学起 王胤斌 马彪 王若瑜 马亚星 陈德胜 《陕西医学杂志》 2026年第3期406-412,共7页
目的:探讨Ras同源基因家族成员A(RhoA)/Rho相关蛋白激酶(ROCK)信号转导通路在原发性膝关节骨性关节炎(KOA)滑膜组织中的表达及意义。方法:收集30例行全膝关节置换术(TKA)的原发性KOA患者的滑膜组织作为观察组,以25例来自下肢离断术的滑... 目的:探讨Ras同源基因家族成员A(RhoA)/Rho相关蛋白激酶(ROCK)信号转导通路在原发性膝关节骨性关节炎(KOA)滑膜组织中的表达及意义。方法:收集30例行全膝关节置换术(TKA)的原发性KOA患者的滑膜组织作为观察组,以25例来自下肢离断术的滑膜组织作为对照组,比较两组样本的外观形态与HE染色病理改变。通过免疫组织化学(IHC)染色、蛋白质免疫印迹(Western blot)及实时荧光定量PCR(RT-qPCR)检测RhoA和ROCK蛋白及mRNA的表达变化。结果:观察组标本呈现高度增生、充血、水肿、细胞排列紊乱及空泡化细胞。对照组标本呈白色,表面光滑无水肿,细胞/基质排列有序且均匀。观察组滑膜炎病理评分及RhoA、ROCK mRNA和蛋白表达水平高于对照组(均P<0.05)。结论:KOA患者滑膜组织中RhoA和ROCK mRNA及蛋白表达水平显著提高,表明RhoA/ROCK信号通路参与了原发性KOA发病过程。 展开更多
关键词 膝关节骨性关节炎 滑膜组织 滑膜炎 Ras同源基因家族成员A rho相关蛋白激酶 信号转导通路 组织形态
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Research Progress on Process Optimization and Performance Control of Additive Manufacturing for Refractory Metals
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作者 Lu Durui Song Suocheng Lu Bingheng 《稀有金属材料与工程》 北大核心 2026年第2期345-364,共20页
Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durabili... Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durability,and corrosion resistance.These metals have body-centered cubic crystal structure,characterized by limited slip systems and impeded dislocation motion,resulting in significant low-temperature brittleness,which poses challenges for the conventional processing.Additive manufacturing technique provides an innovative approach,enabling the production of intricate parts without molds,which significantly improves the efficiency of material usage.This review provides a comprehensive overview of the advancements in additive manufacturing techniques for the production of refractory metals,such as W,Ta,Mo,and Nb,particularly the laser powder bed fusion.In this review,the influence mechanisms of key process parameters(laser power,scan strategy,and powder characteristics)on the evolution of material microstructure,the formation of metallurgical defects,and mechanical properties were discussed.Generally,optimizing powder characteristics,such as sphericity,implementing substrate preheating,and formulating alloying strategies can significantly improve the densification and crack resistance of manufactured parts.Meanwhile,strictly controlling the oxygen impurity content and optimizing the energy density input are also the key factors to achieve the simultaneous improvement in strength and ductility of refractory metals.Although additive manufacturing technique provides an innovative solution for processing refractory metals,critical issues,such as residual stress control,microstructure and performance anisotropy,and process stability,still need to be addressed.This review not only provides a theoretical basis for the additive manufacturing of high-performance refractory metals,but also proposes forward-looking directions for their industrial application. 展开更多
关键词 refractory metals additive manufacturing mechanical properties microstructure evolution optimization of printing process
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PID Steering Control Method of Agricultural Robot Based on Fusion of Particle Swarm Optimization and Genetic Algorithm
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作者 ZHAO Longlian ZHANG Jiachuang +2 位作者 LI Mei DONG Zhicheng LI Junhui 《农业机械学报》 北大核心 2026年第1期358-367,共10页
Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion... Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots. 展开更多
关键词 agricultural robot steering PID control particle swarm optimization algorithm genetic algorithm
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MCPSFOA:Multi-Strategy Enhanced Crested Porcupine-Starfish Optimization Algorithm for Global Optimization and Engineering Design
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作者 Hao Chen Tong Xu +2 位作者 Yutian Huang Dabo Xin Changting Zhong 《Computer Modeling in Engineering & Sciences》 2026年第1期494-545,共52页
Optimization problems are prevalent in various fields of science and engineering,with several real-world applications characterized by high dimensionality and complex search landscapes.Starfish optimization algorithm(... Optimization problems are prevalent in various fields of science and engineering,with several real-world applications characterized by high dimensionality and complex search landscapes.Starfish optimization algorithm(SFOA)is a recently optimizer inspired by swarm intelligence,which is effective for numerical optimization,but it may encounter premature and local convergence for complex optimization problems.To address these challenges,this paper proposes the multi-strategy enhanced crested porcupine-starfish optimization algorithm(MCPSFOA).The core innovation of MCPSFOA lies in employing a hybrid strategy to improve SFOA,which integrates the exploratory mechanisms of SFOA with the diverse search capacity of the Crested Porcupine Optimizer(CPO).This synergy enhances MCPSFOA’s ability to navigate complex and multimodal search spaces.To further prevent premature convergence,MCPSFOA incorporates Lévy flight,leveraging its characteristic long and short jump patterns to enable large-scale exploration and escape from local optima.Subsequently,Gaussian mutation is applied for precise solution tuning,introducing controlled perturbations that enhance accuracy and mitigate the risk of insufficient exploitation.Notably,the population diversity enhancement mechanism periodically identifies and resets stagnant individuals,thereby consistently revitalizing population variety throughout the optimization process.MCPSFOA is rigorously evaluated on 24 classical benchmark functions(including high-dimensional cases),the CEC2017 suite,and the CEC2022 suite.MCPSFOA achieves superior overall performance with Friedman mean ranks of 2.208,2.310 and 2.417 on these benchmark functions,outperforming 11 state-of-the-art algorithms.Furthermore,the practical applicability of MCPSFOA is confirmed through its successful application to five engineering optimization cases,where it also yields excellent results.In conclusion,MCPSFOA is not only a highly effective and reliable optimizer for benchmark functions,but also a practical tool for solving real-world optimization problems. 展开更多
关键词 Global optimization starfish optimization algorithm crested porcupine optimizer METAHEURISTIC Gaussian mutation population diversity enhancement
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Multi-objective topology optimization for cutout design in deployable composite thin-walled structures
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作者 Hao JIN Ning AN +3 位作者 Qilong JIA Chun SHAO Xiaofei MA Jinxiong ZHOU 《Chinese Journal of Aeronautics》 2026年第1期674-694,共21页
Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structu... Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structural rigidity and flexibility,ensuring material integrity during large deformations,and providing adequate load-bearing capacity and stability once deployed.Most research has focused on optimizing cutout size and shape,while topology optimization offers a broader design space.However,the anisotropic properties of woven composite laminates,complex failure criteria,and multi-performance optimization needs have limited the exploration of topology optimization in this field.This work derives the sensitivities of bending stiffness,critical buckling load,and the failure index of woven composite materials with respect to element density,and formulates both single-objective and multi-objective topology optimization models using a linear weighted aggregation approach.The developed method was integrated with the commercial finite element software ABAQUS via a Python script,allowing efficient application to cutout design in various DCTWS configurations to maximize bending stiffness and critical buckling load under material failure constraints.Optimization of a classical tubular hinge resulted in improvements of 107.7%in bending stiffness and 420.5%in critical buckling load compared to level-set topology optimization results reported in the literature,validating the effectiveness of the approach.To facilitate future research and encourage the broader adoption of topology optimization techniques in DCTWS design,the source code for this work is made publicly available via a Git Hub link:https://github.com/jinhao-ok1/Topo-for-DCTWS.git. 展开更多
关键词 Composite laminates Deployable structures Multi-objective optimization Thin-walled structures Topology optimization
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Several Improved Models of the Mountain Gazelle Optimizer for Solving Optimization Problems
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作者 Farhad Soleimanian Gharehchopogh Keyvan Fattahi Rishakan 《Computer Modeling in Engineering & Sciences》 2026年第1期727-780,共54页
Optimization algorithms are crucial for solving NP-hard problems in engineering and computational sciences.Metaheuristic algorithms,in particular,have proven highly effective in complex optimization scenarios characte... Optimization algorithms are crucial for solving NP-hard problems in engineering and computational sciences.Metaheuristic algorithms,in particular,have proven highly effective in complex optimization scenarios characterized by high dimensionality and intricate variable relationships.The Mountain Gazelle Optimizer(MGO)is notably effective but struggles to balance local search refinement and global space exploration,often leading to premature convergence and entrapment in local optima.This paper presents the Improved MGO(IMGO),which integrates three synergistic enhancements:dynamic chaos mapping using piecewise chaotic sequences to boost explo-ration diversity;Opposition-Based Learning(OBL)with adaptive,diversity-driven activation to speed up convergence;and structural refinements to the position update mechanisms to enhance exploitation.The IMGO underwent a comprehensive evaluation using 52 standardised benchmark functions and seven engineering optimization problems.Benchmark evaluations showed that IMGO achieved the highest rank in best solution quality for 31 functions,the highest rank in mean performance for 18 functions,and the highest rank in worst-case performance for 14 functions among 11 competing algorithms.Statistical validation using Wilcoxon signed-rank tests confirmed that IMGO outperformed individual competitors across 16 to 50 functions,depending on the algorithm.At the same time,Friedman ranking analysis placed IMGO with an average rank of 4.15,compared to the baseline MGO’s 4.38,establishing the best overall performance.The evaluation of engineering problems revealed consistent improvements,including an optimal cost of 1.6896 for the welded beam design vs.MGO’s 1.7249,a minimum cost of 5885.33 for the pressure vessel design vs.MGO’s 6300,and a minimum weight of 2964.52 kg for the speed reducer design vs.MGO’s 2990.00 kg.Ablation studies identified OBL as the strongest individual contributor,whereas complete integration achieved superior performance through synergistic interactions among components.Computational complexity analysis established an O(T×N×5×f(P))time complexity,representing a 1.25×increase in fitness evaluation relative to the baseline MGO,validating the favorable accuracy-efficiency trade-offs for practical optimization applications. 展开更多
关键词 Metaheuristic algorithm dynamical chaos integration opposition-based learning mountain gazelle optimizer optimization
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An Overall Optimization Model Using Metaheuristic Algorithms for the CNN-Based IoT Attack Detection Problem
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作者 Le Thi Hong Van Le Duc Thuan +1 位作者 Pham Van Huong Nguyen Hieu Minh 《Computers, Materials & Continua》 2026年第4期1934-1964,共31页
Optimizing convolutional neural networks(CNNs)for IoT attack detection remains a critical yet challenging task due to the need to balance multiple performance metrics beyond mere accuracy.This study proposes a unified... Optimizing convolutional neural networks(CNNs)for IoT attack detection remains a critical yet challenging task due to the need to balance multiple performance metrics beyond mere accuracy.This study proposes a unified and flexible optimization framework that leverages metaheuristic algorithms to automatically optimize CNN configurations for IoT attack detection.Unlike conventional single-objective approaches,the proposed method formulates a global multi-objective fitness function that integrates accuracy,precision,recall,and model size(speed/model complexity penalty)with adjustable weights.This design enables both single-objective and weightedsum multi-objective optimization,allowing adaptive selection of optimal CNN configurations for diverse deployment requirements.Two representativemetaheuristic algorithms,GeneticAlgorithm(GA)and Particle Swarm Optimization(PSO),are employed to optimize CNNhyperparameters and structure.At each generation/iteration,the best configuration is selected as themost balanced solution across optimization objectives,i.e.,the one achieving themaximum value of the global objective function.Experimental validation on two benchmark datasets,Edge-IIoT and CIC-IoT2023,demonstrates that the proposed GA-and PSO-based models significantly enhance detection accuracy(94.8%–98.3%)and generalization compared with manually tuned CNN configurations,while maintaining compact architectures.The results confirm that the multi-objective framework effectively balances predictive performance and computational efficiency.This work establishes a generalizable and adaptive optimization strategy for deep learning-based IoT attack detection and provides a foundation for future hybrid metaheuristic extensions in broader IoT security applications. 展开更多
关键词 Genetic algorithm(GA) particle swarm optimization(PSO) multi-objective optimization convolutional neural network—CNN IoT attack detection metaheuristic optimization CNN configuration
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Multi-Objective Enhanced Cheetah Optimizer for Joint Optimization of Computation Offloading and Task Scheduling in Fog Computing
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作者 Ahmad Zia Nazia Azim +5 位作者 Bekarystankyzy Akbayan Khalid J.Alzahrani Ateeq Ur Rehman Faheem Ullah Khan Nouf Al-Kahtani Hend Khalid Alkahtani 《Computers, Materials & Continua》 2026年第3期1559-1588,共30页
The cloud-fog computing paradigm has emerged as a novel hybrid computing model that integrates computational resources at both fog nodes and cloud servers to address the challenges posed by dynamic and heterogeneous c... The cloud-fog computing paradigm has emerged as a novel hybrid computing model that integrates computational resources at both fog nodes and cloud servers to address the challenges posed by dynamic and heterogeneous computing networks.Finding an optimal computational resource for task offloading and then executing efficiently is a critical issue to achieve a trade-off between energy consumption and transmission delay.In this network,the task processed at fog nodes reduces transmission delay.Still,it increases energy consumption,while routing tasks to the cloud server saves energy at the cost of higher communication delay.Moreover,the order in which offloaded tasks are executed affects the system’s efficiency.For instance,executing lower-priority tasks before higher-priority jobs can disturb the reliability and stability of the system.Therefore,an efficient strategy of optimal computation offloading and task scheduling is required for operational efficacy.In this paper,we introduced a multi-objective and enhanced version of Cheeta Optimizer(CO),namely(MoECO),to jointly optimize the computation offloading and task scheduling in cloud-fog networks to minimize two competing objectives,i.e.,energy consumption and communication delay.MoECO first assigns tasks to the optimal computational nodes and then the allocated tasks are scheduled for processing based on the task priority.The mathematical modelling of CO needs improvement in computation time and convergence speed.Therefore,MoECO is proposed to increase the search capability of agents by controlling the search strategy based on a leader’s location.The adaptive step length operator is adjusted to diversify the solution and thus improves the exploration phase,i.e.,global search strategy.Consequently,this prevents the algorithm from getting trapped in the local optimal solution.Moreover,the interaction factor during the exploitation phase is also adjusted based on the location of the prey instead of the adjacent Cheetah.This increases the exploitation capability of agents,i.e.,local search capability.Furthermore,MoECO employs a multi-objective Pareto-optimal front to simultaneously minimize designated objectives.Comprehensive simulations in MATLAB demonstrate that the proposed algorithm obtains multiple solutions via a Pareto-optimal front and achieves an efficient trade-off between optimization objectives compared to baseline methods. 展开更多
关键词 Computation offloading task scheduling cheetah optimizer fog computing optimization resource allocation internet of things
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Optimization of Truss Structures Using Nature-Inspired Algorithms with Frequency and Stress Constraints
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作者 Sanjog Chhetri Sapkota Liborio Cavaleri +3 位作者 Ajaya Khatri Siddhi Pandey Satish Paudel Panagiotis G.Asteris 《Computer Modeling in Engineering & Sciences》 2026年第1期436-464,共29页
Optimization is the key to obtaining efficient utilization of resources in structural design.Due to the complex nature of truss systems,this study presents a method based on metaheuristic modelling that minimises stru... Optimization is the key to obtaining efficient utilization of resources in structural design.Due to the complex nature of truss systems,this study presents a method based on metaheuristic modelling that minimises structural weight under stress and frequency constraints.Two new algorithms,the Red Kite Optimization Algorithm(ROA)and Secretary Bird Optimization Algorithm(SBOA),are utilized on five benchmark trusses with 10,18,37,72,and 200-bar trusses.Both algorithms are evaluated against benchmarks in the literature.The results indicate that SBOA always reaches a lighter optimal.Designs with reducing structural weight ranging from 0.02%to 0.15%compared to ROA,and up to 6%–8%as compared to conventional algorithms.In addition,SBOA can achieve 15%–20%faster convergence speed and 10%–18%reduction in computational time with a smaller standard deviation over independent runs,which demonstrates its robustness and reliability.It is indicated that the adaptive exploration mechanism of SBOA,especially its Levy flight–based search strategy,can obviously improve optimization performance for low-and high-dimensional trusses.The research has implications in the context of promoting bio-inspired optimization techniques by demonstrating the viability of SBOA,a reliable model for large-scale structural design that provides significant enhancements in performance and convergence behavior. 展开更多
关键词 optimization truss structures nature-inspired algorithms meta-heuristic algorithms red kite opti-mization algorithm secretary bird optimization algorithm
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Photovoltaic Parameter Estimation Using a Parallelized Triangulation Topology Aggregation Optimization with Real-World Dataset Validation
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作者 Jun Zhe Tan Rodney H.G.Tan +4 位作者 Nor Ashidi Mat Isa Sew Sun Tiang Chun Kit Ang Kuo-Ping Lin Wei Hong Lim 《Computer Modeling in Engineering & Sciences》 2026年第2期691-736,共46页
Accurate estimation of photovoltaic(PV)parameters is essential for optimizing solar module perfor-mance and enhancing resource efficiency in renewable energy systems.This study presents a process innovation by introdu... Accurate estimation of photovoltaic(PV)parameters is essential for optimizing solar module perfor-mance and enhancing resource efficiency in renewable energy systems.This study presents a process innovation by introducing,for the first time,the Triangulation Topology Aggregation Optimizer(TTAO)integrated with parallel computing to address PV parameter estimation challenges.The effectiveness and robustness of TTAO are rigorously evaluated using two standard benchmark datasets(KC200GT and R.T.C.France solar cells)and a real-world dataset(Poly70W solar module)under single-,double-,and triple-diode configurations.Results show that TTAO consistently achieves superior accuracy by producing the lowest RMSE values and faster convergence compared to state-of-the-art metaheuristic algorithms.In addition,the integration of parallel computing significantly enhances computational efficiency,reducing execution time by up to 85%without compromising accuracy.Validation using real-world data further demonstrates TTAO’s adaptability and practical relevance in renewable energy systems,effectively bridging the gap between theoretical modeling and real-world implementation for PV system monitoring and optimization,contributing to climate mitigation through improved solar energy performance. 展开更多
关键词 Photovoltaic(PV) parameters estimation triangulation topology aggregation optimizer(TTAO) parallel computing optimization
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Retraction: MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase
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作者 Oncology Research Editorial Office 《Oncology Research》 2026年第1期622-622,共1页
The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3... The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases. 展开更多
关键词 cellular datawhere tumor suppressor western blots rho associated coiled coil kinase microrna cellular data OSTEOSARCOMA figures
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Advanced Meta-Heuristic Optimization for Accurate Photovoltaic Model Parameterization:A High-Accuracy Estimation Using Spider Wasp Optimization
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作者 Sarah M.Alhammad Diaa Salama AbdElminaam +1 位作者 Asmaa Rizk Ibrahim Ahmed Taha 《Computers, Materials & Continua》 2026年第3期2269-2303,共35页
Accurate parameter extraction of photovoltaic(PV)models plays a critical role in enabling precise performance prediction,optimal system sizing,and effective operational control under diverse environmental conditions.W... Accurate parameter extraction of photovoltaic(PV)models plays a critical role in enabling precise performance prediction,optimal system sizing,and effective operational control under diverse environmental conditions.While a wide range of metaheuristic optimisation techniques have been applied to this problem,many existing methods are hindered by slow convergence rates,susceptibility to premature stagnation,and reduced accuracy when applied to complex multi-diode PV configurations.These limitations can lead to suboptimal modelling,reducing the efficiency of PV system design and operation.In this work,we propose an enhanced hybrid optimisation approach,the modified Spider Wasp Optimization(mSWO)with Opposition-Based Learning algorithm,which integrates the exploration and exploitation capabilities of the Spider Wasp Optimization(SWO)metaheuristic with the diversityenhancing mechanism of Opposition-Based Learning(OBL).The hybridisation is designed to dynamically expand the search space coverage,avoid premature convergence,and improve both convergence speed and precision in highdimensional optimisation tasks.The mSWO algorithm is applied to three well-established PV configurations:the single diode model(SDM),the double diode model(DDM),and the triple diode model(TDM).Real experimental current-voltage(I-V)datasets from a commercial PV module under standard test conditions(STC)are used for evaluation.Comparative analysis is conducted against eighteen advanced metaheuristic algorithms,including BSDE,RLGBO,GWOCS,MFO,EO,TSA,and SCA.Performance metrics include minimum,mean,and maximum root mean square error(RMSE),standard deviation(SD),and convergence behaviour over 30 independent runs.The results reveal that mSWO consistently delivers superior accuracy and robustness across all PV models,achieving the lowest RMSE values of 0.000986022(SDM),0.000982884(DDM),and 0.000982529(TDM),with minimal SD values,indicating remarkable repeatability.Convergence analyses further show that mSWO reaches optimal solutions more rapidly and with fewer oscillations than all competing methods,with the performance gap widening as model complexity increases.These findings demonstrate that mSWO provides a scalable,computationally efficient,and highly reliable framework for PV parameter extraction.Its adaptability to models of growing complexity suggests strong potential for broader applications in renewable energy systems,including performance monitoring,fault detection,and intelligent control,thereby contributing to the optimisation of next-generation solar energy solutions. 展开更多
关键词 modified Spider Wasp Optimizer(mSWO) photovoltaic(PV)modeling meta-heuristic optimization solar energy parameter estimation renewable energy technologies
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Surrogate-Based Dimensional Optimization of a Polymeric Roller for Ore Belt Conveyors Considering Viscoelastic Effects
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作者 Rafiq Said Dias Jabour Marco Antonio Luersen Euclides Alexandre Bernardelli 《Computers, Materials & Continua》 2026年第3期603-623,共21页
The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft ... The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft supported by easels.The external tube and shaft of rollers used in ore conveyor belts are mostly made of steel,resulting in high mass,hindering maintenance and replacement.Aiming to achieve mass reduction,we conducted a structural optimization of a roller with a polymeric external tube(hereafter referred to as a polymeric roller),seeking the optimal values for two design parameters:the inner diameter of the external tube and the shaft diameter.The optimization was constrained by admissible values for maximum stress,maximum deflection and misalignment angle between the shaft and bearings.A finite element model was built in Ansys Workbench to obtain the structural response of the system.The roller considered is composed of an external tube made of high-density polyethylene(HDPE),bearing seats of polyamide 6(PA6),and a steel shaft.To characterize the polymeric materials(HDPE and PA6),stress relaxation tests were conducted,and the data on shear modulus variation over time were inserted into the model to calculate Prony series terms to account for viscoelastic effects.The roller optimization was performed using surrogate modeling based on radial basis functions,with the Globalized Bounded Nelder-Mead(GBNM)algorithm as the optimizer.Two optimization cases were conducted.In the first case,concerning the roller’s initial material settings,the designs found violated the constraints and could not reduce mass.In the second case,by using PA6 in both bearing seats and the tube,a design configuration was found that respected all constraints and reduced the roller mass by 15.5%,equivalent to 5.15 kg.This study is among the first to integrate experimentally obtained viscoelastic data into the surrogate-based optimization of polymeric rollers,combining methodological innovation with industrial relevance. 展开更多
关键词 Conveyor belt rollers structural optimization surrogate modelling VISCOELASTICITY
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Airfoil optimization for Mars rotorcraft blade at large angle of attack and experimental verification
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作者 Bo TANG Qiquan QUAN +2 位作者 Dewei TANG Kaijie ZHU Zongquan DENG 《Chinese Journal of Aeronautics》 2026年第1期191-209,共19页
Although the thin and cold Martian atmosphere provides the feasibility of rotorcraft flight on Mars,rotors designed for denser Earth atmosphere with small angles of attack hardly generate enough thrust for rotorcraft ... Although the thin and cold Martian atmosphere provides the feasibility of rotorcraft flight on Mars,rotors designed for denser Earth atmosphere with small angles of attack hardly generate enough thrust for rotorcraft flight at conventional rotational speeds in the Martian atmosphere.In this paper,we employ the Particle Swarm Optimization(PSO)algorithm to search for the control points of the Bezier curve,completing the parameterization of the airfoil upper and lower curves based on these control points.In order to directly enhance the lift-to-drag ratio of the airfoil at high angles of attack,the NSGA-II algorithm is utilized to optimize the lift-to-drag ratio of NACA 6904 at a=17.5°,Ma=0.43,Re=7600,and CLF 5605 at a=15°,Ma=0.7,Re=7481,respectively.The two-dimensional RANS(Reynolds Average NavierStokes)and k-ωSST turbulence models are employed in the optimization process by CFD to predict the lift and drag characteristics of the airfoil in a Martian environment.Under simulated Mars atmospheric conditions(pressure of 1380 Pa,test temperature of 24°C,equivalent Mars atmospheric density at the surface of 0.0162 g/cm~3),the airfoil after optimized is subjected to rotor lift-drag characteristic tests where a single-rotor lift-drag characteristic test bench is employed for verification.The experimental results demonstrate that the RB-TB-II blade,which is obtained by optimizing the airfoil based on the RB-SWQ-I blade,exhibits a 19.6%increase in Power Loading(PL)and a 20.4%increase in Figure of Merit(FM)compared with the RB-SWQ-I blade.Based on the results of airfoil optimization,increasing the camber at the leading edge of the airfoil under high angles of attack contributes to an improved lift-to-drag ratio. 展开更多
关键词 Airfoil optimization Hovering performance Martian rotorcraft PARAMETERIZATION Rotor blade
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Emittance optimization of gridded thermionic‑cathode electron gun for high‑quality beam injectors
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作者 Xiao‑Yu Peng Hao Hu +3 位作者 Tong‑Ning Hu Jian Pang Jian‑Jun Deng Guang‑Yao Feng 《Nuclear Science and Techniques》 2026年第1期119-129,共11页
Electron beam injectors are pivotal components of large-scale scientific instruments,such as synchrotron radiation sources,free-electron lasers,and electron-positron colliders.The quality of the electron beam produced... Electron beam injectors are pivotal components of large-scale scientific instruments,such as synchrotron radiation sources,free-electron lasers,and electron-positron colliders.The quality of the electron beam produced by the injector critically influences the performance of the entire accelerator-based scientific research apparatus.The injectors of such facilities usually use photocathode and thermionic-cathode electron guns.Although the photocathode injector can produce electron beams of excellent quality,its associated laser system is massive and intricate.The thermionic-cathode electron gun,especially the gridded electron gun injector,has a simple structure capable of generating numerous electron beams.However,its emittance is typically high.In this study,methods to reduce beam emittance are explored through a comprehensive analysis of various grid structures and preliminary design results,examining the evolution of beam phase space at different grid positions.An optimization method for reducing the emittance of a gridded thermionic-cathode electron gun is proposed through theoretical derivation,electromagnetic-field simulation,and beam-dynamics simulation.A 50%reduction in emittance was achieved for a 50 keV,1.7 A electron gun,laying the foundation for the subsequent design of a high-current,low-emittance injector. 展开更多
关键词 Electron gun Gridded Beam injector Beam dynamics Emittance optimization
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MDMOSA:Multi-Objective-Oriented Dwarf Mongoose Optimization for Cloud Task Scheduling
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作者 Olanrewaju Lawrence Abraham Md Asri Ngadi +1 位作者 Johan Bin Mohamad Sharif Mohd Kufaisal Mohd Sidik 《Computers, Materials & Continua》 2026年第3期2062-2096,共35页
Task scheduling in cloud computing is a multi-objective optimization problem,often involving conflicting objectives such as minimizing execution time,reducing operational cost,and maximizing resource utilization.Howev... Task scheduling in cloud computing is a multi-objective optimization problem,often involving conflicting objectives such as minimizing execution time,reducing operational cost,and maximizing resource utilization.However,traditional approaches frequently rely on single-objective optimization methods which are insufficient for capturing the complexity of such problems.To address this limitation,we introduce MDMOSA(Multi-objective Dwarf Mongoose Optimization with Simulated Annealing),a hybrid that integrates multi-objective optimization for efficient task scheduling in Infrastructure-as-a-Service(IaaS)cloud environments.MDMOSA harmonizes the exploration capabilities of the biologically inspired Dwarf Mongoose Optimization(DMO)with the exploitation strengths of Simulated Annealing(SA),achieving a balanced search process.The algorithm aims to optimize task allocation by reducing makespan and financial cost while improving system resource utilization.We evaluate MDMOSA through extensive simulations using the real-world Google Cloud Jobs(GoCJ)dataset within the CloudSim environment.Comparative analysis against benchmarked algorithms such as SMOACO,MOTSGWO,and MFPAGWO reveals that MDMOSA consistently achieves superior performance in terms of scheduling efficiency,cost-effectiveness,and scalability.These results confirm the potential of MDMOSA as a robust and adaptable solution for resource scheduling in dynamic and heterogeneous cloud computing infrastructures. 展开更多
关键词 Cloud computing MULTI-OBJECTIVE task scheduling dwarf mongoose optimization METAHEURISTIC
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