Gestational diabetes mellitus(GDM)is defined as any degree of glucose or carbohydrate intolerance mainly during pregnancy.About 10%to 15%of pregnancies are affected and complicated by gestational diabetes.Due to hormo...Gestational diabetes mellitus(GDM)is defined as any degree of glucose or carbohydrate intolerance mainly during pregnancy.About 10%to 15%of pregnancies are affected and complicated by gestational diabetes.Due to hormonal changes during pregnancy,the requirement for insulin increases,and thus the usual concentration of insulin previously catered for glycemic control is ineffective.In order to meet the body’s demand,the islet cells secrete a higher amount of insulin.GDM occurs when this higher concentration is also unable to control blood glucose.This increased resistance toward insulin is most noticeable during the third trimester of pregnancy,which gradually normalizes after the termination of pregnancy.Various complications do arise,which affect both the mother and her developing fetus.In the mother,miscarriages,delivery of baby via caesarian section,and other complications may result,whereas the fetus may be affected with congenital abnormalities,neonatal hypoglycemia,and even death.Treatment of GDM includes both non-pharmacological and pharmacological interventions.Pharmacological agents are employed when non-pharmacological interventions fail to achieve the desired target.Glyburide,insulin,and metformin are the commonly used pharmacological agents.展开更多
目的观察睡前应用中效胰岛素联合口服磺脲类降糖药治疗2型糖尿病的临床效果。方法选择45例单用口服降糖药治疗失效的2型糖尿病患者,给予格列吡嗪及睡前加用中效胰岛素治疗,观察空腹血糖、餐后2 h血糖、糖化血红蛋白的变化及不良反应。...目的观察睡前应用中效胰岛素联合口服磺脲类降糖药治疗2型糖尿病的临床效果。方法选择45例单用口服降糖药治疗失效的2型糖尿病患者,给予格列吡嗪及睡前加用中效胰岛素治疗,观察空腹血糖、餐后2 h血糖、糖化血红蛋白的变化及不良反应。结果睡前加用中效胰岛素治疗3个月后,FBG(空腹血糖)和2 h BG(餐后二小时血糖),HbAlc(糖化血红蛋白)水平均较治疗前显著降低(P均<0.01)。结论对单用口服降糖药效果欠佳的2型糖尿病,睡前加用中效胰岛素治疗效果显著。展开更多
文摘Gestational diabetes mellitus(GDM)is defined as any degree of glucose or carbohydrate intolerance mainly during pregnancy.About 10%to 15%of pregnancies are affected and complicated by gestational diabetes.Due to hormonal changes during pregnancy,the requirement for insulin increases,and thus the usual concentration of insulin previously catered for glycemic control is ineffective.In order to meet the body’s demand,the islet cells secrete a higher amount of insulin.GDM occurs when this higher concentration is also unable to control blood glucose.This increased resistance toward insulin is most noticeable during the third trimester of pregnancy,which gradually normalizes after the termination of pregnancy.Various complications do arise,which affect both the mother and her developing fetus.In the mother,miscarriages,delivery of baby via caesarian section,and other complications may result,whereas the fetus may be affected with congenital abnormalities,neonatal hypoglycemia,and even death.Treatment of GDM includes both non-pharmacological and pharmacological interventions.Pharmacological agents are employed when non-pharmacological interventions fail to achieve the desired target.Glyburide,insulin,and metformin are the commonly used pharmacological agents.
文摘目的观察睡前应用中效胰岛素联合口服磺脲类降糖药治疗2型糖尿病的临床效果。方法选择45例单用口服降糖药治疗失效的2型糖尿病患者,给予格列吡嗪及睡前加用中效胰岛素治疗,观察空腹血糖、餐后2 h血糖、糖化血红蛋白的变化及不良反应。结果睡前加用中效胰岛素治疗3个月后,FBG(空腹血糖)和2 h BG(餐后二小时血糖),HbAlc(糖化血红蛋白)水平均较治疗前显著降低(P均<0.01)。结论对单用口服降糖药效果欠佳的2型糖尿病,睡前加用中效胰岛素治疗效果显著。
