Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy ...Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling.展开更多
Lin'an City has a long history of growing,processing and selling Carya Cathayensis,a traditional special local product for which the city is well known.In recent years,Lin'an Carya Cathayensis gives full play ...Lin'an City has a long history of growing,processing and selling Carya Cathayensis,a traditional special local product for which the city is well known.In recent years,Lin'an Carya Cathayensis gives full play to the industry cluster advantages and gains the reputation of"regional name brand of Zhejiang".However,it faces the predicament of regional brand operation,so industry transformation and upgrading as well as intensive farming for this brand are inevitable and necessary.This paper analyzes the current regional brand operation mode of Carya Cathayensis in Lin'an to find out that the growth of this brand is constrained by messy business entities,weak brand protection effect,significant lemon market effect,insufficient industry association efforts and wanting brand culture construction,thus it puts forward the conception of a business alliance based regional brand operation mode for the Carya Cathayensis in Lin'an.The results of this study shall provide theoretical guidance and empirical basis for the marketing practice of the regional brand of Carya Cathayensis in Lin'an.展开更多
基金Supported by A grant from the Italian Association for Cancer Research(partly,AIRC Regional grant 2008 No.6421)published under the auspices of the Healthy Stomach Initiative(HIS)
文摘Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling.
基金Supported by National Level Project of Innovation and Entrepreneurship Training Program for Undergraduates(201210341016)Zhejiang Province Project of Technology Innovation Program(2012R412016)+1 种基金Humanities and Social Sciences Research Project of the Ministry of Education(12YJA630192)Philosophy and Social Science Planning Project in Zhejiang Province(10CGGL18YB)
文摘Lin'an City has a long history of growing,processing and selling Carya Cathayensis,a traditional special local product for which the city is well known.In recent years,Lin'an Carya Cathayensis gives full play to the industry cluster advantages and gains the reputation of"regional name brand of Zhejiang".However,it faces the predicament of regional brand operation,so industry transformation and upgrading as well as intensive farming for this brand are inevitable and necessary.This paper analyzes the current regional brand operation mode of Carya Cathayensis in Lin'an to find out that the growth of this brand is constrained by messy business entities,weak brand protection effect,significant lemon market effect,insufficient industry association efforts and wanting brand culture construction,thus it puts forward the conception of a business alliance based regional brand operation mode for the Carya Cathayensis in Lin'an.The results of this study shall provide theoretical guidance and empirical basis for the marketing practice of the regional brand of Carya Cathayensis in Lin'an.
