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Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor 被引量:3
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作者 Yuye Wang Shuwen Zeng +11 位作者 Aurelian Crunteanu Zhenming Xie Georges Humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-Pui Ho 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第6期284-294,共11页
Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatm... Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting relapse.Here,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change nanomaterial.By precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift effect.Based on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical techniques.With this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of cancer.The as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics. 展开更多
关键词 2D nanomaterials Cancer marker detection phase singularity Surface plasmon
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Two-Dimensional Particle Assembly Based on the Synchronized Evolution of Centrosymmetric Off-Axis Acoustic Vortexes
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作者 Ning Ding Gepu Guo +2 位作者 Juan Tu Dong Zhang Qingyu Ma 《Engineering》 2025年第4期139-151,共13页
Acoustic-vortex(AV)tweezers ensure stable particle trapping at a zero-pressure center,while particle assembly between two vortex cores is still prevented by the high-potential barrier.Although a one-dimensional low-pr... Acoustic-vortex(AV)tweezers ensure stable particle trapping at a zero-pressure center,while particle assembly between two vortex cores is still prevented by the high-potential barrier.Although a one-dimensional low-pressure attractive path of particle assembly can be constructed by the interference between two independent cylindrical Bessel beams,it remains challenging to create two-dimensional(2D)neighboring vortexes using a source array in practical applications.In this paper,a three-step phase-reversal strategy of 2D particle assembly based on the synchronized evolution of a centrosymmetric array of M off-axis acoustic vortexes(OA-AVs)with a preset radial offset is proposed based on a ring array of planar sources.By introducing initial vortex phase differences of-2π/M and+2π/M to the vortex array,low-pressure patterns of an M-sided regular polygon and M-branched star are formed by connecting the vortex cores and the field center before and after the tangent state of adjacent OA-AVs.Center-oriented particle assembly is finally realized by a central AV constructed by coincident in-phase OA-AVs.The capability of particle manipulation in the lateral and radial directions is demonstrated by low-pressure patterns with acoustic radiation forces pointing to the field center during a synchronized central approach.The field evolution is certified by experimental field measurements for OA-AVs with different vo rtex numbers,initial vortex phase differences,and radial offsets using a ring array of 16 planar sources.The feasibility of particle assembly in two dimensions is also verified by the accurate manipulation of four particles using the low-pressure patterns of a four-sided polygon,a four-branched star,and a central AV in experiments.The three-step strategy paves a new way for 2D particle assembly based on the synchronize d evolution of centrosymmetric OA-AVs using a simplified single-sided source array,exhibiting excellent potential for the precise navigation and manipulation of cells and particles in biomedical applications. 展开更多
关键词 Centrosymmetric array of off-axis acoustic vortexes phase-reversal strategy Initial phase difference Particle assembly Single-sided ring array
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Double topological phase singularities in highly absorbing ultra-thin film structures for ultrasensitive humidity sensing
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作者 Xiaowen Li Jie Sheng +8 位作者 Zhengji Wen Fangyuan Li Xiran Huang Mingqing Zhang Yi Zhang Duo Cao Xi Shi Feng Liu Jiaming Hao 《Opto-Electronic Advances》 2025年第3期37-47,共11页
Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experi... Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experimental and theoretical investigations of an ultrasensitive and multiplexed phase-sensitive sensor utilizing dual topological PSs in the visible and near-infrared regions.This sensor uses a simple structure,which consists of an ultra-thin highly absorbing film deposited on a metal substrate.We demonstrate the achievement of dual-polarization darkness points for s-and p-polarizations at different incident angles.Furthermore,we theoretically explain the double topological PSs accompanied by a perfect±π-jump near a zero-reflection point,based on the temporal coupled-mode formalism.To validate its multifunctional capabilities,humidity sensing tests were carried out.The results demonstrate that the sensor has a detection limit reaching the level of 0.12‰.These findings go beyond the scope of conventional interference optical coatings and highlight the potential applications of this technology in gas sensing and biosensing domains. 展开更多
关键词 double topological darkness phase singularity thin-film optics ultrasensitive sensing
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Spatial correlation properties and phase singularity annihilation of Gaussian Schell-model beams in the focal region
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作者 刘普生 潘留占 吕百达 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第5期1752-1757,共6页
By using the generalized Debye diffraction integral, this paper studies the spatial correlation properties and phase singularity annihilation of apertured Gaussian Schell-model (GSM) beams in the focal region. It is... By using the generalized Debye diffraction integral, this paper studies the spatial correlation properties and phase singularity annihilation of apertured Gaussian Schell-model (GSM) beams in the focal region. It is shown that the width of the spectral degree of coherence can be larger, less than or equal to the corresponding width of spectral density, which depends not only on the scalar coherence length of the beams, but also on the truncation parameter. With a gradual increase of the truncation parameter, a pair of phase singularities of the spectral degree of coherence in the focal plane approaches each other, resulting in subwavelength structures. Finally, the annihilation of pairs of phase singularities takes place at a certain value of the truncation parameter. With increasing scalar coherence length, the annihilation occurs at the larger truncation parameter. However, the creation process of phase singularities outside the focal plane is not found for GSM beams. 展开更多
关键词 singular optics spatial correlation annihilation of phase singularities truncation parameter
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TOPOLOGICAL STRUCTURE OF THE SINGULAR POINTS OF THE THIRD ORDER PHASE LOCKED LOOP EQUATIONS WITH THE CHARACTER OF DETECTED PHASE BEING g(φ)=(1+k)sinφ/(1+kcosφ)
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作者 金均 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1992年第9期883-889,共7页
In this paper, we study the topological structure of the singular points of the third order phase locked loop equations with the character of detected phase being g(?) =(1+k)sin?/1+kcos?.
关键词 singular point topological structure character of detected phase exponentially asymptotically stable Jordan form
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Inflation and Singularity in Einstein-Cartan Theory
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作者 HUANG Zeng-Guang FANG Wei LU Hui-Qing 《Chinese Physics Letters》 SCIE CAS CSCD 2011年第2期254-257,共4页
Within the framework of Einstein-Cartan theory,we obtain a general condition leading to singularity and inflation for all Bianchi cosmological models.If the spin energy is smaller than anisotropic energy density(i.e.S... Within the framework of Einstein-Cartan theory,we obtain a general condition leading to singularity and inflation for all Bianchi cosmological models.If the spin energy is smaller than anisotropic energy density(i.e.S^(2)σ^(2)<0),the Universe can not avoid singularity.If S^(2)-σ^(2)>-pv/^(2)(pv is vacuum energy density),the Universe can undergo an inflation phase.Examples of Bianchi type-IX,I and V cosmological models are discussed. 展开更多
关键词 phase EINSTEIN singularity
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Knotted Topological Phase Singularities of Electromagnetic Field
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作者 REN Ji-Rong ZHU Tao MO Shu-Fan 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第11期1071-1076,共6页
In this paper,knotted objects (RS vortices) in the theory of topological phase singularity in electromagneticfield have been investigated in details.By using the Duan's topological current theory,we rewrite the to... In this paper,knotted objects (RS vortices) in the theory of topological phase singularity in electromagneticfield have been investigated in details.By using the Duan's topological current theory,we rewrite the topological currentform of RS vortices and use this topological current we reveal that the Hopf invariant of RS vortices is just the sum ofthe linking and self-linking numbers of the knotted RS vortices.Furthermore,the conservation of the Hopf invariant inthe splitting,the mergence and the intersection processes of knotted RS vortices is also discussed. 展开更多
关键词 knotted optical vortex topological current phase singularity
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THE FEASIBILITIES OF USING THE STATISTICAL,FRACTAL AND SINGULAR PROCESSING OF HOMINAL BLOOD PLASMA PHASE IMAGES DURING THE DIAGNOSTICS AND DIFFERENTIATION OF MAMMARY GLAND PATHOLOGICAL STATES
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作者 YU.A.USHENKO 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2012年第1期1-10,共10页
Performed in this work are complex statistical,fractal and singular analyses of phase properties inherent to birefringence networks of protein crystals consisting of optically-thin layers prepared from blood plasma.Wi... Performed in this work are complex statistical,fractal and singular analyses of phase properties inherent to birefringence networks of protein crystals consisting of optically-thin layers prepared from blood plasma.Within the framework of a statistical approach,the authors have investigated values and ranges for changes of statistical moments of thefirst to the fourth orders that characterize coordinate distributions for phase shifts between orthogonal components of amplitudes inherent to laser radiation transformed by blood plasma with various pathologies.In the framework of the fractal approach,determined are the dimensions of self-similar coordinate phase distributions as well as features of transformation of logarithmic dependences for power spectra of these distributions for various types of hominal mammary gland pathologies. 展开更多
关键词 Polarization BIREFRINGENCE phase Jones matrix blood plasma statistic moments FRACTAL singularity
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SINGULAR DOUBLE PHASE EQUATIONS
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作者 刘振海 Nikolaos S.PAPAGEORGIOU 《Acta Mathematica Scientia》 SCIE CSCD 2023年第3期1031-1044,共14页
We study a double phase Dirichlet problem with a reaction that has a parametric singular term. Using the Nehari manifold method, we show that for all small values of the parameter, the problem has at least two positiv... We study a double phase Dirichlet problem with a reaction that has a parametric singular term. Using the Nehari manifold method, we show that for all small values of the parameter, the problem has at least two positive, energy minimizing solutions. 展开更多
关键词 double phase singular term unbalanced growth Musielak-Orlice spaces Nehari manifold positive solutions
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一类具有强奇异的双相Kirchhoff型方程正解的存在性
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作者 王成 储昌木 《合肥师范学院学报》 2026年第1期118-121,共4页
考虑了一类具有强奇异项的双相Kirchhoff型方程Dirichlet边界值问题,利用Nehari流形及Ekeland变分原理获得了该问题正解的存在性.
关键词 双相算子 Kirchhoff型方程 强奇异项 NEHARI流形 变分方法
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Observation of robust subwavelength phase singularity in chiral medium
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作者 Jun-Hee Park Jeongho Ha +4 位作者 Liyi Hsu Guang Yang Yeshaiahu Fainman Alexander V.Sergienko Abdoulaye Ndao 《Advanced Photonics》 2025年第3期132-138,共7页
Photonic devices that exhibit both sensitivity and robustness have long been sought;yet,these characteristics are thought to be mutually exclusive;through sensitivity,a sensor responds to external stimuli,whereas robu... Photonic devices that exhibit both sensitivity and robustness have long been sought;yet,these characteristics are thought to be mutually exclusive;through sensitivity,a sensor responds to external stimuli,whereas robustness embodies the inherent ability of a device to withstand weathering by these same stimuli.This challenge stems from the inherent contradiction between robustness and sensitivity in wave dynamics,which require the coexistence of noise-immune sensitive states and modulation-sensitive transitions between these states.We report and experimentally demonstrate a subwavelength phase singularity in a chiral medium that is resilient to fabrication imperfections and disorder while remaining highly responsive to external stimuli.The combination of subwavelength light confinement and its robustness lays the foundation for the development of hitherto unexplored chip-scale photonics devices,enabling a simultaneous development of high-sensitivity and robust devices in both quantum and classical realms. 展开更多
关键词 PLASMONIC RESONATOR ROBUSTNESS phase singularity SUBWAVELENGTH CHIRALITY METAMATERIALS
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Kalman Filtering for Delayed Singular Systems with Multiplicative Noise 被引量:4
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作者 Xiao Lu Linglong Wang +1 位作者 Haixia Wang Xianghua Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI 2016年第1期51-58,共8页
Kalman filtering problem for singular systems is dealt with, where the measurements consist of instantaneous measurements and delayed ones, and the plant includes multiplicative noise. By utilizing standard singular v... Kalman filtering problem for singular systems is dealt with, where the measurements consist of instantaneous measurements and delayed ones, and the plant includes multiplicative noise. By utilizing standard singular value decomposition, the restricted equivalent delayed system is presented, and the Kalman filters for the restricted equivalent system are given by using the well-known re-organization of innovation analysis lemma. The optimal Kalman filter for the original system is given based on the above Kalman filter by recursive Riccati equations, and a numerical example is presented to show the validity and efficiency of the proposed approach, where the comparison between the filter and predictor is also given. © 2014 Chinese Association of Automation. 展开更多
关键词 ESTIMATION FILTRATION phase noise Riccati equations singular value decomposition
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Creation of topological vortices using Pancharatnam-Berry phase liquid crystal holographic plates 被引量:1
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作者 Xuyue Guo Jinzhan Zhong +3 位作者 Peng Li Bingyan Wei Sheng Liu Jianlin Zhao 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第4期89-93,共5页
Recently,physical fields with topological configurations are evoking increasing attention due to their fascinating structures both in fundamental researches and practical applications.Therein,topological light fields,... Recently,physical fields with topological configurations are evoking increasing attention due to their fascinating structures both in fundamental researches and practical applications.Therein,topological light fields,because of their unique opportunity of combining experimental and analytical studies,are attracting more interest.Here,based on the Pancharatnam-Berry(PB)phase,we report the creation of Hopf linked and Trefoil knotted optical vortices by using phaseonly encoded liquid crystal(LC)holographic plates.Utilizing scanning measurement and the digital holographic interference method,we accurately locate the vortex singularities and map these topological nodal lines in three-dimensions.Compared with the common methods realized by the spatial light modulator(SLM),the phase-only LC plate is more efficient.Meanwhile,the smaller pixel size of the LC element reduces the imperfection induced by optical misalignment and pixellation.Moreover,we analyze the influence of the incident beam size on the topological configuration. 展开更多
关键词 TOPOLOGICAL VORTICES Pancharatnam-Berry phase liquid crystal phase singularity HOLOGRAM
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Study of algorithms of phase advance measurement between BPMs and its application in SSRF 被引量:4
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作者 CHEN Zhichu LENG Yongbin +2 位作者 YUAN Renxian YAN Yingbing ZHOU Weimin 《Nuclear Science and Techniques》 SCIE CAS CSCD 2013年第1期7-11,共5页
As a third generation light source, Shanghai Synchrotron Radiation Facility (SSRF) has up to 140 beam position monitors (BPM) installed to monitor the beam dynamics on its storage ring. Once the operation mode is chos... As a third generation light source, Shanghai Synchrotron Radiation Facility (SSRF) has up to 140 beam position monitors (BPM) installed to monitor the beam dynamics on its storage ring. Once the operation mode is chosen, the betatron functions are determined. Since the sinusoidal betatron oscillation is the dominant component of the transverse motion, these BPMs can be used to measure the motion to get the betatron functions. Three methods are compared to calculate the phase advance among the BPMs in this paper, aiming to find one or more feasible ways to check the beam optics in SSRF. Some experiments have also been made to verify the practicality of the phase information. 展开更多
关键词 上海同步辐射装置 束流动力学 相位信息 测量算法 光源 应用 SSRF 电子回旋
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STUDY ON STRUCTURE OF SINGULARPOINTS OF LAMINAR FLAME SYSTEM
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作者 王秀娥 殷先军 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2005年第5期679-684,共6页
Under some certain assumptions, the physical model of the air combustion system was simplified to a laminar flame system. The mathematical model of the laminar flame system, which was built according to thermodynamics... Under some certain assumptions, the physical model of the air combustion system was simplified to a laminar flame system. The mathematical model of the laminar flame system, which was built according to thermodynamics theory and the corresponding conservative laws, was studied. With the aid of qualitative theory and method of ordinary differential equations, the location of singular points on the Rayleigh curves is determined, the qualitative structure and the stability of the singular points of the laminar flame system, which are located in the areas of deflagration and detonation, are given for different parameter values and uses of combustion. The phase portraits of the laminar flame system in the reaction-stagnation enthalpy and combustion velocity-stagnation enthalpy planes are shown in the corresponding figures. 展开更多
关键词 laminar flame system Rayleigh curve singular point ORBIT phase portrait
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Boundedness of oscillatory singular integral with rough kernels on Triebel-Lizorkin spaces
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作者 ZHANG Chun-jie ZHANG Yan-dan 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2013年第1期90-100,共11页
In this paper, we will prove the Triebel-Lizorkin boundedness for some oscillatory singular integrals with the kernel (x) satisfying a condition introduced by Grafakos and Stefanov. Our theorems will be proved under... In this paper, we will prove the Triebel-Lizorkin boundedness for some oscillatory singular integrals with the kernel (x) satisfying a condition introduced by Grafakos and Stefanov. Our theorems will be proved under various conditions on the phase function, radial and nonradial. Since the L p boundedness of these operators is not complete yet, the theorems extend many known results. 展开更多
关键词 Oscillatory singular integral Triebel-Lizorkin space rough kernel phase function.
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A NOTE TO OSCILLATORY SINGULAR INTEGRALS ON HERZ-TYPE SPACES
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作者 G.Sampson XuJingshi 《Analysis in Theory and Applications》 2003年第1期37-46,共10页
In this paper, we want to improve our previous results. We prove that some oscillatory strong singular integral operators of non-convolution type with non-polynomial phases are bounded from Herz-type Hardy spaces to H... In this paper, we want to improve our previous results. We prove that some oscillatory strong singular integral operators of non-convolution type with non-polynomial phases are bounded from Herz-type Hardy spaces to Herz spaces and from Hardy spaces associated with the Beurling algebras to the Beurling algebras in higher dimensions. 展开更多
关键词 oscillatory singular integral phase Lebesgue space Herz space Beurling algebra Hardy space
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Ill-conditioned stable inversion arising from singularly perturbed zero dynamics
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作者 Xuemei GUO Guoli WANG 《控制理论与应用(英文版)》 EI 2008年第4期385-391,共7页
The ill-conditioned stable inversion is studied for slightly nonminimum phase systems whose zero dynam- ics is singularly perturbed, that is, the relative degree is ill-defined. For these systems, we show that there e... The ill-conditioned stable inversion is studied for slightly nonminimum phase systems whose zero dynam- ics is singularly perturbed, that is, the relative degree is ill-defined. For these systems, we show that there exists an inherent limitation in the bandwidth of a reference trajectory to be tracked when a well-conditioned feedforward input via stable inversion is sought. We assert that, when the violation of this limitation occurs, the so-called reference trajectory redesign is called for. Our analysis results can provide an explicit assessment as well as useful guidance for the reference trajectory redesign if needed. 展开更多
关键词 Nonminimum phase Ill-defined relative degree Stable inversion singularly perturbed zero dynamics
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The Gradient Theory of the Phase Transitions with Dirichlet Boundary Condition
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作者 徐中海 《Northeastern Mathematical Journal》 CSCD 2000年第1期21-35,共15页
In this paper, we study the asymptotic behavior of minimizers (as ε→0) of the variational problems under Dirichlet conditioninf∫ Ω[ε p-1 |Du| p+1εW(x,u)]dx: u∈W 1,p (Ω), u=g, x∈ΩwhereW(x,·) is... In this paper, we study the asymptotic behavior of minimizers (as ε→0) of the variational problems under Dirichlet conditioninf∫ Ω[ε p-1 |Du| p+1εW(x,u)]dx: u∈W 1,p (Ω), u=g, x∈ΩwhereW(x,·) is a nonnegative function with only two zeros α and β. We show that the limit of a sequence of minimizers {u ε} ε>0 (as ε→0) is a solution of another variational problem. 展开更多
关键词 phase transition BV function singular perturbation
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台区三相电压不平衡的主导特征识别及指标构建
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作者 竺炜 黄宁晓 +2 位作者 舒慧莹 胡捷 唐明 《电力科学与技术学报》 北大核心 2025年第2期141-149,共9页
配网台区(变压器)数量巨大,三相不平衡现象普遍。由于台区单相负荷的随机性大,三相电压的各相幅值排序与传统算法的不平衡度都会随时变化。基于采样数据的特征分析,得到各台区三相电压在某时段的主导各相幅值(即有效值)差异,识别严重不... 配网台区(变压器)数量巨大,三相不平衡现象普遍。由于台区单相负荷的随机性大,三相电压的各相幅值排序与传统算法的不平衡度都会随时变化。基于采样数据的特征分析,得到各台区三相电压在某时段的主导各相幅值(即有效值)差异,识别严重不平衡台区,以便人工治理。该方法是平衡成本与效益的可行办法。该文构建了各台区三相电压的时序矩阵,提出了一种基于奇异值分解的各相幅值差异主导特征分析与指标构建方法。研究结果表明:最大奇异值对应的子矩阵是原三相电压时序矩阵的绝对主导成分;从左奇异向量可得到主导各相幅值的排序;由最大奇异值与左奇异向量构建三相主导不平衡度指标。该方法解决了各项幅值排序随时变化的问题,可以唯一确定任选时段的各相幅值。采用算例验证了该不平衡度指标的主导性、唯一性。基于该指标,通过识别-人工治理的滚动循环,可提升并保持配网的整体三相平衡水平。该研究具有较好的实用价值。 展开更多
关键词 配网台区 三相电压不平衡 主导特征 奇异值分解 不平衡度指标
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