From the“Six Rising Dragons”emerging at the Hangzhou Future Sci-Tech City(Haichuang Park)to the archaeological wonders of Liangzhu,widely regarded as a cradle of Chinese civilization,dating back 5000 years.Recently,...From the“Six Rising Dragons”emerging at the Hangzhou Future Sci-Tech City(Haichuang Park)to the archaeological wonders of Liangzhu,widely regarded as a cradle of Chinese civilization,dating back 5000 years.Recently,our reporter has been conducting an in-depth interview in Zhejiang.Marveling at the ingenuity of ancient civilizations,we were amazed by the cutting-edge“intelligence”of humanoid robotics,and unlocked a unique dialogue between millennia-old heritage and the technology shaping tomorrow.展开更多
The object of this article is to develop instruments for the study of the interest of six- and seven-year olds, pedagogues and parents about children＇s books and computers. By way of elaborating children＇s books and...The object of this article is to develop instruments for the study of the interest of six- and seven-year olds, pedagogues and parents about children＇s books and computers. By way of elaborating children＇s books and writing on a computer or tablet, it introduces illiterate children to oral-written speech--an innovative approach to literacy. This process takes place under the guidance of a pedagogue, in collaboration with parents. Thus, before they start school, children in Bulgaria can master the written and spoken language that encourages them to love the book.展开更多
With the establishment of Guangzhou Urban Renewal Bureau,the first of its kind in China,as the background and the starting point,the paper reviews relevant experiences in the UK,Singapore,and Hong Kong,summarizes the ...With the establishment of Guangzhou Urban Renewal Bureau,the first of its kind in China,as the background and the starting point,the paper reviews relevant experiences in the UK,Singapore,and Hong Kong,summarizes the features,responsibilities,and rights of such institutions.Through analyzing three statuses of redevelopment,which are increased,reduced,and retained construction,the paper points out that urban renewal is a process orienting at promoting the comprehensive capacity of the built-up environment.Then the paper summarizes the strength and weakness of the "three olds" reconstruction policy making and implementation in Guangzhou,holding that the strength lies in the effective land consolidation and socially collaboration experiences,while the weakness includes the unclear rights and responsibilities,unsystematic target,and imbalanced interests distribution.It concludes that the goal of urban renewal is to improve the existing built-up environment without damaging the benefits of original stakeholders,to emphasize both fairness and efficiency,and to seek for sustainable city redevelopment with optimized comprehensive capacity.Moreover,the paper clarifies that the primary responsibility of urban renewal is to well maintain the built-up environment and the extended responsibility is to properly coordinate the city redevelopment.Considering that urban renewal is a kind of public administration with distinctive social and processing features,urban renewal should be empowered the necessary implementation priority and administrative permission power via local legislation measures.In addition,an effective social collaboration platform should be established to actively support the urban renewal and to reflect the "new normal" of city redevelopment.展开更多
Do you know any old wives'tales?You probably heard them from your mom.And she heard them from her mom.Many of these tales aren't true,but we talk about them anyway.For example,don't go outside with wet hai...Do you know any old wives'tales?You probably heard them from your mom.And she heard them from her mom.Many of these tales aren't true,but we talk about them anyway.For example,don't go outside with wet hair,or you'll catch a cold.If you drop food and pick it up in under five seconds,it is safe to eat.You should eat a lot when you have a cold,but only eat a little when you have a fever.And eating bread crusts makes your hair curly.展开更多
Find It What did the old woman give Lucy?Once upon a time,a poor girl named Lucy lived in a small village.She was kind and helped others when she could.But she and her mother were often very hungry because they were p...Find It What did the old woman give Lucy?Once upon a time,a poor girl named Lucy lived in a small village.She was kind and helped others when she could.But she and her mother were often very hungry because they were poor.展开更多
[Objectives]To explore the mediating effect of social support between depression and resilience in elderly patients with first-episode stroke.[Methods]The general information questionnaire,PHQ-9 depression screening s...[Objectives]To explore the mediating effect of social support between depression and resilience in elderly patients with first-episode stroke.[Methods]The general information questionnaire,PHQ-9 depression screening scale,Social Support Rating scale and Connor-Davidson Resilience Scale were used to construct and test the mediation model.[Results]The total score of depressive symptoms was(8.64±3.28)points,the detection rate of depressive symptoms was 51.65%,the score of social support was(37.28±5.98)points,and the score of psychological resilience was(22.05±5.25)points.The resilience of patients was positively correlated with social support(r=0.470,P<0.01),and negatively correlated with depressive symptoms(r=-0.470,P<0.01).Social support was negatively correlated with depressive symptoms(r=-0.523,P<0.01).Social support played a partial mediating role between depression and resilience in elderly patients with first-episode stroke,and the mediating effect accounted for 16.1%of the total effect.[Conclusions]Social support can mediate the effect of depression on resilience in elderly patients with first-episode stroke.Medical staff can improve patients'psychological resilience by psychological counseling of depression and improving their social support,so as to promote their subjective well-being and maintain a healthy and positive mental state.展开更多
1 Antoni Gaudíwas sickly as a boy in Reus,Spain,often riding a donkey due to his weak legs.He loved art and nature and was full of ideas.As he grew older and stronger,Gaudíexplored the remains of many old bu...1 Antoni Gaudíwas sickly as a boy in Reus,Spain,often riding a donkey due to his weak legs.He loved art and nature and was full of ideas.As he grew older and stronger,Gaudíexplored the remains of many old buildings near his city,which made him realize what he wanted to do for the rest of his life.展开更多
Objective: To study the effects of starting antiretroviral treatment (ART) prior the age of two years on the growth (height and weight) of HIV-infected children. Methodology: This was a retrospective cohort study. HIV...Objective: To study the effects of starting antiretroviral treatment (ART) prior the age of two years on the growth (height and weight) of HIV-infected children. Methodology: This was a retrospective cohort study. HIV-infected children on ART aged less than 15 years were divided into two groups Group 1 (G1) comprising children who started ART prior 2 years and Group (G2) those put on treatment thereafter. Main Measures: Percentage of children with growth retardation measured by Height for Age (H/A) and Weight for Age (W/A) Results: In total, we included 90 subjects. The median age was 10 years with a slight female predominance (51.2%). Most children were asymptomatic at the time of the study (96.6%), compliant with treatment (81%), 54.8% of children were on cotrimoxazole, 33% knew their status. At initiation, underweight was predominant in group 1 compared to group 2 (52% versus 29.5%;p = 0.015). Conversely, stunted growth predominated in G2 compared to G1 but without significant difference (38% versus 50%;p = 0.147). At the time of our study (median age of 10 years), catch-up height and weight predominated in G1 compared to G2;only a small proportion remained below −2SD (4% versus 18.2%;p = 0.015 and 9% versus 29.5%;p = 0.006 respectively for underweight and stunted growth). Conclusion and Global Health Implications: Growth retardation was common at ART initiation. Catch-up in height was more evident in the early treatment group. Initiation of ART before the age of 2 years rather influences children’s height than weight. The result of this study further emphasizes the need of early ART and closed clinical monitoring to better assess the impact of ART in areas with high rates of undernutrition.展开更多
Villagers in Nujiang have embraced economic development without sacrificing age-old customs.Nujiang,a mountainous region in Yunnan Province,has undergone rapid change in recent years.Once one of China’s poorest areas...Villagers in Nujiang have embraced economic development without sacrificing age-old customs.Nujiang,a mountainous region in Yunnan Province,has undergone rapid change in recent years.Once one of China’s poorest areas,it is now a place where modern homes and infrastructure sit alongside centuries-old traditions.The local ethnic minorities-including the Lisu,Nu and Derung-have embraced new opportunities while holding on to their cultural roots.展开更多
Chic Beijing:An Insider’s Guide to Unique New Places Compiled by Beijing Radio and Television Station Price:RMB 138 Paperback,307 pages Published by Foreign Languages Press&Beijing Publishing Group If you’re pla...Chic Beijing:An Insider’s Guide to Unique New Places Compiled by Beijing Radio and Television Station Price:RMB 138 Paperback,307 pages Published by Foreign Languages Press&Beijing Publishing Group If you’re planning a trip to Beijing,prepare to be swept up in a living mosaic–more than 3,000 years of history,vibrant contemporary culture,and skyline-defining architecture all fusing and flowing across a vast canvas.This book,Chic Beijing:An Insider’s Guide to Unique New Places,allows readers to take a breathtaking journey through Beijing,the majestic metropolitan capital of China.It also unlocks doors that usually stay closed:rooftop gardens overlooking palace rooftops,micro-galleries tucked into 300-year-old courtyards,and cocktail labs where baijiu meets coffee.展开更多
Background:While physical frailty(PF)and cognitive impairment(CI)are established independent predictors of adverse outcomes in older adults,the prognostic significance of their co-occurrence(cognitive frailty,CF)remai...Background:While physical frailty(PF)and cognitive impairment(CI)are established independent predictors of adverse outcomes in older adults,the prognostic significance of their co-occurrence(cognitive frailty,CF)remains underexplored in the Chinese population.We aimed to explore the epidemiology of CF and its mortality predictive value among community-dwelling older Chinese adults.Methods:Data from the Chinese Longitudinal Healthy Longevity Survey(2011–2018).PF was assessed with the Osteoporotic Fractures frailty index,while CI was defined by the Chinese Mini-Mental State Examination(MMSE)(<18/21/25).CF was defined as concurrent PF and CI in non-demented.Cox proportional hazard regression models were used to evaluate hazard ratios(HRs)and 95%confidence intervals(CIs).A systematic review and random-effects meta-analysis complemented primary analyses,incorporating data from 9 cohorts study(n=32,088).Results:This cohort study included 8,012 participants(mean age 85.35±11.06 years,54.6%females)with 49.8%all-cause mortality over 7 years.Baseline prevalence of PF,CI,and CF were 15.4%,21.1%,and 8.0%respectively.Kaplan-Meier analysis revealed significantly reduced survival in participants with CF compared to other groups(log-rank P<0.001).Fully adjusted Cox models demonstrated a mortality gradient:Non-PF and Normal Cognition(reference),PF alone(HR 1.397,95%CI 1.218–1.602),CI alone(HR 1.572,1.412–1.749),and CF(HR 1.919,1.666–2.210;P<0.001).Effect modification analyses showed heightened CF-associated mortality in males and the oldest-old adults(P for interaction<0.001).Meta-analysis confirmed these findings(pooled HR 2.45,95%CIs,1.91–3.31;I2=57%),with heterogeneity partly attributable to the CI assessment tool or and covariate adjustment strategies.Conclusion:This dual analytical approach substantiates CF as a critical mortality predictor in Chinese older adults,exceeding the risks associated with isolated PF or CI.The observed heterogeneity across studies underscores the need for standardized CF diagnostic criteria and adjustment protocols in prognostic research.Our findings advocate for routine CF screening in geriatric assessments,particularly for males and the oldest-old.Future investigations should clarify the temporal dynamics of CF progression and evaluate targeted interventions.展开更多
A young artist reinvents an old sartorial skill from rural ethnic communities into globally recognized high fashion.LACKING a unified writing system,the ancestors of the Miao people,an ethnic group primarily living in...A young artist reinvents an old sartorial skill from rural ethnic communities into globally recognized high fashion.LACKING a unified writing system,the ancestors of the Miao people,an ethnic group primarily living in mountainous areas in central and southwestern China,encoded their history in the exquisite design of traditional clothing,especially embroidery.They express reverence for nature and appreciation of life with needles and threads.展开更多
BACKGROUND Old donor allografts in liver transplantation(LT)account for 25%of all allografts,and their utilization is projected to increase with the aging general population.Older allografts are associated with higher...BACKGROUND Old donor allografts in liver transplantation(LT)account for 25%of all allografts,and their utilization is projected to increase with the aging general population.Older allografts are associated with higher rates of all-cause mortality and graft failure;however,there is limited literature exploring the specific phenotypic changes(e.g.,functional status,cause-specific mortality)observed in different donor:recipient age pairs.AIM To investigate differences in functional impairment and cause-specific mortality between different donor:recipient age pairs.METHODS This was a retrospective analysis of LT patients from the Scientific Registry of Transplant Recipients from 2002 to 2022.Donors were categorized into younger age donors,≤45-years(YAD),middle-aged donors,46-69-years(MAD),and older age donors,≥70-years(OAD).Recipients were categorized into younger age recipients,≤55-years(YAR)and older age recipients,>55-years(OAR)age recipients.Multivariate Fine-Gray competing risk and logistic regression analyses identified independent risk factors for cause-specific mortality and improvements in functional status,respectively.RESULTS Overall,126185 patients were included in the analysis:YAD:YAR(32.7%), YAD:OAR (25.2%), MAD:YAR (17.5%), MAD:OAR (20.7%), OAD:YAR (1.3%), and OAD:OAR (2.7%). Compared toYAD:YAR, OAD pairs had the lowest likelihoods of improved functional status 5 years post-LT (OAD:YAR oddsratio 0.53, 95% confidence interval 0.42-0.67, P < 0.001;OAD:OAR odds ratio 0.67, 95% confidence interval 0.51-0.89, P = 0.006). Donor:recipient age pairs with older donors had higher rates of graft- and infection-relatedmortality compared to those with younger donors (P < 0.001). Meanwhile, donor:recipient age pairs with olderrecipients had higher cardioneurovascular- or malignancy-related deaths compared to those with youngerrecipients (P < 0.001).CONCLUSIONDonor:recipient age mismatch was associated with differences in cause-specific mortality and functional status.These insights could potentially inform age-matched organ allocation strategies, though future work is warranted.展开更多
1 On a Sunday morning,Zheng Shiying drove 130 kilometers to a village on the outskirts of Beijing,not for a hike or a hot spring,but for a cup of coffee.Housed in an old stone building that looks untouched by time,by ...1 On a Sunday morning,Zheng Shiying drove 130 kilometers to a village on the outskirts of Beijing,not for a hike or a hot spring,but for a cup of coffee.Housed in an old stone building that looks untouched by time,by the time Zheng arrived,the caféwas already packed with weekend visitors,and finding a seat was a bit of a challenge.展开更多
BACKGROUND Gastric cancer is among the most prevalent malignancies worldwide.Despite significant advancements in chemoradiotherapy,targeted therapy,and neoadjuvant therapy,conventional surgical intervention remains th...BACKGROUND Gastric cancer is among the most prevalent malignancies worldwide.Despite significant advancements in chemoradiotherapy,targeted therapy,and neoadjuvant therapy,conventional surgical intervention remains the cornerstone of gastric cancer management.Improvements in surgical techniques,coupled with the use of staplers and other advanced instruments,have substantially reduced the incidence of complications and mortality following gastric cancer surgery.However,dysphagia remains a common postoperative complication.AIM To retrospectively investigate the potential factors contributing to dysphagia in patients who have undergone laparoscopic radical gastrectomy for gastric cancer and to explore effective strategies for its postoperative management.METHODS In this retrospective study,we analyzed data from patients who underwent elective laparoscopic total gastrectomy at Lihuili Hospital,Ningbo University,between January 2018 and May 2022.A total of 115 eligible postoperative patients were included.Postoperatively,patients completed questionnaires and were categorized into two groups based on their responses:The dysphagia group(Eating Assessment Tool-10 score≥3)and the non-dysphagia group(Eating Assessment Tool-10 score<3).Risk factors associated with dysphagia following total gastrectomy were assessed usingχ2 tests,Fisher’s exact tests,t-tests,Pearson correlation coefficients,and univariate and multivariate regression analyses.RESULTS Multivariate analysis further identified anastomotic style,prolonged intubation time,advanced age,and low albumin(ALB)levels as independent risk factors for postoperative dysphagia.Implementing targeted preventive measures for high-risk groups may significantly enhance postoperative quality of life.CONCLUSION Univariate analysis revealed that anastomotic style,low serum ALB levels,advanced age,and prolonged intubation time were significantly associated with postoperative dysphagia in gastric cancer patients.Multivariate analysis further identified anastomotic style,prolonged intubation time,advanced age,and low ALB levels as independent risk factors for postoperative dysphagia.Implementing targeted preventive measures for high-risk groups may significantly enhance postoperative quality of life.展开更多
In order to study the effects of the contents of used mortar recycled aggregate(OMRA)and brick recycled aggregate(BRA)on the deformation properties of recycled aggregate concrete(RAC),under uniaxial compression condit...In order to study the effects of the contents of used mortar recycled aggregate(OMRA)and brick recycled aggregate(BRA)on the deformation properties of recycled aggregate concrete(RAC),under uniaxial compression conditions,The RAC of OMRA(0%,5%,10%,and 15%)and BRA(0%,3%,6%,9%,12%,and 15%)were studied.The experimental results show that,under uniaxial compression,the interfacial relationships of RAC containing OMRA and BRA between different materials are more complex,and the failure mechanism is also more complex.The content of OMRA and BRA had significant influence on the deformation behavior of RAC.When the content of OMRA and BRA is high,it is difficult for existing formulas and models to accurately represent the actual value.In this study,the influence of OMRA and BRA content is taken into account,and the existing formulas for calculating concrete deformation are modified,so that these formulas can more accurately calculate the elastic modulus,peak strain and ultimate strain of recycled concrete.The stress-strain formula of Guo concrete fits the stress-strain curve of concrete very well.We modified the formula on the basis of Guo formula to make the formula more suitable for the stress-strain curve of recycled concrete containing old mortar and brick,and the theoretical model proposed has better fitting accuracy.The study provides a valuable reference for nonlinear analysis of recycled aggregate concrete structures under different proportions of OMRA and BRA.展开更多
This study analyzed case and prescription data of children aged 12 to 18 years diagnosed with influenza A from the outpatient and emergency departments at the Women and Children’s Hospital of Ningbo University during...This study analyzed case and prescription data of children aged 12 to 18 years diagnosed with influenza A from the outpatient and emergency departments at the Women and Children’s Hospital of Ningbo University during the influenza epidemic period between February and April 2023.Patients were categorized into two groups based on their medication:the Baloxavir Marboxil group(196 cases)and the Oseltamivir group(126 cases).SPSS Statistics 24.0 software was utilized to compare variables between the two groups,including age,sex,weight,first visit department,number of visits,average prescription cost per patient,drug varieties used,hospitalization rate,and the combined medication usage,to evaluate the relative advantages and disadvantages of the two treatments.The results indicated that the number of visits in the Baloxavir Marboxil group was significantly lower than in the Oseltamivir group,whereas the average prescription cost per patient was higher(P<0.05).There were no significant differences between the two groups regarding age,sex,weight,first visit department,number of drug types used,hospitalization rate,or combined medication usage(P>0.05).When comparing the use of single-class combined drugs,only the quantity of antiviral drugs differed significantly(P<0.05).The Oseltamivir group required more adjuvant treatment with both Chinese and Western antiviral medications.The distribution of the number of combined drug types was concentrated around three and two types in both groups(Baloxavir Marboxil group:41.34%and 39.66%;Oseltamivir group:44.54%and 36.97%).This study highlighted that the new drug,Baloxavir Marboxil,offered certain therapeutic benefits over Oseltamivir in treating influenza among children aged 12 to 18 years,including advantages in single-dose administration,oral compliance,and specific treatment outcomes.The higher unit cost associated with Baloxavir Marboxil might be a factor for further consideration.These findings provided a new reference point for the clinical selection of anti-influenza medications.展开更多
BACKGROUND Total hip arthroplasty(THA)is an increasingly common treatment for older patients with hip osteoarthritis.Psychological stress is common before THA,although its clinical effects on selected parameters such ...BACKGROUND Total hip arthroplasty(THA)is an increasingly common treatment for older patients with hip osteoarthritis.Psychological stress is common before THA,although its clinical effects on selected parameters such as joint function,quality of life,and postoperative complications remain unclear.AIM To investigate the effects of preoperative psychological stress on selected parameters in older patients who underwent THA.METHODS Ninety older patients who underwent THA between January 2023 and August 2024 were divided into two groups by their preoperative self-rated anxiety scale and self-rated depression scale scores,including high-stress(n=42)and lowstress(n=48).The postoperative joint function,short form-36 health survey(SF36)score,incidence of postoperative complications,and other indicators were compared between the two groups.Pearson’s correlation coefficient analysis of the relationship among preoperative psychological stress,quality of life,and postoperative complications was performed.RESULTS Postoperative joint function and quality of life were lower in the high-stress group than they were in the low-stress group(P<0.05).The incidence of postoperative complications was higher in the high-stress group(29.27%)than it was in the low-stress group(9.30%)(P<0.05).Cor-relation analysis revealed that psychological stress was correlated with the Harris hip and SF-36 scores.Total scores on the scale,including physical function,physical pain,general health,mental health,social function,vitality,and emotional function,were negatively correlated(P<0.05).CONCLUSION Preoperative psychological stress results in adverse effects on quality of life and complications in older patients undergoing THA.Therefore,pre-operative psychological interventions should be strengthened to improve postoperative outcomes.展开更多
1 Tuan Pham was feeling pretty good about himself as he approached the 12-mile mark of the Long Beach Half Marathon in Southern California.The run was the 47-year-old's seventh such event,and he couldn't wait ...1 Tuan Pham was feeling pretty good about himself as he approached the 12-mile mark of the Long Beach Half Marathon in Southern California.The run was the 47-year-old's seventh such event,and he couldn't wait to celebrate at the finish line with his teenage son,who had raced ahead.Pham took another step or two,and that was the last thing he could remember.展开更多
文摘From the“Six Rising Dragons”emerging at the Hangzhou Future Sci-Tech City(Haichuang Park)to the archaeological wonders of Liangzhu,widely regarded as a cradle of Chinese civilization,dating back 5000 years.Recently,our reporter has been conducting an in-depth interview in Zhejiang.Marveling at the ingenuity of ancient civilizations,we were amazed by the cutting-edge“intelligence”of humanoid robotics,and unlocked a unique dialogue between millennia-old heritage and the technology shaping tomorrow.
文摘The object of this article is to develop instruments for the study of the interest of six- and seven-year olds, pedagogues and parents about children＇s books and computers. By way of elaborating children＇s books and writing on a computer or tablet, it introduces illiterate children to oral-written speech--an innovative approach to literacy. This process takes place under the guidance of a pedagogue, in collaboration with parents. Thus, before they start school, children in Bulgaria can master the written and spoken language that encourages them to love the book.
基金Funded by the Key Project of the 12th Five-Year Plan of Guangzhou Philosophy and Social Sciences in 2014:Study on Boosting "Three Olds" Reconstruction and Facilitating the Urban Renewal in Guangzhou(Grant No.14Z01)
文摘With the establishment of Guangzhou Urban Renewal Bureau,the first of its kind in China,as the background and the starting point,the paper reviews relevant experiences in the UK,Singapore,and Hong Kong,summarizes the features,responsibilities,and rights of such institutions.Through analyzing three statuses of redevelopment,which are increased,reduced,and retained construction,the paper points out that urban renewal is a process orienting at promoting the comprehensive capacity of the built-up environment.Then the paper summarizes the strength and weakness of the "three olds" reconstruction policy making and implementation in Guangzhou,holding that the strength lies in the effective land consolidation and socially collaboration experiences,while the weakness includes the unclear rights and responsibilities,unsystematic target,and imbalanced interests distribution.It concludes that the goal of urban renewal is to improve the existing built-up environment without damaging the benefits of original stakeholders,to emphasize both fairness and efficiency,and to seek for sustainable city redevelopment with optimized comprehensive capacity.Moreover,the paper clarifies that the primary responsibility of urban renewal is to well maintain the built-up environment and the extended responsibility is to properly coordinate the city redevelopment.Considering that urban renewal is a kind of public administration with distinctive social and processing features,urban renewal should be empowered the necessary implementation priority and administrative permission power via local legislation measures.In addition,an effective social collaboration platform should be established to actively support the urban renewal and to reflect the "new normal" of city redevelopment.
文摘Do you know any old wives'tales?You probably heard them from your mom.And she heard them from her mom.Many of these tales aren't true,but we talk about them anyway.For example,don't go outside with wet hair,or you'll catch a cold.If you drop food and pick it up in under five seconds,it is safe to eat.You should eat a lot when you have a cold,but only eat a little when you have a fever.And eating bread crusts makes your hair curly.
文摘Find It What did the old woman give Lucy?Once upon a time,a poor girl named Lucy lived in a small village.She was kind and helped others when she could.But she and her mother were often very hungry because they were poor.
基金Supported by the National Natural Science Foundation of China(71774049).
文摘[Objectives]To explore the mediating effect of social support between depression and resilience in elderly patients with first-episode stroke.[Methods]The general information questionnaire,PHQ-9 depression screening scale,Social Support Rating scale and Connor-Davidson Resilience Scale were used to construct and test the mediation model.[Results]The total score of depressive symptoms was(8.64±3.28)points,the detection rate of depressive symptoms was 51.65%,the score of social support was(37.28±5.98)points,and the score of psychological resilience was(22.05±5.25)points.The resilience of patients was positively correlated with social support(r=0.470,P<0.01),and negatively correlated with depressive symptoms(r=-0.470,P<0.01).Social support was negatively correlated with depressive symptoms(r=-0.523,P<0.01).Social support played a partial mediating role between depression and resilience in elderly patients with first-episode stroke,and the mediating effect accounted for 16.1%of the total effect.[Conclusions]Social support can mediate the effect of depression on resilience in elderly patients with first-episode stroke.Medical staff can improve patients'psychological resilience by psychological counseling of depression and improving their social support,so as to promote their subjective well-being and maintain a healthy and positive mental state.
文摘1 Antoni Gaudíwas sickly as a boy in Reus,Spain,often riding a donkey due to his weak legs.He loved art and nature and was full of ideas.As he grew older and stronger,Gaudíexplored the remains of many old buildings near his city,which made him realize what he wanted to do for the rest of his life.
文摘Objective: To study the effects of starting antiretroviral treatment (ART) prior the age of two years on the growth (height and weight) of HIV-infected children. Methodology: This was a retrospective cohort study. HIV-infected children on ART aged less than 15 years were divided into two groups Group 1 (G1) comprising children who started ART prior 2 years and Group (G2) those put on treatment thereafter. Main Measures: Percentage of children with growth retardation measured by Height for Age (H/A) and Weight for Age (W/A) Results: In total, we included 90 subjects. The median age was 10 years with a slight female predominance (51.2%). Most children were asymptomatic at the time of the study (96.6%), compliant with treatment (81%), 54.8% of children were on cotrimoxazole, 33% knew their status. At initiation, underweight was predominant in group 1 compared to group 2 (52% versus 29.5%;p = 0.015). Conversely, stunted growth predominated in G2 compared to G1 but without significant difference (38% versus 50%;p = 0.147). At the time of our study (median age of 10 years), catch-up height and weight predominated in G1 compared to G2;only a small proportion remained below −2SD (4% versus 18.2%;p = 0.015 and 9% versus 29.5%;p = 0.006 respectively for underweight and stunted growth). Conclusion and Global Health Implications: Growth retardation was common at ART initiation. Catch-up in height was more evident in the early treatment group. Initiation of ART before the age of 2 years rather influences children’s height than weight. The result of this study further emphasizes the need of early ART and closed clinical monitoring to better assess the impact of ART in areas with high rates of undernutrition.
文摘Villagers in Nujiang have embraced economic development without sacrificing age-old customs.Nujiang,a mountainous region in Yunnan Province,has undergone rapid change in recent years.Once one of China’s poorest areas,it is now a place where modern homes and infrastructure sit alongside centuries-old traditions.The local ethnic minorities-including the Lisu,Nu and Derung-have embraced new opportunities while holding on to their cultural roots.
文摘Chic Beijing:An Insider’s Guide to Unique New Places Compiled by Beijing Radio and Television Station Price:RMB 138 Paperback,307 pages Published by Foreign Languages Press&Beijing Publishing Group If you’re planning a trip to Beijing,prepare to be swept up in a living mosaic–more than 3,000 years of history,vibrant contemporary culture,and skyline-defining architecture all fusing and flowing across a vast canvas.This book,Chic Beijing:An Insider’s Guide to Unique New Places,allows readers to take a breathtaking journey through Beijing,the majestic metropolitan capital of China.It also unlocks doors that usually stay closed:rooftop gardens overlooking palace rooftops,micro-galleries tucked into 300-year-old courtyards,and cocktail labs where baijiu meets coffee.
基金supported by The Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202006)the 2025 High-level traditional Chinese medicine key subject construction project of National Administration of Traditional Chinese Medicine–Evidence-based Traditional Chinese Medicine.
文摘Background:While physical frailty(PF)and cognitive impairment(CI)are established independent predictors of adverse outcomes in older adults,the prognostic significance of their co-occurrence(cognitive frailty,CF)remains underexplored in the Chinese population.We aimed to explore the epidemiology of CF and its mortality predictive value among community-dwelling older Chinese adults.Methods:Data from the Chinese Longitudinal Healthy Longevity Survey(2011–2018).PF was assessed with the Osteoporotic Fractures frailty index,while CI was defined by the Chinese Mini-Mental State Examination(MMSE)(<18/21/25).CF was defined as concurrent PF and CI in non-demented.Cox proportional hazard regression models were used to evaluate hazard ratios(HRs)and 95%confidence intervals(CIs).A systematic review and random-effects meta-analysis complemented primary analyses,incorporating data from 9 cohorts study(n=32,088).Results:This cohort study included 8,012 participants(mean age 85.35±11.06 years,54.6%females)with 49.8%all-cause mortality over 7 years.Baseline prevalence of PF,CI,and CF were 15.4%,21.1%,and 8.0%respectively.Kaplan-Meier analysis revealed significantly reduced survival in participants with CF compared to other groups(log-rank P<0.001).Fully adjusted Cox models demonstrated a mortality gradient:Non-PF and Normal Cognition(reference),PF alone(HR 1.397,95%CI 1.218–1.602),CI alone(HR 1.572,1.412–1.749),and CF(HR 1.919,1.666–2.210;P<0.001).Effect modification analyses showed heightened CF-associated mortality in males and the oldest-old adults(P for interaction<0.001).Meta-analysis confirmed these findings(pooled HR 2.45,95%CIs,1.91–3.31;I2=57%),with heterogeneity partly attributable to the CI assessment tool or and covariate adjustment strategies.Conclusion:This dual analytical approach substantiates CF as a critical mortality predictor in Chinese older adults,exceeding the risks associated with isolated PF or CI.The observed heterogeneity across studies underscores the need for standardized CF diagnostic criteria and adjustment protocols in prognostic research.Our findings advocate for routine CF screening in geriatric assessments,particularly for males and the oldest-old.Future investigations should clarify the temporal dynamics of CF progression and evaluate targeted interventions.
文摘A young artist reinvents an old sartorial skill from rural ethnic communities into globally recognized high fashion.LACKING a unified writing system,the ancestors of the Miao people,an ethnic group primarily living in mountainous areas in central and southwestern China,encoded their history in the exquisite design of traditional clothing,especially embroidery.They express reverence for nature and appreciation of life with needles and threads.
文摘BACKGROUND Old donor allografts in liver transplantation(LT)account for 25%of all allografts,and their utilization is projected to increase with the aging general population.Older allografts are associated with higher rates of all-cause mortality and graft failure;however,there is limited literature exploring the specific phenotypic changes(e.g.,functional status,cause-specific mortality)observed in different donor:recipient age pairs.AIM To investigate differences in functional impairment and cause-specific mortality between different donor:recipient age pairs.METHODS This was a retrospective analysis of LT patients from the Scientific Registry of Transplant Recipients from 2002 to 2022.Donors were categorized into younger age donors,≤45-years(YAD),middle-aged donors,46-69-years(MAD),and older age donors,≥70-years(OAD).Recipients were categorized into younger age recipients,≤55-years(YAR)and older age recipients,>55-years(OAR)age recipients.Multivariate Fine-Gray competing risk and logistic regression analyses identified independent risk factors for cause-specific mortality and improvements in functional status,respectively.RESULTS Overall,126185 patients were included in the analysis:YAD:YAR(32.7%), YAD:OAR (25.2%), MAD:YAR (17.5%), MAD:OAR (20.7%), OAD:YAR (1.3%), and OAD:OAR (2.7%). Compared toYAD:YAR, OAD pairs had the lowest likelihoods of improved functional status 5 years post-LT (OAD:YAR oddsratio 0.53, 95% confidence interval 0.42-0.67, P < 0.001;OAD:OAR odds ratio 0.67, 95% confidence interval 0.51-0.89, P = 0.006). Donor:recipient age pairs with older donors had higher rates of graft- and infection-relatedmortality compared to those with younger donors (P < 0.001). Meanwhile, donor:recipient age pairs with olderrecipients had higher cardioneurovascular- or malignancy-related deaths compared to those with youngerrecipients (P < 0.001).CONCLUSIONDonor:recipient age mismatch was associated with differences in cause-specific mortality and functional status.These insights could potentially inform age-matched organ allocation strategies, though future work is warranted.
文摘1 On a Sunday morning,Zheng Shiying drove 130 kilometers to a village on the outskirts of Beijing,not for a hike or a hot spring,but for a cup of coffee.Housed in an old stone building that looks untouched by time,by the time Zheng arrived,the caféwas already packed with weekend visitors,and finding a seat was a bit of a challenge.
文摘BACKGROUND Gastric cancer is among the most prevalent malignancies worldwide.Despite significant advancements in chemoradiotherapy,targeted therapy,and neoadjuvant therapy,conventional surgical intervention remains the cornerstone of gastric cancer management.Improvements in surgical techniques,coupled with the use of staplers and other advanced instruments,have substantially reduced the incidence of complications and mortality following gastric cancer surgery.However,dysphagia remains a common postoperative complication.AIM To retrospectively investigate the potential factors contributing to dysphagia in patients who have undergone laparoscopic radical gastrectomy for gastric cancer and to explore effective strategies for its postoperative management.METHODS In this retrospective study,we analyzed data from patients who underwent elective laparoscopic total gastrectomy at Lihuili Hospital,Ningbo University,between January 2018 and May 2022.A total of 115 eligible postoperative patients were included.Postoperatively,patients completed questionnaires and were categorized into two groups based on their responses:The dysphagia group(Eating Assessment Tool-10 score≥3)and the non-dysphagia group(Eating Assessment Tool-10 score<3).Risk factors associated with dysphagia following total gastrectomy were assessed usingχ2 tests,Fisher’s exact tests,t-tests,Pearson correlation coefficients,and univariate and multivariate regression analyses.RESULTS Multivariate analysis further identified anastomotic style,prolonged intubation time,advanced age,and low albumin(ALB)levels as independent risk factors for postoperative dysphagia.Implementing targeted preventive measures for high-risk groups may significantly enhance postoperative quality of life.CONCLUSION Univariate analysis revealed that anastomotic style,low serum ALB levels,advanced age,and prolonged intubation time were significantly associated with postoperative dysphagia in gastric cancer patients.Multivariate analysis further identified anastomotic style,prolonged intubation time,advanced age,and low ALB levels as independent risk factors for postoperative dysphagia.Implementing targeted preventive measures for high-risk groups may significantly enhance postoperative quality of life.
基金Funded by the Project of National Key Research and Development Program of China(No.2019YFC1906202)。
文摘In order to study the effects of the contents of used mortar recycled aggregate(OMRA)and brick recycled aggregate(BRA)on the deformation properties of recycled aggregate concrete(RAC),under uniaxial compression conditions,The RAC of OMRA(0%,5%,10%,and 15%)and BRA(0%,3%,6%,9%,12%,and 15%)were studied.The experimental results show that,under uniaxial compression,the interfacial relationships of RAC containing OMRA and BRA between different materials are more complex,and the failure mechanism is also more complex.The content of OMRA and BRA had significant influence on the deformation behavior of RAC.When the content of OMRA and BRA is high,it is difficult for existing formulas and models to accurately represent the actual value.In this study,the influence of OMRA and BRA content is taken into account,and the existing formulas for calculating concrete deformation are modified,so that these formulas can more accurately calculate the elastic modulus,peak strain and ultimate strain of recycled concrete.The stress-strain formula of Guo concrete fits the stress-strain curve of concrete very well.We modified the formula on the basis of Guo formula to make the formula more suitable for the stress-strain curve of recycled concrete containing old mortar and brick,and the theoretical model proposed has better fitting accuracy.The study provides a valuable reference for nonlinear analysis of recycled aggregate concrete structures under different proportions of OMRA and BRA.
基金Ningbo Top Medical and Health Research Program(Grant No.2022020405)Wu Jieping Medical Foundation(Grant No.320.6750.2023-25-3).
文摘This study analyzed case and prescription data of children aged 12 to 18 years diagnosed with influenza A from the outpatient and emergency departments at the Women and Children’s Hospital of Ningbo University during the influenza epidemic period between February and April 2023.Patients were categorized into two groups based on their medication:the Baloxavir Marboxil group(196 cases)and the Oseltamivir group(126 cases).SPSS Statistics 24.0 software was utilized to compare variables between the two groups,including age,sex,weight,first visit department,number of visits,average prescription cost per patient,drug varieties used,hospitalization rate,and the combined medication usage,to evaluate the relative advantages and disadvantages of the two treatments.The results indicated that the number of visits in the Baloxavir Marboxil group was significantly lower than in the Oseltamivir group,whereas the average prescription cost per patient was higher(P<0.05).There were no significant differences between the two groups regarding age,sex,weight,first visit department,number of drug types used,hospitalization rate,or combined medication usage(P>0.05).When comparing the use of single-class combined drugs,only the quantity of antiviral drugs differed significantly(P<0.05).The Oseltamivir group required more adjuvant treatment with both Chinese and Western antiviral medications.The distribution of the number of combined drug types was concentrated around three and two types in both groups(Baloxavir Marboxil group:41.34%and 39.66%;Oseltamivir group:44.54%and 36.97%).This study highlighted that the new drug,Baloxavir Marboxil,offered certain therapeutic benefits over Oseltamivir in treating influenza among children aged 12 to 18 years,including advantages in single-dose administration,oral compliance,and specific treatment outcomes.The higher unit cost associated with Baloxavir Marboxil might be a factor for further consideration.These findings provided a new reference point for the clinical selection of anti-influenza medications.
文摘BACKGROUND Total hip arthroplasty(THA)is an increasingly common treatment for older patients with hip osteoarthritis.Psychological stress is common before THA,although its clinical effects on selected parameters such as joint function,quality of life,and postoperative complications remain unclear.AIM To investigate the effects of preoperative psychological stress on selected parameters in older patients who underwent THA.METHODS Ninety older patients who underwent THA between January 2023 and August 2024 were divided into two groups by their preoperative self-rated anxiety scale and self-rated depression scale scores,including high-stress(n=42)and lowstress(n=48).The postoperative joint function,short form-36 health survey(SF36)score,incidence of postoperative complications,and other indicators were compared between the two groups.Pearson’s correlation coefficient analysis of the relationship among preoperative psychological stress,quality of life,and postoperative complications was performed.RESULTS Postoperative joint function and quality of life were lower in the high-stress group than they were in the low-stress group(P<0.05).The incidence of postoperative complications was higher in the high-stress group(29.27%)than it was in the low-stress group(9.30%)(P<0.05).Cor-relation analysis revealed that psychological stress was correlated with the Harris hip and SF-36 scores.Total scores on the scale,including physical function,physical pain,general health,mental health,social function,vitality,and emotional function,were negatively correlated(P<0.05).CONCLUSION Preoperative psychological stress results in adverse effects on quality of life and complications in older patients undergoing THA.Therefore,pre-operative psychological interventions should be strengthened to improve postoperative outcomes.
文摘1 Tuan Pham was feeling pretty good about himself as he approached the 12-mile mark of the Long Beach Half Marathon in Southern California.The run was the 47-year-old's seventh such event,and he couldn't wait to celebrate at the finish line with his teenage son,who had raced ahead.Pham took another step or two,and that was the last thing he could remember.
