Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
Current evidence for oligodendrocyte precursor cell involvement in Parkinson’s disease:Oligodendroglial cells comprise a large cell population in the substantia nigra(SN).We recently reported a stable portion of olig...Current evidence for oligodendrocyte precursor cell involvement in Parkinson’s disease:Oligodendroglial cells comprise a large cell population in the substantia nigra(SN).We recently reported a stable portion of oligodendrocyte precursor cells(OPCs)in the SN pars compacta(SNpc)in a 1:1 ratio with dopaminergic neurons:15%of cells in neonate and young mice,rising to 20%in aged mice.Moreover,this portion represents only 45%of all oligodendroglial cells in the SNpc and 54%of all oligodendroglial cells in the SN pars reticulata(SNpr)(Fitzgerald et al.,2025).The SN is a deeply located area of the midbrain and the site of dopaminergic degeneration in Parkinson’s disease(PD).Recent advancement of single-cell transcriptomics revealed the involvement of non-neuronal cells in PD,with PD risk variants being strongly associated with oligodendroglia(reviewed by Salazar Campos et al.,2025).展开更多
Oligodendrocyte precursor cells(OPCs)tile the central nervous system ubiquitously,accounting for about 5%of the total cell population in the central nervous system.Beyond their role in myelination,OPCs actively shape ...Oligodendrocyte precursor cells(OPCs)tile the central nervous system ubiquitously,accounting for about 5%of the total cell population in the central nervous system.Beyond their role in myelination,OPCs actively shape neural circuits(Fang and Bai,2023),by releasing neuromodulators,pruning synapses,maintaining the homeostasis of extracellular potassium concentration,and interacting with endothelial cells.展开更多
针对洁净板生产线传统调试过程中存在的周期长、成本高、可靠性低等问题,提出了一种基于数字孪生理念的虚拟调试系统架构。通过使用Visual Components构建高保真三维仿真模型,结合Siemens TIA Portal开发模块化控制逻辑,并利用KEP Serve...针对洁净板生产线传统调试过程中存在的周期长、成本高、可靠性低等问题,提出了一种基于数字孪生理念的虚拟调试系统架构。通过使用Visual Components构建高保真三维仿真模型,结合Siemens TIA Portal开发模块化控制逻辑,并利用KEP Server EX 6搭建OPC UA与TCP/IP混合通信网络,实现了物理仿真层、逻辑控制层和数据交互层的协同集成。以岩棉填充工位为例,进行了端到端信号链路验证与全流程物料流仿真。通过对比仿真与实物机器人的运动数据,验证了该系统在关节角度和角速度方面的平均误差小于0.5°,且误差分布在±0.5°范围内的概率达到97.3%。结果表明,所构建的虚拟调试系统具有较高的运动学精度和可靠性,可为洁净板生产线提供低成本、高效率的数字化预验证平台。展开更多
粤港澳大湾区跨境电商发展活力充沛,依托人工智能技术的OPC(One Person Company,一人公司)创业生态随着数字技术的普及逐步形成。一人跨境电商模式凭借运营灵活、成本可控等优势逐渐兴起,但个人经营者普遍面临着精力有限、资源不足、数...粤港澳大湾区跨境电商发展活力充沛,依托人工智能技术的OPC(One Person Company,一人公司)创业生态随着数字技术的普及逐步形成。一人跨境电商模式凭借运营灵活、成本可控等优势逐渐兴起,但个人经营者普遍面临着精力有限、资源不足、数据分析能力薄弱、供应链整合效率偏低等问题。本文以粤港澳大湾区为研究区域,分析人工智能技术对OPC一人跨境电商盈利能力的提升机制;结合行业报告、湾区政策文件与典型应用案例(如DeepSeek、豆包、WPS智能工具等在跨境电商中的应用场景),采用案例分析法探讨AI在选品、运营、营销、客服、库存管理等核心环节的实际应用效果,探究AI技术如何赋能OPC一人跨境电商重构选品逻辑、精准匹配市场需求、优化资源配置,助力其构建可持续盈利模式。展开更多
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
文摘Current evidence for oligodendrocyte precursor cell involvement in Parkinson’s disease:Oligodendroglial cells comprise a large cell population in the substantia nigra(SN).We recently reported a stable portion of oligodendrocyte precursor cells(OPCs)in the SN pars compacta(SNpc)in a 1:1 ratio with dopaminergic neurons:15%of cells in neonate and young mice,rising to 20%in aged mice.Moreover,this portion represents only 45%of all oligodendroglial cells in the SNpc and 54%of all oligodendroglial cells in the SN pars reticulata(SNpr)(Fitzgerald et al.,2025).The SN is a deeply located area of the midbrain and the site of dopaminergic degeneration in Parkinson’s disease(PD).Recent advancement of single-cell transcriptomics revealed the involvement of non-neuronal cells in PD,with PD risk variants being strongly associated with oligodendroglia(reviewed by Salazar Campos et al.,2025).
基金supported by DeutscheForschungsgemeinschaft(BA 8014/1-1 to XB)University of Saarland(NanoBioMed Young Investigatorgrant 2021 to XB,Anschubsfinanzierung2024to XB,HOMFORExzellenz2025 andAnschubsfinanzierung2025 to LPF)the ChinaPharmaceutical University(UndergraduateInternship Program to YZ).
文摘Oligodendrocyte precursor cells(OPCs)tile the central nervous system ubiquitously,accounting for about 5%of the total cell population in the central nervous system.Beyond their role in myelination,OPCs actively shape neural circuits(Fang and Bai,2023),by releasing neuromodulators,pruning synapses,maintaining the homeostasis of extracellular potassium concentration,and interacting with endothelial cells.
文摘针对洁净板生产线传统调试过程中存在的周期长、成本高、可靠性低等问题,提出了一种基于数字孪生理念的虚拟调试系统架构。通过使用Visual Components构建高保真三维仿真模型,结合Siemens TIA Portal开发模块化控制逻辑,并利用KEP Server EX 6搭建OPC UA与TCP/IP混合通信网络,实现了物理仿真层、逻辑控制层和数据交互层的协同集成。以岩棉填充工位为例,进行了端到端信号链路验证与全流程物料流仿真。通过对比仿真与实物机器人的运动数据,验证了该系统在关节角度和角速度方面的平均误差小于0.5°,且误差分布在±0.5°范围内的概率达到97.3%。结果表明,所构建的虚拟调试系统具有较高的运动学精度和可靠性,可为洁净板生产线提供低成本、高效率的数字化预验证平台。
文摘粤港澳大湾区跨境电商发展活力充沛,依托人工智能技术的OPC(One Person Company,一人公司)创业生态随着数字技术的普及逐步形成。一人跨境电商模式凭借运营灵活、成本可控等优势逐渐兴起,但个人经营者普遍面临着精力有限、资源不足、数据分析能力薄弱、供应链整合效率偏低等问题。本文以粤港澳大湾区为研究区域,分析人工智能技术对OPC一人跨境电商盈利能力的提升机制;结合行业报告、湾区政策文件与典型应用案例(如DeepSeek、豆包、WPS智能工具等在跨境电商中的应用场景),采用案例分析法探讨AI在选品、运营、营销、客服、库存管理等核心环节的实际应用效果,探究AI技术如何赋能OPC一人跨境电商重构选品逻辑、精准匹配市场需求、优化资源配置,助力其构建可持续盈利模式。
