The many roles of jasmonate in plant growth, reproduction, and defense raise interesting questions about how this lipid-derived hormone emerged during evolution. Recent studies indicate that a uhigher plant*5 pathway ...The many roles of jasmonate in plant growth, reproduction, and defense raise interesting questions about how this lipid-derived hormone emerged during evolution. Recent studies indicate that a uhigher plant*5 pathway involving jasmonoyl-L-isoleucine (JA-lle) as the receptor-active ligand is conserved in vascular plants (Bowman et al., 2017;Howe et al., 2018). Within this core sign aling pathway, J AZ protei ns link JA-lle perception to changes in the activity of MYC transcription factors (TFs)(Figure 1) and have emerged as a conserved hub for crosstalk in hormone response pathways.展开更多
Mevalonate kinase (MK)-associated diseases encompass a broad spectrum of rare auto-inflammatory conditions, all resulting from pathogenic variants in the mevalonate kinase gene (MVK). Their clinical manifestations are...Mevalonate kinase (MK)-associated diseases encompass a broad spectrum of rare auto-inflammatory conditions, all resulting from pathogenic variants in the mevalonate kinase gene (MVK). Their clinical manifestations are highly variable, ranging from more or less serious systemic disorders, such as hereditary recurrent fevers, to purely localized pathologies such as porokeratosis. The oldest condition identified as linked to this gene is a metabolic disease called mevalonic aciduria, and the most recent is disseminated superficial actinic porokeratosis, a disease limited to the skin. The modes of inheritance of MK-associated diseases also diverge among the different subtypes: recessive for the systemic subtypes and dominant with a post-zygotic somatic genetic alteration for MVK-associated porokeratosis. This review quickly retraces the historical steps that led to the description of the various MK-associated disease phenotypes and to a better understanding of their pathophysiology, then summarizes and compares the different genetic mechanisms involved in this group of disorders, and finally discusses the diverse causes that could underlie this phenotypic heterogeneity.展开更多
基金the Chemical Sciences, Geosciences, and Biosciences Division, Basic Energy Sciences, Office of Science at the U.SDepartment of Energy through grant DE-FG02-91ER20021+2 种基金the National Science Foundation through grant IOS-1456864the Michigan AgBioResearch through project MICL02278the Plant Resilience Institute at Michigan State University.
文摘The many roles of jasmonate in plant growth, reproduction, and defense raise interesting questions about how this lipid-derived hormone emerged during evolution. Recent studies indicate that a uhigher plant*5 pathway involving jasmonoyl-L-isoleucine (JA-lle) as the receptor-active ligand is conserved in vascular plants (Bowman et al., 2017;Howe et al., 2018). Within this core sign aling pathway, J AZ protei ns link JA-lle perception to changes in the activity of MYC transcription factors (TFs)(Figure 1) and have emerged as a conserved hub for crosstalk in hormone response pathways.
文摘Mevalonate kinase (MK)-associated diseases encompass a broad spectrum of rare auto-inflammatory conditions, all resulting from pathogenic variants in the mevalonate kinase gene (MVK). Their clinical manifestations are highly variable, ranging from more or less serious systemic disorders, such as hereditary recurrent fevers, to purely localized pathologies such as porokeratosis. The oldest condition identified as linked to this gene is a metabolic disease called mevalonic aciduria, and the most recent is disseminated superficial actinic porokeratosis, a disease limited to the skin. The modes of inheritance of MK-associated diseases also diverge among the different subtypes: recessive for the systemic subtypes and dominant with a post-zygotic somatic genetic alteration for MVK-associated porokeratosis. This review quickly retraces the historical steps that led to the description of the various MK-associated disease phenotypes and to a better understanding of their pathophysiology, then summarizes and compares the different genetic mechanisms involved in this group of disorders, and finally discusses the diverse causes that could underlie this phenotypic heterogeneity.
