Objective: To explore the change of pathology and the clinical response rate treated by neoadjuvant chemotherapy with MVP regimen for non-small cell lung cancer. Methods: This is a randomized study in patients with st...Objective: To explore the change of pathology and the clinical response rate treated by neoadjuvant chemotherapy with MVP regimen for non-small cell lung cancer. Methods: This is a randomized study in patients with stage I-lIIa. Among them, 46 patients enrolled in neoadjuvant chemotherapy treated by 1-2 course MVP regimen. MMC was given 6 mg/M2 by intravenous (I.V.) infusion on day1, VDS 2.5-3 mg/M2 I.V. on day1, 8 and/or day15, DDP 90 mg/M2 I.V. on day1. The treatment was recycled every 28 days. The clinical RR evaluated with WHO criteria. All surgical samples were classified with pathology. Results: The overall response rate in 2 courses chemotherapy is better than that in 1 course (P<0.01). The number of patient with pathology grade I-II in 2 course chemotherapy is higher than that in 1 course (P<0.01). But the RR can not completely translated into pathology grade I-II. The pathology grade I-II is closely related with tumor involvement (T) (P<0.01) but not closely related with regional lymph node metastasis (N). It is reasonable to use RR together with PCR to judge the chemotherapy response. NR patients can not be regard as chemotherapy failure. No serve toxicities and surgical mortality were observed. Conclusion: MVP regimen is an effective neoadjuvant treatment regimen for I-IIIa NSCLC.展开更多
A range of powdered Bi:2 212 samples exhibiting the paramagnetic Meissner effect (PME) are systematically examined. Interpretation of the results is made in terms of a phenomenological model in which there is a concen...A range of powdered Bi:2 212 samples exhibiting the paramagnetic Meissner effect (PME) are systematically examined. Interpretation of the results is made in terms of a phenomenological model in which there is a concentration within the material of small local moments that can be polarized during a field cooling. Information about the magnitudes of these local m0oments and their distribution are deduced. Relations between the local moments and the particle sizes, the weak link, oxygen content and the interactions between the local moments are also discussed. Comparison of the results from small particles and bulk samples shows that conclusions obtained from small particle experiments are reliable and universal.展开更多
Damming landslides are very common in China, they ever blocked the rivers and streams completely or partly, and form natural lakes. Now more than 150 damming landslides in China are recognized through field investigat...Damming landslides are very common in China, they ever blocked the rivers and streams completely or partly, and form natural lakes. Now more than 150 damming landslides in China are recognized through field investigation and data collection indoors. These Landslides distribute in steep mountainous counties around the Qinghai—Tibet Plateau, and mainly of which in southwest China and northwest China.. Studies show that the distribution of damming landslides has a close relation with the event of the Tibet plateau upheaval. The thermodynamic effect on the free atmosphere results from rapid upheaval of Qinghai\|Tibet plateau is more and more intensive, it causes air to circulate from east to west. In winter, the high Tibet Plateau leads the cool air gather quickly and high cool potential to be stronger. On one side, an anticyclone cool high pressure forms near the ground surface at the altitude of 4000～5000m, and produces winter monsoon wind. On the other side, the shielding effect of the plateau impedes the air from Siberia touching with the air from south Indian Ocean, which causes the cool air from Siberia enters China frequently and strengthens the cool and drought in northwest China. In summer, the monsoon wind is impeded by the plateau and cannot enter into north China, where it is dry, it can only moves around the plateau and at the edge enters into southwest, south, middle and east China, where the rainfall process is strong. Thus south and east of the plateau become the areas with many damming landslides resulted from heavy rain.展开更多
文摘Objective: To explore the change of pathology and the clinical response rate treated by neoadjuvant chemotherapy with MVP regimen for non-small cell lung cancer. Methods: This is a randomized study in patients with stage I-lIIa. Among them, 46 patients enrolled in neoadjuvant chemotherapy treated by 1-2 course MVP regimen. MMC was given 6 mg/M2 by intravenous (I.V.) infusion on day1, VDS 2.5-3 mg/M2 I.V. on day1, 8 and/or day15, DDP 90 mg/M2 I.V. on day1. The treatment was recycled every 28 days. The clinical RR evaluated with WHO criteria. All surgical samples were classified with pathology. Results: The overall response rate in 2 courses chemotherapy is better than that in 1 course (P<0.01). The number of patient with pathology grade I-II in 2 course chemotherapy is higher than that in 1 course (P<0.01). But the RR can not completely translated into pathology grade I-II. The pathology grade I-II is closely related with tumor involvement (T) (P<0.01) but not closely related with regional lymph node metastasis (N). It is reasonable to use RR together with PCR to judge the chemotherapy response. NR patients can not be regard as chemotherapy failure. No serve toxicities and surgical mortality were observed. Conclusion: MVP regimen is an effective neoadjuvant treatment regimen for I-IIIa NSCLC.
文摘A range of powdered Bi:2 212 samples exhibiting the paramagnetic Meissner effect (PME) are systematically examined. Interpretation of the results is made in terms of a phenomenological model in which there is a concentration within the material of small local moments that can be polarized during a field cooling. Information about the magnitudes of these local m0oments and their distribution are deduced. Relations between the local moments and the particle sizes, the weak link, oxygen content and the interactions between the local moments are also discussed. Comparison of the results from small particles and bulk samples shows that conclusions obtained from small particle experiments are reliable and universal.
文摘Damming landslides are very common in China, they ever blocked the rivers and streams completely or partly, and form natural lakes. Now more than 150 damming landslides in China are recognized through field investigation and data collection indoors. These Landslides distribute in steep mountainous counties around the Qinghai—Tibet Plateau, and mainly of which in southwest China and northwest China.. Studies show that the distribution of damming landslides has a close relation with the event of the Tibet plateau upheaval. The thermodynamic effect on the free atmosphere results from rapid upheaval of Qinghai\|Tibet plateau is more and more intensive, it causes air to circulate from east to west. In winter, the high Tibet Plateau leads the cool air gather quickly and high cool potential to be stronger. On one side, an anticyclone cool high pressure forms near the ground surface at the altitude of 4000～5000m, and produces winter monsoon wind. On the other side, the shielding effect of the plateau impedes the air from Siberia touching with the air from south Indian Ocean, which causes the cool air from Siberia enters China frequently and strengthens the cool and drought in northwest China. In summer, the monsoon wind is impeded by the plateau and cannot enter into north China, where it is dry, it can only moves around the plateau and at the edge enters into southwest, south, middle and east China, where the rainfall process is strong. Thus south and east of the plateau become the areas with many damming landslides resulted from heavy rain.
