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补肾化痰方治疗肥胖型PCOS伴胰岛素抵抗的临床研究
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作者 于庆云 许晓岚 +2 位作者 王蓓蓓 周小平 陈晨 《中文科技期刊数据库(文摘版)医药卫生》 2025年第3期009-014,共6页
观察补肾化痰方治疗肥胖型PCOS(多囊卵巢综合征)伴胰岛素抵抗的临床效果,并讨论其作用机理。方法 临床以60例患者进行分组,采用不同治疗方案,包括单一二甲双胍治疗以及联合补肾化痰方治疗。结果 联合补肾化痰方治疗者,治疗效果、FSH、HD... 观察补肾化痰方治疗肥胖型PCOS(多囊卵巢综合征)伴胰岛素抵抗的临床效果,并讨论其作用机理。方法 临床以60例患者进行分组,采用不同治疗方案,包括单一二甲双胍治疗以及联合补肾化痰方治疗。结果 联合补肾化痰方治疗者,治疗效果、FSH、HDL-C高于对照组,体重、BMI、体脂率等其他指标则则低于对照组(P<0.05)。结论 补肾化痰方能够改善肥胖型PCOS伴胰岛素抵抗患者的临床症状,调节内分泌。 展开更多
关键词 肥胖型pcoS(多囊卵巢综合征) 补肾化痰方 性激素 脂代谢 胰岛素抵抗
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肥胖型PCOS不孕症患者血清铁代谢指标、miR-29a、VIP的变化及临床意义
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作者 王屹雯 任宝红 +1 位作者 周亚红 温丽娜 《中南医学科学杂志》 2025年第3期418-421,共4页
目的探讨肥胖型多囊卵巢综合征(PCOS)不孕症患者血清铁代谢指标、miR-29a、血管活性肠肽(VIP)的变化及其临床意义。方法选取PCOS不孕症患者130例,按照是否肥胖分为肥胖组和非肥胖组;按照随访结果,肥胖组分为促排妊娠成功组和失败组,或... 目的探讨肥胖型多囊卵巢综合征(PCOS)不孕症患者血清铁代谢指标、miR-29a、血管活性肠肽(VIP)的变化及其临床意义。方法选取PCOS不孕症患者130例,按照是否肥胖分为肥胖组和非肥胖组;按照随访结果,肥胖组分为促排妊娠成功组和失败组,或者妊娠结局不良组和良好组。比较各组血清铁蛋白、miR-29a、VIP水平,采用ROC曲线分析铁蛋白、miR-29a及VIP的预测价值。结果肥胖组铁蛋白、miR-29a高于非肥胖组,VIP低于非肥胖组(P<0.05)。失败组铁蛋白、miR-29a高于成功组,VIP低于成功组(P<0.05)。不良组铁蛋白、miR-29a高于良好组,VIP低于良好组(P<0.05)。铁蛋白、miR-29a及VIP对促排妊娠失败具有良好的预测价值,铁蛋白、miR-29a对不良妊娠结局具有良好的预测价值(P<0.05)。结论PCOS不孕症患者血清铁蛋白、miR-29a升高,VIP降低,且与促排妊娠、妊娠结局有明显关系。 展开更多
关键词 肥胖型pcoS 不孕症 铁蛋白 miR-29a VIP 妊娠结局
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Prediction and optimization of flue pressure in sintering process based on SHAP 被引量:1
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作者 Mingyu Wang Jue Tang +2 位作者 Mansheng Chu Quan Shi Zhen Zhang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第2期346-359,共14页
Sinter is the core raw material for blast furnaces.Flue pressure,which is an important state parameter,affects sinter quality.In this paper,flue pressure prediction and optimization were studied based on the shapley a... Sinter is the core raw material for blast furnaces.Flue pressure,which is an important state parameter,affects sinter quality.In this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment measures.First,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction model.The effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment conditions.The operating parameter combination was then pushed.The flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect. 展开更多
关键词 sintering process flue pressure shapley additive explanation PREDICTION optimization
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吴克明教授治疗PCOS排卵障碍性不孕的经验介绍
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作者 魏宇雯 黄菁菁 +1 位作者 昝雪韵 吴克明 《医师在线》 2025年第1期83-86,共4页
多囊卵巢综合征(PCOS)是一种常见的妇科临床难治性疾病,主要影响年轻育龄期女性。由于排卵障碍,患者主要表现为月经稀发、闭经和不孕。临床通过纠正高雄激素血症和改善胰岛素抵抗来调整内分泌紊乱,并促进和恢复卵巢排卵功能,这是维持规... 多囊卵巢综合征(PCOS)是一种常见的妇科临床难治性疾病,主要影响年轻育龄期女性。由于排卵障碍,患者主要表现为月经稀发、闭经和不孕。临床通过纠正高雄激素血症和改善胰岛素抵抗来调整内分泌紊乱,并促进和恢复卵巢排卵功能,这是维持规律性月经和提高生育能力的关键治疗策略。西医在明确病因诊断后,常采用抗雄激素、降低胰岛素抵抗、促排卵等治疗PCOS;中医则在辨证基础上使用中医药进行调经助孕。本文主要介绍吴克明教授采用加减苁蓉菟丝子方配合中成药调经助孕的成功案例和经验,为中医药治疗PCOS排卵障碍性不孕提供借鉴。 展开更多
关键词 pcoS 排卵障碍 吴克明 调经助孕 经验介绍
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PCOS患者发生高同型半胱氨酸血症的危险因素分析
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作者 杨岩婷 虎宁 +3 位作者 刘琳 霍虎艳 杨欣 王芳 《生殖医学杂志》 2025年第6期728-734,共7页
目的分析多囊卵巢综合征(PCOS)患者发生高同型半胱氨酸血症(HHCY)的危险因素。方法回顾性分析2018年9月至2023年6月在兰州大学第二医院生殖医学科门诊就诊的387例PCOS患者的临床资料,根据血清同型半胱氨酸(HCY)水平是否≥15 mmol/L分为... 目的分析多囊卵巢综合征(PCOS)患者发生高同型半胱氨酸血症(HHCY)的危险因素。方法回顾性分析2018年9月至2023年6月在兰州大学第二医院生殖医学科门诊就诊的387例PCOS患者的临床资料,根据血清同型半胱氨酸(HCY)水平是否≥15 mmol/L分为两组:病例组(HHCY组,n=108)和对照组(NHHCY组,n=279),比较两组间的外周血激素水平及生化指标,单因素及多因素Logistic分析PCOS患者罹患HHCY的危险因素,采用Pearson统计分析HCY水平与血清激素、生化指标间的相关性。结果与对照组比较,病例组年龄较小,且血中总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil)、尿素(Urea)及肌酐(Cr)水平均显著高于对照组(P<0.05)。多因素Logistic回归分析显示,Urea[OR=1.204,95%CI(1.010,1.435)]是PCOS患者发生HHCY的独立危险因素(P<0.05)。相关性分析显示,PCOS患者血清T(r=0.119,P=0.023)、TBil(r=0.130,P=0.011)、IBil(r=0.103,P=0.042)、DBil(r=0.113,P=0.026)和Urea(r=0.113,P=0.026)与HCY呈显著正相关,年龄(r=-0.108,P=0.035)与HCY呈显著负相关。结论血清高尿素水平与PCOS患者发生HHCY存在关联,胆红素代谢对PCOS患者发生HHCY的风险发挥着潜在作用。 展开更多
关键词 多囊卵巢综合征 高同型半胱氨酸血症 同型半胱氨酸 危险因素
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Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System 被引量:1
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作者 Hongliang Hao Caifeng Wen +5 位作者 Feifei Xue Hao Qiu Ning Yang Yuwen Zhang Chaoyu Wang Edwin E.Nyakilla 《Energy Engineering》 EI 2025年第1期285-306,共22页
Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longe... Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems. 展开更多
关键词 Electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy
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Research progress of structural regulation and composition optimization to strengthen absorbing mechanism in emerging composites for efficient electromagnetic protection 被引量:4
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作者 Pengfei Yin Di Lan +7 位作者 Changfang Lu Zirui Jia Ailing Feng Panbo Liu Xuetao Shi Hua Guo Guanglei Wu Jian Wang 《Journal of Materials Science & Technology》 2025年第1期204-223,共20页
With the increasing complexity of the current electromagnetic environment,excessive microwave radi-ation not only does harm to human health but also forms various electromagnetic interference to so-phisticated electro... With the increasing complexity of the current electromagnetic environment,excessive microwave radi-ation not only does harm to human health but also forms various electromagnetic interference to so-phisticated electronic instruments.Therefore,the design and preparation of electromagnetic absorbing composites represent an efficient approach to mitigate the current hazards of electromagnetic radiation.However,traditional electromagnetic absorbers are difficult to satisfy the demands of actual utilization in the face of new challenges,and emerging absorbents have garnered increasing attention due to their structure and performance-based advantages.In this review,several emerging composites of Mxene-based,biochar-based,chiral,and heat-resisting are discussed in detail,including their synthetic strategy,structural superiority and regulation method,and final optimization of electromagnetic absorption ca-pacity.These insights provide a comprehensive reference for the future development of new-generation electromagnetic-wave absorption composites.Moreover,the potential development directions of these emerging absorbers have been proposed as well. 展开更多
关键词 Microwave absorption Structural regulation Performance optimization Emerging composites Synthetic strategy
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A survey on multi-objective,model-based,oil and gas field development optimization:Current status and future directions 被引量:1
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作者 Auref Rostamian Matheus Bernardelli de Moraes +1 位作者 Denis Jose Schiozer Guilherme Palermo Coelho 《Petroleum Science》 2025年第1期508-526,共19页
In the area of reservoir engineering,the optimization of oil and gas production is a complex task involving a myriad of interconnected decision variables shaping the production system's infrastructure.Traditionall... In the area of reservoir engineering,the optimization of oil and gas production is a complex task involving a myriad of interconnected decision variables shaping the production system's infrastructure.Traditionally,this optimization process was centered on a single objective,such as net present value,return on investment,cumulative oil production,or cumulative water production.However,the inherent complexity of reservoir exploration necessitates a departure from this single-objective approach.Mul-tiple conflicting production and economic indicators must now be considered to enable more precise and robust decision-making.In response to this challenge,researchers have embarked on a journey to explore field development optimization of multiple conflicting criteria,employing the formidable tools of multi-objective optimization algorithms.These algorithms delve into the intricate terrain of production strategy design,seeking to strike a delicate balance between the often-contrasting objectives.Over the years,a plethora of these algorithms have emerged,ranging from a priori methods to a posteriori approach,each offering unique insights and capabilities.This survey endeavors to encapsulate,catego-rize,and scrutinize these invaluable contributions to field development optimization,which grapple with the complexities of multiple conflicting objective functions.Beyond the overview of existing methodologies,we delve into the persisting challenges faced by researchers and practitioners alike.Notably,the application of multi-objective optimization techniques to production optimization is hin-dered by the resource-intensive nature of reservoir simulation,especially when confronted with inherent uncertainties.As a result of this survey,emerging opportunities have been identified that will serve as catalysts for pivotal research endeavors in the future.As intelligent and more efficient algo-rithms continue to evolve,the potential for addressing hitherto insurmountable field development optimization obstacles becomes increasingly viable.This discussion on future prospects aims to inspire critical research,guiding the way toward innovative solutions in the ever-evolving landscape of oil and gas production optimization. 展开更多
关键词 Derivative-free algorithms Ensemble-based optimization Gradient-based methods Life-cycle optimization Reservoir field development and management
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Reactive Power Optimization Model of Active Distribution Network with New Energy and Electric Vehicles 被引量:1
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作者 Chenxu Wang Jing Bian Rui Yuan 《Energy Engineering》 2025年第3期985-1003,共19页
Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power o... Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power optimization based on clustering-local relaxation-correction is proposed.Firstly,the k-medoids clustering algorithm is used to divide the reduced power scene into periods.Then,the discrete variables and continuous variables are optimized in the same period of time.Finally,the number of input groups of parallel capacitor banks(CB)in multiple periods is fixed,and then the secondary static reactive power optimization correction is carried out by using the continuous reactive power output device based on the static reactive power compensation device(SVC),the new energy grid-connected inverter,and the electric vehicle charging station.According to the characteristics of the model,a hybrid optimization algorithm with a cross-feedback mechanism is used to solve different types of variables,and an improved artificial hummingbird algorithm based on tent chaotic mapping and adaptive mutation is proposed to improve the solution efficiency.The simulation results show that the proposed decoupling strategy can obtain satisfactory optimization resultswhile strictly guaranteeing the dynamic constraints of discrete variables,and the hybrid algorithm can effectively solve the mixed integer nonlinear optimization problem. 展开更多
关键词 Active distribution network new energy electric vehicles dynamic reactive power optimization kmedoids clustering hybrid optimization algorithm
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A Multi-Objective Particle Swarm Optimization Algorithm Based on Decomposition and Multi-Selection Strategy
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作者 Li Ma Cai Dai +1 位作者 Xingsi Xue Cheng Peng 《Computers, Materials & Continua》 SCIE EI 2025年第1期997-1026,共30页
The multi-objective particle swarm optimization algorithm(MOPSO)is widely used to solve multi-objective optimization problems.In the article,amulti-objective particle swarm optimization algorithmbased on decomposition... The multi-objective particle swarm optimization algorithm(MOPSO)is widely used to solve multi-objective optimization problems.In the article,amulti-objective particle swarm optimization algorithmbased on decomposition and multi-selection strategy is proposed to improve the search efficiency.First,two update strategies based on decomposition are used to update the evolving population and external archive,respectively.Second,a multiselection strategy is designed.The first strategy is for the subspace without a non-dominated solution.Among the neighbor particles,the particle with the smallest penalty-based boundary intersection value is selected as the global optimal solution and the particle far away fromthe search particle and the global optimal solution is selected as the personal optimal solution to enhance global search.The second strategy is for the subspace with a non-dominated solution.In the neighbor particles,two particles are randomly selected,one as the global optimal solution and the other as the personal optimal solution,to enhance local search.The third strategy is for Pareto optimal front(PF)discontinuity,which is identified by the cumulative number of iterations of the subspace without non-dominated solutions.In the subsequent iteration,a new probability distribution is used to select from the remaining subspaces to search.Third,an adaptive inertia weight update strategy based on the dominated degree is designed to further improve the search efficiency.Finally,the proposed algorithmis compared with fivemulti-objective particle swarm optimization algorithms and five multi-objective evolutionary algorithms on 22 test problems.The results show that the proposed algorithm has better performance. 展开更多
关键词 Multi-objective optimization multi-objective particle swarm optimization DECOMPOSITION multi-selection strategy
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Enhanced Lead and Zinc Removal via Prosopis Cineraria Leaves Powder: A Study on Isotherms and RSM Optimization 被引量:1
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作者 Rakesh Namdeti Gaddala Babu Rao +7 位作者 Nageswara Rao Lakkimsetty Noor Mohammed Said Qahoor Naveen Prasad B.S Uma Reddy Meka Prema.P.M Doaa Salim Musallam Samhan Al-Kathiri Muayad Abdullah Ahmed Qatan Hafidh Ahmed Salim Ba Alawi 《Journal of Environmental & Earth Sciences》 2025年第1期292-305,共14页
This study investigates the potential of Prosopis cineraria Leaves Powder(PCLP)as a biosorbent for removing lead(Pb)and zinc(Zn)from aqueous solutions,optimizing the process using Response Surface Methodology(RSM).Pro... This study investigates the potential of Prosopis cineraria Leaves Powder(PCLP)as a biosorbent for removing lead(Pb)and zinc(Zn)from aqueous solutions,optimizing the process using Response Surface Methodology(RSM).Prosopis cineraria,commonly known as Khejri,is a drought-resistant tree with significant promise in environmental applications.The research employed a Central Composite Design(CCD)to examine the independent and combined effects of key process variables,including initial metal ion concentration,contact time,pH,and PCLP dosage.RSM was used to develop mathematical models that explain the relationship between these factors and the efficiency of metal removal,allowing the determination of optimal operating conditions.The experimental results indicated that the Langmuir isotherm model was the most appropriate for describing the biosorption of both metals,suggesting favorable adsorption characteristics.Additionally,the D-R isotherm confirmed that chemisorption was the primary mechanism involved in the biosorption process.For lead removal,the optimal conditions were found to be 312.23 K temperature,pH 4.72,58.5 mg L-1 initial concentration,and 0.27 g biosorbent dosage,achieving an 83.77%removal efficiency.For zinc,the optimal conditions were 312.4 K,pH 5.86,53.07 mg L-1 initial concentration,and the same biosorbent dosage,resulting in a 75.86%removal efficiency.These findings highlight PCLP’s potential as an effective,eco-friendly biosorbent for sustainable heavy metal removal in water treatment. 展开更多
关键词 Prosopis Cineraria LEAD ZINC Isotherms optimization
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经阴道超声血流参数联合血清IL-12水平对PCOS不孕症IVF-ET妊娠失败的预测价值
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作者 徐梦晗 闵洁 +1 位作者 明亮 彭国平 《生殖医学杂志》 2025年第5期618-623,共6页
目的探讨经阴道超声血流参数联合血清白细胞介素-12(IL-12)水平对多囊卵巢综合征(PCOS)不孕症IVF-ET妊娠失败的预估效能。方法选取2022年7月至2024年7月本院收治的148例PCOS不孕症行IVF-ET治疗的患者为研究对象,根据妊娠结局分为妊娠成... 目的探讨经阴道超声血流参数联合血清白细胞介素-12(IL-12)水平对多囊卵巢综合征(PCOS)不孕症IVF-ET妊娠失败的预估效能。方法选取2022年7月至2024年7月本院收治的148例PCOS不孕症行IVF-ET治疗的患者为研究对象,根据妊娠结局分为妊娠成功组(妊娠成功,n=60)和妊娠失败组(妊娠失败,n=88)。所有患者均经阴道彩色多普勒超声仪检测子宫血流动力学参数[阻力指数(RI)、搏动指数(PI)、收缩与舒张末期最大血流速度比值(S/D)],采用ELISA法检测血清IL-12水平,比较两组间IL-12水平及子宫血流动力参数。多因素Logistic回归分析影响PCOS不孕症IVF-ET妊娠失败的因素,受试者工作特征(ROC)曲线分析经阴道超声血流参数联合血清IL-12水平对PCOS不孕症IVF-ET妊娠失败的预测价值。结果与妊娠成功组相比,妊娠失败组患者睾酮(T)水平[(6.98±0.78)nmol/L vs.(5.65±0.63)nmol/L]、阴道超声血流参数(RI、PI、S/D)、血清IL-12水平[(17.65±2.14)ng/ml vs.(15.43±1.88)ng/ml]均显著升高(P<0.05)。多因素Logistic回归分析显示,T[OR=2.685,95%CI(2.061,3.498)]、IL-12[OR=3.748,95%CI(2.174,6.463)]、RI[OR=5.054,95%CI(2.995,8.529)]、PI[OR=4.108,95%CI(2.572,6.563)]、S/D[OR=3.886,95%CI(2.590,5.830)]均是PCOS不孕症IVF-ET妊娠失败的影响因素(P<0.05)。检测效能评估显示,经阴道超声血流参数(RI、PI、S/D)联合血清IL-12水平对PCOS不孕症IVF-ET妊娠失败预测的曲线下面积(AUC)均显著高于RI(Z=4.485)、PI(Z=5.049)、S/D(Z=4.351)及IL-12水平(Z=4.441)的单独预测(P<0.05)。结论PCOS不孕症IVF-ET妊娠失败患者血清中IL-12水平升高,经阴道超声血流参数联合血清IL-12水平对PCOS不孕症IVF-ET妊娠失败的预测价值较高。 展开更多
关键词 经阴道超声血流参数 白细胞介素-12 多囊卵巢综合征 不孕症 体外受精-胚胎移植 妊娠
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Evolutionary Particle Swarm Optimization Algorithm Based on Collective Prediction for Deployment of Base Stations
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作者 Jiaying Shen Donglin Zhu +5 位作者 Yujia Liu Leyi Wang Jialing Hu Zhaolong Ouyang Changjun Zhou Taiyong Li 《Computers, Materials & Continua》 SCIE EI 2025年第1期345-369,共25页
The wireless signals emitted by base stations serve as a vital link connecting people in today’s society and have been occupying an increasingly important role in real life.The development of the Internet of Things(I... The wireless signals emitted by base stations serve as a vital link connecting people in today’s society and have been occupying an increasingly important role in real life.The development of the Internet of Things(IoT)relies on the support of base stations,which provide a solid foundation for achieving a more intelligent way of living.In a specific area,achieving higher signal coverage with fewer base stations has become an urgent problem.Therefore,this article focuses on the effective coverage area of base station signals and proposes a novel Evolutionary Particle Swarm Optimization(EPSO)algorithm based on collective prediction,referred to herein as ECPPSO.Introducing a new strategy called neighbor-based evolution prediction(NEP)addresses the issue of premature convergence often encountered by PSO.ECPPSO also employs a strengthening evolution(SE)strategy to enhance the algorithm’s global search capability and efficiency,ensuring enhanced robustness and a faster convergence speed when solving complex optimization problems.To better adapt to the actual communication needs of base stations,this article conducts simulation experiments by changing the number of base stations.The experimental results demonstrate thatunder the conditionof 50 ormore base stations,ECPPSOconsistently achieves the best coverage rate exceeding 95%,peaking at 99.4400%when the number of base stations reaches 80.These results validate the optimization capability of the ECPPSO algorithm,proving its feasibility and effectiveness.Further ablative experiments and comparisons with other algorithms highlight the advantages of ECPPSO. 展开更多
关键词 Particle swarm optimization effective coverage area global optimization base station deployment
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PCOS患者外周血AMH水平与基础窦卵泡数量的相关性分析
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作者 蒋如煜 黄晨阳 +1 位作者 陈磊 王珊珊 《生殖医学杂志》 2025年第6期735-740,共6页
目的探讨多囊卵巢综合征(PCOS)患者外周血抗苗勒管激素(AMH)水平与基础窦卵泡数量(AFC)的相关性。方法回顾性分析2020年1月至2024年5月于我院就诊的PCOS不孕症患者及作为对照的单纯输卵管因素不孕症患者的临床资料,通过倾向评分匹配法... 目的探讨多囊卵巢综合征(PCOS)患者外周血抗苗勒管激素(AMH)水平与基础窦卵泡数量(AFC)的相关性。方法回顾性分析2020年1月至2024年5月于我院就诊的PCOS不孕症患者及作为对照的单纯输卵管因素不孕症患者的临床资料,通过倾向评分匹配法平衡组间混杂因素的差异,共获得1192例患者作为研究对象,其中PCOS组和对照组各596例。比较两组患者外周血AMH及基础性激素水平,分析外周血AMH与性激素相关性。进一步采用单因素分析外周血AMH与AFC的关系,并结合阈值、交互作用分析,研究PCOS患者外周血AMH水平与AFC之间关系及效应值变化。结果PCOS组外周血AMH、黄体生成素(LH)、睾酮(T)水平均显著高于对照组(P<0.05)。相关性分析可知,PCOS患者外周血AMH水平与LH(r=0.740)、T(r=0.728)水平呈正相关(P<0.05);调整性激素水平等其他混杂因素,单因素分析结果显示,PCOS组患者AMH、AFC及体质量指数(BMI)均显著增加(P<0.05)。交互作用分析结果显示,PCOS患者外周血AMH与BMI对AFC存在协同效应(P<0.05)。阈值效应分析显示,随着AMH增加,AFC呈上升趋势;在对照组中,当AMH≥3.9 ng/ml时,AFC显著增加(P<0.05);而AMH<3.9 ng/ml时,AMH与AFC未显示明显的相关性;在PCOS组,AMH水平与AFC呈线性正相关。随着BMI增加,AFC呈上升趋势。在对照组中,当BMI≥23.5 kg/m^(2)时,AFC明显增加(P<0.05);而BMI<23.5 kg/m^(2)时,BMI与AFC未显示明显的相关性。在PCOS组,BMI与AFC呈线性正相关。结论外周血AMH水平与AFC呈正相关,尤其是PCOS人群,随着AMH水平增加,AFC增多;而在非PCOS人群中,当AMH低于一定水平时(3.9 ng/ml),AFC与外周血AMH水平并无显著相关性,当AMH高于一定水平时(3.9 ng/ml),随着AMH水平增加,AFC增多。 展开更多
关键词 多囊卵巢综合征 抗苗勒管激素 基础窦卵泡 相关性分析 阈值效应分析
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Fast-zoom and high-resolution sparse compound-eye camera based on dual-end collaborative optimization 被引量:1
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作者 Yi Zheng Hao-Ran Zhang +5 位作者 Xiao-Wei Li You-Ran Zhao Zhao-Song Li Ye-Hao Hou Chao Liu Qiong-Hua Wang 《Opto-Electronic Advances》 2025年第6期4-15,共12页
Due to the limitations of spatial bandwidth product and data transmission bandwidth,the field of view,resolution,and imaging speed constrain each other in an optical imaging system.Here,a fast-zoom and high-resolution... Due to the limitations of spatial bandwidth product and data transmission bandwidth,the field of view,resolution,and imaging speed constrain each other in an optical imaging system.Here,a fast-zoom and high-resolution sparse compound-eye camera(CEC)based on dual-end collaborative optimization is proposed,which provides a cost-effective way to break through the trade-off among the field of view,resolution,and imaging speed.In the optical end,a sparse CEC based on liquid lenses is designed,which can realize large-field-of-view imaging in real time,and fast zooming within 5 ms.In the computational end,a disturbed degradation model driven super-resolution network(DDMDSR-Net)is proposed to deal with complex image degradation issues in actual imaging situations,achieving high-robustness and high-fidelity resolution enhancement.Based on the proposed dual-end collaborative optimization framework,the angular resolution of the CEC can be enhanced from 71.6"to 26.0",which provides a solution to realize high-resolution imaging for array camera dispensing with high optical hardware complexity and data transmission bandwidth.Experiments verify the advantages of the CEC based on dual-end collaborative optimization in high-fidelity reconstruction of real scene images,kilometer-level long-distance detection,and dynamic imaging and precise recognition of targets of interest. 展开更多
关键词 compound-eye camera ZOOM high resolution collaborative optimization
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Physics and data-driven alternative optimization enabled ultra-low-sampling single-pixel imaging 被引量:1
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作者 Yifei Zhang Yingxin Li +5 位作者 Zonghao Liu Fei Wang Guohai Situ Mu Ku Chen Haoqiang Wang Zihan Geng 《Advanced Photonics Nexus》 2025年第3期55-66,共12页
Single-pixel imaging(SPI)enables efficient sensing in challenging conditions.However,the requirement for numerous samplings constrains its practicality.We address the challenge of high-quality SPI reconstruction at ul... Single-pixel imaging(SPI)enables efficient sensing in challenging conditions.However,the requirement for numerous samplings constrains its practicality.We address the challenge of high-quality SPI reconstruction at ultra-low sampling rates.We develop an alternative optimization with physics and a data-driven diffusion network(APD-Net).It features alternative optimization driven by the learned task-agnostic natural image prior and the task-specific physics prior.During the training stage,APD-Net harnesses the power of diffusion models to capture data-driven statistics of natural signals.In the inference stage,the physics prior is introduced as corrective guidance to ensure consistency between the physics imaging model and the natural image probability distribution.Through alternative optimization,APD-Net reconstructs data-efficient,high-fidelity images that are statistically and physically compliant.To accelerate reconstruction,initializing images with the inverse SPI physical model reduces the need for reconstruction inference from 100 to 30 steps.Through both numerical simulations and real prototype experiments,APD-Net achieves high-quality,full-color reconstructions of complex natural images at a low sampling rate of 1%.In addition,APD-Net’s tuning-free nature ensures robustness across various imaging setups and sampling rates.Our research offers a broadly applicable approach for various applications,including but not limited to medical imaging and industrial inspection. 展开更多
关键词 single-pixel imaging deep learning alternative optimization
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PCOS中的自噬异常及中医药靶向干预的研究进展
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作者 杨鑫鑫 贾志诚 +3 位作者 石梦雨 李永谦 王培璇 郭颖 《中国实验方剂学杂志》 北大核心 2025年第3期313-322,共10页
多囊卵巢综合征(PCOS)是一种常见的妇科内分泌和生殖功能障碍性疾病,主要临床表现为排卵障碍、胰岛素抵抗、高雄激素血症、肥胖等,该病的发生发展与细胞凋亡、自噬、氧化应激、炎症反应等生物调控过程密切相关。自噬作为一种维持细胞稳... 多囊卵巢综合征(PCOS)是一种常见的妇科内分泌和生殖功能障碍性疾病,主要临床表现为排卵障碍、胰岛素抵抗、高雄激素血症、肥胖等,该病的发生发展与细胞凋亡、自噬、氧化应激、炎症反应等生物调控过程密切相关。自噬作为一种维持细胞稳态的清除机制,在维持卵母细胞生长、发育和成熟过程中发挥着关键作用,探究疾病发生发展过程中的自噬机制,有助于设计通过调控自噬干预PCOS的治疗方法。现有研究表明,自噬在PCOS的发病过程中起着重要作用,能够多层次、多途径、多靶点影响疾病进展。中医药通过靶向自噬信号通路、调控因子及非编码单链RNA分子的表达,来调控PCOS患者卵巢颗粒细胞自噬或子宫内膜自噬,从而缓解炎症、调节PCOS代谢障碍、平衡激素水平,有效改善PCOS胰岛素抵抗、高雄激素血症、排卵障碍等病理状态。该文章对治疗PCOS的中药复方和中药提取物及涉及的主要自噬通路和调控因子进行归纳总结,以期从中医药调控自噬的角度为今后PCOS的治疗提供相关参考和建议。 展开更多
关键词 多囊卵巢综合征 自噬 信号通路 调控因子 机制 中药复方 中药提取物
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DDoS Attack Autonomous Detection Model Based on Multi-Strategy Integrate Zebra Optimization Algorithm
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作者 Chunhui Li Xiaoying Wang +2 位作者 Qingjie Zhang Jiaye Liang Aijing Zhang 《Computers, Materials & Continua》 SCIE EI 2025年第1期645-674,共30页
Previous studies have shown that deep learning is very effective in detecting known attacks.However,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convol... Previous studies have shown that deep learning is very effective in detecting known attacks.However,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convolutional Neural Networks(CNN)combined with LSTM,and so on are built by simple stacking,which has the problems of feature loss,low efficiency,and low accuracy.Therefore,this paper proposes an autonomous detectionmodel for Distributed Denial of Service attacks,Multi-Scale Convolutional Neural Network-Bidirectional Gated Recurrent Units-Single Headed Attention(MSCNN-BiGRU-SHA),which is based on a Multistrategy Integrated Zebra Optimization Algorithm(MI-ZOA).The model undergoes training and testing with the CICDDoS2019 dataset,and its performance is evaluated on a new GINKS2023 dataset.The hyperparameters for Conv_filter and GRU_unit are optimized using the Multi-strategy Integrated Zebra Optimization Algorithm(MIZOA).The experimental results show that the test accuracy of the MSCNN-BiGRU-SHA model based on the MIZOA proposed in this paper is as high as 0.9971 in the CICDDoS 2019 dataset.The evaluation accuracy of the new dataset GINKS2023 created in this paper is 0.9386.Compared to the MSCNN-BiGRU-SHA model based on the Zebra Optimization Algorithm(ZOA),the detection accuracy on the GINKS2023 dataset has improved by 5.81%,precisionhas increasedby 1.35%,the recallhas improvedby 9%,and theF1scorehas increasedby 5.55%.Compared to the MSCNN-BiGRU-SHA models developed using Grid Search,Random Search,and Bayesian Optimization,the MSCNN-BiGRU-SHA model optimized with the MI-ZOA exhibits better performance in terms of accuracy,precision,recall,and F1 score. 展开更多
关键词 Distributed denial of service attack intrusion detection deep learning zebra optimization algorithm multi-strategy integrated zebra optimization algorithm
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Joint jammer selection and power optimization in covert communications against a warden with uncertain locations 被引量:1
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作者 Zhijun Han Yiqing Zhou +3 位作者 Yu Zhang Tong-Xing Zheng Ling Liu Jinglin Shi 《Digital Communications and Networks》 2025年第4期1113-1123,共11页
In covert communications,joint jammer selection and power optimization are important to improve performance.However,existing schemes usually assume a warden with a known location and perfect Channel State Information(... In covert communications,joint jammer selection and power optimization are important to improve performance.However,existing schemes usually assume a warden with a known location and perfect Channel State Information(CSI),which is difficult to achieve in practice.To be more practical,it is important to investigate covert communications against a warden with uncertain locations and imperfect CSI,which makes it difficult for legitimate transceivers to estimate the detection probability of the warden.First,the uncertainty caused by the unknown warden location must be removed,and the Optimal Detection Position(OPTDP)of the warden is derived which can provide the best detection performance(i.e.,the worst case for a covert communication).Then,to further avoid the impractical assumption of perfect CSI,the covert throughput is maximized using only the channel distribution information.Given this OPTDP based worst case for covert communications,the jammer selection,the jamming power,the transmission power,and the transmission rate are jointly optimized to maximize the covert throughput(OPTDP-JP).To solve this coupling problem,a Heuristic algorithm based on Maximum Distance Ratio(H-MAXDR)is proposed to provide a sub-optimal solution.First,according to the analysis of the covert throughput,the node with the maximum distance ratio(i.e.,the ratio of the distances from the jammer to the receiver and that to the warden)is selected as the friendly jammer(MAXDR).Then,the optimal transmission and jamming power can be derived,followed by the optimal transmission rate obtained via the bisection method.In numerical and simulation results,it is shown that although the location of the warden is unknown,by assuming the OPTDP of the warden,the proposed OPTDP-JP can always satisfy the covertness constraint.In addition,with an uncertain warden and imperfect CSI,the covert throughput provided by OPTDP-JP is 80%higher than the existing schemes when the covertness constraint is 0.9,showing the effectiveness of OPTDP-JP. 展开更多
关键词 Covert communications Uncertain warden Jammer selection Power optimization Throughput maximization
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Prediction of Shear Bond Strength of Asphalt Concrete Pavement Using Machine Learning Models and Grid Search Optimization Technique
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作者 Quynh-Anh Thi Bui Dam Duc Nguyen +2 位作者 Hiep Van Le Indra Prakash Binh Thai Pham 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期691-712,共22页
Determination of Shear Bond strength(SBS)at interlayer of double-layer asphalt concrete is crucial in flexible pavement structures.The study used three Machine Learning(ML)models,including K-Nearest Neighbors(KNN),Ext... Determination of Shear Bond strength(SBS)at interlayer of double-layer asphalt concrete is crucial in flexible pavement structures.The study used three Machine Learning(ML)models,including K-Nearest Neighbors(KNN),Extra Trees(ET),and Light Gradient Boosting Machine(LGBM),to predict SBS based on easily determinable input parameters.Also,the Grid Search technique was employed for hyper-parameter tuning of the ML models,and cross-validation and learning curve analysis were used for training the models.The models were built on a database of 240 experimental results and three input variables:temperature,normal pressure,and tack coat rate.Model validation was performed using three statistical criteria:the coefficient of determination(R2),the Root Mean Square Error(RMSE),and the mean absolute error(MAE).Additionally,SHAP analysis was also used to validate the importance of the input variables in the prediction of the SBS.Results show that these models accurately predict SBS,with LGBM providing outstanding performance.SHAP(Shapley Additive explanation)analysis for LGBM indicates that temperature is the most influential factor on SBS.Consequently,the proposed ML models can quickly and accurately predict SBS between two layers of asphalt concrete,serving practical applications in flexible pavement structure design. 展开更多
关键词 Shear bond asphalt pavement grid search optimization machine learning
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