A distributed model predictive control(MPC) scheme with one-step delay communication is proposed for on-line optimization and control of large-scale systems in this paper. Cooperation between subsystems is achieved by...A distributed model predictive control(MPC) scheme with one-step delay communication is proposed for on-line optimization and control of large-scale systems in this paper. Cooperation between subsystems is achieved by exchanging information with neighbor-to-neighbor communication and by optimizing the local problem with the improved performance index in the neighborhood. A distributed MPC algorithm with one-step delay communication is developed for the situation that there is a one-step delay in the information available from its neighbors when a subsystem solves the local optimization problem. The nominal stability is employed for the whole system under the distributed MPC algorithm without the inequality constraints. Finally, the case study of the reactor-storage-separator(RSS) system is illustrated to test the practicality of the presented control algorithm.展开更多
Calcium carboaluminate was successfully prepared by a simple and efficient one-step method,and the effects of temperature,time,raw material ratio,carbonate type and heavy CaCO_(3)particle size on the products were inv...Calcium carboaluminate was successfully prepared by a simple and efficient one-step method,and the effects of temperature,time,raw material ratio,carbonate type and heavy CaCO_(3)particle size on the products were investigated in detail.The results show that increasing the temperature and extending the reaction time can enhance the yield and crystallisation degree of calcium carboaluminate.The proportion of Ca(OH)_(2),Al(OH)_(3)and CaCO_(3)is a pivotal factor in the synthesis of calcium carboaluminate.When the ratio of Ca(OH)_(2),Al(OH)_(3)and CaCO_(3)is 3:2:1,the diffraction peaks of calcium carboaluminate in the products are relatively sharp and strong.Furthermore,the purity and crystallinity of the synthesized calcium carboaluminate are higher when heavy CaCO_(3)with the particle size of 120 mesh is used as the carbonate raw material,in comparison to CO_(2),Na_(2)CO_(3)and light CaCO_(3).As results,a simple and efficient method for the synthesis of calcium carboaluminate is proposed,which will provide a solid experimental foundation and technical support for the industrial application of calcium carboaluminate in marine concrete.展开更多
The three-dimensional(3D) Pd-based nanoflower structures,assembled from two-dimensional(2D)nanosheets,are characterized by their stable and ordered configurations.These structures have been extensively designed as ano...The three-dimensional(3D) Pd-based nanoflower structures,assembled from two-dimensional(2D)nanosheets,are characterized by their stable and ordered configurations.These structures have been extensively designed as anode materials for fuel cells.However,the exploration of trimetallic nanoflowers with porous architectures remains limited.In this study,we present a straightforward one-step solvothermal method for the synthesis of trimetallic Pd Cu Ni porous nanoflowers(PNFs).Leveraging several unique advantages,such as an open superstructure,high porosity,and enhanced electronic interactions among the trimetals,the resulting Pd Cu Ni PNFs demonstrate significantly improved electrochemical performance,with mass activities reaching 5.94 and 10.14 A/mg for the ethanol oxidation reaction(EOR)and the ethylene glycol oxidation reaction(EGOR),respectively.Furthermore,the Pd Cu Ni PNFs exhibit optimized d-band centers and the most negative onset oxidation potential,indicating enhanced antitoxicity and stability.This study not only provides a novel perspective on the synthesis of 3D porous nanomaterials but also highlights the potential application value of trimetallic nanoalloys in catalysis.展开更多
The flight envelope of Air Turbo Rocket(ATR)engines is broader compared to conventional aero-engines,and designing a full-envelope controller using traditional methods poses significant challenges due to a burdensome ...The flight envelope of Air Turbo Rocket(ATR)engines is broader compared to conventional aero-engines,and designing a full-envelope controller using traditional methods poses significant challenges due to a burdensome design process.To address this issue,this paper proposes a self-learning neural network controller design method based on Reinforcement Learning(RL).Additionally,a method for predictive compensation and stability rewards is proposed to reduce the system oscillation caused by actuator delay.This approach simplifies the actuator to a firstorder inertial element exhibiting pure delay.A simulation environment for the ATR engineactuator system is first established.Based on this environment,a self-learning neural network controller using a predictive compensator and the Proximal Policy Optimization(PPO)algorithm is then developed.Furthermore,the temporal difference signals from the controller output are integrated into the reward function to enhance system stability.The proposed method is validated through numerical simulations and semi-physical experiments.The numerical simulation results demonstrate that the proposed method increases the system's tolerance to delays from 20 ms to 400 ms.Under an actuator delay of 400 ms,the average steady-state error remains less than0.1%,the overshoot is limited to 1%,and the settling time does not exceed 3 s.Moreover,compared to the traditional method,the proposed method exhibits higher adaptability to model errors and variations in flight conditions.In the conducted semi-physical simulation experiments,the proposed method achieves stable control of a real electric pump.展开更多
The development of polymeric materials that exhibit blue thermally activated delayed fluorescence(TADF)is of great interest for optoelectronic applications.However,achieving TADF in polymers often requires an elaborat...The development of polymeric materials that exhibit blue thermally activated delayed fluorescence(TADF)is of great interest for optoelectronic applications.However,achieving TADF in polymers often requires an elaborate monomer design.The high-energy local triplet state(^(3)LE)of carbazole complicates its application despite the molecular orbital arrangement being suitable for blue emission.Here,we present an approach to polymer design that makes it possible to solve this problem.We demonstrate the in situ formation of a TADF donor-acceptor system during Suzuki polycondensation,creating an extended carbazole-based donor matrix coupled with a triazine acceptor.The resulting polymer exhibited efficient TADF with a low energy gap(ΔE_(ST))value if a phenyl N-substituent,enabling essential electron delocalization,was present in the carbazole moiety.This work establishes a versatile platform for developing carbazole-based TADF polymers,overcoming the fundamental limitations that hinder their widespread application.展开更多
Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the ...Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.展开更多
Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while...Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while the potential for further vibration reduction remains debated,largely due to unclear underlying mechanisms.In light of the popularization of electronic detonators and the representativeness of double-hole configurationsfor multiple blastholes,it is essential to investigate the vibration characteristics induced by time-delayed double blastholes.Therefore,a series of doubleborehole experimental blasts was conducted in an underground roadway to clarify the variation in vibration from single-hole to dual-hole conditions.Based on the experimental data and inherent limitations,an exact full-fieldtheoretical model was further employed to systematically analyze the effects of delay time,charge length,and borehole inclination angle on vibrations induced by various doublehole configurations.The experimental data and theoretical analysis reveal that the general scaled distance effectively predicts vibrations in delayed blasting but does not reflectvibration reduction.Increasing delay time causes fluctuatingPPVs,which stabilize slightly above single-hole PPVs as delay times exceed a certain value.The delayed blasting primarily reduces near-fieldfrequencies.Longer charge lengths in double boreholes increase PPV levels and attenuation rates within a certain length,and the vibration behavior of combined long and short charge lengths is governed by the long blasthole.Larger blasthole inclination angles enhance vibration amplitude and reduce PPV attenuation rates.Optimizing inclination angles is more critical than adjusting delay times,and parallel boreholes offer the best vibration control.展开更多
A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescenc...A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.展开更多
Delayed neurocognitive recovery following anesthesia and surgery is a common complication in older adult patients.Synapses are fundamental to cognitive function.The activity of synapses heavily depends on the energy s...Delayed neurocognitive recovery following anesthesia and surgery is a common complication in older adult patients.Synapses are fundamental to cognitive function.The activity of synapses heavily depends on the energy supplied by synaptic mitochondria,which are significantly influenced by oxidative stress.Sirtuin 3 is a histone deacetylase located in the mitochondrial matrix that plays a pivotal role in regulating mitochondrial function.However,it remains unclear whether and how sirtuin 3 is involved in the development of delayed cognitive recovery.Therefore,in this study,we investigated the potential role of sirtuin 3 in synapses during delayed neurocognitive recovery.Our results showed that anesthesia and surgery induced cognitive impairment in mice and reduced sirtuin 3 protein expression.Overexpression of sirtuin 3 inhibited opening of the mitochondrial permeability transition pore by reducing acetylation of K166 on cyclophilin D and also rescued cognitive impairment.Aged mice carrying the cyclophilin D-K166R mutation exhibited significantly reduced cognitive impairment.Similarly,administering the mitochondrial permeability transition pore blocker,cyclosporine A,effectively alleviated the decline in synaptic mitochondrial function and cognitive impairment caused by anesthesia and surgery in aged mice.These results indicate that the sirtuin 3/cyclophilin D-K166/mPTP signaling pathway in hippocampal synaptic mitochondria is involved in delayed neurocognitive recovery of aged mice,suggesting this pathway could serve as a potential target for treatment.展开更多
Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay di...Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.展开更多
Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid...Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid(RA)can suppress the neurotoxic effects of CO.This study further explores,in vivo and in vitro,the molecular mechanisms by which RA alleviates CO-induced central nervous system damage.Methods:A cytotoxic model was established using the mouse hippocampal neuronal cell line HT22 and primary oligodendrocytes exposed to CO,and a DEACMP animal model was established in adult Kunming mice.Cell viability and apoptosis of hippocampal neurons and oligodendrocytes were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay and Annexin V/propidium iodide(PI)double staining.The transcriptional and protein expression of each gene was detected using real time fluorescence quantitative PCR(RT-qPCR)and Western blotting.Long noncoding RNA(lncRNA)SNHG15 and LINGO-1 were knocked down or overexpressed to observe changes in neurons and oligodendrocytes.In DEACMP mice,SNHG15 or LINGO-1 were knocked down to assess changes in central nervous tissue and downstream protein expression.Results:RA at 10 and 20μmol/L significantly reversed CO-induced apoptosis of hippocampal neurons and oligodendrocytes,downregulation of SNHG15 and LINGO-1,and upregulation of brain-derived neurotrophic factor(BDNF)and tyrosine kinase receptor B(TrkB)(all P<0.05).Overexpression of SNHG15 or LINGO-1 weakened the protective effect of RA against CO-induced cytotoxicity(all P<0.05).Knockdown of SNHG15 or LINGO-1 alleviated CO-induced apoptosis of hippocampal neurons and oligodendrocytes and upregulated BDNF and TrkB expression levels(all P<0.05).Experiments in DEACMP model mice showed that knockdown of SNHG15 or LINGO-1 mitigated central nervous system injury in DEACMP(all P<0.05).Conclusion:RA alleviates CO-induced apoptosis of hippocampal neurons and oligodendrocytes,thereby reducing central nervous system injury and exerting neuroprotective effects.LncRNA SNHG15 and LINGO-1 are key molecules mediating RA induced inhibition of neuronal apoptosis and are associated with the BDNF/TrkB pathway.These findings provide a theoretical framework for optimizing the clinical treatment of DEACMP and lay an experimental foundation for elucidating its molecular mechanisms.展开更多
Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide(LLO),leading to voltage and capac...Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide(LLO),leading to voltage and capacity fading.Herein,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room temperature.Density functional theory(DFT)calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry(DEMS)indicates that the Cr_(x)B complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy Li^(+)migration,The voltage and capacity fading of the modified cathode(LLO-C_(r)B)are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface(CEI)composed of balanced organic/inorganic composition.Therefore,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g^(-1)(with a retention rate of 95.1%).This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.展开更多
Wireless communication-enabled Cooperative Adaptive Cruise Control(CACC)is expected to improve the safety and traffic capacity of vehicle platoons.Existing CACC considers a conventional communication delay with fixed ...Wireless communication-enabled Cooperative Adaptive Cruise Control(CACC)is expected to improve the safety and traffic capacity of vehicle platoons.Existing CACC considers a conventional communication delay with fixed Vehicular Communication Network(VCN)topologies.However,when the network is under attack,the communication delay may be much higher,and the stability of the system may not be guaranteed.This paper proposes a novel communication Delay Aware CACC with Dynamic Network Topologies(DADNT).The main idea is that for various communication delays,in order to maximize the traffic capacity while guaranteeing stability and minimizing the following error,the CACC should dynamically adjust the VCN network topology to achieve the minimum inter-vehicle spacing.To this end,a multi-objective optimization problem is formulated,and a 3-step Divide-And-Conquer sub-optimal solution(3DAC)is proposed.Simulation results show that with 3DAC,the proposed DADNT with CACC can reduce the inter-vehicle spacing by 5%,10%,and 14%,respectively,compared with the traditional CACC with fixed one-vehicle,two-vehicle,and three-vehicle look-ahead network topologies,thereby improving the traffic efficiency.展开更多
The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled p...The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.展开更多
In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave so...In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.展开更多
The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivativ...The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivative operator.Additionally,time delays in the potential field force and coupling force transmission are both considered.Firstly,based on the delay decoupling formula,combined with statistical mean method and the fractional-order Shapiro–Loginov formula,the“statistic synchronization”among particles is obtained,revealing the statistical equivalence between the mean field behavior of the system and the behavior of individual particles.Due to the existence of the coupling delay,the impact of the coupling force on synchronization exhibits non-monotonic,which is different from the previous monotonic effects.Then,two kinds of theoretical expression of output amplitude gains G and G are derived by time-delay decoupling formula and small delay approximation theorem,respectively.Compared to G,G is an exact theoretical solution,which means that G is not only more accurate in the region of small delay,but also applies to the region of large delay.Finally,the study of the output amplitude gain G and its resonance behavior are explored.Due to the presence of the potential field delay,a new resonance phenomenon termed“periodic resonance”is discovered,which arises from the periodic matching between the potential field delay and the driving frequency.This resonance phenomenon is analyzed qualitatively and quantitatively,uncovering undiscovered characteristics in previous studies.展开更多
A Langevin delayed fractional system with multiple delays in control,is a delayed fractional system that includes delay parameters in both state and control,is first introduced.This paper is devoted to investigating t...A Langevin delayed fractional system with multiple delays in control,is a delayed fractional system that includes delay parameters in both state and control,is first introduced.This paper is devoted to investigating the relative controllability of the Langevin delayed fractional system with multiple delays in control.For linear systems to be relatively controllable,necessary and sufficient circumstances are identified by introducing and employing the Gramian matrix.The sufficient conditions for the relative controllability of semilinear systems are ofered based on Schauder's fixed point theorem.As an unusual approach,the controllability results of the delayed system are built for the first time on the exact solution produced by the MittagLeffler type function although controllability ones in the literature are built on the Volterra integral equations or the mild solutions produced by resolvent families.展开更多
In this work,one-step growth models using hyperspectral imaging(HSI)(400-1000 nm)were successfully developed in order to estimate the microbial loads,minimum growth temperature(T_(min))and maximum specific growth rate...In this work,one-step growth models using hyperspectral imaging(HSI)(400-1000 nm)were successfully developed in order to estimate the microbial loads,minimum growth temperature(T_(min))and maximum specific growth rate(μ_(max))of Brochothrix thermosphacta in chilled beef at isothermal temperatures(4-25℃).Three different methods were compared for model development,particularly using(Model Ⅰ)the predicted microbial loads from partial least squares regression of the whole spectral variables;(Model Ⅱ)the selected spectral variables related to microbial loads;and(Model Ⅲ)the first principal scores of HSI spectra by principal component analysis.Consequently,Model Ⅰ showed the best ability to predict the microbial loads of B.thermosphacta,with the coefficient of determination(R_(v)^(2))and root mean square error in internal validation(RMSEV)of 0.921 and 0.498(lg(CFU/g)).The T_(min)(-12.32℃)andμmax can be well estimated with R^(2) and root mean square error(RMSE)of 0.971 and 0.276(lg(CFU/g)),respectively.The upward trend ofμmax with temperature was similar to that of the plate count method.HSI technique thus can be used as a simple method for one-step growth simulation of B.thermosphacta in chilled beef during storage.展开更多
This paper deals with the problem of robust stabilization for uncertain Takagi-Sugeno(T-S)fuzzy neutral systems with input delays and distributed delays.The purpose is to design a state feedback fuzzy controller with ...This paper deals with the problem of robust stabilization for uncertain Takagi-Sugeno(T-S)fuzzy neutral systems with input delays and distributed delays.The purpose is to design a state feedback fuzzy controller with a H∞performance such that the resulting closed-loop system is robustly stable.Sufficient conditions for the solvability of the problem are obtained by utilizing proper Lyapunov functional together with the linear matrix inequality(LMI)approach,especially two different improved results on robust H∞controller design with relaxed conditions are obtained.Finally,we provide two examples to verify the effectiveness of our design method and give some principle for choosing the proper controller under certain circumstances.展开更多
BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory disease.High oxidative stress is a treatment target for IBD.Cerium oxide(CeO2)nanomaterials as nanozymes with antioxidant activity ...BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory disease.High oxidative stress is a treatment target for IBD.Cerium oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of colitis.AIM To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in IBD.METHODS H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic activity.Subsequently,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic inflammation.The effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,respectively.Finally,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood biochemistry.RESULTS H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy mice.No significant damage to major organs was observed in healthy mice following H-CeO2 administration.CONCLUSION The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.展开更多
基金the National Natural Science Foundation of China(No.61203110)the Shanghai Natural Science Foundation(No.13ZR1418900)the Innovation Programs of Shanghai Municipal Education Commission(Nos.12ZZ155 and 14YZ107)
文摘A distributed model predictive control(MPC) scheme with one-step delay communication is proposed for on-line optimization and control of large-scale systems in this paper. Cooperation between subsystems is achieved by exchanging information with neighbor-to-neighbor communication and by optimizing the local problem with the improved performance index in the neighborhood. A distributed MPC algorithm with one-step delay communication is developed for the situation that there is a one-step delay in the information available from its neighbors when a subsystem solves the local optimization problem. The nominal stability is employed for the whole system under the distributed MPC algorithm without the inequality constraints. Finally, the case study of the reactor-storage-separator(RSS) system is illustrated to test the practicality of the presented control algorithm.
基金Funded by the National Nature Science Foundation of China(No.52078321)。
文摘Calcium carboaluminate was successfully prepared by a simple and efficient one-step method,and the effects of temperature,time,raw material ratio,carbonate type and heavy CaCO_(3)particle size on the products were investigated in detail.The results show that increasing the temperature and extending the reaction time can enhance the yield and crystallisation degree of calcium carboaluminate.The proportion of Ca(OH)_(2),Al(OH)_(3)and CaCO_(3)is a pivotal factor in the synthesis of calcium carboaluminate.When the ratio of Ca(OH)_(2),Al(OH)_(3)and CaCO_(3)is 3:2:1,the diffraction peaks of calcium carboaluminate in the products are relatively sharp and strong.Furthermore,the purity and crystallinity of the synthesized calcium carboaluminate are higher when heavy CaCO_(3)with the particle size of 120 mesh is used as the carbonate raw material,in comparison to CO_(2),Na_(2)CO_(3)and light CaCO_(3).As results,a simple and efficient method for the synthesis of calcium carboaluminate is proposed,which will provide a solid experimental foundation and technical support for the industrial application of calcium carboaluminate in marine concrete.
基金supported by the National Natural Science Foundation of China (No.52274304)。
文摘The three-dimensional(3D) Pd-based nanoflower structures,assembled from two-dimensional(2D)nanosheets,are characterized by their stable and ordered configurations.These structures have been extensively designed as anode materials for fuel cells.However,the exploration of trimetallic nanoflowers with porous architectures remains limited.In this study,we present a straightforward one-step solvothermal method for the synthesis of trimetallic Pd Cu Ni porous nanoflowers(PNFs).Leveraging several unique advantages,such as an open superstructure,high porosity,and enhanced electronic interactions among the trimetals,the resulting Pd Cu Ni PNFs demonstrate significantly improved electrochemical performance,with mass activities reaching 5.94 and 10.14 A/mg for the ethanol oxidation reaction(EOR)and the ethylene glycol oxidation reaction(EGOR),respectively.Furthermore,the Pd Cu Ni PNFs exhibit optimized d-band centers and the most negative onset oxidation potential,indicating enhanced antitoxicity and stability.This study not only provides a novel perspective on the synthesis of 3D porous nanomaterials but also highlights the potential application value of trimetallic nanoalloys in catalysis.
基金co-supported by the National Science and Technology Major Project(No.J2019-Ⅲ-0010-0054)the National Natural Science Foundation of China(No.52336002)。
文摘The flight envelope of Air Turbo Rocket(ATR)engines is broader compared to conventional aero-engines,and designing a full-envelope controller using traditional methods poses significant challenges due to a burdensome design process.To address this issue,this paper proposes a self-learning neural network controller design method based on Reinforcement Learning(RL).Additionally,a method for predictive compensation and stability rewards is proposed to reduce the system oscillation caused by actuator delay.This approach simplifies the actuator to a firstorder inertial element exhibiting pure delay.A simulation environment for the ATR engineactuator system is first established.Based on this environment,a self-learning neural network controller using a predictive compensator and the Proximal Policy Optimization(PPO)algorithm is then developed.Furthermore,the temporal difference signals from the controller output are integrated into the reward function to enhance system stability.The proposed method is validated through numerical simulations and semi-physical experiments.The numerical simulation results demonstrate that the proposed method increases the system's tolerance to delays from 20 ms to 400 ms.Under an actuator delay of 400 ms,the average steady-state error remains less than0.1%,the overshoot is limited to 1%,and the settling time does not exceed 3 s.Moreover,compared to the traditional method,the proposed method exhibits higher adaptability to model errors and variations in flight conditions.In the conducted semi-physical simulation experiments,the proposed method achieves stable control of a real electric pump.
基金supported by the Russian Science Foundation (No. 25-13-00300)the Centre for Optical and Laser Materials Research (SPbSU) and Saint Petersburg State University for measuring the quantum yields of luminescence within the framework of research project(No.125021902439-8)。
文摘The development of polymeric materials that exhibit blue thermally activated delayed fluorescence(TADF)is of great interest for optoelectronic applications.However,achieving TADF in polymers often requires an elaborate monomer design.The high-energy local triplet state(^(3)LE)of carbazole complicates its application despite the molecular orbital arrangement being suitable for blue emission.Here,we present an approach to polymer design that makes it possible to solve this problem.We demonstrate the in situ formation of a TADF donor-acceptor system during Suzuki polycondensation,creating an extended carbazole-based donor matrix coupled with a triazine acceptor.The resulting polymer exhibited efficient TADF with a low energy gap(ΔE_(ST))value if a phenyl N-substituent,enabling essential electron delocalization,was present in the carbazole moiety.This work establishes a versatile platform for developing carbazole-based TADF polymers,overcoming the fundamental limitations that hinder their widespread application.
文摘Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.
基金supported by the National Natural Science Foundation of China(Grant Nos.42407267 and 52374152)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20220975).
文摘Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while the potential for further vibration reduction remains debated,largely due to unclear underlying mechanisms.In light of the popularization of electronic detonators and the representativeness of double-hole configurationsfor multiple blastholes,it is essential to investigate the vibration characteristics induced by time-delayed double blastholes.Therefore,a series of doubleborehole experimental blasts was conducted in an underground roadway to clarify the variation in vibration from single-hole to dual-hole conditions.Based on the experimental data and inherent limitations,an exact full-fieldtheoretical model was further employed to systematically analyze the effects of delay time,charge length,and borehole inclination angle on vibrations induced by various doublehole configurations.The experimental data and theoretical analysis reveal that the general scaled distance effectively predicts vibrations in delayed blasting but does not reflectvibration reduction.Increasing delay time causes fluctuatingPPVs,which stabilize slightly above single-hole PPVs as delay times exceed a certain value.The delayed blasting primarily reduces near-fieldfrequencies.Longer charge lengths in double boreholes increase PPV levels and attenuation rates within a certain length,and the vibration behavior of combined long and short charge lengths is governed by the long blasthole.Larger blasthole inclination angles enhance vibration amplitude and reduce PPV attenuation rates.Optimizing inclination angles is more critical than adjusting delay times,and parallel boreholes offer the best vibration control.
文摘A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.
基金supported by the National Natural Science Foundation of China,Nos.81701040(to HM),82071180(to HM),82271206(to TL),82171191(to YW),82371211(to YW)the Natural Science Foundation of Beijing,No.7212023(to HM)Key Subject of the Natural Science Foundation ofJiangsu Province for Colleges and Universities,No.23KJA320009(to YW).
文摘Delayed neurocognitive recovery following anesthesia and surgery is a common complication in older adult patients.Synapses are fundamental to cognitive function.The activity of synapses heavily depends on the energy supplied by synaptic mitochondria,which are significantly influenced by oxidative stress.Sirtuin 3 is a histone deacetylase located in the mitochondrial matrix that plays a pivotal role in regulating mitochondrial function.However,it remains unclear whether and how sirtuin 3 is involved in the development of delayed cognitive recovery.Therefore,in this study,we investigated the potential role of sirtuin 3 in synapses during delayed neurocognitive recovery.Our results showed that anesthesia and surgery induced cognitive impairment in mice and reduced sirtuin 3 protein expression.Overexpression of sirtuin 3 inhibited opening of the mitochondrial permeability transition pore by reducing acetylation of K166 on cyclophilin D and also rescued cognitive impairment.Aged mice carrying the cyclophilin D-K166R mutation exhibited significantly reduced cognitive impairment.Similarly,administering the mitochondrial permeability transition pore blocker,cyclosporine A,effectively alleviated the decline in synaptic mitochondrial function and cognitive impairment caused by anesthesia and surgery in aged mice.These results indicate that the sirtuin 3/cyclophilin D-K166/mPTP signaling pathway in hippocampal synaptic mitochondria is involved in delayed neurocognitive recovery of aged mice,suggesting this pathway could serve as a potential target for treatment.
文摘Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.
基金supported by the Natural Science Foundation of Hunan Province(2021JJ31089)the Scientific Research Project of Health Commission of Hunan Province(202203104548),China。
文摘Objective:The neurotoxicity of carbon monoxide(CO)to the central nervous system is a key pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Our previous study found that retinoic acid(RA)can suppress the neurotoxic effects of CO.This study further explores,in vivo and in vitro,the molecular mechanisms by which RA alleviates CO-induced central nervous system damage.Methods:A cytotoxic model was established using the mouse hippocampal neuronal cell line HT22 and primary oligodendrocytes exposed to CO,and a DEACMP animal model was established in adult Kunming mice.Cell viability and apoptosis of hippocampal neurons and oligodendrocytes were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay and Annexin V/propidium iodide(PI)double staining.The transcriptional and protein expression of each gene was detected using real time fluorescence quantitative PCR(RT-qPCR)and Western blotting.Long noncoding RNA(lncRNA)SNHG15 and LINGO-1 were knocked down or overexpressed to observe changes in neurons and oligodendrocytes.In DEACMP mice,SNHG15 or LINGO-1 were knocked down to assess changes in central nervous tissue and downstream protein expression.Results:RA at 10 and 20μmol/L significantly reversed CO-induced apoptosis of hippocampal neurons and oligodendrocytes,downregulation of SNHG15 and LINGO-1,and upregulation of brain-derived neurotrophic factor(BDNF)and tyrosine kinase receptor B(TrkB)(all P<0.05).Overexpression of SNHG15 or LINGO-1 weakened the protective effect of RA against CO-induced cytotoxicity(all P<0.05).Knockdown of SNHG15 or LINGO-1 alleviated CO-induced apoptosis of hippocampal neurons and oligodendrocytes and upregulated BDNF and TrkB expression levels(all P<0.05).Experiments in DEACMP model mice showed that knockdown of SNHG15 or LINGO-1 mitigated central nervous system injury in DEACMP(all P<0.05).Conclusion:RA alleviates CO-induced apoptosis of hippocampal neurons and oligodendrocytes,thereby reducing central nervous system injury and exerting neuroprotective effects.LncRNA SNHG15 and LINGO-1 are key molecules mediating RA induced inhibition of neuronal apoptosis and are associated with the BDNF/TrkB pathway.These findings provide a theoretical framework for optimizing the clinical treatment of DEACMP and lay an experimental foundation for elucidating its molecular mechanisms.
基金financially supported by the National Natural Science Foundation of China(No.12304077)the Natural Science Foundation of Science and Technology Department of Sichuan Province(No.23NSFSC6224)+3 种基金Sichuan Science and Technology Program(No.2024NSFSC0989)the Key Laboratory of Computational Physics of Sichuan Province(No.YBUJSWL-YB-2022-03)the Material Corrosion and Protection Key Laboratory of Sichuan Province(No.2023CL14 and No.2023CL01)the National Innovation Practice Project(No.202411079005S).
文摘Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide(LLO),leading to voltage and capacity fading.Herein,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room temperature.Density functional theory(DFT)calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry(DEMS)indicates that the Cr_(x)B complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy Li^(+)migration,The voltage and capacity fading of the modified cathode(LLO-C_(r)B)are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface(CEI)composed of balanced organic/inorganic composition.Therefore,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g^(-1)(with a retention rate of 95.1%).This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.
基金supported by the National Natural Science Foundation of China under Grant U21A20449in part by Jiangsu Provincial Key Research and Development Program under Grant BE2021013-2。
文摘Wireless communication-enabled Cooperative Adaptive Cruise Control(CACC)is expected to improve the safety and traffic capacity of vehicle platoons.Existing CACC considers a conventional communication delay with fixed Vehicular Communication Network(VCN)topologies.However,when the network is under attack,the communication delay may be much higher,and the stability of the system may not be guaranteed.This paper proposes a novel communication Delay Aware CACC with Dynamic Network Topologies(DADNT).The main idea is that for various communication delays,in order to maximize the traffic capacity while guaranteeing stability and minimizing the following error,the CACC should dynamically adjust the VCN network topology to achieve the minimum inter-vehicle spacing.To this end,a multi-objective optimization problem is formulated,and a 3-step Divide-And-Conquer sub-optimal solution(3DAC)is proposed.Simulation results show that with 3DAC,the proposed DADNT with CACC can reduce the inter-vehicle spacing by 5%,10%,and 14%,respectively,compared with the traditional CACC with fixed one-vehicle,two-vehicle,and three-vehicle look-ahead network topologies,thereby improving the traffic efficiency.
基金supported by Fund of State Key Laboratory of IPOC(BUPT)(No.IPOC2021ZT16),China.
文摘The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.
基金Supported by the National Natural Science Foundation of China(12261050)Science and Technology Project of Department of Education of Jiangxi Province(GJJ2201612 and GJJ211027)Natural Science Foundation of Jiangxi Province of China(20212BAB202021)。
文摘In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.
基金supported by the Natural Science Foundation of Sichuan Province,China(Youth Science Foundation)(Grant No.2022NSFSC1952).
文摘The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivative operator.Additionally,time delays in the potential field force and coupling force transmission are both considered.Firstly,based on the delay decoupling formula,combined with statistical mean method and the fractional-order Shapiro–Loginov formula,the“statistic synchronization”among particles is obtained,revealing the statistical equivalence between the mean field behavior of the system and the behavior of individual particles.Due to the existence of the coupling delay,the impact of the coupling force on synchronization exhibits non-monotonic,which is different from the previous monotonic effects.Then,two kinds of theoretical expression of output amplitude gains G and G are derived by time-delay decoupling formula and small delay approximation theorem,respectively.Compared to G,G is an exact theoretical solution,which means that G is not only more accurate in the region of small delay,but also applies to the region of large delay.Finally,the study of the output amplitude gain G and its resonance behavior are explored.Due to the presence of the potential field delay,a new resonance phenomenon termed“periodic resonance”is discovered,which arises from the periodic matching between the potential field delay and the driving frequency.This resonance phenomenon is analyzed qualitatively and quantitatively,uncovering undiscovered characteristics in previous studies.
文摘A Langevin delayed fractional system with multiple delays in control,is a delayed fractional system that includes delay parameters in both state and control,is first introduced.This paper is devoted to investigating the relative controllability of the Langevin delayed fractional system with multiple delays in control.For linear systems to be relatively controllable,necessary and sufficient circumstances are identified by introducing and employing the Gramian matrix.The sufficient conditions for the relative controllability of semilinear systems are ofered based on Schauder's fixed point theorem.As an unusual approach,the controllability results of the delayed system are built for the first time on the exact solution produced by the MittagLeffler type function although controllability ones in the literature are built on the Volterra integral equations or the mild solutions produced by resolvent families.
基金supported by Key Research&Development Program of Jiangsu Province in China(BE2020693)Major Project of Science and Technology of Anhui Province(201903a06020010)+1 种基金Joint Key Project of Science and Technology Innovation of Yangtze River Delta in Anhui Province(202004g01020009)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘In this work,one-step growth models using hyperspectral imaging(HSI)(400-1000 nm)were successfully developed in order to estimate the microbial loads,minimum growth temperature(T_(min))and maximum specific growth rate(μ_(max))of Brochothrix thermosphacta in chilled beef at isothermal temperatures(4-25℃).Three different methods were compared for model development,particularly using(Model Ⅰ)the predicted microbial loads from partial least squares regression of the whole spectral variables;(Model Ⅱ)the selected spectral variables related to microbial loads;and(Model Ⅲ)the first principal scores of HSI spectra by principal component analysis.Consequently,Model Ⅰ showed the best ability to predict the microbial loads of B.thermosphacta,with the coefficient of determination(R_(v)^(2))and root mean square error in internal validation(RMSEV)of 0.921 and 0.498(lg(CFU/g)).The T_(min)(-12.32℃)andμmax can be well estimated with R^(2) and root mean square error(RMSE)of 0.971 and 0.276(lg(CFU/g)),respectively.The upward trend ofμmax with temperature was similar to that of the plate count method.HSI technique thus can be used as a simple method for one-step growth simulation of B.thermosphacta in chilled beef during storage.
基金Research Project of Huzhou University under Grunt KYL21223。
文摘This paper deals with the problem of robust stabilization for uncertain Takagi-Sugeno(T-S)fuzzy neutral systems with input delays and distributed delays.The purpose is to design a state feedback fuzzy controller with a H∞performance such that the resulting closed-loop system is robustly stable.Sufficient conditions for the solvability of the problem are obtained by utilizing proper Lyapunov functional together with the linear matrix inequality(LMI)approach,especially two different improved results on robust H∞controller design with relaxed conditions are obtained.Finally,we provide two examples to verify the effectiveness of our design method and give some principle for choosing the proper controller under certain circumstances.
文摘BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory disease.High oxidative stress is a treatment target for IBD.Cerium oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of colitis.AIM To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in IBD.METHODS H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic activity.Subsequently,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic inflammation.The effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,respectively.Finally,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood biochemistry.RESULTS H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy mice.No significant damage to major organs was observed in healthy mice following H-CeO2 administration.CONCLUSION The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.
