Organic electrochemical transistors(OECTs),essential components in bioelectronics,serve as a bridge between biological systems and electronic interfaces by converting ionic signals into electronic currents,making them...Organic electrochemical transistors(OECTs),essential components in bioelectronics,serve as a bridge between biological systems and electronic interfaces by converting ionic signals into electronic currents,making them crucial for applications like implantable biosensors,wearable health monitors,and neuromorphic computing architectures[1,2].Despite their ability to bind directly to biological fluids and tissues,and excellent conformal interfaces with dynamic surfaces such as human skin,due to repeated electrochemical cycling,exposure to environmental factors,and parasitic reactions,OECTs still face persistent stability issues that often manifest as hysteresis in device performance,continuously limiting their potential for long-term bioelectronic applications[3,4].Therefore,addressing this instability is crucial to unlocking the full potential of OECTs in chronic medical monitoring,adaptive biohybrid systems,and energy-efficient neuromorphic hardware.展开更多
CONSPECTUS:The biointerface between biological tissues and electronic devices serves as a medium for matter transport,signal transmission,and energy conversion.However,significant disparities in properties,such as mec...CONSPECTUS:The biointerface between biological tissues and electronic devices serves as a medium for matter transport,signal transmission,and energy conversion.However,significant disparities in properties,such as mechanical modulus and water content,between tissues and electronics,present a key challenge in bioelectronics,leading to biointerface mismatches that severely impact their performance and long-term stability.Organic electrochemical transistors(OECTs),fabricated with soft,hydrophilic organic semiconductors,offer unique advantages,including low operating voltage,high transconductance,and compatibility with aqueous environments.展开更多
Neuromorphic computing targets realizing biomimetic or intelligence systems capable of processing abundant tasks in parallel analogously to our brain,and organic electrochemical transistors(OECTs)that rely on the mixe...Neuromorphic computing targets realizing biomimetic or intelligence systems capable of processing abundant tasks in parallel analogously to our brain,and organic electrochemical transistors(OECTs)that rely on the mixed ionic-electronic synergistic couple possess significant similarity to biological systems for implementing synaptic functions.However,the lack of reliable stretchability for synaptic OECTs,where mechanical deformation occurs,leads to consequent degradation of electrical performance.Herein,we demonstrate stretchable synaptic OECTs by adopting a three-dimensional poly(3-hexylthiophene)(P3HT)/styrene-ethylene-butylene-styrene(SEBS)blend porous elastic film for neuromorphic computing.Such architecture shows the full capability to emulate biological synaptic behaviors.Adjusting the accumulated layer numbers of porous film enables tunable OECT output and hysteresis,resulting in transition in plasticity.Especially,with a trilayer porous film,large-scale conductance and hysteresis are endorsed for efficient mimicking of memory-dependent synapse behavior.Benefitted from the interconnected three-dimensional porous structures,corresponding stretchable synaptic OECTs exhibit excellent mechanical robustness when stretched at a 30%strain,and maintain reliable electrical characteristics after 500 stretching cycles.Furthermore,near-ideal weight updates with near-zero nonlinearities,symmetricity in long-term potentiation(LTP)and depression,and applications for image simulation are validated.This work paves a universal design strategy toward highperformance stretchable neuromorphic computing architecture and could be extended to other flexible/stretchable electronics.展开更多
Organic electrochemical transistors(OECTs)have been hailed as highly sensitive biomolecular sensors among organic electronic devices due to their superior stability in an aqueous environment and high transconductance....Organic electrochemical transistors(OECTs)have been hailed as highly sensitive biomolecular sensors among organic electronic devices due to their superior stability in an aqueous environment and high transconductance.At the same time,plasmon based sensors are known to provide high sensitivity for biosensing due to the highly localized plasmonic field.Here we report a plasmonic OECT(POET)device that synchronizes the advantages of OECTs and plasmonic sensors on a single platform.The platform is fabricated by a simple,cost-effective,and high-throughput nanoimprinting process,which allows plasmonic resonance peak tuning to a given visible wavelength of interest for versatile biosensing.With glucose sensing as proof,a five-times sensitivity enhancement is obtained for POET compared to a regular(non-plasmonic)OECT.Thus,the POET paves the way to a new paradigm of optoelectronic sensors that combines the inherent high sensitivity of OECTs and localized plasmonic field to sense a vast realm of biomolecules.展开更多
Organic field-effect transistors(OFETs) are recently considered to be attractive candidate for bioelectronic applications owing to their prominent biocompatibility,intrinsical flexibility,and potentially low cost asso...Organic field-effect transistors(OFETs) are recently considered to be attractive candidate for bioelectronic applications owing to their prominent biocompatibility,intrinsical flexibility,and potentially low cost associated with their solution processibility.Over the last few years,bioelectronic-application-motivated OFETs have attracted increasing attention towards next generation of biosensors,healthcare elements and artificial neural interfaces.This mini review highlights the basic principles and recent progress in OFET based bioelectronics devices.The key strategies and the forecast perspectives of this research field are also briefly summarized.展开更多
Organic electronics have gained significant attention in the field of biosensors owing to their immense potential for economical,lightweight,and adaptable sensing devices.This review explores the potential of organic ...Organic electronics have gained significant attention in the field of biosensors owing to their immense potential for economical,lightweight,and adaptable sensing devices.This review explores the potential of organic electronics-based biosensors as a revolutionary technology for biosensing applications.The focus is on two types of organic biosensors:organic field effect transistor(OFET)and organic electrochemical transistor(OECT)biosensors.OFET biosensors have found extensive application in glucose,DNA,enzyme,ion,and gas sensing applications,but suffer from limitations related to low sensitivity and selectivity.On the other hand,OECT biosensors have shown superior performance in sensitivity,selectivity,and signal-to-noise ratio,owing to their unique mechanism of operation,which involves the modulation of electrolyte concentration to regulate the conductivity of the active layer.Recent advancements in OECT biosensors have demonstrated their potential for biomedical and environmental sensing,including the detection of neurotransmitters,bacteria,and heavy metals.Overall,the future directions of OFET and OECT biosensors involve overcoming these challenges and developing advanced devices with improved sensitivity,selectivity,reproducibility,and stability.The potential applications span diverse fields including human health,food analysis,and environment monitoring.Continued research and development in organic biosensors hold great promise for significant advancements in sensing technology,opening up new possibilities for biomedical and environmental applications.展开更多
文摘Organic electrochemical transistors(OECTs),essential components in bioelectronics,serve as a bridge between biological systems and electronic interfaces by converting ionic signals into electronic currents,making them crucial for applications like implantable biosensors,wearable health monitors,and neuromorphic computing architectures[1,2].Despite their ability to bind directly to biological fluids and tissues,and excellent conformal interfaces with dynamic surfaces such as human skin,due to repeated electrochemical cycling,exposure to environmental factors,and parasitic reactions,OECTs still face persistent stability issues that often manifest as hysteresis in device performance,continuously limiting their potential for long-term bioelectronic applications[3,4].Therefore,addressing this instability is crucial to unlocking the full potential of OECTs in chronic medical monitoring,adaptive biohybrid systems,and energy-efficient neuromorphic hardware.
基金supported by National Key R&D Program of China(2024YFF0509300)National Natural Science Foundation of China(T2425010).
文摘CONSPECTUS:The biointerface between biological tissues and electronic devices serves as a medium for matter transport,signal transmission,and energy conversion.However,significant disparities in properties,such as mechanical modulus and water content,between tissues and electronics,present a key challenge in bioelectronics,leading to biointerface mismatches that severely impact their performance and long-term stability.Organic electrochemical transistors(OECTs),fabricated with soft,hydrophilic organic semiconductors,offer unique advantages,including low operating voltage,high transconductance,and compatibility with aqueous environments.
基金This work was financially supported by the National Key Research&Development Program of China(No.2022YFE0134800)the National Science Foundation of China(Nos.U21A20492,62275041,and 62273073)+2 种基金the Sichuan Science and Technology Program(Nos.2022YFH0081,2022YFG0012,2022YFG0013,and 2022NSFSC0877)This work was also sponsored by the Sichuan Province Key Laboratory of Display Science and Technology,and Qiantang Science&Technology Innovation CenterW.H.also thanks the financial support of the UESTC Excellent Young Scholar Project。
文摘Neuromorphic computing targets realizing biomimetic or intelligence systems capable of processing abundant tasks in parallel analogously to our brain,and organic electrochemical transistors(OECTs)that rely on the mixed ionic-electronic synergistic couple possess significant similarity to biological systems for implementing synaptic functions.However,the lack of reliable stretchability for synaptic OECTs,where mechanical deformation occurs,leads to consequent degradation of electrical performance.Herein,we demonstrate stretchable synaptic OECTs by adopting a three-dimensional poly(3-hexylthiophene)(P3HT)/styrene-ethylene-butylene-styrene(SEBS)blend porous elastic film for neuromorphic computing.Such architecture shows the full capability to emulate biological synaptic behaviors.Adjusting the accumulated layer numbers of porous film enables tunable OECT output and hysteresis,resulting in transition in plasticity.Especially,with a trilayer porous film,large-scale conductance and hysteresis are endorsed for efficient mimicking of memory-dependent synapse behavior.Benefitted from the interconnected three-dimensional porous structures,corresponding stretchable synaptic OECTs exhibit excellent mechanical robustness when stretched at a 30%strain,and maintain reliable electrical characteristics after 500 stretching cycles.Furthermore,near-ideal weight updates with near-zero nonlinearities,symmetricity in long-term potentiation(LTP)and depression,and applications for image simulation are validated.This work paves a universal design strategy toward highperformance stretchable neuromorphic computing architecture and could be extended to other flexible/stretchable electronics.
基金J.T.acknowledges the National Science Foundation(CAREER:ECCS-1351757)for financial support.
文摘Organic electrochemical transistors(OECTs)have been hailed as highly sensitive biomolecular sensors among organic electronic devices due to their superior stability in an aqueous environment and high transconductance.At the same time,plasmon based sensors are known to provide high sensitivity for biosensing due to the highly localized plasmonic field.Here we report a plasmonic OECT(POET)device that synchronizes the advantages of OECTs and plasmonic sensors on a single platform.The platform is fabricated by a simple,cost-effective,and high-throughput nanoimprinting process,which allows plasmonic resonance peak tuning to a given visible wavelength of interest for versatile biosensing.With glucose sensing as proof,a five-times sensitivity enhancement is obtained for POET compared to a regular(non-plasmonic)OECT.Thus,the POET paves the way to a new paradigm of optoelectronic sensors that combines the inherent high sensitivity of OECTs and localized plasmonic field to sense a vast realm of biomolecules.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB12010000)the National Natural Science Foundation of China(21422310,61571423)
文摘Organic field-effect transistors(OFETs) are recently considered to be attractive candidate for bioelectronic applications owing to their prominent biocompatibility,intrinsical flexibility,and potentially low cost associated with their solution processibility.Over the last few years,bioelectronic-application-motivated OFETs have attracted increasing attention towards next generation of biosensors,healthcare elements and artificial neural interfaces.This mini review highlights the basic principles and recent progress in OFET based bioelectronics devices.The key strategies and the forecast perspectives of this research field are also briefly summarized.
基金Songshan Lake Materials Laboratory 2022SLABFN06the National Natural Science Foundation of China(51902109)+3 种基金Basic Research Program of Guangzhou 202201010546Special Funds for the Cultivation of Guangdong college students’Scientific and Technological Innovation(‘Climbing Program’,pdjh2021b0136)National Nature Science Foundation of China(No.52003091)the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515140155)for financial support.
文摘Organic electronics have gained significant attention in the field of biosensors owing to their immense potential for economical,lightweight,and adaptable sensing devices.This review explores the potential of organic electronics-based biosensors as a revolutionary technology for biosensing applications.The focus is on two types of organic biosensors:organic field effect transistor(OFET)and organic electrochemical transistor(OECT)biosensors.OFET biosensors have found extensive application in glucose,DNA,enzyme,ion,and gas sensing applications,but suffer from limitations related to low sensitivity and selectivity.On the other hand,OECT biosensors have shown superior performance in sensitivity,selectivity,and signal-to-noise ratio,owing to their unique mechanism of operation,which involves the modulation of electrolyte concentration to regulate the conductivity of the active layer.Recent advancements in OECT biosensors have demonstrated their potential for biomedical and environmental sensing,including the detection of neurotransmitters,bacteria,and heavy metals.Overall,the future directions of OFET and OECT biosensors involve overcoming these challenges and developing advanced devices with improved sensitivity,selectivity,reproducibility,and stability.The potential applications span diverse fields including human health,food analysis,and environment monitoring.Continued research and development in organic biosensors hold great promise for significant advancements in sensing technology,opening up new possibilities for biomedical and environmental applications.
