Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
Oligodendrocyte precursor cells(OPCs)tile the central nervous system ubiquitously,accounting for about 5%of the total cell population in the central nervous system.Beyond their role in myelination,OPCs actively shape ...Oligodendrocyte precursor cells(OPCs)tile the central nervous system ubiquitously,accounting for about 5%of the total cell population in the central nervous system.Beyond their role in myelination,OPCs actively shape neural circuits(Fang and Bai,2023),by releasing neuromodulators,pruning synapses,maintaining the homeostasis of extracellular potassium concentration,and interacting with endothelial cells.展开更多
针对洁净板生产线传统调试过程中存在的周期长、成本高、可靠性低等问题,提出了一种基于数字孪生理念的虚拟调试系统架构。通过使用Visual Components构建高保真三维仿真模型,结合Siemens TIA Portal开发模块化控制逻辑,并利用KEP Serve...针对洁净板生产线传统调试过程中存在的周期长、成本高、可靠性低等问题,提出了一种基于数字孪生理念的虚拟调试系统架构。通过使用Visual Components构建高保真三维仿真模型,结合Siemens TIA Portal开发模块化控制逻辑,并利用KEP Server EX 6搭建OPC UA与TCP/IP混合通信网络,实现了物理仿真层、逻辑控制层和数据交互层的协同集成。以岩棉填充工位为例,进行了端到端信号链路验证与全流程物料流仿真。通过对比仿真与实物机器人的运动数据,验证了该系统在关节角度和角速度方面的平均误差小于0.5°,且误差分布在±0.5°范围内的概率达到97.3%。结果表明,所构建的虚拟调试系统具有较高的运动学精度和可靠性,可为洁净板生产线提供低成本、高效率的数字化预验证平台。展开更多
针对伺服阀生产过程中存在的设备种类繁多、不同供应商设备之间无法交换数据、数据集成工作复杂困难的问题,提出基于OPC UA (Object Linking and Embedding for Process Control Unified Architecture)和ETL (Extract-Transform-Load)...针对伺服阀生产过程中存在的设备种类繁多、不同供应商设备之间无法交换数据、数据集成工作复杂困难的问题,提出基于OPC UA (Object Linking and Embedding for Process Control Unified Architecture)和ETL (Extract-Transform-Load)的综合解决方案。该方案使用OPC UA作为通信协议完成设备之间的高效通信,利用ETL技术设计并实现了伺服阀综合应用系统。样机试验验证了方案的有效性。该方案实现了产线信息化过程中的设备互操作能力,是确保伺服阀质量可靠性和性能一致性的关键基础技术。展开更多
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
基金supported by DeutscheForschungsgemeinschaft(BA 8014/1-1 to XB)University of Saarland(NanoBioMed Young Investigatorgrant 2021 to XB,Anschubsfinanzierung2024to XB,HOMFORExzellenz2025 andAnschubsfinanzierung2025 to LPF)the ChinaPharmaceutical University(UndergraduateInternship Program to YZ).
文摘Oligodendrocyte precursor cells(OPCs)tile the central nervous system ubiquitously,accounting for about 5%of the total cell population in the central nervous system.Beyond their role in myelination,OPCs actively shape neural circuits(Fang and Bai,2023),by releasing neuromodulators,pruning synapses,maintaining the homeostasis of extracellular potassium concentration,and interacting with endothelial cells.
文摘针对洁净板生产线传统调试过程中存在的周期长、成本高、可靠性低等问题,提出了一种基于数字孪生理念的虚拟调试系统架构。通过使用Visual Components构建高保真三维仿真模型,结合Siemens TIA Portal开发模块化控制逻辑,并利用KEP Server EX 6搭建OPC UA与TCP/IP混合通信网络,实现了物理仿真层、逻辑控制层和数据交互层的协同集成。以岩棉填充工位为例,进行了端到端信号链路验证与全流程物料流仿真。通过对比仿真与实物机器人的运动数据,验证了该系统在关节角度和角速度方面的平均误差小于0.5°,且误差分布在±0.5°范围内的概率达到97.3%。结果表明,所构建的虚拟调试系统具有较高的运动学精度和可靠性,可为洁净板生产线提供低成本、高效率的数字化预验证平台。
文摘针对伺服阀生产过程中存在的设备种类繁多、不同供应商设备之间无法交换数据、数据集成工作复杂困难的问题,提出基于OPC UA (Object Linking and Embedding for Process Control Unified Architecture)和ETL (Extract-Transform-Load)的综合解决方案。该方案使用OPC UA作为通信协议完成设备之间的高效通信,利用ETL技术设计并实现了伺服阀综合应用系统。样机试验验证了方案的有效性。该方案实现了产线信息化过程中的设备互操作能力,是确保伺服阀质量可靠性和性能一致性的关键基础技术。
