Living under ongoing shelling and missile attacks could cause a widespread of disruption of everyday life and emotional distress.Coping with such distress could be associated with the personal resources of religion an...Living under ongoing shelling and missile attacks could cause a widespread of disruption of everyday life and emotional distress.Coping with such distress could be associated with the personal resources of religion and spirituality.The present study aimed to examine the relationships between religiosity and spirituality with Post Traumatic stress Disorder(PTSD)symptoms among a civilian population frequently exposed to missile and rocket threats.One hundred and twenty-four(N=124)civilian participants living within 10 km from shelling and missile attacks fired towards them,completed demographic,religiosity,spirituality,and PTSD questionnaires.The study findings demonstrate that religiosity is associated with higher levels of PTSD symptoms while spirituality is associated with lower levels of PTSD symptoms.When dividing the sample into two groupsreligious and secular,no association was found between religiosity and PTSD symptoms among the religious group,whereas among the secular group,there was a positive association.Spirituality was negatively associated with PTSD symptoms among both groups.This study may offer a significant contribution to models of intervention following continued exposure to trauma,emphasizing the importance of spiritually and sensitivity to religion while coping with PTSD symptoms.Theoretical and practical implications are discussed.展开更多
According to the viewpoint of historical materialism,the economic base determines the superstructure.In the long process of its development,capitalism has not only shaped political and economic institutions within cou...According to the viewpoint of historical materialism,the economic base determines the superstructure.In the long process of its development,capitalism has not only shaped political and economic institutions within countries but also profoundly impacted the development and transition of the world order.However,since the international financial crisis展开更多
Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe in...Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)vs.control group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively safe.展开更多
Over the past 40 years of reform and opening up, the CPC has led hundreds of millions of Chinese people in creating what will go down in history as a development miracle, in discovering a path of socialism with Chines...Over the past 40 years of reform and opening up, the CPC has led hundreds of millions of Chinese people in creating what will go down in history as a development miracle, in discovering a path of socialism with Chinese characteristics, and in enabling scientific socialism to shine with renewed vigor in the 21st century, thus accomplishing a great and unprecedented cause.展开更多
The koala^1 is a cutie,but does it steal^2 too much of the limelight^3？A new study adds quantitative detail to an ongoing debate over whether such＂conservation mascots^4＂receive publicity and funding to the detrime...The koala^1 is a cutie,but does it steal^2 too much of the limelight^3？A new study adds quantitative detail to an ongoing debate over whether such＂conservation mascots^4＂receive publicity and funding to the detriment of^5 animals typically deemed less attractive.展开更多
Consultation-liaison psychiatry (CLP) was first established in China after liberation in 1949. It has developed more rapidly over the last two decades but, despite major regional differences in the level of CLP, the o...Consultation-liaison psychiatry (CLP) was first established in China after liberation in 1949. It has developed more rapidly over the last two decades but, despite major regional differences in the level of CLP, the overall practice of CLP in the country remains quite basic, largely limited to case-based consultation with other medical departments. There is little ongoing collaboration between departments of psychiatry and other departments, and medical students and non- psychiatric clinicians rarely get training in CLP.展开更多
Generally, hysteroscopy is not appropriate for pregnant women without an indication. What if a patient undergoes hysteroscopy accidentally during the early gestational period? We here report a rare case of a woman who...Generally, hysteroscopy is not appropriate for pregnant women without an indication. What if a patient undergoes hysteroscopy accidentally during the early gestational period? We here report a rare case of a woman who continued pregnancy after a diagnostic hysteroscopy was performed in early pregnancy and delivered a healthy baby. The patient had a history of infertility and oligomenorrhea, probably due to a previous induced abortion. A hysteroscopy was performed after the end of her "menstruation" for assessment of her uterine cavity. Early pregnancy, instead of the expected intrauterine adhesions, was suspected, and the procedure was immediately ceased. Subsequent tests confirmed the diagnosis of pregnancy. She had a fullterm delivery by elective caesarean section. The success of this case was attributed to the use of vaginoscopic techniques in hysteroscopy and correct judgment and decision-making during the procedure. This case report provides some useful methods and experience that might be helpful when a similar situation occurs in clinical practice.展开更多
Purpose: To evaluate age related ovarian response to controlled ovarian hyperstimulation, clinical pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing assisted reproduction treatment (ART) with a...Purpose: To evaluate age related ovarian response to controlled ovarian hyperstimulation, clinical pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing assisted reproduction treatment (ART) with antimullerian hormone (AMH) levels of <5 pmol/l. Methods: Retrospective analysis of data from 63 women with AMH of In-vitro?fertilization, IVF and intracytoplasmic sperm injection, ICSI) cycle. Results were analyzed after dividing patients in two groups, group 1 included women of ≤38 years and group 2 > 38 years of age. Non parametric variables were expressed as median (Interquartile range) and compared by Kruskal-Wallis test. Categorical variables were expressed as numbers with proportions (%) and compared by Fisher’s exact test. Results: There was no statistical difference in body max index, level of antimullerian hormone (AMH), follicle stimulating hormone (FSH), dose of gonadotrophins used and cycles cancellation rate in two groups. Although number of oocytes retrieved (median 5), clinical pregnancy (18.4%) and ongoing pregnancy rate beyond 20 weeks (18.4%) was higher in group 1, there was no statistical difference between the two groups. There was one miscarriage in group 2. Conclusion: Women with extremely low-serum AMH levels can still have clinical pregnancy and ongoing pregnancies beyond 20 weeks after ART, though chances will be lower than women with normal ovarian reserve.展开更多
Plants must maintain a balance between their carbon(C)supply and utilization during the day–night cycle for continuous growth since C starvation often causes irreversible damage to crop production.It is not well know...Plants must maintain a balance between their carbon(C)supply and utilization during the day–night cycle for continuous growth since C starvation often causes irreversible damage to crop production.It is not well known how C fixation and allocation in the leaves of crops such as maize adapt to sudden environmental changes.Here,to quantify primary C fixation and partitioning in photosynthetic maize leaves under extended darkness and to relate these factors to plant growth,maize seedlings were subjected to extended darkness(ED)for three successive days at the 6 th leaf fully expanded stage(V6).ED reduced plant growth and leaf chlorophyll levels but not the rate of net CO_2 exchange.As a result of the reduction in photoassimilates,the accumulation of starch and total soluble carbohydrates(TSC)in mature leaves also decreased under ED.However,the percentage of the daily C fixation reserved in mature leaves increased.These transient C pools were largely composed of TSC and were mainly used for consumption by increased nocturnal respiration rather than for transport.As the days went on,both the amount of C accumulated and the percentage of the daily fixed C that was reserved in leaves decreased,which could be largely accounted for by the attenuated starch synthesis in all treatments.The activities of ADPglucose pyrophosphorylase and soluble starch synthase decreased significantly over time.Therefore,this study concluded that both starch and TSC are involved in the coordination of the C supply and plant growth under a sudden C shortage but that they may be involved in different ways.While the ratio of reserved C to daily fixed C increased to maintain blade function under acute C starvation,both the amount and the proportion of C reserved in mature leaves decreased as plant growth continued in order to meet the growth demands of the plant.展开更多
Jiang Zemin, 67, was elected President of the People’s Republic of China on March 27 at the ongoing first, session of the Eighth National People’s Congress. He was also re-elected Chairman of the Central Military Co...Jiang Zemin, 67, was elected President of the People’s Republic of China on March 27 at the ongoing first, session of the Eighth National People’s Congress. He was also re-elected Chairman of the Central Military Commission of the country. Meanwhile, a non-Communist politician and a leading businessman, Rong Yiren, 77, was elected Vice-President. Qiao Shi, 69, was voted as Chairman of the Eighth National People’ Congress Standing Committee. Li Pemg’s re-appointment as Premier,展开更多
China’s toy makers are exploring new ways to break the bottlenecks of development as the ongoing European crisis continues to impact demand,according to Xinhua.Toy makers are actively expanding industrial reaches,enr...China’s toy makers are exploring new ways to break the bottlenecks of development as the ongoing European crisis continues to impact demand,according to Xinhua.Toy makers are actively expanding industrial reaches,enriching cultural elements in products and tapping into the domestic market in their attempts to survive global headwinds,reporters from展开更多
“Don’t worry!”Xaiyakone Tammavong stressed to his parents in Laos.“We’re safe in Wuhan.The measures taken by the Chinese government have been very effective.I feel the situation improving with each passing day.”...“Don’t worry!”Xaiyakone Tammavong stressed to his parents in Laos.“We’re safe in Wuhan.The measures taken by the Chinese government have been very effective.I feel the situation improving with each passing day.”Every day,Tammavong shares a video call with his parents to tell them about life in China amid the country’s ongoing fight against the COVID-19 epidemic.展开更多
China's top education authorities on Friday gave detailed suggestions on when students should go to bed to ensure sufficient sleep amid ongoing efforts to reduce students,burden.Gen erally speaking,primary school ...China's top education authorities on Friday gave detailed suggestions on when students should go to bed to ensure sufficient sleep amid ongoing efforts to reduce students,burden.Gen erally speaking,primary school stude nts should go to bed before 9:20 pm.展开更多
Introduction.The study of catastrophic events that affected past marine ecosystems provides us the unique opportunity to establish models which can be applied to ongoing environmental changes and to understand future ...Introduction.The study of catastrophic events that affected past marine ecosystems provides us the unique opportunity to establish models which can be applied to ongoing environmental changes and to understand future evolution of the biotas.The growing interest of the society for the ongoing and potential future environmental changes attests for the value represented by the analysis of past climatic changes.In the case of the Toarcian Oceanic Anoxic Event(T-OAE,Early Jurassic;~182 Ma),a dramatic change of marine ecosystems related to massive extinction has been documented in several areas around the world.The Pliensbachian–Toarcian transition and the T-OAE are two global episodes recording worldwide palaeoenvironmental perturbations(Jenkyns,1988;Jenkyns and Clayton,1997;Hesselbo et al.,2007).The end of the Pliensbachian regression is followed by a transgression occurring in the Early Toarcian(Haq et al.,1987;de Graciansky et al.,1999).This transgression was also coeval with a widespread deposition of black shales(Jenkyns,1988),a global warming(Garcia Joral et al.,2011;Korte and Hesselbo,2011;Suan et al.,2011),and perturbations of the carbon cycle indicated by a negative carbon isotopic excursion(CIE)documented in both marine and terrestrial material(Jenkyns and Clayton,1986;Schouten et al.,2000;Hesselbo et al.,2007;Al-Suwaidi et al.,2010;Caruthers et al.,2011;Izumi et al.,2012;Reolid,2014).展开更多
Glioblastoma multiforme(GBM)is the most aggressive and common malig-nant primary brain tumor.Patients with GBM often have poor prognoses,with a median survival of∼15 months.Enhanced understanding of the molecular bio...Glioblastoma multiforme(GBM)is the most aggressive and common malig-nant primary brain tumor.Patients with GBM often have poor prognoses,with a median survival of∼15 months.Enhanced understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications,the most recent of which classified these tumors into new categories and made some changes in their nomenclature and grading system.This review aims to give a panoramic view of the last 3 years’findings in glioblastoma characterization,its heterogeneity,and current advances in its treatment.Several molecular parameters have been used to achieve an accurate and personalized characterization of glioblastoma in patients,including epigenetic,genetic,transcriptomic and metabolic features,as well as age-and sex-related patterns and the involvement of several noncoding RNAs in glioblastoma progression.Astrocyte-like neural stem cells and outer radial glial-like cells from the subven-tricular zone have been proposed as agents involved in GBM of IDH-wildtype origin,but this remains controversial.Glioblastoma metabolism is characterized by upregulation of the PI3K/Akt/mTOR signaling pathway,promotion of the gly-colytic flux,maintenance of lipid storage,and other features.This metabolism also contributes to glioblastoma’s resistance to conventional therapies.Tumor heterogeneity,a hallmark of GBM,has been shown to affect the genetic expresion,modulation of metabolic pathways,and immune system evasion.GBM’s aggressive invasion potential is modulated by cell-to-cell crosstalk within the tumor microenvironment and altered expressions of specific genes,such as ANXA2,GBP2,FN1,PHIP,and GLUT3.Nevertheless,the rising number of active clinical trials illustrates the efforts to identify new targets and drugs to treat this malignancy.Immunotherapy is still relevant for research purposes,given the amount of ongoing clinical trials based on this strategy to treat GBM,and neoantigen and nucleic acid-based vaccines are gaining importance due to their antitumoral activity by inducing the immune response.Furthermore,there are clinical trials focused on the PI3K/Akt/mTOR axis,angiogenesis,and tumor heterogeneity for developing molecular-targeted therapies against GBM.Other strategies,such as nanodelivery and computational models,may improve the drug pharmacokinetics and the prognosis of patients with GBM.展开更多
The effect of microelement on health is a new subject ongoing since the seventies. Some diseases may be related to changes of some elements. Since the last few years changes of Cu, Zn and other elements in the serum a...The effect of microelement on health is a new subject ongoing since the seventies. Some diseases may be related to changes of some elements. Since the last few years changes of Cu, Zn and other elements in the serum and lung of silicosis have展开更多
The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling are used as a traditional Chinese medicine for the treatment of Oketsu syndromes.Recently,our research group has been examining the constituents of C.kwangsiensis,C....The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling are used as a traditional Chinese medicine for the treatment of Oketsu syndromes.Recently,our research group has been examining the constituents of C.kwangsiensis,C.phaeocaulis and C.wenyujin.As part of our ongoing research for biologically active sesquiterpenoids from the genus Curcuma and to provide a potential explanation for展开更多
INTRODUCTION As we face the ongoing global pandemic of COVID-19,doctors,nurses,ambulance officers,paramedics and many other health workers answer the call to serve in time-pressured,unfamiliar,chaotic and often-trauma...INTRODUCTION As we face the ongoing global pandemic of COVID-19,doctors,nurses,ambulance officers,paramedics and many other health workers answer the call to serve in time-pressured,unfamiliar,chaotic and often-traumatic environments.1 We know how to look after ourselves in an infectious physical environment,but it is equally important to look after ourselves psychologically at this time.展开更多
Editorial Our new column Insights is an ongoing series of interviews prepared by the China CDC Weekly team with researchers,policymakers,experts,and other leaders that strives to disseminate experiences,knowledge,and ...Editorial Our new column Insights is an ongoing series of interviews prepared by the China CDC Weekly team with researchers,policymakers,experts,and other leaders that strives to disseminate experiences,knowledge,and perspectives in global and public health with a wider community.At the discretion of the Weekly’s team,these interviews will be written into articles,shared as videos,and/or presented as transcripts to best promote plain-language principles and to ease understanding of non-specialized academic readers.展开更多
文摘Living under ongoing shelling and missile attacks could cause a widespread of disruption of everyday life and emotional distress.Coping with such distress could be associated with the personal resources of religion and spirituality.The present study aimed to examine the relationships between religiosity and spirituality with Post Traumatic stress Disorder(PTSD)symptoms among a civilian population frequently exposed to missile and rocket threats.One hundred and twenty-four(N=124)civilian participants living within 10 km from shelling and missile attacks fired towards them,completed demographic,religiosity,spirituality,and PTSD questionnaires.The study findings demonstrate that religiosity is associated with higher levels of PTSD symptoms while spirituality is associated with lower levels of PTSD symptoms.When dividing the sample into two groupsreligious and secular,no association was found between religiosity and PTSD symptoms among the religious group,whereas among the secular group,there was a positive association.Spirituality was negatively associated with PTSD symptoms among both groups.This study may offer a significant contribution to models of intervention following continued exposure to trauma,emphasizing the importance of spiritually and sensitivity to religion while coping with PTSD symptoms.Theoretical and practical implications are discussed.
文摘According to the viewpoint of historical materialism,the economic base determines the superstructure.In the long process of its development,capitalism has not only shaped political and economic institutions within countries but also profoundly impacted the development and transition of the world order.However,since the international financial crisis
基金This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16040302,XDA01030505)the National Natural Science Foundation of China(81971336)+1 种基金Jiangsu Provincial Key Medical Center(YXZXB2016004)Jiangsu Provincial Obstetrics and Gynecology Innovation Center(CXZX202229)。
文摘Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)vs.control group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively safe.
文摘Over the past 40 years of reform and opening up, the CPC has led hundreds of millions of Chinese people in creating what will go down in history as a development miracle, in discovering a path of socialism with Chinese characteristics, and in enabling scientific socialism to shine with renewed vigor in the 21st century, thus accomplishing a great and unprecedented cause.
文摘The koala^1 is a cutie,but does it steal^2 too much of the limelight^3？A new study adds quantitative detail to an ongoing debate over whether such＂conservation mascots^4＂receive publicity and funding to the detriment of^5 animals typically deemed less attractive.
文摘Consultation-liaison psychiatry (CLP) was first established in China after liberation in 1949. It has developed more rapidly over the last two decades but, despite major regional differences in the level of CLP, the overall practice of CLP in the country remains quite basic, largely limited to case-based consultation with other medical departments. There is little ongoing collaboration between departments of psychiatry and other departments, and medical students and non- psychiatric clinicians rarely get training in CLP.
文摘Generally, hysteroscopy is not appropriate for pregnant women without an indication. What if a patient undergoes hysteroscopy accidentally during the early gestational period? We here report a rare case of a woman who continued pregnancy after a diagnostic hysteroscopy was performed in early pregnancy and delivered a healthy baby. The patient had a history of infertility and oligomenorrhea, probably due to a previous induced abortion. A hysteroscopy was performed after the end of her "menstruation" for assessment of her uterine cavity. Early pregnancy, instead of the expected intrauterine adhesions, was suspected, and the procedure was immediately ceased. Subsequent tests confirmed the diagnosis of pregnancy. She had a fullterm delivery by elective caesarean section. The success of this case was attributed to the use of vaginoscopic techniques in hysteroscopy and correct judgment and decision-making during the procedure. This case report provides some useful methods and experience that might be helpful when a similar situation occurs in clinical practice.
文摘Purpose: To evaluate age related ovarian response to controlled ovarian hyperstimulation, clinical pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing assisted reproduction treatment (ART) with antimullerian hormone (AMH) levels of <5 pmol/l. Methods: Retrospective analysis of data from 63 women with AMH of In-vitro?fertilization, IVF and intracytoplasmic sperm injection, ICSI) cycle. Results were analyzed after dividing patients in two groups, group 1 included women of ≤38 years and group 2 > 38 years of age. Non parametric variables were expressed as median (Interquartile range) and compared by Kruskal-Wallis test. Categorical variables were expressed as numbers with proportions (%) and compared by Fisher’s exact test. Results: There was no statistical difference in body max index, level of antimullerian hormone (AMH), follicle stimulating hormone (FSH), dose of gonadotrophins used and cycles cancellation rate in two groups. Although number of oocytes retrieved (median 5), clinical pregnancy (18.4%) and ongoing pregnancy rate beyond 20 weeks (18.4%) was higher in group 1, there was no statistical difference between the two groups. There was one miscarriage in group 2. Conclusion: Women with extremely low-serum AMH levels can still have clinical pregnancy and ongoing pregnancies beyond 20 weeks after ART, though chances will be lower than women with normal ovarian reserve.
基金supported by the National Key Research and Development Program of China(2016YFD0300301)the earmarked fund for China Agriculture Research System of MOF and MARA(CARS-02-13)the Education Department of Jiangxi Province,China(190233)。
文摘Plants must maintain a balance between their carbon(C)supply and utilization during the day–night cycle for continuous growth since C starvation often causes irreversible damage to crop production.It is not well known how C fixation and allocation in the leaves of crops such as maize adapt to sudden environmental changes.Here,to quantify primary C fixation and partitioning in photosynthetic maize leaves under extended darkness and to relate these factors to plant growth,maize seedlings were subjected to extended darkness(ED)for three successive days at the 6 th leaf fully expanded stage(V6).ED reduced plant growth and leaf chlorophyll levels but not the rate of net CO_2 exchange.As a result of the reduction in photoassimilates,the accumulation of starch and total soluble carbohydrates(TSC)in mature leaves also decreased under ED.However,the percentage of the daily C fixation reserved in mature leaves increased.These transient C pools were largely composed of TSC and were mainly used for consumption by increased nocturnal respiration rather than for transport.As the days went on,both the amount of C accumulated and the percentage of the daily fixed C that was reserved in leaves decreased,which could be largely accounted for by the attenuated starch synthesis in all treatments.The activities of ADPglucose pyrophosphorylase and soluble starch synthase decreased significantly over time.Therefore,this study concluded that both starch and TSC are involved in the coordination of the C supply and plant growth under a sudden C shortage but that they may be involved in different ways.While the ratio of reserved C to daily fixed C increased to maintain blade function under acute C starvation,both the amount and the proportion of C reserved in mature leaves decreased as plant growth continued in order to meet the growth demands of the plant.
文摘Jiang Zemin, 67, was elected President of the People’s Republic of China on March 27 at the ongoing first, session of the Eighth National People’s Congress. He was also re-elected Chairman of the Central Military Commission of the country. Meanwhile, a non-Communist politician and a leading businessman, Rong Yiren, 77, was elected Vice-President. Qiao Shi, 69, was voted as Chairman of the Eighth National People’ Congress Standing Committee. Li Pemg’s re-appointment as Premier,
文摘China’s toy makers are exploring new ways to break the bottlenecks of development as the ongoing European crisis continues to impact demand,according to Xinhua.Toy makers are actively expanding industrial reaches,enriching cultural elements in products and tapping into the domestic market in their attempts to survive global headwinds,reporters from
文摘“Don’t worry!”Xaiyakone Tammavong stressed to his parents in Laos.“We’re safe in Wuhan.The measures taken by the Chinese government have been very effective.I feel the situation improving with each passing day.”Every day,Tammavong shares a video call with his parents to tell them about life in China amid the country’s ongoing fight against the COVID-19 epidemic.
文摘China's top education authorities on Friday gave detailed suggestions on when students should go to bed to ensure sufficient sleep amid ongoing efforts to reduce students,burden.Gen erally speaking,primary school stude nts should go to bed before 9:20 pm.
基金This is a contribution of the IGCP-655 project of the IUGS and UNESCO.
文摘Introduction.The study of catastrophic events that affected past marine ecosystems provides us the unique opportunity to establish models which can be applied to ongoing environmental changes and to understand future evolution of the biotas.The growing interest of the society for the ongoing and potential future environmental changes attests for the value represented by the analysis of past climatic changes.In the case of the Toarcian Oceanic Anoxic Event(T-OAE,Early Jurassic;~182 Ma),a dramatic change of marine ecosystems related to massive extinction has been documented in several areas around the world.The Pliensbachian–Toarcian transition and the T-OAE are two global episodes recording worldwide palaeoenvironmental perturbations(Jenkyns,1988;Jenkyns and Clayton,1997;Hesselbo et al.,2007).The end of the Pliensbachian regression is followed by a transgression occurring in the Early Toarcian(Haq et al.,1987;de Graciansky et al.,1999).This transgression was also coeval with a widespread deposition of black shales(Jenkyns,1988),a global warming(Garcia Joral et al.,2011;Korte and Hesselbo,2011;Suan et al.,2011),and perturbations of the carbon cycle indicated by a negative carbon isotopic excursion(CIE)documented in both marine and terrestrial material(Jenkyns and Clayton,1986;Schouten et al.,2000;Hesselbo et al.,2007;Al-Suwaidi et al.,2010;Caruthers et al.,2011;Izumi et al.,2012;Reolid,2014).
基金Ministerio de Ciencia e Innovación,Grant/Award Number:PID2019-105010RB-I00Agencia de Innovación y Desarrollo de Andalucía,Grant/Award Numbers:BIO 267,UMA18-FEDERJA-220。
文摘Glioblastoma multiforme(GBM)is the most aggressive and common malig-nant primary brain tumor.Patients with GBM often have poor prognoses,with a median survival of∼15 months.Enhanced understanding of the molecular biology of central nervous system tumors has led to modifications in their classifications,the most recent of which classified these tumors into new categories and made some changes in their nomenclature and grading system.This review aims to give a panoramic view of the last 3 years’findings in glioblastoma characterization,its heterogeneity,and current advances in its treatment.Several molecular parameters have been used to achieve an accurate and personalized characterization of glioblastoma in patients,including epigenetic,genetic,transcriptomic and metabolic features,as well as age-and sex-related patterns and the involvement of several noncoding RNAs in glioblastoma progression.Astrocyte-like neural stem cells and outer radial glial-like cells from the subven-tricular zone have been proposed as agents involved in GBM of IDH-wildtype origin,but this remains controversial.Glioblastoma metabolism is characterized by upregulation of the PI3K/Akt/mTOR signaling pathway,promotion of the gly-colytic flux,maintenance of lipid storage,and other features.This metabolism also contributes to glioblastoma’s resistance to conventional therapies.Tumor heterogeneity,a hallmark of GBM,has been shown to affect the genetic expresion,modulation of metabolic pathways,and immune system evasion.GBM’s aggressive invasion potential is modulated by cell-to-cell crosstalk within the tumor microenvironment and altered expressions of specific genes,such as ANXA2,GBP2,FN1,PHIP,and GLUT3.Nevertheless,the rising number of active clinical trials illustrates the efforts to identify new targets and drugs to treat this malignancy.Immunotherapy is still relevant for research purposes,given the amount of ongoing clinical trials based on this strategy to treat GBM,and neoantigen and nucleic acid-based vaccines are gaining importance due to their antitumoral activity by inducing the immune response.Furthermore,there are clinical trials focused on the PI3K/Akt/mTOR axis,angiogenesis,and tumor heterogeneity for developing molecular-targeted therapies against GBM.Other strategies,such as nanodelivery and computational models,may improve the drug pharmacokinetics and the prognosis of patients with GBM.
文摘The effect of microelement on health is a new subject ongoing since the seventies. Some diseases may be related to changes of some elements. Since the last few years changes of Cu, Zn and other elements in the serum and lung of silicosis have
文摘The rhizomes of Curcuma wenyujin Y.H.Chen et C.Ling are used as a traditional Chinese medicine for the treatment of Oketsu syndromes.Recently,our research group has been examining the constituents of C.kwangsiensis,C.phaeocaulis and C.wenyujin.As part of our ongoing research for biologically active sesquiterpenoids from the genus Curcuma and to provide a potential explanation for
基金The authors have not declared a specific grant for this research from any funding agency in the public,commercial or not-for-profit sectors.
文摘INTRODUCTION As we face the ongoing global pandemic of COVID-19,doctors,nurses,ambulance officers,paramedics and many other health workers answer the call to serve in time-pressured,unfamiliar,chaotic and often-traumatic environments.1 We know how to look after ourselves in an infectious physical environment,but it is equally important to look after ourselves psychologically at this time.
文摘Editorial Our new column Insights is an ongoing series of interviews prepared by the China CDC Weekly team with researchers,policymakers,experts,and other leaders that strives to disseminate experiences,knowledge,and perspectives in global and public health with a wider community.At the discretion of the Weekly’s team,these interviews will be written into articles,shared as videos,and/or presented as transcripts to best promote plain-language principles and to ease understanding of non-specialized academic readers.
