Rapid screening of inorganic arsenic(iAs)in groundwater used for drinking by hundreds of millions of mostly rural residents worldwide is crucial for health protection.Most commercial field test kits are based on the G...Rapid screening of inorganic arsenic(iAs)in groundwater used for drinking by hundreds of millions of mostly rural residents worldwide is crucial for health protection.Most commercial field test kits are based on the Gutzeit reaction that uses mercury-based reagents for color development,an environmental concern that increasingly limits its utilization.This study further improves the Molybdenum Blue(MB)colorimetric method to allow for faster screening with more stable reagents.More importantly,a portable three-channel colorimeter is developed for screening iAs relative to the WHO drinking water guideline value(10μg/L).Adding the reducing reagents in sequence not only prolongs the storage time to>7 days,but also accelerates the color development time to 6 min in conjunction with lowering the H_(2)SO_(4) concentration in chromogenic reagents.The optimal pH ranges from 1.2 to 1.3 and is achieved by acidifying groundwater to 1%(V/V)HCl.With detection limits of 3.7μg/L for inorganic arsenate(iAs(V))and 3.8μg/L for inorganic arsenite(iAs(Ⅲ)),testing groundwater with-10μg/L of As has a precision<20%.The method works well for a range of phosphate concentrations of 48-950μg/L(0.5-10μmol/L).Concentrations of total_iAs(6-300μg/L),iAs(V)(6-230μg/L)and iAs(Ⅲ)(0-170μg/L)for 14 groundwater samples from Yinchuan Plain,Pearl River Delta,and Jianghan Plain,are in excellent agreements(linear regression slope:0.969-1.029)with the benchmark methods.The improved chemistry here lays the foundation for the MB colorimetric method to become a commercially viable screening tool,with further engineering and design improvement of the colorimeter.展开更多
Acrylamide(AA)is a neurotoxin and carcinogen that formed during the thermal food processing.Conventional quantification techniques are difficult to realize on-site detection of AA.Herein,a flower-like bimetallic FeCu ...Acrylamide(AA)is a neurotoxin and carcinogen that formed during the thermal food processing.Conventional quantification techniques are difficult to realize on-site detection of AA.Herein,a flower-like bimetallic FeCu nanozyme(FeCuzyme)sensor and portable platform were developed for naked-eye and on-site detection of AA.The FeCuzyme was successfully prepared and exhibited flower-like structure with 3D catalytic centers.Fe/Cu atoms were considered as active center and ligand frameworks were used as cofactor,resulting in collaborative substrate-binding features and remarkably peroxidase-like activity.During the catalytic process,the 3,3′,5,5′-tetrame-thylbenzidine(TMB)oxidation can be quenched by glutathione(GSH),and then restored after thiolene Michael addition reaction between GSH and AA.Given the“on–off–on”effect for TMB oxidation and high PODlike activity,FeCuzyme sensor exhibited a wide linear relationship from 0.50 to 18.00μM(R^(2)=0.9987)and high sensitivity(LOD=0.2360μM)with high stability.The practical application of FeCuzyme sensor was successfully validated by HPLC method.Furthermore,a FeCuzyme portable platform was designed with smartphone/laptop,and which can be used for naked-eye and on-site quantitative determination of AA in real food samples.This research provides a way for rational design of a novel nanozyme-based sensing platform for AA detection.展开更多
One of the primary tasks of earthquake early warning(EEW)systems is to predict potential earthquake damage rapidly and accurately.Cumulative absolute velocity(CAV),Arias intensity(I_(A)),and spectrum intensity(SI)are ...One of the primary tasks of earthquake early warning(EEW)systems is to predict potential earthquake damage rapidly and accurately.Cumulative absolute velocity(CAV),Arias intensity(I_(A)),and spectrum intensity(SI)are important parameters for measuring ground motion intensity and assessing earthquake damage.Due to the limited available information in EEW,CAV,I_(A),and SI cannot be accurately predicted using traditional EEW methods.In this paper,we propose an end-to-end deep learning-based Ground motion Intensity prediction Network(ENGINet)for on-site EEW.The aim of the ENGINet is to predict CAV,I_(A),and SI rapidly and reliably.ENGINet is based on a convolutional neural network and recurrent neural network.The inputs of the network are three-component acceleration records,three-component velocity records,and three-component displacement records obtained by a single station.The results from the test dataset show that at 3 s after the P-wave arrival,compared with the baseline models and other traditional methods,ENGINet has better performance in predicting CAV,I_(A),and SI.Our results indicate that ENGINet can quickly and accurately predict CAV,I_(A),and SI to some extent and has good potential in EEW efforts.展开更多
The vonoprazan(VPZ)triple therapy regimen for Helicobacter pylori(H.pylori)eradication developed by Han et al employs a scientifically rigorous clinical trial design.This multicenter randomized controlled trial establ...The vonoprazan(VPZ)triple therapy regimen for Helicobacter pylori(H.pylori)eradication developed by Han et al employs a scientifically rigorous clinical trial design.This multicenter randomized controlled trial establishes a standardized treatment framework aimed at improving H.pylori eradication rates,focusing on simplifying treatment regimens,shortening therapy duration,and optimizing therapeutic outcomes.The core of clinical translation lies in improving drug accessibility,establishing multidimensional safety evaluation systems,and optimizing cost-effectiveness.Conducting regional adaptability studies and comprehensive safety assessments is crucial for enhancing VPZ regimen effectiveness in China’s diverse healthcare environments.This study provides important evidence-based support for optimizing H.pylori treatment strategies in China,though further validation of universal applicability for nationwide implementation remains necessary.展开更多
Language policies are of great significance to a nation’s stability,unity,and development.Uzbekistan’s language policies have reflected the political,economic,and cultural dynamics of different periods throughout hi...Language policies are of great significance to a nation’s stability,unity,and development.Uzbekistan’s language policies have reflected the political,economic,and cultural dynamics of different periods throughout historical changes,influencing social structures and ethnic relations.This paper summarizes the characteristics of Uzbekistan’s language policies in different eras:During the Tsarist Russian period,the Russification of language policies hindered the development of local languages;in the Soviet era,policies adopted a dual approach,promoting both Russian and prioritizing ethnic languages;after independence,Uzbekistan established Uzbek as the state language and emphasized foreign language education.The current language policy in Uzbekistan presents a complex landscape:While emphasizing the dominant role of the national language helps preserve its heritage,it may easily spark ethnic and political tensions;promoting pluralism and inclusivity brings benefits but faces challenges in balancing language statuses,resource allocation,management,and communication;modernization efforts encounter difficulties in standardizing dialects and foreign loanwords;and in international exchanges,there is a need to balance relations with global lingua francas.In conclusion,Uzbekistan’s language policies have undergone unique transformations and face numerous challenges.In-depth research is crucial for improving the country’s policies and enhancing China-Uzbekistan cooperation.Proactive measures are needed to address these challenges,ensuring the sustainability of language policies and fostering greater national prosperity.展开更多
To accomplish on-site separation, preconcentration and cold storage of highly volatile organic compounds(VOCs) from water samples as well as their rapid transportation to laboratory, a high-throughput miniaturized pur...To accomplish on-site separation, preconcentration and cold storage of highly volatile organic compounds(VOCs) from water samples as well as their rapid transportation to laboratory, a high-throughput miniaturized purge-and-trap(μP&T) device integrating semiconductor refrigeration storage was developed in this work. Water samples were poured into the purge vessels and purged with purified air generated by an air pump. The VOCs in water samples were then separated and preconcentrated with sorbent tubes. After their complete separation and preconcentration, the tubes were subsequently preserved in the semiconductor refrigeration unit of the μP&T device. Notably, the high integration, small size, light weight, and low power consumption of the device makes it easy to be hand-carried to the field and transport by drone from remote locations, significantly enhancing the flexibility of field sampling. The performances of the device were evaluated by comparing analytical figures of merit for the detection of four cyclic volatile methylsiloxanes(cVMSs) in water. Compared to conventional collection and preservation methods, our proposed device preserved the VOCs more consistently in the sorbent tubes, with less than 5% loss of all analytes, and maintained stability for at least 20 days at 4℃. As a proof-of-concept,10 municipal wastewater samples were pretreated using this device with recoveries ranging from 82.5% to 99.9% for the target VOCs.展开更多
Taking Zhejiang Province as an example,this paper explores the mechanisms and implementation pathways through which the low-altitude economy drives the transformation and upgrading of the tourism industry.It finds tha...Taking Zhejiang Province as an example,this paper explores the mechanisms and implementation pathways through which the low-altitude economy drives the transformation and upgrading of the tourism industry.It finds that the low-altitude economy can effectively promote the development of high-end and diversified tourism in Zhejiang by innovating tourism formats,optimizing resource allocation,and enhancing tourist experiences.Besides,it analyzes the current development status of the low-altitude economy in Zhejiang and its potential for integration with tourism,revealing specific enabling pathways for tourism transformation,including low-altitude sightseeing,aviation tourism,and low-altitude sports.Finally,it proposes policy recommendations such as strengthening policy support,enhancing infrastructure development,and cultivating market entities.The findings aim to provide theoretical references and practical guidance for the high-quality development of tourism in Zhejiang Province.展开更多
The demand for Chinese-Western medicine collaboration has grown significantly,but current integration methods have substantial limitations.This article analyzes core issues in developing and implementing synergistic C...The demand for Chinese-Western medicine collaboration has grown significantly,but current integration methods have substantial limitations.This article analyzes core issues in developing and implementing synergistic Chinese-Western medicine clinical treatment strategies and explores the transformation from traditional integration to genuine synergistic models.We analyzed methodological obstacles in synergistic strategy development through literature review and theoretical analysis,and explored applications of intelligent technology in strategy development.Four core challenges were identified:(1)Treatment timing coordination difficulties caused by different decision-making approaches,with Chinese medicine using syndrome-based assessments and Western medicine relying on standardized measurements;(2)Treatment selection complexities when integrating different types of evidence,lacking frameworks for evaluating and combining diverse evidence sources;(3)Obstacles in incorporating patient preferences systematically,with inadequate assessment methods and unclear integration mechanisms;(4)Implementation barriers in translating synergistic strategies into clinical practice,requiring changes in organizational structures,workflows,and evaluation systems.Large language models(LLMs)and other intelligent technologies offer technical support for addressing these methodological challenges.This article examines current challenges in developing synergistic Chinese-Western medicine clinical strategies,analyzing the shift from traditional integration toward synergistic approaches and identifying four core methodological obstacles.Exploring intelligent technology applications provides insights to inform future research directions and clinical practice development in integrated healthcare delivery.展开更多
Currently,we have entered the era of artificial intelligence(AI).The rapid development and wide application of AI technology have exerted a profound impact on all fields of society.Against this backdrop,this paper con...Currently,we have entered the era of artificial intelligence(AI).The rapid development and wide application of AI technology have exerted a profound impact on all fields of society.Against this backdrop,this paper conducts an in-depth analysis focusing on general education in AI.First,it expounds the necessity of AI general education in cultivating the core literacy of vocational college students.Then,it puts forward effective implementation paths for such general education.The purpose is to provide valuable references for promoting the reform and innovative development of vocational education.展开更多
The integration of Global Navigation Satellite System(GNSS)technology into railway train control systems is a crucial step toward achieving the vision of a digital railway.Traditional train control systems undergo ext...The integration of Global Navigation Satellite System(GNSS)technology into railway train control systems is a crucial step toward achieving the vision of a digital railway.Traditional train control systems undergo extensive in-house tests and prolonged field tests for certification and approval before operational deployment,leading to high costs,delays,and operational disruptions.This paper introduces a GNSS-based train control localization framework which eliminates the need for on-site testing by leveraging train movement dynamics and 3D environment modeling to create a zero on-site testing platform.The proposed framework simulates train movement and the surrounding 3D environment using collected railway line location data and environmental attributes to generate realistic multipath signals and obscuration effects.This approach enables comprehensive laboratory-based case studies for train localization,reducing the huge amount test of needed for physical field trials.The framework is established in house,using the data collected at the Test Base of China Academy of Railway Sciences(Circular Railway).Results from the open area and cutting environment tests demonstrate high localization accuracy repeatability within the simulated environment,validating the feasibility and effectiveness of zero on-site testing for GNSS-based train control systems.This research highlights the potential of GNSS simulation platforms in enhancing cost efficiency,operational safety,and accuracy for future digital railways.展开更多
Oncology covers a wide range of knowledge and is more difficult compared to other clinical disciplines.Therefore,it is crucial to seek an efficient teaching method for oncology education.In recent years,China’s inter...Oncology covers a wide range of knowledge and is more difficult compared to other clinical disciplines.Therefore,it is crucial to seek an efficient teaching method for oncology education.In recent years,China’s internet technology has achieved rapid development.Massive Open Online Course(MOOC),a blended learning approach based on internet technology,has strong applicability to medical education.It can not only improve teaching quality but also promote further reform of the discipline.Based on this,our study searched for relevant research at home and abroad and reviewed the implementation path of integrating MOOC and blended learning in oncology education.This provides a theoretical foundation for the innovation of oncology teaching models,improves the level of oncology teaching,and lays a solid foundation for talent reserves in oncology departments.展开更多
In the wave of higher education internationalization,college students’career education is faced with problems such as inadequate integration of international elements in teaching content,insufficient depth of interna...In the wave of higher education internationalization,college students’career education is faced with problems such as inadequate integration of international elements in teaching content,insufficient depth of international cooperation in practical links,lack of international professional experience among the teaching staff,and insufficient emphasis on the cultivation of multicultural adaptability in the education model.Based on this,this paper deeply explores the new requirements put forward by internationalization for college students’career education and its diversified implementation paths from the perspective of higher education internationalization.It aims to build a comprehensive and multi-level career education system and improve students’international competitiveness through strategies such as constructing an internationalized curriculum system,expanding international cooperation practice projects,strengthening international exchanges and training for teachers,and integrating multicultural education.展开更多
The efficient implementation of the Advanced Encryption Standard(AES)is crucial for network data security.This paper presents novel hardware implementations of the AES S-box,a core component,using tower field represen...The efficient implementation of the Advanced Encryption Standard(AES)is crucial for network data security.This paper presents novel hardware implementations of the AES S-box,a core component,using tower field representations and Boolean Satisfiability(SAT)solvers.Our research makes several significant contri-butions to the field.Firstly,we have optimized the GF(24)inversion,achieving a remarkable 31.35%area reduction(15.33 GE)compared to the best known implementations.Secondly,we have enhanced multiplication implementa-tions for transformation matrices using a SAT-method based on local solutions.This approach has yielded notable improvements,such as a 22.22%reduction in area(42.00 GE)for the top transformation matrix in GF((24)2)-type S-box implementation.Furthermore,we have proposed new implementations of GF(((22)2)2)-type and GF((24)2)-type S-boxes,with the GF(((22)2)2)-type demonstrating superior performance.This implementation offers two variants:a small area variant that sets new area records,and a fast variant that establishes new benchmarks in Area-Execution-Time(AET)and energy consumption.Our approach significantly improves upon existing S-box implementations,offering advancements in area,speed,and energy consumption.These optimizations contribute to more efficient and secure AES implementations,potentially enhancing various cryptographic applications in the field of network security.展开更多
Objective:The World Health Organization recommends annual preventive chemotherapy with a single dose of praziquantel at≥75%treatment coverage,but as of 2021,the national coverage rate in Nigeria among children falls ...Objective:The World Health Organization recommends annual preventive chemotherapy with a single dose of praziquantel at≥75%treatment coverage,but as of 2021,the national coverage rate in Nigeria among children falls below 10%.This qualitative study sought to explore the barriers and facilitators to implementing large-scale praziquantel mass drug administration(MDA)programs for school-aged children in Nigeria to delineate tools and strategies that could improve the scaling-up and effectiveness of school-based praziquantel MDA programs.Methods:An exploratory qualitative study was conducted with stakeholders with experience in MDAs involving praziquantel or related preventive chemotherapy drugs in Nigeria.Through snowball sampling,30 stakeholders with experience in praziquantel school-based MDA in Nigeria were interviewed.An inductive approach was used to generate broad themes based on the barriers and facilitators identified by the key informants.Results:A total of 45 barriers and 36 facilitators were identified and grouped inductively into eight themes:funding and resources,design and composition of praziquantel tablets,knowledge and awareness mobilization,government,nongovernmental organization,and school engagement,data management,logistics,training,and security.Conclusion:This qualitative study reveals a wide range of barriers and facilitators in the MDA of praziquantel in Nigeria and uncovered critical points along the implementation pathway based on the locus of the barriers and facilitators identified.Collaboration with national,international,and non-profit organizations,and drug education through promotional materials,were the most frequently mentioned facilitators of the MDA program.In addition,insufficient program funding,and the complexity of the supply chain were the most cited barriers.展开更多
Background:Community-based first responders face high levels of workplace stressors that can pro-foundly impact their physical and mental health.Mindfulness-based interventions have shown promise in decreasing stress ...Background:Community-based first responders face high levels of workplace stressors that can pro-foundly impact their physical and mental health.Mindfulness-based interventions have shown promise in decreasing stress and increasing psychological resilience;however,implementation is difficult due to unpredictability of the job,department culture,and generational preferences.The objective of this qualitative study was to identify and enhance understanding of the specific needs and potential barriers and facilitators for the implementation of mindfulness-based programming for community-based first responders.Methods:A phenomenological qualitative study design was used to gain insights into the lived experiences of first responders and elicit perceptions regarding barriers and facilitators for engaging in mindfulness activities.During virtual semi-structured interviews,eleven career firefighters and emergency medical service(EMS)providers offered feedback relative to worksite mindfulness practices,and the use of a stress reduction smartphone application.The Consolidated Framework for Implementation Research was used to guide the analysis relative to barriers and facilitators of implementation success and sustainability.Results:First responders expressed openness to mindfulness-based interventions and a smartphone app that would provide stress reduction content,however,they were adamant that programming needed to be accessible and easily integrated into their workday.They also reinforced that organizational culture and leadership support for their health and well-being were overarching factors essential for implementation success.Conclusions:First responders were supportive of evidence-based mindfulness practices,optimally developed and/or facilitated by someone with intimate knowledge of their unique work environments and challenges.Organizational culture and leadership support were essential for implementation success and sustainability.展开更多
Under the background of the new era,strengthening curriculum ideological and political construction has become one of the important tasks for colleges and universities to achieve curriculum teaching reform in recent y...Under the background of the new era,strengthening curriculum ideological and political construction has become one of the important tasks for colleges and universities to achieve curriculum teaching reform in recent years.How to subtly and effectively infiltrate the ideological and political ideas of the curriculum in the teaching of specialized courses,and achieve the effect of“salt into taste”is the biggest difficulty in the current construction of curriculum ideological and political education in colleges and universities.Based on this,this paper first analyzes the characteristics of carrying out ideological and political teaching in professional courses in colleges and universities,then expounds on the existing problems and implementation paths of current ideological and political teaching in professional courses in colleges and universities,and finally analyzes its teaching practice results,aiming to further promote the construction and development of ideological and political teaching in colleges and universities and provide some references for peers.展开更多
Chemistry science popularization for lower grades(Grades 1-2)in primary schools is an important part of science enlightenment education.However,in practice,it generally faces practical dilemmas such as insufficient co...Chemistry science popularization for lower grades(Grades 1-2)in primary schools is an important part of science enlightenment education.However,in practice,it generally faces practical dilemmas such as insufficient content adaptability,a single implementation method,and a lack of coordination mechanisms.Based on Piaget’s Cognitive Development Theory and the STSE(Science,Technology,Society,Environment)educational concept,this study constructed a four-in-one strategy system of“content development-teaching implementation-collaborative linkage-guarantee support”through literature analysis,action research,and empirical comparison.An empirical study was conducted in two primary schools for one academic year.The results show that this strategy system can increase students’interest in participating in chemistry science popularization by 42 percentage points,the compliance rate of observation ability reaches 85%,and the collaborative participation of families,schools,and society rises to 85%.The core strategies formed in the study,including“age-appropriate content screening,interactive teaching implementation,three-dimensional collaborative promotion,and full-process guarantee support,”provide a replicable practical model for the standardized and efficient development of chemistry science popularization for lower grades in primary schools.They also offer empirical references for fulfilling the requirement of“strengthening the pertinence and effectiveness of science popularization”in the Law of the People’s Republic of China on Popularization of Science and Technology(revised in 2024).展开更多
Objective:This study aimed to explore the strategies used by acute care hospitals in implementing a national standard for comprehensive care.Methods:A qualitative descriptive study was conducted with 28 care professio...Objective:This study aimed to explore the strategies used by acute care hospitals in implementing a national standard for comprehensive care.Methods:A qualitative descriptive study was conducted with 28 care professionals(20 nurses,two doctors,and six allied health professionals)recruited from a broad range of Australian acute care hospitals.Data were collected using semi-structured interviews from March to August 2023.The interviews were audio-recorded,transcribed,and thematically analyzed.Results:Strategies for implementing the Comprehensive Care Standard(CCS)vary,even within a health service organization.We identifiedstrategies hospitals used regarding the implementation team and plan,communication,education and training,documentation system,patient care plan,networking,incentives and pressure,feedback,and reflectingand evaluating.Conclusions:This interview study sheds light on the various strategies adopted by hospitals in implementing the CCS,providing a practical foundation to inform implementation efforts both within Australia and internationally.展开更多
Within the perspective of curriculum-based ideological and political education,this paper takes a secondary vocational English reading class themed“Invention and Innovation”as an example to delve into the process fr...Within the perspective of curriculum-based ideological and political education,this paper takes a secondary vocational English reading class themed“Invention and Innovation”as an example to delve into the process from instructional content design to implementation.In terms of instructional design,the paper highlights key elements.Profoundly,it discusses the strategies for teaching implementation,including the setting of teaching objectives,the selection of reading instructional materials,and the design and advancement of teaching activities.The aim is to effectively integrate ideological and political elements into secondary vocational English reading instruction,with the hope of providing useful references and insights for the teaching of English reading in secondary vocational education.展开更多
基金the National Key R&D Program of China(No.2021YFA0715900)the National Natural Science Foundation of China(No.41831279)+2 种基金the Shenzhen Key Laboratory of Precision Measurement and Early Warning Technology for Urban Environmental Health Risks(No.ZDSYS20220606100604008)the Guangdong Province Bureau of Education(No.2020KCXTD006)the Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control(No.2023B1212060002).
文摘Rapid screening of inorganic arsenic(iAs)in groundwater used for drinking by hundreds of millions of mostly rural residents worldwide is crucial for health protection.Most commercial field test kits are based on the Gutzeit reaction that uses mercury-based reagents for color development,an environmental concern that increasingly limits its utilization.This study further improves the Molybdenum Blue(MB)colorimetric method to allow for faster screening with more stable reagents.More importantly,a portable three-channel colorimeter is developed for screening iAs relative to the WHO drinking water guideline value(10μg/L).Adding the reducing reagents in sequence not only prolongs the storage time to>7 days,but also accelerates the color development time to 6 min in conjunction with lowering the H_(2)SO_(4) concentration in chromogenic reagents.The optimal pH ranges from 1.2 to 1.3 and is achieved by acidifying groundwater to 1%(V/V)HCl.With detection limits of 3.7μg/L for inorganic arsenate(iAs(V))and 3.8μg/L for inorganic arsenite(iAs(Ⅲ)),testing groundwater with-10μg/L of As has a precision<20%.The method works well for a range of phosphate concentrations of 48-950μg/L(0.5-10μmol/L).Concentrations of total_iAs(6-300μg/L),iAs(V)(6-230μg/L)and iAs(Ⅲ)(0-170μg/L)for 14 groundwater samples from Yinchuan Plain,Pearl River Delta,and Jianghan Plain,are in excellent agreements(linear regression slope:0.969-1.029)with the benchmark methods.The improved chemistry here lays the foundation for the MB colorimetric method to become a commercially viable screening tool,with further engineering and design improvement of the colorimeter.
基金supported by the National Natural Science Foundation of China(32060577 and 32360619)Natural Science Foundation of Jiangxi Province(20224ACB203016 and 20212BAB203034)the Open Project of China Food Flavor and Nutrition Health Innovation Center(CFC2023B-013).
文摘Acrylamide(AA)is a neurotoxin and carcinogen that formed during the thermal food processing.Conventional quantification techniques are difficult to realize on-site detection of AA.Herein,a flower-like bimetallic FeCu nanozyme(FeCuzyme)sensor and portable platform were developed for naked-eye and on-site detection of AA.The FeCuzyme was successfully prepared and exhibited flower-like structure with 3D catalytic centers.Fe/Cu atoms were considered as active center and ligand frameworks were used as cofactor,resulting in collaborative substrate-binding features and remarkably peroxidase-like activity.During the catalytic process,the 3,3′,5,5′-tetrame-thylbenzidine(TMB)oxidation can be quenched by glutathione(GSH),and then restored after thiolene Michael addition reaction between GSH and AA.Given the“on–off–on”effect for TMB oxidation and high PODlike activity,FeCuzyme sensor exhibited a wide linear relationship from 0.50 to 18.00μM(R^(2)=0.9987)and high sensitivity(LOD=0.2360μM)with high stability.The practical application of FeCuzyme sensor was successfully validated by HPLC method.Furthermore,a FeCuzyme portable platform was designed with smartphone/laptop,and which can be used for naked-eye and on-site quantitative determination of AA in real food samples.This research provides a way for rational design of a novel nanozyme-based sensing platform for AA detection.
基金Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant No.2024B08。
文摘One of the primary tasks of earthquake early warning(EEW)systems is to predict potential earthquake damage rapidly and accurately.Cumulative absolute velocity(CAV),Arias intensity(I_(A)),and spectrum intensity(SI)are important parameters for measuring ground motion intensity and assessing earthquake damage.Due to the limited available information in EEW,CAV,I_(A),and SI cannot be accurately predicted using traditional EEW methods.In this paper,we propose an end-to-end deep learning-based Ground motion Intensity prediction Network(ENGINet)for on-site EEW.The aim of the ENGINet is to predict CAV,I_(A),and SI rapidly and reliably.ENGINet is based on a convolutional neural network and recurrent neural network.The inputs of the network are three-component acceleration records,three-component velocity records,and three-component displacement records obtained by a single station.The results from the test dataset show that at 3 s after the P-wave arrival,compared with the baseline models and other traditional methods,ENGINet has better performance in predicting CAV,I_(A),and SI.Our results indicate that ENGINet can quickly and accurately predict CAV,I_(A),and SI to some extent and has good potential in EEW efforts.
文摘The vonoprazan(VPZ)triple therapy regimen for Helicobacter pylori(H.pylori)eradication developed by Han et al employs a scientifically rigorous clinical trial design.This multicenter randomized controlled trial establishes a standardized treatment framework aimed at improving H.pylori eradication rates,focusing on simplifying treatment regimens,shortening therapy duration,and optimizing therapeutic outcomes.The core of clinical translation lies in improving drug accessibility,establishing multidimensional safety evaluation systems,and optimizing cost-effectiveness.Conducting regional adaptability studies and comprehensive safety assessments is crucial for enhancing VPZ regimen effectiveness in China’s diverse healthcare environments.This study provides important evidence-based support for optimizing H.pylori treatment strategies in China,though further validation of universal applicability for nationwide implementation remains necessary.
基金the 2023 Open Project of the Kazakhstan Research Center at YiIi Normal University,Study on National Language Education Policy in Kazakhstan Under the Belt and Road Initiative(No.2023HSKSTYJYB007).
文摘Language policies are of great significance to a nation’s stability,unity,and development.Uzbekistan’s language policies have reflected the political,economic,and cultural dynamics of different periods throughout historical changes,influencing social structures and ethnic relations.This paper summarizes the characteristics of Uzbekistan’s language policies in different eras:During the Tsarist Russian period,the Russification of language policies hindered the development of local languages;in the Soviet era,policies adopted a dual approach,promoting both Russian and prioritizing ethnic languages;after independence,Uzbekistan established Uzbek as the state language and emphasized foreign language education.The current language policy in Uzbekistan presents a complex landscape:While emphasizing the dominant role of the national language helps preserve its heritage,it may easily spark ethnic and political tensions;promoting pluralism and inclusivity brings benefits but faces challenges in balancing language statuses,resource allocation,management,and communication;modernization efforts encounter difficulties in standardizing dialects and foreign loanwords;and in international exchanges,there is a need to balance relations with global lingua francas.In conclusion,Uzbekistan’s language policies have undergone unique transformations and face numerous challenges.In-depth research is crucial for improving the country’s policies and enhancing China-Uzbekistan cooperation.Proactive measures are needed to address these challenges,ensuring the sustainability of language policies and fostering greater national prosperity.
基金the National Natural Science Foundation of China (No. 22306146)the PhD Scientific Research Startup Foundation of Xihua University (No. RX2200002003) for their financial support。
文摘To accomplish on-site separation, preconcentration and cold storage of highly volatile organic compounds(VOCs) from water samples as well as their rapid transportation to laboratory, a high-throughput miniaturized purge-and-trap(μP&T) device integrating semiconductor refrigeration storage was developed in this work. Water samples were poured into the purge vessels and purged with purified air generated by an air pump. The VOCs in water samples were then separated and preconcentrated with sorbent tubes. After their complete separation and preconcentration, the tubes were subsequently preserved in the semiconductor refrigeration unit of the μP&T device. Notably, the high integration, small size, light weight, and low power consumption of the device makes it easy to be hand-carried to the field and transport by drone from remote locations, significantly enhancing the flexibility of field sampling. The performances of the device were evaluated by comparing analytical figures of merit for the detection of four cyclic volatile methylsiloxanes(cVMSs) in water. Compared to conventional collection and preservation methods, our proposed device preserved the VOCs more consistently in the sorbent tubes, with less than 5% loss of all analytes, and maintained stability for at least 20 days at 4℃. As a proof-of-concept,10 municipal wastewater samples were pretreated using this device with recoveries ranging from 82.5% to 99.9% for the target VOCs.
文摘Taking Zhejiang Province as an example,this paper explores the mechanisms and implementation pathways through which the low-altitude economy drives the transformation and upgrading of the tourism industry.It finds that the low-altitude economy can effectively promote the development of high-end and diversified tourism in Zhejiang by innovating tourism formats,optimizing resource allocation,and enhancing tourist experiences.Besides,it analyzes the current development status of the low-altitude economy in Zhejiang and its potential for integration with tourism,revealing specific enabling pathways for tourism transformation,including low-altitude sightseeing,aviation tourism,and low-altitude sports.Finally,it proposes policy recommendations such as strengthening policy support,enhancing infrastructure development,and cultivating market entities.The findings aim to provide theoretical references and practical guidance for the high-quality development of tourism in Zhejiang Province.
基金supported by the National Natural Science Foundation of China(No.82204931).
文摘The demand for Chinese-Western medicine collaboration has grown significantly,but current integration methods have substantial limitations.This article analyzes core issues in developing and implementing synergistic Chinese-Western medicine clinical treatment strategies and explores the transformation from traditional integration to genuine synergistic models.We analyzed methodological obstacles in synergistic strategy development through literature review and theoretical analysis,and explored applications of intelligent technology in strategy development.Four core challenges were identified:(1)Treatment timing coordination difficulties caused by different decision-making approaches,with Chinese medicine using syndrome-based assessments and Western medicine relying on standardized measurements;(2)Treatment selection complexities when integrating different types of evidence,lacking frameworks for evaluating and combining diverse evidence sources;(3)Obstacles in incorporating patient preferences systematically,with inadequate assessment methods and unclear integration mechanisms;(4)Implementation barriers in translating synergistic strategies into clinical practice,requiring changes in organizational structures,workflows,and evaluation systems.Large language models(LLMs)and other intelligent technologies offer technical support for addressing these methodological challenges.This article examines current challenges in developing synergistic Chinese-Western medicine clinical strategies,analyzing the shift from traditional integration toward synergistic approaches and identifying four core methodological obstacles.Exploring intelligent technology applications provides insights to inform future research directions and clinical practice development in integrated healthcare delivery.
文摘Currently,we have entered the era of artificial intelligence(AI).The rapid development and wide application of AI technology have exerted a profound impact on all fields of society.Against this backdrop,this paper conducts an in-depth analysis focusing on general education in AI.First,it expounds the necessity of AI general education in cultivating the core literacy of vocational college students.Then,it puts forward effective implementation paths for such general education.The purpose is to provide valuable references for promoting the reform and innovative development of vocational education.
基金supported by the National Natural Science Foundation of China(62027809,U2268206,T2222015,U2468202).
文摘The integration of Global Navigation Satellite System(GNSS)technology into railway train control systems is a crucial step toward achieving the vision of a digital railway.Traditional train control systems undergo extensive in-house tests and prolonged field tests for certification and approval before operational deployment,leading to high costs,delays,and operational disruptions.This paper introduces a GNSS-based train control localization framework which eliminates the need for on-site testing by leveraging train movement dynamics and 3D environment modeling to create a zero on-site testing platform.The proposed framework simulates train movement and the surrounding 3D environment using collected railway line location data and environmental attributes to generate realistic multipath signals and obscuration effects.This approach enables comprehensive laboratory-based case studies for train localization,reducing the huge amount test of needed for physical field trials.The framework is established in house,using the data collected at the Test Base of China Academy of Railway Sciences(Circular Railway).Results from the open area and cutting environment tests demonstrate high localization accuracy repeatability within the simulated environment,validating the feasibility and effectiveness of zero on-site testing for GNSS-based train control systems.This research highlights the potential of GNSS simulation platforms in enhancing cost efficiency,operational safety,and accuracy for future digital railways.
基金Mechanism of Nanotechnology-driven Polyphyllin I in Sensitizing PD-1 Monoclonal Antibody in Breast Cancer(82204922)Nanotechnology-driven Polyphyllin I Affects Mitochondrial Homeostasis via Cuproptosis and Its Mechanism in Breast Cancer Treatment(ZZ18-YQ-022)。
文摘Oncology covers a wide range of knowledge and is more difficult compared to other clinical disciplines.Therefore,it is crucial to seek an efficient teaching method for oncology education.In recent years,China’s internet technology has achieved rapid development.Massive Open Online Course(MOOC),a blended learning approach based on internet technology,has strong applicability to medical education.It can not only improve teaching quality but also promote further reform of the discipline.Based on this,our study searched for relevant research at home and abroad and reviewed the implementation path of integrating MOOC and blended learning in oncology education.This provides a theoretical foundation for the innovation of oncology teaching models,improves the level of oncology teaching,and lays a solid foundation for talent reserves in oncology departments.
文摘In the wave of higher education internationalization,college students’career education is faced with problems such as inadequate integration of international elements in teaching content,insufficient depth of international cooperation in practical links,lack of international professional experience among the teaching staff,and insufficient emphasis on the cultivation of multicultural adaptability in the education model.Based on this,this paper deeply explores the new requirements put forward by internationalization for college students’career education and its diversified implementation paths from the perspective of higher education internationalization.It aims to build a comprehensive and multi-level career education system and improve students’international competitiveness through strategies such as constructing an internationalized curriculum system,expanding international cooperation practice projects,strengthening international exchanges and training for teachers,and integrating multicultural education.
基金supported in part by the National Natural Science Foundation of China(No.62162016)in part by the Innovation Project of Guangxi Graduate Education(Nos.YCBZ2023132 and YCSW2023304).
文摘The efficient implementation of the Advanced Encryption Standard(AES)is crucial for network data security.This paper presents novel hardware implementations of the AES S-box,a core component,using tower field representations and Boolean Satisfiability(SAT)solvers.Our research makes several significant contri-butions to the field.Firstly,we have optimized the GF(24)inversion,achieving a remarkable 31.35%area reduction(15.33 GE)compared to the best known implementations.Secondly,we have enhanced multiplication implementa-tions for transformation matrices using a SAT-method based on local solutions.This approach has yielded notable improvements,such as a 22.22%reduction in area(42.00 GE)for the top transformation matrix in GF((24)2)-type S-box implementation.Furthermore,we have proposed new implementations of GF(((22)2)2)-type and GF((24)2)-type S-boxes,with the GF(((22)2)2)-type demonstrating superior performance.This implementation offers two variants:a small area variant that sets new area records,and a fast variant that establishes new benchmarks in Area-Execution-Time(AET)and energy consumption.Our approach significantly improves upon existing S-box implementations,offering advancements in area,speed,and energy consumption.These optimizations contribute to more efficient and secure AES implementations,potentially enhancing various cryptographic applications in the field of network security.
基金the Flourish Collective,a Cluster of Scholarly Prominence at the University of Toronto,Scarborough。
文摘Objective:The World Health Organization recommends annual preventive chemotherapy with a single dose of praziquantel at≥75%treatment coverage,but as of 2021,the national coverage rate in Nigeria among children falls below 10%.This qualitative study sought to explore the barriers and facilitators to implementing large-scale praziquantel mass drug administration(MDA)programs for school-aged children in Nigeria to delineate tools and strategies that could improve the scaling-up and effectiveness of school-based praziquantel MDA programs.Methods:An exploratory qualitative study was conducted with stakeholders with experience in MDAs involving praziquantel or related preventive chemotherapy drugs in Nigeria.Through snowball sampling,30 stakeholders with experience in praziquantel school-based MDA in Nigeria were interviewed.An inductive approach was used to generate broad themes based on the barriers and facilitators identified by the key informants.Results:A total of 45 barriers and 36 facilitators were identified and grouped inductively into eight themes:funding and resources,design and composition of praziquantel tablets,knowledge and awareness mobilization,government,nongovernmental organization,and school engagement,data management,logistics,training,and security.Conclusion:This qualitative study reveals a wide range of barriers and facilitators in the MDA of praziquantel in Nigeria and uncovered critical points along the implementation pathway based on the locus of the barriers and facilitators identified.Collaboration with national,international,and non-profit organizations,and drug education through promotional materials,were the most frequently mentioned facilitators of the MDA program.In addition,insufficient program funding,and the complexity of the supply chain were the most cited barriers.
文摘Background:Community-based first responders face high levels of workplace stressors that can pro-foundly impact their physical and mental health.Mindfulness-based interventions have shown promise in decreasing stress and increasing psychological resilience;however,implementation is difficult due to unpredictability of the job,department culture,and generational preferences.The objective of this qualitative study was to identify and enhance understanding of the specific needs and potential barriers and facilitators for the implementation of mindfulness-based programming for community-based first responders.Methods:A phenomenological qualitative study design was used to gain insights into the lived experiences of first responders and elicit perceptions regarding barriers and facilitators for engaging in mindfulness activities.During virtual semi-structured interviews,eleven career firefighters and emergency medical service(EMS)providers offered feedback relative to worksite mindfulness practices,and the use of a stress reduction smartphone application.The Consolidated Framework for Implementation Research was used to guide the analysis relative to barriers and facilitators of implementation success and sustainability.Results:First responders expressed openness to mindfulness-based interventions and a smartphone app that would provide stress reduction content,however,they were adamant that programming needed to be accessible and easily integrated into their workday.They also reinforced that organizational culture and leadership support for their health and well-being were overarching factors essential for implementation success.Conclusions:First responders were supportive of evidence-based mindfulness practices,optimally developed and/or facilitated by someone with intimate knowledge of their unique work environments and challenges.Organizational culture and leadership support were essential for implementation success and sustainability.
文摘Under the background of the new era,strengthening curriculum ideological and political construction has become one of the important tasks for colleges and universities to achieve curriculum teaching reform in recent years.How to subtly and effectively infiltrate the ideological and political ideas of the curriculum in the teaching of specialized courses,and achieve the effect of“salt into taste”is the biggest difficulty in the current construction of curriculum ideological and political education in colleges and universities.Based on this,this paper first analyzes the characteristics of carrying out ideological and political teaching in professional courses in colleges and universities,then expounds on the existing problems and implementation paths of current ideological and political teaching in professional courses in colleges and universities,and finally analyzes its teaching practice results,aiming to further promote the construction and development of ideological and political teaching in colleges and universities and provide some references for peers.
基金Projects of Shaanxi Provincial Department of Science and Technology(2020JQ-886,2022JM-075)Education Science Planning Project of Shaanxi Province during the“14th Five-Year Plan”Period(SGH22Y1392)+6 种基金Scientific Research Program of Shaanxi Provincial Department of Education(23JP146,23JP147)Science and Technology Program of Xi’an(No.22GXFW0112)Three-Year Action Plan Project of Xi’an University(21XJZZ0001-11)Basic Education Research Project of Xi’an in 2022(2022JYZX28)2022“Xi’an University-Xi’an Academy of Social Sciences”Strategic Cooperation Projects(22ZL10,22ZL11)Doctoral Start-up Fund of Xi’an University(06005017)Key Discipline of Analytical Chemistry in Shaanxi Province(09009001)。
文摘Chemistry science popularization for lower grades(Grades 1-2)in primary schools is an important part of science enlightenment education.However,in practice,it generally faces practical dilemmas such as insufficient content adaptability,a single implementation method,and a lack of coordination mechanisms.Based on Piaget’s Cognitive Development Theory and the STSE(Science,Technology,Society,Environment)educational concept,this study constructed a four-in-one strategy system of“content development-teaching implementation-collaborative linkage-guarantee support”through literature analysis,action research,and empirical comparison.An empirical study was conducted in two primary schools for one academic year.The results show that this strategy system can increase students’interest in participating in chemistry science popularization by 42 percentage points,the compliance rate of observation ability reaches 85%,and the collaborative participation of families,schools,and society rises to 85%.The core strategies formed in the study,including“age-appropriate content screening,interactive teaching implementation,three-dimensional collaborative promotion,and full-process guarantee support,”provide a replicable practical model for the standardized and efficient development of chemistry science popularization for lower grades in primary schools.They also offer empirical references for fulfilling the requirement of“strengthening the pertinence and effectiveness of science popularization”in the Law of the People’s Republic of China on Popularization of Science and Technology(revised in 2024).
基金supported by an Australian Government Research Training Program Scholarshippart of the project“Improving quality of care for people with dementia in the acute care setting(eQC)”which is funded by the National Health and Medical Research Council of the Australian Government(No.APP1140459)。
文摘Objective:This study aimed to explore the strategies used by acute care hospitals in implementing a national standard for comprehensive care.Methods:A qualitative descriptive study was conducted with 28 care professionals(20 nurses,two doctors,and six allied health professionals)recruited from a broad range of Australian acute care hospitals.Data were collected using semi-structured interviews from March to August 2023.The interviews were audio-recorded,transcribed,and thematically analyzed.Results:Strategies for implementing the Comprehensive Care Standard(CCS)vary,even within a health service organization.We identifiedstrategies hospitals used regarding the implementation team and plan,communication,education and training,documentation system,patient care plan,networking,incentives and pressure,feedback,and reflectingand evaluating.Conclusions:This interview study sheds light on the various strategies adopted by hospitals in implementing the CCS,providing a practical foundation to inform implementation efforts both within Australia and internationally.
文摘Within the perspective of curriculum-based ideological and political education,this paper takes a secondary vocational English reading class themed“Invention and Innovation”as an example to delve into the process from instructional content design to implementation.In terms of instructional design,the paper highlights key elements.Profoundly,it discusses the strategies for teaching implementation,including the setting of teaching objectives,the selection of reading instructional materials,and the design and advancement of teaching activities.The aim is to effectively integrate ideological and political elements into secondary vocational English reading instruction,with the hope of providing useful references and insights for the teaching of English reading in secondary vocational education.
