Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stab...Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stability.However,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in SIBs.Thus,it is of significance to boost the sodium storage performance of NVP cathode material.Up to now,many methods have been developed to optimize the electrochemical performance of NVP cathode material.In this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology design.The foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so on.Furthermore,the challenges and prospects of high-performance NVP cathode material are also put forward.It is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.展开更多
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were ...Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were reported to be potential anti-fibrotic agents.Herein,structure-based hit-to-lead optimization of natural isoaurostatin(8.98μmol/L)resulted in several potent inhibitors of PDE4 with half maximal inhibitory concentration(IC_(50))values ranging from 35 nmol/L to 126 nmol/L.Co-crystal structures revealed that isoaurostatin compounds exhibited different binding patterns from the classic PDE4 inhibitor rolipram and the analogues would favor to be Z configurations other than the corresponding E isomers.Finally,lead 2–9 showed remarkable in vitro/in vivo anti-fibrotic effects indicating its potential as a novel anti-IPF agent.展开更多
Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design...Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design(CAD)system that presents a new method for DED classification called(IAOO-PSO),which is a powerful Feature Selection technique(FS)that integrates with Opposition-Based Learning(OBL)and Particle Swarm Optimization(PSO).We improve the speed of convergence with the PSO algorithmand the exploration with the IAOO algorithm.The IAOO is demonstrated to possess superior global optimization capabilities,as validated on the IEEE Congress on Evolutionary Computation 2022(CEC’22)benchmark suite and compared with seven Metaheuristic(MH)algorithms.Additionally,an IAOO-PSO model based on Support Vector Machines(SVMs)classifier is proposed for FS and classification,where the IAOO-PSO is used to identify the most relevant features.This model was applied to the DED dataset comprising 20,000 cases and 26 features,achieving a high classification accuracy of 99.8%,which significantly outperforms other optimization algorithms.The experimental results demonstrate the reliability,success,and efficiency of the IAOO-PSO technique for both FS and classification in the detection of DED.展开更多
The method for optimizing the hydraulic fracturing parameters of the cube development infill well pad was proposed,aiming at the well pattern characteristic of“multi-layer and multi-period”of the infill wells in Sic...The method for optimizing the hydraulic fracturing parameters of the cube development infill well pad was proposed,aiming at the well pattern characteristic of“multi-layer and multi-period”of the infill wells in Sichuan Basin.The fracture propagation and inter-well interference model were established based on the evolution of 4D in-situ stress,and the evolution characteristics of stress and the mechanism of interference between wells were analyzed.The research shows that the increase in horizontal stress difference and the existence of natural fractures/faults are the main reasons for inter-well interference.Inter-well interference is likely to occur near the fracture zones and between the infill wells and parent wells that have been in production for a long time.When communication channels are formed between the infill wells and parent wells,it can increase the productivity of parent wells in the short term.However,it will have a delayed negative impact on the long-term sustained production of both infill wells and parent wells.The change trend of in-situ stress caused by parent well production is basically consistent with the decline trend of pore pressure.The lateral disturbance range of in-situ stress is initially the same as the fracture length and reaches 1.5 to 1.6 times that length after 2.5 years.The key to avoiding inter-well interference is to optimize the fracturing parameters.By adopting the M-shaped well pattern,the optimal well spacing for the infill wells is 300 m,the cluster spacing is 10 m,and the liquid volume per stage is 1800 m^(3).展开更多
基金partly supported by the National Natural Science Foundation of China(Grant No.52272225).
文摘Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural stability.However,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in SIBs.Thus,it is of significance to boost the sodium storage performance of NVP cathode material.Up to now,many methods have been developed to optimize the electrochemical performance of NVP cathode material.In this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology design.The foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so on.Furthermore,the challenges and prospects of high-performance NVP cathode material are also put forward.It is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.
基金supported by the Natural Science Foundation of China(Nos.22277019,82150204,22307031,22377023,22077143,and 82003594)Key Project of Guangdong Natural Science Foundation(No.2016A030311033)+2 种基金Fundamental Research Funds for Hainan University(Nos.KYQD(ZR)-21031,KYQD(ZR)-21108,KYQD(ZR)-23003,and XTCX2022JKA01)Guangdong Provincial Key Laboratory of Construction Foundation(No.2023B1212060022)Science Foundation of Hainan Province(Nos.KJRC2023B10,824YXQN420,and 324MS018)。
文摘Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were reported to be potential anti-fibrotic agents.Herein,structure-based hit-to-lead optimization of natural isoaurostatin(8.98μmol/L)resulted in several potent inhibitors of PDE4 with half maximal inhibitory concentration(IC_(50))values ranging from 35 nmol/L to 126 nmol/L.Co-crystal structures revealed that isoaurostatin compounds exhibited different binding patterns from the classic PDE4 inhibitor rolipram and the analogues would favor to be Z configurations other than the corresponding E isomers.Finally,lead 2–9 showed remarkable in vitro/in vivo anti-fibrotic effects indicating its potential as a novel anti-IPF agent.
文摘Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design(CAD)system that presents a new method for DED classification called(IAOO-PSO),which is a powerful Feature Selection technique(FS)that integrates with Opposition-Based Learning(OBL)and Particle Swarm Optimization(PSO).We improve the speed of convergence with the PSO algorithmand the exploration with the IAOO algorithm.The IAOO is demonstrated to possess superior global optimization capabilities,as validated on the IEEE Congress on Evolutionary Computation 2022(CEC’22)benchmark suite and compared with seven Metaheuristic(MH)algorithms.Additionally,an IAOO-PSO model based on Support Vector Machines(SVMs)classifier is proposed for FS and classification,where the IAOO-PSO is used to identify the most relevant features.This model was applied to the DED dataset comprising 20,000 cases and 26 features,achieving a high classification accuracy of 99.8%,which significantly outperforms other optimization algorithms.The experimental results demonstrate the reliability,success,and efficiency of the IAOO-PSO technique for both FS and classification in the detection of DED.
基金Supported by the General Program of the NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA(52374004)National Key Research and Development Program(2023YFF06141022023YFE0110900)。
文摘The method for optimizing the hydraulic fracturing parameters of the cube development infill well pad was proposed,aiming at the well pattern characteristic of“multi-layer and multi-period”of the infill wells in Sichuan Basin.The fracture propagation and inter-well interference model were established based on the evolution of 4D in-situ stress,and the evolution characteristics of stress and the mechanism of interference between wells were analyzed.The research shows that the increase in horizontal stress difference and the existence of natural fractures/faults are the main reasons for inter-well interference.Inter-well interference is likely to occur near the fracture zones and between the infill wells and parent wells that have been in production for a long time.When communication channels are formed between the infill wells and parent wells,it can increase the productivity of parent wells in the short term.However,it will have a delayed negative impact on the long-term sustained production of both infill wells and parent wells.The change trend of in-situ stress caused by parent well production is basically consistent with the decline trend of pore pressure.The lateral disturbance range of in-situ stress is initially the same as the fracture length and reaches 1.5 to 1.6 times that length after 2.5 years.The key to avoiding inter-well interference is to optimize the fracturing parameters.By adopting the M-shaped well pattern,the optimal well spacing for the infill wells is 300 m,the cluster spacing is 10 m,and the liquid volume per stage is 1800 m^(3).
