Cardiovascular diseases constitute a marked threat to global health,and the emergence of spatial omics technologies has revolutionized cardiovascular research.This review explores the application of spatial omics,incl...Cardiovascular diseases constitute a marked threat to global health,and the emergence of spatial omics technologies has revolutionized cardiovascular research.This review explores the application of spatial omics,including spatial transcriptomics,spatial proteomics,spatial metabolomics,spatial genomics,and spatial epigenomics,providing more insight into the molecular and cellular foundations of cardiovascular disease and highlighting the critical contributions of spatial omics to cardiovascular science,and discusses future prospects,including technological advancements,integration of multi-omics,and clinical applications.These developments should contribute to the understanding of cardiovascular diseases and guide the progress of precision medicine,targeted therapies,and personalized treatments.展开更多
基金supported by the National Natural Science Fund for Distinguished Young Scholars of China(82125004,to J.S.)the Beijing Natural Science Foundation(Z240015,to J.S.)the Frontier Biotechnology Key Project of National Key R&D Program of Ministry of Science and Technology of China(2023YFC3404300,to J.S.).
文摘Cardiovascular diseases constitute a marked threat to global health,and the emergence of spatial omics technologies has revolutionized cardiovascular research.This review explores the application of spatial omics,including spatial transcriptomics,spatial proteomics,spatial metabolomics,spatial genomics,and spatial epigenomics,providing more insight into the molecular and cellular foundations of cardiovascular disease and highlighting the critical contributions of spatial omics to cardiovascular science,and discusses future prospects,including technological advancements,integration of multi-omics,and clinical applications.These developments should contribute to the understanding of cardiovascular diseases and guide the progress of precision medicine,targeted therapies,and personalized treatments.
