The fully biodegradable polymer blends remain challenges for the application due to their undesirable comprehensive performance.Herei n,remarkable combi nation of superior mechanical performa nee,bacterial resista nee...The fully biodegradable polymer blends remain challenges for the application due to their undesirable comprehensive performance.Herei n,remarkable combi nation of superior mechanical performa nee,bacterial resista nee,and con trollable degradability is realized in the biodegradable poly(L-lactide)/poly(butylene succinate)(PLLA/PBSU)blends by stabilizing the epoxide group modified titanium dioxide nan oparticles(m-TiO_(2))at the PLLA-PBSU in terface through reactive blending.The m-TiO_(2) can not only act as in terfacial compatibilizer but also play the role of photodegradation catalyst:on the one hand,binary grafted nanoparticles were in situ formed and stabilized at the interface to enhance the compatibility between polymer phases.As a consequence,the mechanical properties of the blend,such as the elongation at break,notched impact strength and tensile yield strength,were simultaneously improved.On the other hand,antibacterial and photocatalytic degradation performance of the composite films was synergistically improved.It was found that the m-TiO_(2 )incorporated PLLA/PBSU films exhibit more effective antibacterial activity than the neat PLLA/PBSU films.Moreover,the analysis of photodegradable properties revealed that that m-TiO_(2) nan oparticles could act as a photocatalyst to accelerate the photodegradati on rate of polymers.This study paves a new strategy to fabricate advaneed PLLA/PBSU blend materials with excellent mechanical performance,antibacterial and photocatalytic degradation performance,which enables the potential utilization of fully degradable polymers.展开更多
The intracellular delivery of metal-organic frameworks(MOFs)encapsulated with functional biomolecules represents a promising av-enue in the field of biomedicine and biosensing.To improve the cellular uptake efficiency...The intracellular delivery of metal-organic frameworks(MOFs)encapsulated with functional biomolecules represents a promising av-enue in the field of biomedicine and biosensing.To improve the cellular uptake efficiency of MOFs,here we report the fabrication of cancer cell-derived exosome membra ne(EM)-coated zeolitic imidazolate framework-8(EM-ZIF-8)nan oparticles by using a microfluidic son ication device.展开更多
Developing multi-eleme nt composites is a promisi ng way for high perform a nee supercapacitor material developme nt,and simplifying the synthesis steps is critical for reducing the preparation costs and successful pr...Developing multi-eleme nt composites is a promisi ng way for high perform a nee supercapacitor material developme nt,and simplifying the synthesis steps is critical for reducing the preparation costs and successful promotion of the materials.A novel one-step selective reaction strategy is developed,and successfully used to prepare four-element ZnO-CoSe_(2)(ZOCS)nano-spherical composites,to be used as supercapacitor materials.Started form nano-spherical glycerate templates,under the optimal synthesis condition,the obtained ZOCS-0.125 electrode material exhibits a specific capacitance of 450.7 F/g at 1 A/g and a good rate performance by keeping 76.8%capacitance at 20 A/g.Moreover,the ZOCS-0.125 electrode exhibits excellent cycle stability of 114.9%capacitance retention after 5000 cycles at 10 A/g.An asymmetric supercapacitor assembled by ZOCS-0.125 and activated carbon electrodes delivers an energy density of 22.35 Wh/kg at 825 W/kg,and a cycle stability of 105.6%capacitance retention after 5000 cycles.This work not only shows the good potential of the facilely prepared ZnO-CoSe_(2) composite electrode material,but also dem on strates a new strategy for low cost and high performance multielement composite material development,that can be used in a wide range of applications.展开更多
The genome editing tool,clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9 system,has achieved successful therapeutic efficacy via precise modification of the genome and exceeded previous genome en...The genome editing tool,clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9 system,has achieved successful therapeutic efficacy via precise modification of the genome and exceeded previous genome engineering methods owing to its versatility and simplicity.Rapid expansion in biomedical research has benefited from this newly emerged technique,such as genetic diseases treatment,cancer characterization,and plant improvement.However,the key challenge is efficient delivery of CRISPR components in vivo and nanotechnology plays an in dispensable role in non viral gene delivery.In this review,we will first briefly describe the mechanism and delivery strategies of CRISPR/Cas9 system.Furthermore,the past and current researches of nan oparticles based CRISPR/Cas9 system delivery for genome editi ng will be highlighted.Fin ally,we will discuss the challe nges and prospects of CRISPR/Cas9 system combi ned with nano tech no logy for clinical translation in the future.展开更多
基金by the Major Project of Natural Science Foundation of Zhejiang Province of China(No.LD19E030001)the National Nature Science Foundation of China(No.51903071).
文摘The fully biodegradable polymer blends remain challenges for the application due to their undesirable comprehensive performance.Herei n,remarkable combi nation of superior mechanical performa nee,bacterial resista nee,and con trollable degradability is realized in the biodegradable poly(L-lactide)/poly(butylene succinate)(PLLA/PBSU)blends by stabilizing the epoxide group modified titanium dioxide nan oparticles(m-TiO_(2))at the PLLA-PBSU in terface through reactive blending.The m-TiO_(2) can not only act as in terfacial compatibilizer but also play the role of photodegradation catalyst:on the one hand,binary grafted nanoparticles were in situ formed and stabilized at the interface to enhance the compatibility between polymer phases.As a consequence,the mechanical properties of the blend,such as the elongation at break,notched impact strength and tensile yield strength,were simultaneously improved.On the other hand,antibacterial and photocatalytic degradation performance of the composite films was synergistically improved.It was found that the m-TiO_(2 )incorporated PLLA/PBSU films exhibit more effective antibacterial activity than the neat PLLA/PBSU films.Moreover,the analysis of photodegradable properties revealed that that m-TiO_(2) nan oparticles could act as a photocatalyst to accelerate the photodegradati on rate of polymers.This study paves a new strategy to fabricate advaneed PLLA/PBSU blend materials with excellent mechanical performance,antibacterial and photocatalytic degradation performance,which enables the potential utilization of fully degradable polymers.
基金This work was supported financially by the National Natural Science Foundation of China(Nos.22025402,91959101,and 21904028)Chinese Academy of Sciences(Nos.YJKYYQ20190068 and ZDBS-LY-SLH025)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000).
文摘The intracellular delivery of metal-organic frameworks(MOFs)encapsulated with functional biomolecules represents a promising av-enue in the field of biomedicine and biosensing.To improve the cellular uptake efficiency of MOFs,here we report the fabrication of cancer cell-derived exosome membra ne(EM)-coated zeolitic imidazolate framework-8(EM-ZIF-8)nan oparticles by using a microfluidic son ication device.
基金supported by the National Natural Science Foundation of China(No.21875066)the Shanghai Leading Academic Discipline Project(No.B502)the Shanghai Key Laboratory Project(No.08DZ2230500).
文摘Developing multi-eleme nt composites is a promisi ng way for high perform a nee supercapacitor material developme nt,and simplifying the synthesis steps is critical for reducing the preparation costs and successful promotion of the materials.A novel one-step selective reaction strategy is developed,and successfully used to prepare four-element ZnO-CoSe_(2)(ZOCS)nano-spherical composites,to be used as supercapacitor materials.Started form nano-spherical glycerate templates,under the optimal synthesis condition,the obtained ZOCS-0.125 electrode material exhibits a specific capacitance of 450.7 F/g at 1 A/g and a good rate performance by keeping 76.8%capacitance at 20 A/g.Moreover,the ZOCS-0.125 electrode exhibits excellent cycle stability of 114.9%capacitance retention after 5000 cycles at 10 A/g.An asymmetric supercapacitor assembled by ZOCS-0.125 and activated carbon electrodes delivers an energy density of 22.35 Wh/kg at 825 W/kg,and a cycle stability of 105.6%capacitance retention after 5000 cycles.This work not only shows the good potential of the facilely prepared ZnO-CoSe_(2) composite electrode material,but also dem on strates a new strategy for low cost and high performance multielement composite material development,that can be used in a wide range of applications.
基金This work was supported by the National Natural Science Foundation of China(Nos.81673374 and 81872810)Wuhan Science and Technology Plan for Applied Fundamental Research(No.2017060201010146)Fundamental Research Funds for the Central Universities(No.2018KFYYXJJ019).
文摘The genome editing tool,clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9 system,has achieved successful therapeutic efficacy via precise modification of the genome and exceeded previous genome engineering methods owing to its versatility and simplicity.Rapid expansion in biomedical research has benefited from this newly emerged technique,such as genetic diseases treatment,cancer characterization,and plant improvement.However,the key challenge is efficient delivery of CRISPR components in vivo and nanotechnology plays an in dispensable role in non viral gene delivery.In this review,we will first briefly describe the mechanism and delivery strategies of CRISPR/Cas9 system.Furthermore,the past and current researches of nan oparticles based CRISPR/Cas9 system delivery for genome editi ng will be highlighted.Fin ally,we will discuss the challe nges and prospects of CRISPR/Cas9 system combi ned with nano tech no logy for clinical translation in the future.
