Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging,and high-temporal-resolution electrical recording and stimulation.However,fabricating transpar...Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging,and high-temporal-resolution electrical recording and stimulation.However,fabricating transparent,flexible,and mechanically robust neural electrodes with high electrochemical performance remains challenging.In this study,we fabricated transparent(72.7%at 570 nm),mechanically robust(0.05%resistance change after 50k bending cycles)ultrathin Au microelectrodes for micro-electrocorticography(µECoG)using a hexadentate metal-polymer ligand bonding with an EDTA/PSS seed layer.These transparentµECoG arrays,fabricated with biocompatible gold,exhibit excellent electrochemical properties(0.73Ω·cm^(2))for neural recording and stimulation with long-term stability.We recorded brain surface waves in vivo,maintaining a low baseline noise and a high signalto-noise ratio during acute and two-week recordings.In addition,we successfully performed optogenetic modulation without light-induced artifacts at 7.32 mW/mm^(2)laser power density.This approach shows great potential for scalable,implantable neural electrodes and wearable optoelectronic devices in digital healthcare systems.展开更多
基金supported in part by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2022-NR069917,RS-2024-00416319)in part by the‘DGIST intramural grant’(25-IRJoint-03)+1 种基金in part by an Ideas Grant from the National Health and Medical Research Council(NHMRC)of Australia(APP1188414)in part by the Interdisciplinary Research Initiatives Program from College of Engineering and College of Medicine,Seoul National University(grant no.800-20240490).
文摘Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging,and high-temporal-resolution electrical recording and stimulation.However,fabricating transparent,flexible,and mechanically robust neural electrodes with high electrochemical performance remains challenging.In this study,we fabricated transparent(72.7%at 570 nm),mechanically robust(0.05%resistance change after 50k bending cycles)ultrathin Au microelectrodes for micro-electrocorticography(µECoG)using a hexadentate metal-polymer ligand bonding with an EDTA/PSS seed layer.These transparentµECoG arrays,fabricated with biocompatible gold,exhibit excellent electrochemical properties(0.73Ω·cm^(2))for neural recording and stimulation with long-term stability.We recorded brain surface waves in vivo,maintaining a low baseline noise and a high signalto-noise ratio during acute and two-week recordings.In addition,we successfully performed optogenetic modulation without light-induced artifacts at 7.32 mW/mm^(2)laser power density.This approach shows great potential for scalable,implantable neural electrodes and wearable optoelectronic devices in digital healthcare systems.
