This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass ...This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass transfer coefficients and air psychrometric correlations, the model provides insights into the impact of design and operational parameters on the exchanger cooling performance. Validated against an established numerical model, it accurately simulates cooling behavior with a Root Mean Square Deviation of 0.43 - 1.18˚C under varying inlet air conditions. The results show that tube geometry, including equivalent diameter, flatness ratio, and length significantly influences cooling outcomes. Smaller diameters enhance wet-bulb effectiveness but reduce cooling capacity, while increased flatness and length improve both. For example, extending the flatness ratio of a 15 mm diameter, 0.6 m long tube from 1 (circular) to 4 raises the exchange surface area from 0.028 to 0.037 m2, increasing wet-bulb effectiveness from 60% to 71%. Recommended diameters range from 5 mm for tubes under 0.5 m to 1 cm for tubes 0.5 to 1 m in length. Optimal air velocities depend on tube length: 1 m/s for tubes under 0.8 m, 1.5 m/s for lengths of 0.8 to 1.2 m, and up to 2 m/s for longer tubes. This model offers a practical alternative to complex numerical and CFD methods, with potential applications in cooling tower optimization for thermal and nuclear power plants and geothermal heat exchangers.展开更多
Objective To analyze the problems of China’s pharmacovigilance organization system,and to provide targeted suggestions for improving it.Methods The relevant literature at home and abroad was reviewed to compared the ...Objective To analyze the problems of China’s pharmacovigilance organization system,and to provide targeted suggestions for improving it.Methods The relevant literature at home and abroad was reviewed to compared the differences in pharmacovigilance organizations in the United States,the European Union,Japan and China.Then,the problems of China’s pharmacovigilance organization management were found out.Results and Conclusion China’s pharmacovigilance organizational system has problems such as inadequate organizational setup,immature institutional construction,no coordination mechanism for pharmacovigilance practice,and industry associations of third-party organizations having no role to play.It is recommended to carry out theoretical and methodological research on the pharmacovigilance organizational system to provide practical guidance for optimizing the system with Chinese characteristics.展开更多
Propeller design is a highly intricate and interdisciplinary task that necessitates careful trade-offs between radiated noise levels and aerodynamic efficiency.To achieve efficient trade-off designs,an enhanced on-the...Propeller design is a highly intricate and interdisciplinary task that necessitates careful trade-offs between radiated noise levels and aerodynamic efficiency.To achieve efficient trade-off designs,an enhanced on-the-fly unsteady adjoint-based aerodynamic and aeroacoustic optimization methodology is developed,which maintains the fidelity of the Navier-Stokes solution for unsteady flow and of the moving-medium Ffowcs Williams-Hawkings(FW-H)formulation for capturing tonal noise.Furthermore,this on-the-fly approach enables a unified architecture for discreteadjoint sensitivity analysis encompassing both aerodynamics and aeroacoustics,facilitating effective multi-objective weighted optimizations.Subsequently,this proposed methodology is applied to perform trade-off optimizations between aerodynamics and aeroacoustics for a propeller by employing varying weighting factors to comprehend their influence on optimal configurations.The results demonstrate a positive correlation between efficiency and noise sensitivities,and thus indicate an inherent synchronicity where pursing noise reduction through purely aeroacoustic optimization inevitably entails sacrificing aerodynamic efficiency.However,by effectively incorporating appropriate weighting factors(recommended to range from 0.25 to 0.5)into the multi-objective function combined with both aerodynamics and aeroacoustics,it becomes feasible to achieve efficiency enhancement and noise reduction simultaneously.Key findings show that reducing blade planform size and equipping“rotated-S”shaped airfoil profiles in the tip region can effectively restrain noise levels while maintaining aerodynamic performance.展开更多
Objective To analyze the problems of China’s pharmacovigilance legislation,and to provide some suggestions for improving it.Methods Relevant literature at home and abroad were studied to compare the laws and regulati...Objective To analyze the problems of China’s pharmacovigilance legislation,and to provide some suggestions for improving it.Methods Relevant literature at home and abroad were studied to compare the laws and regulations of the United States,the European Union,Japan and China.Then,the problems of China’s pharmacovigilance legislation were analyzed.Results and Conclusion The Chinese pharmacovigilance legislation has such problems as nontransparent formulation process,poor dynamic adaptability,insufficient use of the attention mechanism,fragmentation of laws and regulations,and poor connection of laws and regulations,which should be optimized.It is recommended to carry out theoretical and methodological research on pharmacovigilance legislation to provide practical guidance for optimizing pharmacovigilance legislation with Chinese characteristics.展开更多
Simultaneously,reducing an acoustic metamaterial’s weight and sound pressure level is an important but difficult topic.Considering the law of mass,traditional lightweight acoustic metamaterials make it difficult to c...Simultaneously,reducing an acoustic metamaterial’s weight and sound pressure level is an important but difficult topic.Considering the law of mass,traditional lightweight acoustic metamaterials make it difficult to control noise efficiently in real-life applications.In this study,a novel optimization-driven design scheme is developed to obtain lightweight acoustic metamaterials with a strong sound insulation capability for additive manufacturing.In the proposed design scheme,a topology optimization method for an acoustic metamaterial in the acoustic-solid interaction system is implemented to obtain an initial cross-sectional topology of the acoustic microstructure during the conceptual design phase.Then,in the detailed design phase,the parametric model for a higher-dimensional design is formulated based on the topology optimization result.An adaptive Kriging interpolation approach is proposed to accurately reformulate a much easier surrogate model from the original parameterization formulation to avoid repeating calls for nonlinear analyses in the 3D acoustic-structure interaction system.A surrogate model was used to optimize a ready-to-print acoustic metamaterial with improved noise reduction performance.Experimental verification based on an impedance tube is implemented.Results demonstrate characteristics of the devised metamaterial as well as the proposed method.展开更多
In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the op...In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.展开更多
The numerical dispersion phenomenon in the finite-difference forward modeling simulations of the wave equation significantly affects the imaging accuracy in acoustic reflection logging.This issue is particularly prono...The numerical dispersion phenomenon in the finite-difference forward modeling simulations of the wave equation significantly affects the imaging accuracy in acoustic reflection logging.This issue is particularly pronounced in the reverse time migration(RTM)method used for shear-wave(S-wave)logging imaging.This not only affects imaging accuracy but also introduces ambiguities in the interpretation of logging results.To address this challenge,this study proposes the use of a least-squares difference coefficient optimization algorithm aiming to suppress the numerical dispersion phenomenon in the RTM of S-wave reflection imaging logging.By optimizing the difference coefficients,the high-precision finite-difference algorithm serves as an effective operator for both forward and backward RTM processes.This approach is instrumental in eliminating migration illusions,which are often caused by numerical dispersion.The effectiveness of this optimized algorithm is demonstrated through numerical results,which indicate that it can achieve more accurate forward imaging results across various conditions,including high-and low-velocity strata,and is effective in both large and small spatial grids.The results of processing real data demonstrate that numerical dispersion optimization effectively reduces migration artifacts and diminishes ambiguities in logging interpretations.This optimization offers crucial technical support to the RTM method,enhancing its capability for accurately modeling and imaging S-wave reflections.展开更多
Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion...Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots.展开更多
Electron beam injectors are pivotal components of large-scale scientific instruments,such as synchrotron radiation sources,free-electron lasers,and electron-positron colliders.The quality of the electron beam produced...Electron beam injectors are pivotal components of large-scale scientific instruments,such as synchrotron radiation sources,free-electron lasers,and electron-positron colliders.The quality of the electron beam produced by the injector critically influences the performance of the entire accelerator-based scientific research apparatus.The injectors of such facilities usually use photocathode and thermionic-cathode electron guns.Although the photocathode injector can produce electron beams of excellent quality,its associated laser system is massive and intricate.The thermionic-cathode electron gun,especially the gridded electron gun injector,has a simple structure capable of generating numerous electron beams.However,its emittance is typically high.In this study,methods to reduce beam emittance are explored through a comprehensive analysis of various grid structures and preliminary design results,examining the evolution of beam phase space at different grid positions.An optimization method for reducing the emittance of a gridded thermionic-cathode electron gun is proposed through theoretical derivation,electromagnetic-field simulation,and beam-dynamics simulation.A 50%reduction in emittance was achieved for a 50 keV,1.7 A electron gun,laying the foundation for the subsequent design of a high-current,low-emittance injector.展开更多
To achieve low-carbon regulation of electric vehicle(EV)charging loads under the“dual carbon”goals,this paper proposes a coordinated scheduling strategy that integrates dynamic carbon factor prediction and multiobje...To achieve low-carbon regulation of electric vehicle(EV)charging loads under the“dual carbon”goals,this paper proposes a coordinated scheduling strategy that integrates dynamic carbon factor prediction and multiobjective optimization.First,a dual-convolution enhanced improved Crossformer prediction model is constructed,which employs parallel 1×1 global and 3×3 local convolutionmodules(Integrated Convolution Block,ICB)formultiscale feature extraction,combinedwith anAdaptive Spectral Block(ASB)to enhance time-series fluctuationmodeling.Based on high-precision predictions,a carbon-electricity cost joint optimization model is further designed to balance economic,environmental,and grid-friendly objectives.The model’s superiority was validated through a case study using real-world data from a renewable-heavy grid.Simulation results show that the proposed multi-objective strategy demonstrated a superior balance compared to baseline and benchmark models,achieving a 15.8%reduction in carbon emissions and a 5.2%reduction in economic costs,while still providing a substantial 22.2%reduction in the peak-valley difference.Its balanced performance significantly outperformed both a single-objective strategy and a state-of-the-art Model Predictive Control(MPC)benchmark,highlighting the advantage of a global optimization approach.This study provides theoretical and technical pathways for dynamic carbon factor-driven EV charging optimization.展开更多
As Internet of Things(IoT)applications expand,Mobile Edge Computing(MEC)has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices.Edge-side computation offloading plays...As Internet of Things(IoT)applications expand,Mobile Edge Computing(MEC)has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices.Edge-side computation offloading plays a pivotal role in MEC performance but remains challenging due to complex task topologies,conflicting objectives,and limited resources.This paper addresses high-dimensional multi-objective offloading for serial heterogeneous tasks in MEC.We jointly consider task heterogeneity,high-dimensional objectives,and flexible resource scheduling,modeling the problem as a Many-objective optimization.To solve it,we propose a flexible framework integrating an improved cooperative co-evolutionary algorithm based on decomposition(MOCC/D)and a flexible scheduling strategy.Experimental results on benchmark functions and simulation scenarios show that the proposed method outperforms existing approaches in both convergence and solution quality.展开更多
The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is m...The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is mainly used for finite element analysis at present,and the effectiveness of the surrogate material model has been fully confirmed.However,there are some accuracy problems when dealing with boundary elements using the surrogate material model,which will affect the topology optimization results.In this study,a boundary element reconstruction(BER)model is proposed based on the surrogate material model under the MMC topology optimization framework to improve the accuracy of topology optimization.The proposed BER model can reconstruct the boundary elements by refining the local meshes and obtaining new nodes in boundary elements.Then the density of boundary elements is recalculated using the new node information,which is more accurate than the original model.Based on the new density of boundary elements,the material properties and volume information of the boundary elements are updated.Compared with other finite element analysis methods,the BER model is simple and feasible and can improve computational accuracy.Finally,the effectiveness and superiority of the proposed method are verified by comparing it with the optimization results of the original surrogate material model through several numerical examples.展开更多
Due to the digital transformation tendency among cultural institutions and the substantial influence of the social media platform,the demands of visual communication keep increasing for promoting traditional cultural ...Due to the digital transformation tendency among cultural institutions and the substantial influence of the social media platform,the demands of visual communication keep increasing for promoting traditional cultural artifacts online.As an effective medium,posters serve to attract public attention and facilitate broader engagement with cultural artifacts.However,existing poster generation methods mainly rely on fixed templates and manual design,which limits their scalability and adaptability to the diverse visual and semantic features of the artifacts.Therefore,we propose CAPGen,an automated aesthetic Cultural Artifacts Poster Generation framework built on a Multimodal Large Language Model(MLLM)with integrated iterative optimization.During our research,we collaborated with designers to define principles of graphic design for cultural artifact posters,to guide the MLLM in generating layout parameters.Later,we generated these parameters into posters.Finally,we refined the posters using an MLLM integrated with a multi-round iterative optimization mechanism.Qualitative results show that CAPGen consistently outperforms baseline methods in both visual quality and aesthetic performance.Furthermore,ablation studies indicate that the prompt,iterative optimization mechanism,and design principles significantly enhance the effectiveness of poster generation.展开更多
Owing to their global search capabilities and gradient-free operation,metaheuristic algorithms are widely applied to a wide range of optimization problems.However,their computational demands become prohibitive when ta...Owing to their global search capabilities and gradient-free operation,metaheuristic algorithms are widely applied to a wide range of optimization problems.However,their computational demands become prohibitive when tackling high-dimensional optimization challenges.To effectively address these challenges,this study introduces cooperative metaheuristics integrating dynamic dimension reduction(DR).Building upon particle swarm optimization(PSO)and differential evolution(DE),the proposed cooperative methods C-PSO and C-DE are developed.In the proposed methods,the modified principal components analysis(PCA)is utilized to reduce the dimension of design variables,thereby decreasing computational costs.The dynamic DR strategy implements periodic execution of modified PCA after a fixed number of iterations,resulting in the important dimensions being dynamically identified.Compared with the static one,the dynamic DR strategy can achieve precise identification of important dimensions,thereby enabling accelerated convergence toward optimal solutions.Furthermore,the influence of cumulative contribution rate thresholds on optimization problems with different dimensions is investigated.Metaheuristic algorithms(PSO,DE)and cooperative metaheuristics(C-PSO,C-DE)are examined by 15 benchmark functions and two engineering design problems(speed reducer and composite pressure vessel).Comparative results demonstrate that the cooperative methods achieve significantly superior performance compared to standard methods in both solution accuracy and computational efficiency.Compared to standard metaheuristic algorithms,cooperative metaheuristics achieve a reduction in computational cost of at least 40%.The cooperative metaheuristics can be effectively used to tackle both high-dimensional unconstrained and constrained optimization problems.展开更多
Automated essay scoring(AES)systems have gained significant importance in educational settings,offering a scalable,efficient,and objective method for evaluating student essays.However,developing AES systems for Arabic...Automated essay scoring(AES)systems have gained significant importance in educational settings,offering a scalable,efficient,and objective method for evaluating student essays.However,developing AES systems for Arabic poses distinct challenges due to the language’s complex morphology,diglossia,and the scarcity of annotated datasets.This paper presents a hybrid approach to Arabic AES by combining text-based,vector-based,and embeddingbased similarity measures to improve essay scoring accuracy while minimizing the training data required.Using a large Arabic essay dataset categorized into thematic groups,the study conducted four experiments to evaluate the impact of feature selection,data size,and model performance.Experiment 1 established a baseline using a non-machine learning approach,selecting top-N correlated features to predict essay scores.The subsequent experiments employed 5-fold cross-validation.Experiment 2 showed that combining embedding-based,text-based,and vector-based features in a Random Forest(RF)model achieved an R2 of 88.92%and an accuracy of 83.3%within a 0.5-point tolerance.Experiment 3 further refined the feature selection process,demonstrating that 19 correlated features yielded optimal results,improving R2 to 88.95%.In Experiment 4,an optimal data efficiency training approach was introduced,where training data portions increased from 5%to 50%.The study found that using just 10%of the data achieved near-peak performance,with an R2 of 85.49%,emphasizing an effective trade-off between performance and computational costs.These findings highlight the potential of the hybrid approach for developing scalable Arabic AES systems,especially in low-resource environments,addressing linguistic challenges while ensuring efficient data usage.展开更多
Rapid urbanization in China has led to spatial antagonism between urban development and farmland protection and ecological security maintenance.Multi-objective spatial collaborative optimization is a powerful method f...Rapid urbanization in China has led to spatial antagonism between urban development and farmland protection and ecological security maintenance.Multi-objective spatial collaborative optimization is a powerful method for achieving sustainable regional development.Previous studies on multi-objective spatial optimization do not involve spatial corrections to simulation results based on the natural endowment of space resources.This study proposes an Ecological Security-Food Security-Urban Sustainable Development(ES-FS-USD)spatial optimization framework.This framework combines the non-dominated sorting genetic algorithm II(NSGA-II)and patch-generating land use simulation(PLUS)model with an ecological protection importance evaluation,comprehensive agricultural productivity evaluation,and urban sustainable development potential assessment and optimizes the territorial space in the Yangtze River Delta(YRD)region in 2035.The proposed sustainable development(SD)scenario can effectively reduce the destruction of landscape patterns of various land-use types while considering both ecological and economic benefits.The simulation results were further revised by evaluating the land-use suitability of the YRD region.According to the revised spatial pattern for the YRD in 2035,the farmland area accounts for 43.59%of the total YRD,which is 5.35%less than that in 2010.Forest,grassland,and water area account for 40.46%of the total YRD—an increase of 1.42%compared with the case in 2010.Construction land accounts for 14.72%of the total YRD—an increase of 2.77%compared with the case in 2010.The ES-FS-USD spatial optimization framework ensures that spatial optimization outcomes are aligned with the natural endowments of land resources,thereby promoting the sustainable use of land resources,improving the ability of spatial management,and providing valuable insights for decision makers.展开更多
At present,energy consumption is one of the main bottlenecks in autonomous mobile robot development.To address the challenge of high energy consumption in path planning for autonomous mobile robots navigating unknown ...At present,energy consumption is one of the main bottlenecks in autonomous mobile robot development.To address the challenge of high energy consumption in path planning for autonomous mobile robots navigating unknown and complex environments,this paper proposes an Attention-Enhanced Dueling Deep Q-Network(ADDueling DQN),which integrates a multi-head attention mechanism and a prioritized experience replay strategy into a Dueling-DQN reinforcement learning framework.A multi-objective reward function,centered on energy efficiency,is designed to comprehensively consider path length,terrain slope,motion smoothness,and obstacle avoidance,enabling optimal low-energy trajectory generation in 3D space from the source.The incorporation of a multihead attention mechanism allows the model to dynamically focus on energy-critical state features—such as slope gradients and obstacle density—thereby significantly improving its ability to recognize and avoid energy-intensive paths.Additionally,the prioritized experience replay mechanism accelerates learning from key decision-making experiences,suppressing inefficient exploration and guiding the policy toward low-energy solutions more rapidly.The effectiveness of the proposed path planning algorithm is validated through simulation experiments conducted in multiple off-road scenarios.Results demonstrate that AD-Dueling DQN consistently achieves the lowest average energy consumption across all tested environments.Moreover,the proposed method exhibits faster convergence and greater training stability compared to baseline algorithms,highlighting its global optimization capability under energy-aware objectives in complex terrains.This study offers an efficient and scalable intelligent control strategy for the development of energy-conscious autonomous navigation systems.展开更多
Multi-label feature selection(MFS)is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels.However,traditional centralized methods face significant chal...Multi-label feature selection(MFS)is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels.However,traditional centralized methods face significant challenges in privacy-sensitive and distributed settings,often neglecting label dependencies and suffering from low computational efficiency.To address these issues,we introduce a novel framework,Fed-MFSDHBCPSO—federated MFS via dual-layer hybrid breeding cooperative particle swarm optimization algorithm with manifold and sparsity regularization(DHBCPSO-MSR).Leveraging the federated learning paradigm,Fed-MFSDHBCPSO allows clients to perform local feature selection(FS)using DHBCPSO-MSR.Locally selected feature subsets are encrypted with differential privacy(DP)and transmitted to a central server,where they are securely aggregated and refined through secure multi-party computation(SMPC)until global convergence is achieved.Within each client,DHBCPSO-MSR employs a dual-layer FS strategy.The inner layer constructs sample and label similarity graphs,generates Laplacian matrices to capture the manifold structure between samples and labels,and applies L2,1-norm regularization to sparsify the feature subset,yielding an optimized feature weight matrix.The outer layer uses a hybrid breeding cooperative particle swarm optimization algorithm to further refine the feature weight matrix and identify the optimal feature subset.The updated weight matrix is then fed back to the inner layer for further optimization.Comprehensive experiments on multiple real-world multi-label datasets demonstrate that Fed-MFSDHBCPSO consistently outperforms both centralized and federated baseline methods across several key evaluation metrics.展开更多
文摘This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass transfer coefficients and air psychrometric correlations, the model provides insights into the impact of design and operational parameters on the exchanger cooling performance. Validated against an established numerical model, it accurately simulates cooling behavior with a Root Mean Square Deviation of 0.43 - 1.18˚C under varying inlet air conditions. The results show that tube geometry, including equivalent diameter, flatness ratio, and length significantly influences cooling outcomes. Smaller diameters enhance wet-bulb effectiveness but reduce cooling capacity, while increased flatness and length improve both. For example, extending the flatness ratio of a 15 mm diameter, 0.6 m long tube from 1 (circular) to 4 raises the exchange surface area from 0.028 to 0.037 m2, increasing wet-bulb effectiveness from 60% to 71%. Recommended diameters range from 5 mm for tubes under 0.5 m to 1 cm for tubes 0.5 to 1 m in length. Optimal air velocities depend on tube length: 1 m/s for tubes under 0.8 m, 1.5 m/s for lengths of 0.8 to 1.2 m, and up to 2 m/s for longer tubes. This model offers a practical alternative to complex numerical and CFD methods, with potential applications in cooling tower optimization for thermal and nuclear power plants and geothermal heat exchangers.
文摘Objective To analyze the problems of China’s pharmacovigilance organization system,and to provide targeted suggestions for improving it.Methods The relevant literature at home and abroad was reviewed to compared the differences in pharmacovigilance organizations in the United States,the European Union,Japan and China.Then,the problems of China’s pharmacovigilance organization management were found out.Results and Conclusion China’s pharmacovigilance organizational system has problems such as inadequate organizational setup,immature institutional construction,no coordination mechanism for pharmacovigilance practice,and industry associations of third-party organizations having no role to play.It is recommended to carry out theoretical and methodological research on the pharmacovigilance organizational system to provide practical guidance for optimizing the system with Chinese characteristics.
基金supported by the National Science and Technology Major Project,China(No.Y2019-I-0018-0017)the National Natural Science Foundation of China(No.11602200)+1 种基金Hunan Innovative Province Construction Special Fund,China(No.2021GK1020)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China。
文摘Propeller design is a highly intricate and interdisciplinary task that necessitates careful trade-offs between radiated noise levels and aerodynamic efficiency.To achieve efficient trade-off designs,an enhanced on-the-fly unsteady adjoint-based aerodynamic and aeroacoustic optimization methodology is developed,which maintains the fidelity of the Navier-Stokes solution for unsteady flow and of the moving-medium Ffowcs Williams-Hawkings(FW-H)formulation for capturing tonal noise.Furthermore,this on-the-fly approach enables a unified architecture for discreteadjoint sensitivity analysis encompassing both aerodynamics and aeroacoustics,facilitating effective multi-objective weighted optimizations.Subsequently,this proposed methodology is applied to perform trade-off optimizations between aerodynamics and aeroacoustics for a propeller by employing varying weighting factors to comprehend their influence on optimal configurations.The results demonstrate a positive correlation between efficiency and noise sensitivities,and thus indicate an inherent synchronicity where pursing noise reduction through purely aeroacoustic optimization inevitably entails sacrificing aerodynamic efficiency.However,by effectively incorporating appropriate weighting factors(recommended to range from 0.25 to 0.5)into the multi-objective function combined with both aerodynamics and aeroacoustics,it becomes feasible to achieve efficiency enhancement and noise reduction simultaneously.Key findings show that reducing blade planform size and equipping“rotated-S”shaped airfoil profiles in the tip region can effectively restrain noise levels while maintaining aerodynamic performance.
文摘Objective To analyze the problems of China’s pharmacovigilance legislation,and to provide some suggestions for improving it.Methods Relevant literature at home and abroad were studied to compare the laws and regulations of the United States,the European Union,Japan and China.Then,the problems of China’s pharmacovigilance legislation were analyzed.Results and Conclusion The Chinese pharmacovigilance legislation has such problems as nontransparent formulation process,poor dynamic adaptability,insufficient use of the attention mechanism,fragmentation of laws and regulations,and poor connection of laws and regulations,which should be optimized.It is recommended to carry out theoretical and methodological research on pharmacovigilance legislation to provide practical guidance for optimizing pharmacovigilance legislation with Chinese characteristics.
基金supported by the National Key Research and Development Program of China(No.2023YFB4604800)the National Natural Science Foundation of China(No.52075195)the Inelligent Manufacturing Equipment and Technology Open Foundation(No.IMETKF2023016).
文摘Simultaneously,reducing an acoustic metamaterial’s weight and sound pressure level is an important but difficult topic.Considering the law of mass,traditional lightweight acoustic metamaterials make it difficult to control noise efficiently in real-life applications.In this study,a novel optimization-driven design scheme is developed to obtain lightweight acoustic metamaterials with a strong sound insulation capability for additive manufacturing.In the proposed design scheme,a topology optimization method for an acoustic metamaterial in the acoustic-solid interaction system is implemented to obtain an initial cross-sectional topology of the acoustic microstructure during the conceptual design phase.Then,in the detailed design phase,the parametric model for a higher-dimensional design is formulated based on the topology optimization result.An adaptive Kriging interpolation approach is proposed to accurately reformulate a much easier surrogate model from the original parameterization formulation to avoid repeating calls for nonlinear analyses in the 3D acoustic-structure interaction system.A surrogate model was used to optimize a ready-to-print acoustic metamaterial with improved noise reduction performance.Experimental verification based on an impedance tube is implemented.Results demonstrate characteristics of the devised metamaterial as well as the proposed method.
基金Supported by the National Natural Science Foundation of China(12071133)Natural Science Foundation of Henan Province(252300421993)Key Scientific Research Project of Higher Education Institutions in Henan Province(25B110005)。
文摘In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.
基金supported by Scientific Research and Technology Development Project of CNPC(2021DJ4002,2022DJ3908).
文摘The numerical dispersion phenomenon in the finite-difference forward modeling simulations of the wave equation significantly affects the imaging accuracy in acoustic reflection logging.This issue is particularly pronounced in the reverse time migration(RTM)method used for shear-wave(S-wave)logging imaging.This not only affects imaging accuracy but also introduces ambiguities in the interpretation of logging results.To address this challenge,this study proposes the use of a least-squares difference coefficient optimization algorithm aiming to suppress the numerical dispersion phenomenon in the RTM of S-wave reflection imaging logging.By optimizing the difference coefficients,the high-precision finite-difference algorithm serves as an effective operator for both forward and backward RTM processes.This approach is instrumental in eliminating migration illusions,which are often caused by numerical dispersion.The effectiveness of this optimized algorithm is demonstrated through numerical results,which indicate that it can achieve more accurate forward imaging results across various conditions,including high-and low-velocity strata,and is effective in both large and small spatial grids.The results of processing real data demonstrate that numerical dispersion optimization effectively reduces migration artifacts and diminishes ambiguities in logging interpretations.This optimization offers crucial technical support to the RTM method,enhancing its capability for accurately modeling and imaging S-wave reflections.
文摘Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots.
基金supported by the Hundred-person Program of Chinese Academy of Sciences and the National Natural Science Foundation of China(No.11905074).
文摘Electron beam injectors are pivotal components of large-scale scientific instruments,such as synchrotron radiation sources,free-electron lasers,and electron-positron colliders.The quality of the electron beam produced by the injector critically influences the performance of the entire accelerator-based scientific research apparatus.The injectors of such facilities usually use photocathode and thermionic-cathode electron guns.Although the photocathode injector can produce electron beams of excellent quality,its associated laser system is massive and intricate.The thermionic-cathode electron gun,especially the gridded electron gun injector,has a simple structure capable of generating numerous electron beams.However,its emittance is typically high.In this study,methods to reduce beam emittance are explored through a comprehensive analysis of various grid structures and preliminary design results,examining the evolution of beam phase space at different grid positions.An optimization method for reducing the emittance of a gridded thermionic-cathode electron gun is proposed through theoretical derivation,electromagnetic-field simulation,and beam-dynamics simulation.A 50%reduction in emittance was achieved for a 50 keV,1.7 A electron gun,laying the foundation for the subsequent design of a high-current,low-emittance injector.
基金Supported by State Grid Corporation of China Science and Technology Project:Research on Key Technologies for Intelligent Carbon Metrology in Vehicle-to-Grid Interaction(Project Number:B3018524000Q).
文摘To achieve low-carbon regulation of electric vehicle(EV)charging loads under the“dual carbon”goals,this paper proposes a coordinated scheduling strategy that integrates dynamic carbon factor prediction and multiobjective optimization.First,a dual-convolution enhanced improved Crossformer prediction model is constructed,which employs parallel 1×1 global and 3×3 local convolutionmodules(Integrated Convolution Block,ICB)formultiscale feature extraction,combinedwith anAdaptive Spectral Block(ASB)to enhance time-series fluctuationmodeling.Based on high-precision predictions,a carbon-electricity cost joint optimization model is further designed to balance economic,environmental,and grid-friendly objectives.The model’s superiority was validated through a case study using real-world data from a renewable-heavy grid.Simulation results show that the proposed multi-objective strategy demonstrated a superior balance compared to baseline and benchmark models,achieving a 15.8%reduction in carbon emissions and a 5.2%reduction in economic costs,while still providing a substantial 22.2%reduction in the peak-valley difference.Its balanced performance significantly outperformed both a single-objective strategy and a state-of-the-art Model Predictive Control(MPC)benchmark,highlighting the advantage of a global optimization approach.This study provides theoretical and technical pathways for dynamic carbon factor-driven EV charging optimization.
基金supported by Youth Talent Project of Scientific Research Program of Hubei Provincial Department of Education under Grant Q20241809Doctoral Scientific Research Foundation of Hubei University of Automotive Technology under Grant 202404.
文摘As Internet of Things(IoT)applications expand,Mobile Edge Computing(MEC)has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices.Edge-side computation offloading plays a pivotal role in MEC performance but remains challenging due to complex task topologies,conflicting objectives,and limited resources.This paper addresses high-dimensional multi-objective offloading for serial heterogeneous tasks in MEC.We jointly consider task heterogeneity,high-dimensional objectives,and flexible resource scheduling,modeling the problem as a Many-objective optimization.To solve it,we propose a flexible framework integrating an improved cooperative co-evolutionary algorithm based on decomposition(MOCC/D)and a flexible scheduling strategy.Experimental results on benchmark functions and simulation scenarios show that the proposed method outperforms existing approaches in both convergence and solution quality.
基金supported by the Science and Technology Research Project of Henan Province(242102241055)the Industry-University-Research Collaborative Innovation Base on Automobile Lightweight of“Science and Technology Innovation in Central Plains”(2024KCZY315)the Opening Fund of State Key Laboratory of Structural Analysis,Optimization and CAE Software for Industrial Equipment(GZ2024A03-ZZU).
文摘The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is mainly used for finite element analysis at present,and the effectiveness of the surrogate material model has been fully confirmed.However,there are some accuracy problems when dealing with boundary elements using the surrogate material model,which will affect the topology optimization results.In this study,a boundary element reconstruction(BER)model is proposed based on the surrogate material model under the MMC topology optimization framework to improve the accuracy of topology optimization.The proposed BER model can reconstruct the boundary elements by refining the local meshes and obtaining new nodes in boundary elements.Then the density of boundary elements is recalculated using the new node information,which is more accurate than the original model.Based on the new density of boundary elements,the material properties and volume information of the boundary elements are updated.Compared with other finite element analysis methods,the BER model is simple and feasible and can improve computational accuracy.Finally,the effectiveness and superiority of the proposed method are verified by comparing it with the optimization results of the original surrogate material model through several numerical examples.
基金supported by the National Key Research and Development Program of China(2023YFF0906502)the Postgraduate Research and Innovation Project of Hunan Province under Grant(CX20240473).
文摘Due to the digital transformation tendency among cultural institutions and the substantial influence of the social media platform,the demands of visual communication keep increasing for promoting traditional cultural artifacts online.As an effective medium,posters serve to attract public attention and facilitate broader engagement with cultural artifacts.However,existing poster generation methods mainly rely on fixed templates and manual design,which limits their scalability and adaptability to the diverse visual and semantic features of the artifacts.Therefore,we propose CAPGen,an automated aesthetic Cultural Artifacts Poster Generation framework built on a Multimodal Large Language Model(MLLM)with integrated iterative optimization.During our research,we collaborated with designers to define principles of graphic design for cultural artifact posters,to guide the MLLM in generating layout parameters.Later,we generated these parameters into posters.Finally,we refined the posters using an MLLM integrated with a multi-round iterative optimization mechanism.Qualitative results show that CAPGen consistently outperforms baseline methods in both visual quality and aesthetic performance.Furthermore,ablation studies indicate that the prompt,iterative optimization mechanism,and design principles significantly enhance the effectiveness of poster generation.
基金funded by National Natural Science Foundation of China(Nos.12402142,11832013 and 11572134)Natural Science Foundation of Hubei Province(No.2024AFB235)+1 种基金Hubei Provincial Department of Education Science and Technology Research Project(No.Q20221714)the Opening Foundation of Hubei Key Laboratory of Digital Textile Equipment(Nos.DTL2023019 and DTL2022012).
文摘Owing to their global search capabilities and gradient-free operation,metaheuristic algorithms are widely applied to a wide range of optimization problems.However,their computational demands become prohibitive when tackling high-dimensional optimization challenges.To effectively address these challenges,this study introduces cooperative metaheuristics integrating dynamic dimension reduction(DR).Building upon particle swarm optimization(PSO)and differential evolution(DE),the proposed cooperative methods C-PSO and C-DE are developed.In the proposed methods,the modified principal components analysis(PCA)is utilized to reduce the dimension of design variables,thereby decreasing computational costs.The dynamic DR strategy implements periodic execution of modified PCA after a fixed number of iterations,resulting in the important dimensions being dynamically identified.Compared with the static one,the dynamic DR strategy can achieve precise identification of important dimensions,thereby enabling accelerated convergence toward optimal solutions.Furthermore,the influence of cumulative contribution rate thresholds on optimization problems with different dimensions is investigated.Metaheuristic algorithms(PSO,DE)and cooperative metaheuristics(C-PSO,C-DE)are examined by 15 benchmark functions and two engineering design problems(speed reducer and composite pressure vessel).Comparative results demonstrate that the cooperative methods achieve significantly superior performance compared to standard methods in both solution accuracy and computational efficiency.Compared to standard metaheuristic algorithms,cooperative metaheuristics achieve a reduction in computational cost of at least 40%.The cooperative metaheuristics can be effectively used to tackle both high-dimensional unconstrained and constrained optimization problems.
基金funded by Deanship of Graduate studies and Scientific Research at Jouf University under grant No.(DGSSR-2024-02-01264).
文摘Automated essay scoring(AES)systems have gained significant importance in educational settings,offering a scalable,efficient,and objective method for evaluating student essays.However,developing AES systems for Arabic poses distinct challenges due to the language’s complex morphology,diglossia,and the scarcity of annotated datasets.This paper presents a hybrid approach to Arabic AES by combining text-based,vector-based,and embeddingbased similarity measures to improve essay scoring accuracy while minimizing the training data required.Using a large Arabic essay dataset categorized into thematic groups,the study conducted four experiments to evaluate the impact of feature selection,data size,and model performance.Experiment 1 established a baseline using a non-machine learning approach,selecting top-N correlated features to predict essay scores.The subsequent experiments employed 5-fold cross-validation.Experiment 2 showed that combining embedding-based,text-based,and vector-based features in a Random Forest(RF)model achieved an R2 of 88.92%and an accuracy of 83.3%within a 0.5-point tolerance.Experiment 3 further refined the feature selection process,demonstrating that 19 correlated features yielded optimal results,improving R2 to 88.95%.In Experiment 4,an optimal data efficiency training approach was introduced,where training data portions increased from 5%to 50%.The study found that using just 10%of the data achieved near-peak performance,with an R2 of 85.49%,emphasizing an effective trade-off between performance and computational costs.These findings highlight the potential of the hybrid approach for developing scalable Arabic AES systems,especially in low-resource environments,addressing linguistic challenges while ensuring efficient data usage.
基金National Natural Science Foundation of China,No.42301470,No.52270185,No.42171389Capacity Building Program of Local Colleges and Universities in Shanghai,No.21010503300。
文摘Rapid urbanization in China has led to spatial antagonism between urban development and farmland protection and ecological security maintenance.Multi-objective spatial collaborative optimization is a powerful method for achieving sustainable regional development.Previous studies on multi-objective spatial optimization do not involve spatial corrections to simulation results based on the natural endowment of space resources.This study proposes an Ecological Security-Food Security-Urban Sustainable Development(ES-FS-USD)spatial optimization framework.This framework combines the non-dominated sorting genetic algorithm II(NSGA-II)and patch-generating land use simulation(PLUS)model with an ecological protection importance evaluation,comprehensive agricultural productivity evaluation,and urban sustainable development potential assessment and optimizes the territorial space in the Yangtze River Delta(YRD)region in 2035.The proposed sustainable development(SD)scenario can effectively reduce the destruction of landscape patterns of various land-use types while considering both ecological and economic benefits.The simulation results were further revised by evaluating the land-use suitability of the YRD region.According to the revised spatial pattern for the YRD in 2035,the farmland area accounts for 43.59%of the total YRD,which is 5.35%less than that in 2010.Forest,grassland,and water area account for 40.46%of the total YRD—an increase of 1.42%compared with the case in 2010.Construction land accounts for 14.72%of the total YRD—an increase of 2.77%compared with the case in 2010.The ES-FS-USD spatial optimization framework ensures that spatial optimization outcomes are aligned with the natural endowments of land resources,thereby promoting the sustainable use of land resources,improving the ability of spatial management,and providing valuable insights for decision makers.
文摘At present,energy consumption is one of the main bottlenecks in autonomous mobile robot development.To address the challenge of high energy consumption in path planning for autonomous mobile robots navigating unknown and complex environments,this paper proposes an Attention-Enhanced Dueling Deep Q-Network(ADDueling DQN),which integrates a multi-head attention mechanism and a prioritized experience replay strategy into a Dueling-DQN reinforcement learning framework.A multi-objective reward function,centered on energy efficiency,is designed to comprehensively consider path length,terrain slope,motion smoothness,and obstacle avoidance,enabling optimal low-energy trajectory generation in 3D space from the source.The incorporation of a multihead attention mechanism allows the model to dynamically focus on energy-critical state features—such as slope gradients and obstacle density—thereby significantly improving its ability to recognize and avoid energy-intensive paths.Additionally,the prioritized experience replay mechanism accelerates learning from key decision-making experiences,suppressing inefficient exploration and guiding the policy toward low-energy solutions more rapidly.The effectiveness of the proposed path planning algorithm is validated through simulation experiments conducted in multiple off-road scenarios.Results demonstrate that AD-Dueling DQN consistently achieves the lowest average energy consumption across all tested environments.Moreover,the proposed method exhibits faster convergence and greater training stability compared to baseline algorithms,highlighting its global optimization capability under energy-aware objectives in complex terrains.This study offers an efficient and scalable intelligent control strategy for the development of energy-conscious autonomous navigation systems.
文摘Multi-label feature selection(MFS)is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels.However,traditional centralized methods face significant challenges in privacy-sensitive and distributed settings,often neglecting label dependencies and suffering from low computational efficiency.To address these issues,we introduce a novel framework,Fed-MFSDHBCPSO—federated MFS via dual-layer hybrid breeding cooperative particle swarm optimization algorithm with manifold and sparsity regularization(DHBCPSO-MSR).Leveraging the federated learning paradigm,Fed-MFSDHBCPSO allows clients to perform local feature selection(FS)using DHBCPSO-MSR.Locally selected feature subsets are encrypted with differential privacy(DP)and transmitted to a central server,where they are securely aggregated and refined through secure multi-party computation(SMPC)until global convergence is achieved.Within each client,DHBCPSO-MSR employs a dual-layer FS strategy.The inner layer constructs sample and label similarity graphs,generates Laplacian matrices to capture the manifold structure between samples and labels,and applies L2,1-norm regularization to sparsify the feature subset,yielding an optimized feature weight matrix.The outer layer uses a hybrid breeding cooperative particle swarm optimization algorithm to further refine the feature weight matrix and identify the optimal feature subset.The updated weight matrix is then fed back to the inner layer for further optimization.Comprehensive experiments on multiple real-world multi-label datasets demonstrate that Fed-MFSDHBCPSO consistently outperforms both centralized and federated baseline methods across several key evaluation metrics.
