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miR-129-5p调控RhoA/ROCK通路对代谢相关的脂肪性肝病大鼠肝损伤的影响
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作者 张彩英 全养雅 +1 位作者 许若思 陈露 《中国临床解剖学杂志》 北大核心 2026年第1期70-77,共8页
目的 探讨微小RNA-129-5p(miR-129-5p)调控Rho激酶(RhoA)/Rho蛋白相关卷曲螺旋激酶(ROCK)通路对代谢相关的脂肪性肝病(MAFLD)大鼠肝损伤的影响。方法 收集28例2024年6月至12月期间于我院进行治疗的MAFLD患者为MAFLD组,另收集28例健康体... 目的 探讨微小RNA-129-5p(miR-129-5p)调控Rho激酶(RhoA)/Rho蛋白相关卷曲螺旋激酶(ROCK)通路对代谢相关的脂肪性肝病(MAFLD)大鼠肝损伤的影响。方法 收集28例2024年6月至12月期间于我院进行治疗的MAFLD患者为MAFLD组,另收集28例健康体检者作为对照组;qRT-PCR法检测MAFLD组和对照组血清中miR-129-5p、RhoA、ROCK mRNA表达。双荧光素酶报告基因实验验证miR-129-5p与RhoA的互作;构建MAFLD大鼠,将造模成功的大鼠随机分为MAFLD组、阴性对照(NC agomir)组(尾静脉注射NC agomir)、miR-129-5p激动剂(miR-129-5p agomir)组(尾静脉注射miR-129-5p agomir)、溶血磷脂酸(LPA)(尾静脉注射miR-129-5p agomir+1 mg/kg的LPA),每组12只,另选择12只正常大鼠为NC组,NC组和MAFLD组注射等量生理盐水。检测各组血清中肝功能、血脂、炎症因子以及肝组织中TC、TG的表达;qRT-PCR法检测MAFLD大鼠肝组织miR-129-5p、RhoA、ROCK mRNA表达;HE染色和油红O染色检测肝组织病理学;TUNEL染色检测肝组织细胞凋亡;Western blot检测肝组织中RhoA、ROCK蛋白表达。结果 与对照组比较,MAFLD组血清中miR-129-5p表达降低,RhoA和ROCK mRNA表达升高(P<0.05)。miR-129-5p可以靶向负调控RhoA。NC组肝脏组织正常;MAFLD组和NC agomir组肝脏组织可见肝细胞脂肪变性、形态明显肿胀且呈气球样变及呈空泡化和大量红色脂肪滴;miR-129-5p agomir组有少量肝细胞轻度脂肪变性,胞质内可见微小的圆形空泡和脂肪滴明显减少;LPA组肝细胞脂肪变性进一步加重,脂肪滴进一步增多。MAFLD组肝脏和血清中TC、肝脏和血清中TG、LDL-C、AST、ALT、TNF-α、IL-6、IL-1β、RhoA mRNA和蛋白、ROCK mRNA和蛋白、凋亡率高于NC组,HDL-C、miR-129-5p低于NC组(P<0.05);miR-129-5p agomir组肝脏和血清中TC、肝脏和血清中TG、LDL-C、AST、ALT、TNF-α、IL-6、IL-1β、RhoA mRNA和蛋白、ROCK mRNA和蛋白、凋亡率低于MAFLD组、NC agomir组,HDL-C、miR-129-5p高于MAFLD组、NC agomir组(P<0.05);LPA组肝脏和血清中TC、肝脏和血清中TG、LDL-C、AST、ALT、TNF-α、IL-6、IL-1β、RhoA mRNA和蛋白、ROCK mRNA和蛋白、凋亡率高于miR-129-5p agomir组,HDL-C低于miR-129-5p agomir组(P<0.05)。结论 miR-129-5p可能通过靶向负调控RhoA/ROCK通路缓解MAFLD引起的肝损伤。 展开更多
关键词 微小RNA-129-5p rho蛋白相关卷曲螺旋激酶 rho激酶 代谢相关的脂肪性肝病 肝损伤
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基于RhoA/ROCK通路探讨沙库巴曲缬沙坦治疗慢性心力衰竭的作用机制
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作者 孙丽娜 张艳华 《淮海医药》 2026年第1期92-95,共4页
目的:基于Rho蛋白A/Rho相关蛋白激(RhoA/ROCK)通路探讨沙库巴曲缬沙坦治疗慢性心力衰竭(CHF)的作用机制。方法:选取郑州市中心医院2022年6月—2024年1月收治的116例CHF患者开展前瞻性研究,采用数字抽签法随机分为常规组(58例)和试验组(5... 目的:基于Rho蛋白A/Rho相关蛋白激(RhoA/ROCK)通路探讨沙库巴曲缬沙坦治疗慢性心力衰竭(CHF)的作用机制。方法:选取郑州市中心医院2022年6月—2024年1月收治的116例CHF患者开展前瞻性研究,采用数字抽签法随机分为常规组(58例)和试验组(58例),常规组予以常规药物治疗,试验组采用沙库巴曲缬沙坦辅助常规药物治疗,比较2组心脏超声指标[左室射血分数(LVEF)、心排血量(CO)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)]、心室重构生化指标[基质外金属蛋白酶2(MMP2)、基质外金属蛋白酶9(MMP9)、氨基末端B型利钠肽前体(NT-proBNP)、半乳糖凝集素-3(Gal-3)]及RhoA、ROCK的mRNA相对表达量(RhoA mRNA、ROCK mRNA),Pearson法分析RhoA、ROCK与CHF患者心脏超声指标及心室重构生化指标的相关性。结果:治疗后,试验组LVEF、CO高于常规组,LVEDV、LVESV低于常规组,MMP2、MMP9、NT-proBNP、Gal-3低于常规组,差异均有统计学意义(P<0.05)。试验组RhoA mRNA、ROCK mRNA[(0.58±0.13)、(0.66±0.13)]均低于常规组[(1.02±0.44)、(1.25±0.39)],差异有统计学意义(P<0.05)。经Pearson相关性系数检验,RhoA mRNA与LVEF、CO呈负相关,与LVEDV、LVESV、MMP2、MMP9、NT-proBNP、Gal-3呈正相关(r=-0.252,-0.254,0.353,0.350,0.354,0.352,0.351,0.355;P<0.05);ROCK mRNA与LVEF、CO呈负相关,与LVEDV、LVESV、MMP2、MMP9、NT-proBNP、Gal-3正相关(r=-0.261,-0.258,0.356,0.352,0.354,0.355,0.357,0.356;P<0.05)。结论:过表达RhoA、ROCK可加重CHF患者病情并引起心室重构,应用沙库巴曲缬沙坦辅助治疗可通过抑制RhoA/ROCK通路信号而逆转患者心室重构。 展开更多
关键词 慢性心力衰竭 沙库巴曲缬沙坦 心室重构 rho蛋白A/rho相关蛋白激
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Multi-Neighborhood Enhanced Harris Hawks Optimization for Efficient Allocation of Hybrid Renewable Energy System with Cost and Emission Reduction
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作者 Elaine Yi-Ling Wu 《Computer Modeling in Engineering & Sciences》 2025年第4期1185-1214,共30页
Hybrid renewable energy systems(HRES)offer cost-effectiveness,low-emission power solutions,and reduced dependence on fossil fuels.However,the renewable energy allocation problem remains challenging due to complex syst... Hybrid renewable energy systems(HRES)offer cost-effectiveness,low-emission power solutions,and reduced dependence on fossil fuels.However,the renewable energy allocation problem remains challenging due to complex system interactions and multiple operational constraints.This study develops a novel Multi-Neighborhood Enhanced Harris Hawks Optimization(MNEHHO)algorithm to address the allocation of HRES components.The proposed approach integrates key technical parameters,including charge-discharge efficiency,storage device configurations,and renewable energy fraction.We formulate a comprehensive mathematical model that simultaneously minimizes levelized energy costs and pollutant emissions while maintaining system reliability.The MNEHHO algorithm employs multiple neighborhood structures to enhance solution diversity and exploration capabilities.The model’s effectiveness is validated through case studies across four distinct institutional energy demand profiles.Results demonstrate that our approach successfully generates practically feasible HRES configurations while achieving significant reductions in costs and emissions compared to conventional methods.The enhanced search mechanisms of MNEHHO show superior performance in avoiding local optima and achieving consistent solutions.Experimental results demonstrate concrete improvements in solution quality(up to 46% improvement in objective value)and computational efficiency(average coefficient of variance of 24%-27%)across diverse institutional settings.This confirms the robustness and scalability of our method under various operational scenarios,providing a reliable framework for solving renewable energy allocation problems. 展开更多
关键词 Hybrid renewable energy system multi-neighborhood enhanced Harris Hawks optimization costemission optimization renewable energy allocation problem reliability
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白术内酯Ⅰ调节RhoA/ROCK信号通路对肺炎链球菌肺炎幼年大鼠肺损伤的影响
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作者 张泰 赵云鹏 刘辛 《中国免疫学杂志》 北大核心 2026年第3期671-675,共5页
目的:探究白术内酯Ⅰ(ATLⅠ)调节Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路对肺炎链球菌(SP)肺炎幼年大鼠肺损伤的影响。方法:除对照组10只幼年大鼠外,其余大鼠构建SP模型后分为SP组、ATLⅠ低、中、高剂量(ATL... 目的:探究白术内酯Ⅰ(ATLⅠ)调节Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋蛋白激酶(ROCK)信号通路对肺炎链球菌(SP)肺炎幼年大鼠肺损伤的影响。方法:除对照组10只幼年大鼠外,其余大鼠构建SP模型后分为SP组、ATLⅠ低、中、高剂量(ATLⅠ-L、M、H)组和激活剂组,每组10只。检测各组大鼠肺组织湿干重比(W/D);HE染色观察大鼠肺组织病理学变化;对BALF中的中性粒细胞、巨噬细胞和淋巴细胞计数;试剂盒检测肺组织MPO活性;ELISA检测血清和BALF中TNF-α、IL-6、IL-10水平;Western blot检测肺组织中RhoA、ROCK表达。结果:与对照组相比,SP组大鼠肺组织病理改变明显,肺泡间质水肿,炎症细胞浸润;肺W/D、中性粒细胞数、巨噬细胞数、淋巴细胞数、MPO活性、血清和BALF中TNF-α、IL-6水平、RhoA、ROCK表达升高,IL-10水平降低(P<0.05);与SP组相比,ATLⅠ-L、M、H组大鼠肺组织结构病变有不同程度的改善,肺部炎症和肺泡水肿明显减轻,中性粒细胞数、巨噬细胞数、淋巴细胞数减少,肺W/D、MPO活性、血清和BALF中TNF-α、IL-6水平、RhoA、ROCK表达下降,IL-10水平升高(P<0.05);RhoA/ROCK信号通路激活剂减弱ATLⅠ对SP肺炎幼年大鼠肺损伤的改善作用(P<0.05)。结论:ATLⅠ能够抑制SP肺炎幼年大鼠炎症反应,改善肺损伤,其作用机制可能与激活RhoA/ROCK信号通路有关。 展开更多
关键词 白术内酯Ⅰ 肺炎链球菌肺炎 幼年大鼠 肺损伤 Ras同源基因家族成员A/rho相关卷曲螺旋蛋白激酶信号通路
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Rho GTP酶激活蛋白9在肾透明细胞癌中的表达及临床意义的生物信息学分析
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作者 王佳龙 殷桂草 李一帆 《临床肿瘤学杂志》 2026年第1期25-31,共7页
目的 探讨Rho GTP酶激活蛋白9(ARHGAP9)在肾透明细胞癌(KIRC)中的表达、临床预后价值及与免疫细胞浸润的相关性。方法 基于癌症基因组图谱计划数据库及临床样本验证,比较ARHGAP9在KIRC肿瘤组织与正常组织中的表达差异。通过分层分析,探... 目的 探讨Rho GTP酶激活蛋白9(ARHGAP9)在肾透明细胞癌(KIRC)中的表达、临床预后价值及与免疫细胞浸润的相关性。方法 基于癌症基因组图谱计划数据库及临床样本验证,比较ARHGAP9在KIRC肿瘤组织与正常组织中的表达差异。通过分层分析,探讨ARHGAP9表达水平及其DNA启动子甲基化状态与患者临床病理特征的关系。利用检索相互作用的基因/蛋白质的搜索工具平台构建ARHGAP9的蛋白互作网络,并对互作基因进行京都基因与基因组百科全书通路富集分析。进一步应用肿瘤免疫评估资源数据库算法,评估ARHGAP9表达与肿瘤微环境中免疫细胞浸润水平的关联。结合Cox比例风险回归模型,评估ARHGAP9表达及关键免疫细胞浸润对KIRC患者预后的独立预测价值。结果 ARHGAP9在多种肿瘤中差异表达并与患者预后相关(P<0.05)。ARHGAP9的mRNA和蛋白表达水平在KIRC中上调(P<0.05)。KIRC中ARHGAP9的mRNA和蛋白表达以及DNA启动子的甲基化水平与组织学分级、TNM分期和淋巴结分期有关(P<0.05)。功能富集分析结果表明,ARHGAP9参与调节鞘脂信号通路、环磷酸腺苷信号通路、Ras信号通路以及Wnt信号通路。ARHGAP9的表达与CD4^(+)T细胞、CD8^(+)T细胞、中性粒细胞、树突状细胞、B细胞和巨噬细胞的浸润水平相关(P<0.05)。单因素和多因素Cox回归分析显示,ARHGAP9高表达是KIRC患者预后的独立危险因素。结论 ARHGAP9在KIRC中高表达并与不良预后相关,可能作为KIRC患者预后的可靠生物标志物和治疗的潜在靶点。 展开更多
关键词 肾透明细胞癌 rho GTP酶激活蛋白9 临床意义 预后 免疫浸润
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An Adaptive Cubic Regularisation Algorithm Based on Affine Scaling Methods for Constrained Optimization
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作者 PEI Yonggang WANG Jingyi 《应用数学》 北大核心 2026年第1期258-277,共20页
In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the op... In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported. 展开更多
关键词 Constrained optimization Adaptive cubic regularisation Affine scaling Global convergence
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RhoA/ROCK信号转导通路在原发性膝关节骨性关节炎滑膜组织中的表达及意义
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作者 杨天翔 王怡 +5 位作者 刘学起 王胤斌 马彪 王若瑜 马亚星 陈德胜 《陕西医学杂志》 2026年第3期406-412,共7页
目的:探讨Ras同源基因家族成员A(RhoA)/Rho相关蛋白激酶(ROCK)信号转导通路在原发性膝关节骨性关节炎(KOA)滑膜组织中的表达及意义。方法:收集30例行全膝关节置换术(TKA)的原发性KOA患者的滑膜组织作为观察组,以25例来自下肢离断术的滑... 目的:探讨Ras同源基因家族成员A(RhoA)/Rho相关蛋白激酶(ROCK)信号转导通路在原发性膝关节骨性关节炎(KOA)滑膜组织中的表达及意义。方法:收集30例行全膝关节置换术(TKA)的原发性KOA患者的滑膜组织作为观察组,以25例来自下肢离断术的滑膜组织作为对照组,比较两组样本的外观形态与HE染色病理改变。通过免疫组织化学(IHC)染色、蛋白质免疫印迹(Western blot)及实时荧光定量PCR(RT-qPCR)检测RhoA和ROCK蛋白及mRNA的表达变化。结果:观察组标本呈现高度增生、充血、水肿、细胞排列紊乱及空泡化细胞。对照组标本呈白色,表面光滑无水肿,细胞/基质排列有序且均匀。观察组滑膜炎病理评分及RhoA、ROCK mRNA和蛋白表达水平高于对照组(均P<0.05)。结论:KOA患者滑膜组织中RhoA和ROCK mRNA及蛋白表达水平显著提高,表明RhoA/ROCK信号通路参与了原发性KOA发病过程。 展开更多
关键词 膝关节骨性关节炎 滑膜组织 滑膜炎 Ras同源基因家族成员A rho相关蛋白激酶 信号转导通路 组织形态
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Review of Metaheuristic Optimization Techniques for Enhancing E-Health Applications
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作者 Qun Song Chao Gao +3 位作者 Han Wu Zhiheng Rao Huafeng Qin Simon Fong 《Computers, Materials & Continua》 2026年第2期185-233,共49页
Metaheuristic algorithms,renowned for strong global search capabilities,are effective tools for solving complex optimization problems and show substantial potential in e-Health applications.This review provides a syst... Metaheuristic algorithms,renowned for strong global search capabilities,are effective tools for solving complex optimization problems and show substantial potential in e-Health applications.This review provides a systematic overview of recent advancements in metaheuristic algorithms and highlights their applications in e-Health.We selected representative algorithms published between 2019 and 2024,and quantified their influence using an entropy-weighted method based on journal impact factors and citation counts.CThe Harris Hawks Optimizer(HHO)demonstrated the highest early citation impact.The study also examined applications in disease prediction models,clinical decision support,and intelligent health monitoring.Notably,the Chaotic Salp Swarm Algorithm(CSSA)achieved 99.69% accuracy in detecting Novel Coronavirus Pneumonia.Future research should progress in three directions:improving theoretical reliability and performance predictability in medical contexts;designing more adaptive and deployable mechanisms for real-world systems;and integrating ethical,privacy,and technological considerations to enable precision medicine,digital twins,and intelligent medical devices. 展开更多
关键词 Metaheuristic optimization E-HEALTH disease diagnosis medical resource optimization complex optimization
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Research Progress on Process Optimization and Performance Control of Additive Manufacturing for Refractory Metals
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作者 Lu Durui Song Suocheng Lu Bingheng 《稀有金属材料与工程》 北大核心 2026年第2期345-364,共20页
Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durabili... Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durability,and corrosion resistance.These metals have body-centered cubic crystal structure,characterized by limited slip systems and impeded dislocation motion,resulting in significant low-temperature brittleness,which poses challenges for the conventional processing.Additive manufacturing technique provides an innovative approach,enabling the production of intricate parts without molds,which significantly improves the efficiency of material usage.This review provides a comprehensive overview of the advancements in additive manufacturing techniques for the production of refractory metals,such as W,Ta,Mo,and Nb,particularly the laser powder bed fusion.In this review,the influence mechanisms of key process parameters(laser power,scan strategy,and powder characteristics)on the evolution of material microstructure,the formation of metallurgical defects,and mechanical properties were discussed.Generally,optimizing powder characteristics,such as sphericity,implementing substrate preheating,and formulating alloying strategies can significantly improve the densification and crack resistance of manufactured parts.Meanwhile,strictly controlling the oxygen impurity content and optimizing the energy density input are also the key factors to achieve the simultaneous improvement in strength and ductility of refractory metals.Although additive manufacturing technique provides an innovative solution for processing refractory metals,critical issues,such as residual stress control,microstructure and performance anisotropy,and process stability,still need to be addressed.This review not only provides a theoretical basis for the additive manufacturing of high-performance refractory metals,but also proposes forward-looking directions for their industrial application. 展开更多
关键词 refractory metals additive manufacturing mechanical properties microstructure evolution optimization of printing process
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PID Steering Control Method of Agricultural Robot Based on Fusion of Particle Swarm Optimization and Genetic Algorithm
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作者 ZHAO Longlian ZHANG Jiachuang +2 位作者 LI Mei DONG Zhicheng LI Junhui 《农业机械学报》 北大核心 2026年第1期358-367,共10页
Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion... Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots. 展开更多
关键词 agricultural robot steering PID control particle swarm optimization algorithm genetic algorithm
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MCPSFOA:Multi-Strategy Enhanced Crested Porcupine-Starfish Optimization Algorithm for Global Optimization and Engineering Design
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作者 Hao Chen Tong Xu +2 位作者 Yutian Huang Dabo Xin Changting Zhong 《Computer Modeling in Engineering & Sciences》 2026年第1期494-545,共52页
Optimization problems are prevalent in various fields of science and engineering,with several real-world applications characterized by high dimensionality and complex search landscapes.Starfish optimization algorithm(... Optimization problems are prevalent in various fields of science and engineering,with several real-world applications characterized by high dimensionality and complex search landscapes.Starfish optimization algorithm(SFOA)is a recently optimizer inspired by swarm intelligence,which is effective for numerical optimization,but it may encounter premature and local convergence for complex optimization problems.To address these challenges,this paper proposes the multi-strategy enhanced crested porcupine-starfish optimization algorithm(MCPSFOA).The core innovation of MCPSFOA lies in employing a hybrid strategy to improve SFOA,which integrates the exploratory mechanisms of SFOA with the diverse search capacity of the Crested Porcupine Optimizer(CPO).This synergy enhances MCPSFOA’s ability to navigate complex and multimodal search spaces.To further prevent premature convergence,MCPSFOA incorporates Lévy flight,leveraging its characteristic long and short jump patterns to enable large-scale exploration and escape from local optima.Subsequently,Gaussian mutation is applied for precise solution tuning,introducing controlled perturbations that enhance accuracy and mitigate the risk of insufficient exploitation.Notably,the population diversity enhancement mechanism periodically identifies and resets stagnant individuals,thereby consistently revitalizing population variety throughout the optimization process.MCPSFOA is rigorously evaluated on 24 classical benchmark functions(including high-dimensional cases),the CEC2017 suite,and the CEC2022 suite.MCPSFOA achieves superior overall performance with Friedman mean ranks of 2.208,2.310 and 2.417 on these benchmark functions,outperforming 11 state-of-the-art algorithms.Furthermore,the practical applicability of MCPSFOA is confirmed through its successful application to five engineering optimization cases,where it also yields excellent results.In conclusion,MCPSFOA is not only a highly effective and reliable optimizer for benchmark functions,but also a practical tool for solving real-world optimization problems. 展开更多
关键词 Global optimization starfish optimization algorithm crested porcupine optimizer METAHEURISTIC Gaussian mutation population diversity enhancement
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A Review of Optimization Methods for Pole-shoe Structures in Large-scale Salient Pole Synchronous Motors
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作者 Pengcheng Ma Jinxiu Chen Yiwei Ding 《CES Transactions on Electrical Machines and Systems》 2026年第1期28-43,共16页
Optimizing the rotor pole-shoe structure of large salient pole synchronous motors is critical for improving their performance and efficiency,allowing for enhanced responsiveness to grid demands and adjustments in oper... Optimizing the rotor pole-shoe structure of large salient pole synchronous motors is critical for improving their performance and efficiency,allowing for enhanced responsiveness to grid demands and adjustments in operating conditions.This paper provides a comprehensive review of various pole-shoe structures for salient pole synchronous motor rotors and their associated optimization techniques.First,it outlines the role of the pole-shoe structure and examines the theoretical theories of key electromagnetic parameters,including the pole-arc coefficient,voltage waveform coefficient,and armature reaction coefficient.Regarding structural design,this paper explores several configurations,including the threesegment arc,five-segment arc,single eccentric pole-arc combined with two chordal surface sections,and asymmetric poles.The effects of these designs on the air-gap magnetic field distribution and voltage waveform are evaluated.In terms of methodology,this paper reviews the application of numerical solutions to electromagnetic field inverse problems and the use of optimization algorithms for electrical machine structural optimization.This study illustrates the application of improved simulated annealing algorithms,tabu search algorithms,and particle swarm optimization algorithms for single-objective optimization of five-segment arc pole-shoe structures.Additionally,this paper discusses the use of vector tabu search and multi-objective quantum evolutionary algorithms for the multi-objective optimization of five-segment arc pole-shoe structures.The study concludes that multi-objective optimization algorithms are underutilized for pole-shoe structure optimization and suggests that multi-objective particle swarm optimization could be more extensively employed for this purpose.Furthermore,the potential application of topology optimization methods for the design of salient-pole synchronous motor rotor magnetic poles is proposed. 展开更多
关键词 Electromagnetic field inverse problem Fivesegment arc pole-shoe Multi-objective optimization Particle swarm optimization Rotor pole-shoe Structural optimization
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A satellite layout-structure integrated optimization method based on thermal metamaterials
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作者 Senlin HUO Bingxiao DU +2 位作者 Wei CONG Yong ZHAO Xianqi CHEN 《Chinese Journal of Aeronautics》 2026年第2期328-340,共13页
In the conceptual design phase of the satellite thermal management system,components layout optimization and structural topology optimization of satellite panel can meet global and local thermal management requirement... In the conceptual design phase of the satellite thermal management system,components layout optimization and structural topology optimization of satellite panel can meet global and local thermal management requirements,respectively.However,achieving non-interfering coupling between these two optimization processes remains a challenge.An integrated layout-structure design method based on thermal metamaterials is proposed,which comprises two design stages.In the first stage,components layout optimization is conducted to maximize temperature uniformity within the satellite module,yielding a globally optimized layout with balanced thermal characteristics.In the second stage,topology optimization guided by the design principle of thermal metamaterials is implemented in critical local panel regions to satisfy differentiated heat transfer requirements of components with diverse functional and thermal sensitivity properties.The key innovation lies in utilizing thermal metamaterials as a mediator to synergistically couple global components layout optimization with local structural topology optimization,which enables customized local heat flux manipulation without interfering with the globally optimized temperature field derived from the layout optimization.The method introduces neither additional mass nor special materials,offering advantages of low cost,high reliability,and strong versatility.It provides a new solution paradigm for the design of passive thermal management systems in satellites. 展开更多
关键词 Layout optimization METAMATERIALS SATELLITES Structure design Thermal management Topology optimization
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Multi-objective topology optimization for cutout design in deployable composite thin-walled structures
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作者 Hao JIN Ning AN +3 位作者 Qilong JIA Chun SHAO Xiaofei MA Jinxiong ZHOU 《Chinese Journal of Aeronautics》 2026年第1期674-694,共21页
Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structu... Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structural rigidity and flexibility,ensuring material integrity during large deformations,and providing adequate load-bearing capacity and stability once deployed.Most research has focused on optimizing cutout size and shape,while topology optimization offers a broader design space.However,the anisotropic properties of woven composite laminates,complex failure criteria,and multi-performance optimization needs have limited the exploration of topology optimization in this field.This work derives the sensitivities of bending stiffness,critical buckling load,and the failure index of woven composite materials with respect to element density,and formulates both single-objective and multi-objective topology optimization models using a linear weighted aggregation approach.The developed method was integrated with the commercial finite element software ABAQUS via a Python script,allowing efficient application to cutout design in various DCTWS configurations to maximize bending stiffness and critical buckling load under material failure constraints.Optimization of a classical tubular hinge resulted in improvements of 107.7%in bending stiffness and 420.5%in critical buckling load compared to level-set topology optimization results reported in the literature,validating the effectiveness of the approach.To facilitate future research and encourage the broader adoption of topology optimization techniques in DCTWS design,the source code for this work is made publicly available via a Git Hub link:https://github.com/jinhao-ok1/Topo-for-DCTWS.git. 展开更多
关键词 Composite laminates Deployable structures Multi-objective optimization Thin-walled structures Topology optimization
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Several Improved Models of the Mountain Gazelle Optimizer for Solving Optimization Problems
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作者 Farhad Soleimanian Gharehchopogh Keyvan Fattahi Rishakan 《Computer Modeling in Engineering & Sciences》 2026年第1期727-780,共54页
Optimization algorithms are crucial for solving NP-hard problems in engineering and computational sciences.Metaheuristic algorithms,in particular,have proven highly effective in complex optimization scenarios characte... Optimization algorithms are crucial for solving NP-hard problems in engineering and computational sciences.Metaheuristic algorithms,in particular,have proven highly effective in complex optimization scenarios characterized by high dimensionality and intricate variable relationships.The Mountain Gazelle Optimizer(MGO)is notably effective but struggles to balance local search refinement and global space exploration,often leading to premature convergence and entrapment in local optima.This paper presents the Improved MGO(IMGO),which integrates three synergistic enhancements:dynamic chaos mapping using piecewise chaotic sequences to boost explo-ration diversity;Opposition-Based Learning(OBL)with adaptive,diversity-driven activation to speed up convergence;and structural refinements to the position update mechanisms to enhance exploitation.The IMGO underwent a comprehensive evaluation using 52 standardised benchmark functions and seven engineering optimization problems.Benchmark evaluations showed that IMGO achieved the highest rank in best solution quality for 31 functions,the highest rank in mean performance for 18 functions,and the highest rank in worst-case performance for 14 functions among 11 competing algorithms.Statistical validation using Wilcoxon signed-rank tests confirmed that IMGO outperformed individual competitors across 16 to 50 functions,depending on the algorithm.At the same time,Friedman ranking analysis placed IMGO with an average rank of 4.15,compared to the baseline MGO’s 4.38,establishing the best overall performance.The evaluation of engineering problems revealed consistent improvements,including an optimal cost of 1.6896 for the welded beam design vs.MGO’s 1.7249,a minimum cost of 5885.33 for the pressure vessel design vs.MGO’s 6300,and a minimum weight of 2964.52 kg for the speed reducer design vs.MGO’s 2990.00 kg.Ablation studies identified OBL as the strongest individual contributor,whereas complete integration achieved superior performance through synergistic interactions among components.Computational complexity analysis established an O(T×N×5×f(P))time complexity,representing a 1.25×increase in fitness evaluation relative to the baseline MGO,validating the favorable accuracy-efficiency trade-offs for practical optimization applications. 展开更多
关键词 Metaheuristic algorithm dynamical chaos integration opposition-based learning mountain gazelle optimizer optimization
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Painted Wolf Optimization:A Novel Nature-Inspired Metaheuristic Algorithm for Real-World Optimization Problems
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作者 Saeid Sheikhi 《Computers, Materials & Continua》 2026年第5期243-271,共29页
Metaheuristic optimization algorithms continue to be essential for solving complex real-world problems,yet existingmethods often struggle with balancing exploration and exploitation across diverse problem landscapes.T... Metaheuristic optimization algorithms continue to be essential for solving complex real-world problems,yet existingmethods often struggle with balancing exploration and exploitation across diverse problem landscapes.This paper proposes a novel nature-inspired metaheuristic optimization algorithm named the Painted Wolf Optimization(PWO)algorithm.The main inspiration for the PWO algorithm is the group behavior and hunting strategy of painted wolves,also known as African wild dogs in the wild,particularly their unique consensus-based voting rally mechanism,a behavior fundamentally distinct fromthe social dynamics of grey wolves.In this innovative process,pack members explore different areas to find prey;then,they hold a pre-hunting voting rally based on the alpha member to determine who will begin the hunt and attack the prey.The efficiency of the proposed PWO algorithm is evaluated by a comparison study with other well-known optimization algorithms on 33 test functions,including the Congress on Evolutionary Computation(CEC)2017 suite and different real-world engineering design cases.Furthermore,the algorithm’s performance is further tested across a spectrum of optimization problems with extensive unknown search spaces.This includes its application within the field of cybersecurity,specifically in the context of training a machine learning-based intrusion detection system(ML-IDS),achieving an accuracy of 0.90 and an F-measure of 0.9290.Statistical analyses using the Wilcoxon signed-rank test(all p<0.05)indicate that the PWO algorithm outperforms existing state-of-the-art algorithms,providing superior solutions in diverse and unpredictable optimization landscapes.This demonstrates its potential as a robust method for tackling complex optimization problems in various fields.The source code for thePWOalgorithmis publicly available at https://github.com/saeidsheikhi/Painted-Wolf-Optimization. 展开更多
关键词 optimization painted wolf optimization algorithm metaheuristic algorithm nature-inspired computing swarm intelligence
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A collaborative optimization design method of platform location and well trajectory for a complex-structure well factory
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作者 WANG Ge GAO Deli HUANG Wenjun 《Petroleum Exploration and Development》 2026年第1期261-271,共11页
Using platform-target matching deviation,anti-collision difficulty,trajectory complexity,and total drilling footage as objective functions,and comprehensively considering constraints such as platform layout area,drill... Using platform-target matching deviation,anti-collision difficulty,trajectory complexity,and total drilling footage as objective functions,and comprehensively considering constraints such as platform layout area,drilling extension limits,underground target distribution and trajectory collision risks,a model of platform location-wellbore trajectory collaborative optimization for a complex-structure well factory is developed.A hybrid heuristic algorithm is proposed by combining an improved sparrow search algorithm(ISSA)for optimizing platform parameters in the outer layer and a directed artificial bee colony algorithm(DABC)for optimizing trajectory parameters in the inner layer.The alternating iteration of ISSA-DABC facilitates the resolution of the collaborative optimization problem.The ISSA-DABC provides an effective solution to the platform-trajectory collaborative optimization problem for complex-structure well factories and overcomes the tendency of the traditional platform-trajectory stepwise optimization workflow to become trapped in local optima and yield inconsistent designs.The ISSA-DABC has a strong global search capability,fast convergence and good robustness,and can simultaneously satisfy multiple engineering constraints on drilling footage,trajectory complexity and collision risk,and enables automated,workflow-wide generation of constraint-compliant,near-globally optimal platform-trajectory configurations.Field applications further demonstrate that ISSA-DABC significantly reduces the objective function value and collision risk,yielding more rational platform layouts and well factory design parameters. 展开更多
关键词 complex-structure well factory ISSA DABC platform-trajectory collaborative optimization well factory parameter optimization
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An Overall Optimization Model Using Metaheuristic Algorithms for the CNN-Based IoT Attack Detection Problem
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作者 Le Thi Hong Van Le Duc Thuan +1 位作者 Pham Van Huong Nguyen Hieu Minh 《Computers, Materials & Continua》 2026年第4期1934-1964,共31页
Optimizing convolutional neural networks(CNNs)for IoT attack detection remains a critical yet challenging task due to the need to balance multiple performance metrics beyond mere accuracy.This study proposes a unified... Optimizing convolutional neural networks(CNNs)for IoT attack detection remains a critical yet challenging task due to the need to balance multiple performance metrics beyond mere accuracy.This study proposes a unified and flexible optimization framework that leverages metaheuristic algorithms to automatically optimize CNN configurations for IoT attack detection.Unlike conventional single-objective approaches,the proposed method formulates a global multi-objective fitness function that integrates accuracy,precision,recall,and model size(speed/model complexity penalty)with adjustable weights.This design enables both single-objective and weightedsum multi-objective optimization,allowing adaptive selection of optimal CNN configurations for diverse deployment requirements.Two representativemetaheuristic algorithms,GeneticAlgorithm(GA)and Particle Swarm Optimization(PSO),are employed to optimize CNNhyperparameters and structure.At each generation/iteration,the best configuration is selected as themost balanced solution across optimization objectives,i.e.,the one achieving themaximum value of the global objective function.Experimental validation on two benchmark datasets,Edge-IIoT and CIC-IoT2023,demonstrates that the proposed GA-and PSO-based models significantly enhance detection accuracy(94.8%–98.3%)and generalization compared with manually tuned CNN configurations,while maintaining compact architectures.The results confirm that the multi-objective framework effectively balances predictive performance and computational efficiency.This work establishes a generalizable and adaptive optimization strategy for deep learning-based IoT attack detection and provides a foundation for future hybrid metaheuristic extensions in broader IoT security applications. 展开更多
关键词 Genetic algorithm(GA) particle swarm optimization(PSO) multi-objective optimization convolutional neural network—CNN IoT attack detection metaheuristic optimization CNN configuration
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Path planning of unmanned surface vehicles based on improved particle swarm optimization algorithm with consideration of particle sight distance
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作者 WANG Cheng YANG Junnan +3 位作者 ZHANG Xinyang QIAN Zhong ZHU Ye LIU Hong 《上海海事大学学报》 北大核心 2026年第1期9-19,共11页
To enhance the accuracy of path planning of unmanned surface vehicles(USVs),the particle swarm optimization algorithm(PSO)is improved based on species migration strategies observed in ecology.By incorporating the conc... To enhance the accuracy of path planning of unmanned surface vehicles(USVs),the particle swarm optimization algorithm(PSO)is improved based on species migration strategies observed in ecology.By incorporating the concept of particle sight distance,an improved algorithm,called SD-IPSO,is proposed for the real-time autonomous navigation of USVs in marine environments.The algorithm refines the individual behavior pattern of particles in the population,effectively improving both local and global search capabilities while avoiding premature convergence.The effectiveness of the algorithm is validated using standard test functions from CEC-2017 function library,assessing it from multiple dimensions.Sensitivity analysis is conducted on key parameters in the algorithm,including particle sight distance and population size.Results indicate that compared with PSO,SD-IPSO demonstrates significant advantages in optimization accuracy and convergence speed.The application of SD-IPSO in path planning is further investigated through a 14-point traveling salesman problem(TSP)example and navigation autonomous tests of USVs in marine environments.Findings demonstrate that the proposed algorithm exhibits superior optimization capabilities and can effectively address the path planning challenges of USVs. 展开更多
关键词 particle swarm optimization algorithm(PSO) sight distance unmanned surface vehicle(USV)
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Multi-Objective Enhanced Cheetah Optimizer for Joint Optimization of Computation Offloading and Task Scheduling in Fog Computing
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作者 Ahmad Zia Nazia Azim +5 位作者 Bekarystankyzy Akbayan Khalid J.Alzahrani Ateeq Ur Rehman Faheem Ullah Khan Nouf Al-Kahtani Hend Khalid Alkahtani 《Computers, Materials & Continua》 2026年第3期1559-1588,共30页
The cloud-fog computing paradigm has emerged as a novel hybrid computing model that integrates computational resources at both fog nodes and cloud servers to address the challenges posed by dynamic and heterogeneous c... The cloud-fog computing paradigm has emerged as a novel hybrid computing model that integrates computational resources at both fog nodes and cloud servers to address the challenges posed by dynamic and heterogeneous computing networks.Finding an optimal computational resource for task offloading and then executing efficiently is a critical issue to achieve a trade-off between energy consumption and transmission delay.In this network,the task processed at fog nodes reduces transmission delay.Still,it increases energy consumption,while routing tasks to the cloud server saves energy at the cost of higher communication delay.Moreover,the order in which offloaded tasks are executed affects the system’s efficiency.For instance,executing lower-priority tasks before higher-priority jobs can disturb the reliability and stability of the system.Therefore,an efficient strategy of optimal computation offloading and task scheduling is required for operational efficacy.In this paper,we introduced a multi-objective and enhanced version of Cheeta Optimizer(CO),namely(MoECO),to jointly optimize the computation offloading and task scheduling in cloud-fog networks to minimize two competing objectives,i.e.,energy consumption and communication delay.MoECO first assigns tasks to the optimal computational nodes and then the allocated tasks are scheduled for processing based on the task priority.The mathematical modelling of CO needs improvement in computation time and convergence speed.Therefore,MoECO is proposed to increase the search capability of agents by controlling the search strategy based on a leader’s location.The adaptive step length operator is adjusted to diversify the solution and thus improves the exploration phase,i.e.,global search strategy.Consequently,this prevents the algorithm from getting trapped in the local optimal solution.Moreover,the interaction factor during the exploitation phase is also adjusted based on the location of the prey instead of the adjacent Cheetah.This increases the exploitation capability of agents,i.e.,local search capability.Furthermore,MoECO employs a multi-objective Pareto-optimal front to simultaneously minimize designated objectives.Comprehensive simulations in MATLAB demonstrate that the proposed algorithm obtains multiple solutions via a Pareto-optimal front and achieves an efficient trade-off between optimization objectives compared to baseline methods. 展开更多
关键词 Computation offloading task scheduling cheetah optimizer fog computing optimization resource allocation internet of things
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