AIM:To describe ocular biometric parameters among Han and Uyghur myopic adults in Xinjiang,China.METHODS:A cross-sectional study was conducted.The different ocular biometric parameters collected using Pentacam were an...AIM:To describe ocular biometric parameters among Han and Uyghur myopic adults in Xinjiang,China.METHODS:A cross-sectional study was conducted.The different ocular biometric parameters collected using Pentacam were analyzed,including corneal curvature,corneal astigmatism(CA),horizontal corneal diameter(white-to-white,WTW),corneal volume(CV),pupil diameter(PD),anterior chamber angle(ACA),anterior chamber depth(ACD),anterior chamber volume(ACV)and axial length(AL).RESULTS:In total,2932 participants were included in the final analysis,comprising 2310 Han and 622 Uyghur adults.Adults in the high myopia(HM)group had steeper K2,larger CA,smaller WTW and longer AL in both the Uyghur and Han adults(all P<0.05).The moderate myopia(MM)and HM group had deeper ACV,ACD and wider ACA than the low myopia(all P<0.05)in Han adults,however there were no differences in anterior chamber indices with Uyghur adults.In the Uyghur adults,we noticed that CV,WTW,and ACD were smaller,ACA was narrower,PD was larger,and AL was shorter(all P<0.05).We also noticed sex differences:males had flatter corneas,deeper ACD and ACV,and larger WTW than females(all P<0.05).In the correlation analysis,WTW was positively correlated with ACD and ACV but negatively correlated with K1,K2 and CV(all P<0.05).Narrower ACA was associated with larger PD(rU=-0.25,rH=-0.16,all P<0.01).CONCLUSION:The Han population have different biometric parameters in eyes with HM compared to the Uyghur population,and the Uyghur population may anatomically more susceptible to primary angle closure glaucoma than the Han population.展开更多
AIM:To assess and compare the variations and agreements across different ocular biometric parameters using swept-source optical coherence tomography(SS-OCT)and Scheimpflug tomography in patients diagnosed with catarac...AIM:To assess and compare the variations and agreements across different ocular biometric parameters using swept-source optical coherence tomography(SS-OCT)and Scheimpflug tomography in patients diagnosed with cataract.METHODS:This prospective case series was conducted at Tianjin Medical University Eye Hospital.In total,212 eyes from 212 patients scheduled for phacoemulsification were included.Eyes were evaluated preoperatively using two SSOCT devices(IOLMaster700 and CASIA2)and Scheimpflug tomography(Pentacam).Central corneal thickness(CCT),anterior chamber depth(ACD),aqueous depth(AQD),white-to-white distance(WTW),flat simulated keratometry(Kf),steep simulated keratometry(Ks),mean keratometry(Km),and total corneal keratometry(TKm)were measured.Intraclass correlation coefficient(ICC),95%confidence intervals(CI)and limits of agreement(LoA)widths were conducted to assess differences and correlations between devices.RESULTS:All parameters,except for Ks,were significantly different.Pairwise comparison revealed no significant differences between keratometry obtained by IOLMaster 700 and Pentacam.LoA widths of all paired comparisons for Ks were>0.80 D.Except for WTW between IOLMaster 700 and CASIA2 and between CASIA2 and Pentacam,other Pearson’s coefficients between devices showed a strong correlation(all r>0.95).The ICC of WTW(ICC=0.438,95%CI 0.167-0.625)showed poor reliability.The reliability of CCT,ACD,and AQD was excellent(all ICC>0.95),whereas that of TKm was good(ICC=0.827,95%CI 0.221-0.939).A significant linear correlation was also observed among devices.CONCLUSION:The ocular parameters derived from the use of IOLMaster700,CASIA2,and Pentacam exhibit significant discrepancies;as such,measurements from these devices should not be deemed as interchangeable.展开更多
AIM:To analyze ocular parameters and refractive status in children aged 3-12y and to explore differences in these parameters across age groups with identical refractive status for studying refractive progression.METHO...AIM:To analyze ocular parameters and refractive status in children aged 3-12y and to explore differences in these parameters across age groups with identical refractive status for studying refractive progression.METHODS:Demographic characteristics,cycloplegic refraction data,and ocular parameters of the participants were collected.Changes in ocular parameters were described according to different age groups.After adjusting for refractive factors,the relationship between age and ocular parameters was explored.Standard regression coefficients(β)obtained from multiple linear regressions were used to compare the magnitude of the effect of age on the parameters and ocular components on refractive power.RESULTS:Data were collected from the right eyes of 1504 participants.Lens thickness(LT)decreased with age,whereas the axial length(AL)and anterior chamber depth(ACD)increased.In the high-hyperopia group,changes in age were only associated with AL and LT.In the low-myopia group,the increase in age was also associated with corneal astigmatism.In the overall model,theβvalue for LT was the highest at 0.41,whereasβfor ACD and AL was significant in all groups except for the high-hyperopia group.Theβvalue of the LT on refractive power in children was slightly greater in the low age group than in the high age group.CONCLUSION:Among children with the same refractive status,the older the age,the longer the axis length and the thinner the lens.The lens affected refractive power in children in the younger age group more than in the older age group.The ocular parameter most affected by age was LT.展开更多
AIM:To compare the changes in preschool refractive status,ocular biological parameters,and higher-order aberrations in children with retinopathy of prematurity(ROP)after retinal laser photocoagulation or anti-vascular...AIM:To compare the changes in preschool refractive status,ocular biological parameters,and higher-order aberrations in children with retinopathy of prematurity(ROP)after retinal laser photocoagulation or anti-vascular endothelial growth factor(anti-VEGF)treatment and explore their underlying factors.METHODS:This observational study involved 118 eyes of 59 children,aged 3 to 6y,with ROP followed up between March 2023 and October 2024.They were divided into the laser,anti-VEGF,and anti-VEGF+laser groups.The laser group received a single session of laser photocoagulation.The anti-VEGF group received a single anti-VEGF treatment.The anti-VEGF+laser group received a single anti-VEGF treatment after birth followed by supplementary laser treatment within 2wk to 6mo.Ocular biological parameters were measured using IOL Master 700 and Pentacam HR.Right-eye higher-order aberrations were measured using the OPD-Scan III.Best-corrected visual acuities(BCVA),refractive statuses,ocular biological parameters,and higherorder aberrations were assessed and compared.Multiple linear regression analysis was conducted to evaluate the relationships among ocular biological parameters,higherorder aberrations,spherical equivalent(SE),and treatment methods.Pearson’s correlation coefficients were used to assess the relationships between the SE and higher-order aberrations.RESULTS:The laser group had a higher incidence of myopia and a lower SE than the anti-VEGF group.The incidence of astigmatism and cylindrical power were significantly lower for the anti-VEGF than for the laser and anti-VEGF+laser groups(P<0.05).The anterior corneal surface astigmatism was higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group.The anterior corneal surface K2 and lens thickness were higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group.The whole-eye higher-order aberration root mean square(RMS)values for the right eye were significantly higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group.The whole-eye trefoil RMS values for the right eye were also significantly higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group(P<0.05).Laser treatment was significantly associated with SE,anterior corneal surface curvature and astigmatism,lens thickness,whole-eye highorder aberrations,and whole-eye trefoil(all P<0.05).CONCLUSION:Children with ROP who received laser treatment have higher myopia and astigmatism than those who received anti-VEGF treatment.Children treated with laser or supplementary laser treatment have higher anterior corneal astigmatism,anterior corneal curvature,thicker lenses,whole-eye higher-order aberrations,and whole-eye trefoil.The cause of myopia in children with ROP after laser treatment is increased anterior corneal surface curvature and lens thickness.展开更多
AIM:To investigate the effects of diode laser treatment on ocular biometric parameters in premature infants with retinopathy of prematurity(ROP).METHODS:Premature infants who received diode laser treatment for ROP(n=6...AIM:To investigate the effects of diode laser treatment on ocular biometric parameters in premature infants with retinopathy of prematurity(ROP).METHODS:Premature infants who received diode laser treatment for ROP(n=68)and premature infants with spontaneous regressed ROP without treatment(n=50)were performed longitudinal ocular biometric measurements including anterior chamber depth,lens thickness and axial length as follows:1 d prior to laser treatment,and 3,6,9,and 12 mo after the laser treatment.RESULTS:The mean birth weight,gestational age and initial examination time values were 936.53±302.07 g,26.66±2.42 wk,36.26±2.73 wk in the treatment group and 959.78±260.08 g,27.28±2.10 wk,36.56±2.54 wk in the control group.There was no statistically significant difference in these demographic characteristics of the groups.Anterior chamber depth,lens thickness and axial length demonstrated statistically significant linear increases during the study period in the two groups(P<0.001 for each).There were no statistically significant differences between the two groups in terms of anterior chamber depth after laser treatment.Measurements of the lens thickness at 9 th and 12 th months(9 th month 3.70±0.22 vs 3.60±0.21 mm,P=0.017;12 th month 3.81±0.21 vs 3.69±0.22 mm,P=0.002)and the axial length at 12 th month(19.35±0.79 vs 19.13±0.54 mm,P=0.031)after laser treatment were statistically higher in the treatment group.CONCLUSION:Diode laser retinal photocoagulation treatment in premature infants seems to increase the lens thickness and axial length.展开更多
AIM:To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.METHODS:In this hospital-based prospective study,410 patients undergoing cataract ...AIM:To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.METHODS:In this hospital-based prospective study,410 patients undergoing cataract surgery(226 Han patients in Tianjin and 184 Uyghur patients in Xinjiang)were enrolled.The differences in axial length(AL),anterior chamber depth(ACD),keratometry[steep K(Ks)and flat K(Kf)],and corneal astigmatism(CA)measured using IOL Master 700 were compared between Han and Uyghur patients.RESULTS:The average age of Han patients was higher than that of Uyghur patients(70.22±8.54 vs 63.04±9.56y,P<0.001).After adjusting for age factors,Han patients had longer AL(23.51±1.05 vs 22.86±0.92 mm,P<0.001),deeper ACD(3.06±0.44 vs 2.97±0.37 mm,P=0.001),greater Kf(43.95±1.40 vs 43.42±1.69 D,P=0.001),steeper Ks(45.00±1.47 vs 44.26±1.71 D,P=0.001),and higher CA(1.04±0.68 vs 0.79±0.65,P=0.025)than Uyghur patients.Intra-ethnic male patients had longer AL,deeper ACD,and lower keratometry than female patients;however,CA between the sexes was almost similar.In the correlation analysis,we observed a positive correlation between AL and ACD in patients of both ethnicities(rHan=0.48,rUyghur=0.44,P<0.001),while AL was negatively correlated with Kf(rHan=-0.42,rUyghur=-0.64,P<0.001)and Ks(rHan=-0.38,rUyghur=-0.66,P<0.001).Additionally,Kf was positively correlated with Ks(rHan=0.89,rUyghur=0.93,P<0.001).CONCLUSION:There are differences in ocular biometric parameters between individuals of Han ethnicity in Tianjin and those of Uyghur ethnicity in Xinjiang undergoing cataract surgery.These ethnic variances can enhance our understanding of ocular diseases related to these parameters and provide guidance for surgical procedures.展开更多
AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python technology.METHODS:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtai...AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python technology.METHODS:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes respectively.The corresponding photo pixels-actual length ratio was acquired by a proportional scale.The edge coordinates were identified artificially by ginput function.Circle and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal view.The curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric principles.Next,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in vitro.The results were compared between in vivo and in vitro.RESULTS:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the keratometer.The horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°respectively.For the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical planes.CONCLUSION:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in Matlab.There are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of binoculus.This study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.展开更多
AIM:To compare relative peripheral refractive errors(RPREs)in Chinese children with and without myopic anisometropia(MAI)and to explore the relationship between RPRE and myopia.METHODS:This observational cross-section...AIM:To compare relative peripheral refractive errors(RPREs)in Chinese children with and without myopic anisometropia(MAI)and to explore the relationship between RPRE and myopia.METHODS:This observational cross-sectional study included 160 children divided into two groups according to the interocular spherical equivalent refraction(SER)difference≥1.0 D in the MAI group(n=80)and<1.0 D in the non-MAI group(n=80).The MAI group was further divided into two subgroups:ΔSER<2.0 D group and ΔSER≥2.0 D group.Basic ocular biometric parameters of axial length(AL),average keratometry(Ave K),cylinder(CYL),surface regularity index(SRI),and surface asymmetry index(SAI)were recorded.In addition,multispectral refraction topography was performed to measure RPRE,and the parameters were recorded as total refraction difference value(TRDV),refraction difference value(RDV)0-10,RDV10-20,RDV20-30,RDV30-40,RDV40-53,RDV-superior(RDV-S),RDV-inferior(RDV-I),RDV-temporal(RDV-T)and RDV-nasal(RDV-N).RESULTS:In the non-MAI group,the interocular differences of all parameters of RPRE were not significant.In the MAI group,the interocular differences of TRDV,RDV10-53,RDV-S,RDV-I,RDV-T,and RDV-N were significant.In subgroup analysis,the interocular differences of TRDV,RDV30-53,RDV-I,and RDV-T were significant in ΔSER<2.0 D group and ΔSER≥2.0 D group,but the interocular differences of RDV10-30,RDV-S and RDV-N were only significant in the ΔSER≥2.0 D group.In correlation analysis,ΔTRDV,ΔRDV 10-53,ΔRDV-S,and ΔRDV-N were negatively correlated with ΔSER but positively correlated with ΔAL.CONCLUSION:The more myopic eyes have larger hyperopic RPRE in Chinese children with MAI in certain retinal range,and partialΔRPRE is closely associated with ΔSER and ΔAL.展开更多
To the Editor:The prevalence of high myopia(HM)has been increasing globally,particularly in the young Chinese population.[1]Most early investigations on ocular biometric parameters in myopic individuals focused primar...To the Editor:The prevalence of high myopia(HM)has been increasing globally,particularly in the young Chinese population.[1]Most early investigations on ocular biometric parameters in myopic individuals focused primarily on children,adolescents,and elderly individuals with cataracts,leaving a dearth of research on ocular biometric parameters among young adults with HM.Additionally,the associations between ocular biometric parameters and axial length(AL)in individuals with HM are unclear.[2,3]Therefore,understanding the ocular biometric characteristics of young Chinese individuals with HM and their correlations with AL is crucial.展开更多
Despite an increasing number of researches focused on the photo-biological effects of lighting on visual and nonvisual health,insights into the phosphor-free white LED lamps with different spectral power distributions...Despite an increasing number of researches focused on the photo-biological effects of lighting on visual and nonvisual health,insights into the phosphor-free white LED lamps with different spectral power distributions remain unclear.In this study,human factors experiments were conducted with 30 participants.Variations in ocular physiological parameters and melatonin circadian rhythms were assessed for participants in an ordinary lamp,a fullspectrum lamp,and four phosphor-free white LED lamps rich in the 535–589 nm yellow-green light.It was observed that ocular functions exhibited significantly higher improvements under the four phosphor-free LED lamps compared to the ordinary and full-spectrum lamps,indicating the advantageous effects of phosphor-free lamps rich in the 535–589 nm yellow-green light on both visual and non-visual health.展开更多
基金Supported by the National Natural Science Foundation of China(No.81960181).
文摘AIM:To describe ocular biometric parameters among Han and Uyghur myopic adults in Xinjiang,China.METHODS:A cross-sectional study was conducted.The different ocular biometric parameters collected using Pentacam were analyzed,including corneal curvature,corneal astigmatism(CA),horizontal corneal diameter(white-to-white,WTW),corneal volume(CV),pupil diameter(PD),anterior chamber angle(ACA),anterior chamber depth(ACD),anterior chamber volume(ACV)and axial length(AL).RESULTS:In total,2932 participants were included in the final analysis,comprising 2310 Han and 622 Uyghur adults.Adults in the high myopia(HM)group had steeper K2,larger CA,smaller WTW and longer AL in both the Uyghur and Han adults(all P<0.05).The moderate myopia(MM)and HM group had deeper ACV,ACD and wider ACA than the low myopia(all P<0.05)in Han adults,however there were no differences in anterior chamber indices with Uyghur adults.In the Uyghur adults,we noticed that CV,WTW,and ACD were smaller,ACA was narrower,PD was larger,and AL was shorter(all P<0.05).We also noticed sex differences:males had flatter corneas,deeper ACD and ACV,and larger WTW than females(all P<0.05).In the correlation analysis,WTW was positively correlated with ACD and ACV but negatively correlated with K1,K2 and CV(all P<0.05).Narrower ACA was associated with larger PD(rU=-0.25,rH=-0.16,all P<0.01).CONCLUSION:The Han population have different biometric parameters in eyes with HM compared to the Uyghur population,and the Uyghur population may anatomically more susceptible to primary angle closure glaucoma than the Han population.
基金Supported by Tianjin Key Medical Discipline (Specialty) Construction Project (No.TJYXZDXK-037A)Weifang Science and Technology Bureau Project (No.2020YX065).
文摘AIM:To assess and compare the variations and agreements across different ocular biometric parameters using swept-source optical coherence tomography(SS-OCT)and Scheimpflug tomography in patients diagnosed with cataract.METHODS:This prospective case series was conducted at Tianjin Medical University Eye Hospital.In total,212 eyes from 212 patients scheduled for phacoemulsification were included.Eyes were evaluated preoperatively using two SSOCT devices(IOLMaster700 and CASIA2)and Scheimpflug tomography(Pentacam).Central corneal thickness(CCT),anterior chamber depth(ACD),aqueous depth(AQD),white-to-white distance(WTW),flat simulated keratometry(Kf),steep simulated keratometry(Ks),mean keratometry(Km),and total corneal keratometry(TKm)were measured.Intraclass correlation coefficient(ICC),95%confidence intervals(CI)and limits of agreement(LoA)widths were conducted to assess differences and correlations between devices.RESULTS:All parameters,except for Ks,were significantly different.Pairwise comparison revealed no significant differences between keratometry obtained by IOLMaster 700 and Pentacam.LoA widths of all paired comparisons for Ks were>0.80 D.Except for WTW between IOLMaster 700 and CASIA2 and between CASIA2 and Pentacam,other Pearson’s coefficients between devices showed a strong correlation(all r>0.95).The ICC of WTW(ICC=0.438,95%CI 0.167-0.625)showed poor reliability.The reliability of CCT,ACD,and AQD was excellent(all ICC>0.95),whereas that of TKm was good(ICC=0.827,95%CI 0.221-0.939).A significant linear correlation was also observed among devices.CONCLUSION:The ocular parameters derived from the use of IOLMaster700,CASIA2,and Pentacam exhibit significant discrepancies;as such,measurements from these devices should not be deemed as interchangeable.
基金Supported by the National Natural Science Foundation of China(No.82171093).
文摘AIM:To analyze ocular parameters and refractive status in children aged 3-12y and to explore differences in these parameters across age groups with identical refractive status for studying refractive progression.METHODS:Demographic characteristics,cycloplegic refraction data,and ocular parameters of the participants were collected.Changes in ocular parameters were described according to different age groups.After adjusting for refractive factors,the relationship between age and ocular parameters was explored.Standard regression coefficients(β)obtained from multiple linear regressions were used to compare the magnitude of the effect of age on the parameters and ocular components on refractive power.RESULTS:Data were collected from the right eyes of 1504 participants.Lens thickness(LT)decreased with age,whereas the axial length(AL)and anterior chamber depth(ACD)increased.In the high-hyperopia group,changes in age were only associated with AL and LT.In the low-myopia group,the increase in age was also associated with corneal astigmatism.In the overall model,theβvalue for LT was the highest at 0.41,whereasβfor ACD and AL was significant in all groups except for the high-hyperopia group.Theβvalue of the LT on refractive power in children was slightly greater in the low age group than in the high age group.CONCLUSION:Among children with the same refractive status,the older the age,the longer the axis length and the thinner the lens.The lens affected refractive power in children in the younger age group more than in the older age group.The ocular parameter most affected by age was LT.
基金Supported by Key Research and Development Program of Shaanxi Province(No.2024SF-YBXM-320)the Clinical Research Project of the Fourth Military Medical University(No.2022LC2247)Medical Staff Training Boosting Project of Xijing Hospital,Air Force Medical University(No.XJZT24CY52).
文摘AIM:To compare the changes in preschool refractive status,ocular biological parameters,and higher-order aberrations in children with retinopathy of prematurity(ROP)after retinal laser photocoagulation or anti-vascular endothelial growth factor(anti-VEGF)treatment and explore their underlying factors.METHODS:This observational study involved 118 eyes of 59 children,aged 3 to 6y,with ROP followed up between March 2023 and October 2024.They were divided into the laser,anti-VEGF,and anti-VEGF+laser groups.The laser group received a single session of laser photocoagulation.The anti-VEGF group received a single anti-VEGF treatment.The anti-VEGF+laser group received a single anti-VEGF treatment after birth followed by supplementary laser treatment within 2wk to 6mo.Ocular biological parameters were measured using IOL Master 700 and Pentacam HR.Right-eye higher-order aberrations were measured using the OPD-Scan III.Best-corrected visual acuities(BCVA),refractive statuses,ocular biological parameters,and higherorder aberrations were assessed and compared.Multiple linear regression analysis was conducted to evaluate the relationships among ocular biological parameters,higherorder aberrations,spherical equivalent(SE),and treatment methods.Pearson’s correlation coefficients were used to assess the relationships between the SE and higher-order aberrations.RESULTS:The laser group had a higher incidence of myopia and a lower SE than the anti-VEGF group.The incidence of astigmatism and cylindrical power were significantly lower for the anti-VEGF than for the laser and anti-VEGF+laser groups(P<0.05).The anterior corneal surface astigmatism was higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group.The anterior corneal surface K2 and lens thickness were higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group.The whole-eye higher-order aberration root mean square(RMS)values for the right eye were significantly higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group.The whole-eye trefoil RMS values for the right eye were also significantly higher for the laser and anti-VEGF+laser groups than for the anti-VEGF group(P<0.05).Laser treatment was significantly associated with SE,anterior corneal surface curvature and astigmatism,lens thickness,whole-eye highorder aberrations,and whole-eye trefoil(all P<0.05).CONCLUSION:Children with ROP who received laser treatment have higher myopia and astigmatism than those who received anti-VEGF treatment.Children treated with laser or supplementary laser treatment have higher anterior corneal astigmatism,anterior corneal curvature,thicker lenses,whole-eye higher-order aberrations,and whole-eye trefoil.The cause of myopia in children with ROP after laser treatment is increased anterior corneal surface curvature and lens thickness.
文摘AIM:To investigate the effects of diode laser treatment on ocular biometric parameters in premature infants with retinopathy of prematurity(ROP).METHODS:Premature infants who received diode laser treatment for ROP(n=68)and premature infants with spontaneous regressed ROP without treatment(n=50)were performed longitudinal ocular biometric measurements including anterior chamber depth,lens thickness and axial length as follows:1 d prior to laser treatment,and 3,6,9,and 12 mo after the laser treatment.RESULTS:The mean birth weight,gestational age and initial examination time values were 936.53±302.07 g,26.66±2.42 wk,36.26±2.73 wk in the treatment group and 959.78±260.08 g,27.28±2.10 wk,36.56±2.54 wk in the control group.There was no statistically significant difference in these demographic characteristics of the groups.Anterior chamber depth,lens thickness and axial length demonstrated statistically significant linear increases during the study period in the two groups(P<0.001 for each).There were no statistically significant differences between the two groups in terms of anterior chamber depth after laser treatment.Measurements of the lens thickness at 9 th and 12 th months(9 th month 3.70±0.22 vs 3.60±0.21 mm,P=0.017;12 th month 3.81±0.21 vs 3.69±0.22 mm,P=0.002)and the axial length at 12 th month(19.35±0.79 vs 19.13±0.54 mm,P=0.031)after laser treatment were statistically higher in the treatment group.CONCLUSION:Diode laser retinal photocoagulation treatment in premature infants seems to increase the lens thickness and axial length.
基金Supported by Tianjin Higher Education Commission Science and Technology Development Fund Project(No.2022ZD057)Tianjin Binhai New Area Health Commission Science and Technology Project(No.2022BWKZ003)+4 种基金Tianjin Key Laboratory of Retinal Function and Disease Open Project(No.2021tjswmm002)Tianjin Health Researh(No.TJWJ2023ZD002)General Project of Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2020D01A06)Special Fund for Youth of Clinical Research Center in Tianjin Medical University Eye Hospital(No.2020QN02)Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-037A)。
文摘AIM:To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.METHODS:In this hospital-based prospective study,410 patients undergoing cataract surgery(226 Han patients in Tianjin and 184 Uyghur patients in Xinjiang)were enrolled.The differences in axial length(AL),anterior chamber depth(ACD),keratometry[steep K(Ks)and flat K(Kf)],and corneal astigmatism(CA)measured using IOL Master 700 were compared between Han and Uyghur patients.RESULTS:The average age of Han patients was higher than that of Uyghur patients(70.22±8.54 vs 63.04±9.56y,P<0.001).After adjusting for age factors,Han patients had longer AL(23.51±1.05 vs 22.86±0.92 mm,P<0.001),deeper ACD(3.06±0.44 vs 2.97±0.37 mm,P=0.001),greater Kf(43.95±1.40 vs 43.42±1.69 D,P=0.001),steeper Ks(45.00±1.47 vs 44.26±1.71 D,P=0.001),and higher CA(1.04±0.68 vs 0.79±0.65,P=0.025)than Uyghur patients.Intra-ethnic male patients had longer AL,deeper ACD,and lower keratometry than female patients;however,CA between the sexes was almost similar.In the correlation analysis,we observed a positive correlation between AL and ACD in patients of both ethnicities(rHan=0.48,rUyghur=0.44,P<0.001),while AL was negatively correlated with Kf(rHan=-0.42,rUyghur=-0.64,P<0.001)and Ks(rHan=-0.38,rUyghur=-0.66,P<0.001).Additionally,Kf was positively correlated with Ks(rHan=0.89,rUyghur=0.93,P<0.001).CONCLUSION:There are differences in ocular biometric parameters between individuals of Han ethnicity in Tianjin and those of Uyghur ethnicity in Xinjiang undergoing cataract surgery.These ethnic variances can enhance our understanding of ocular diseases related to these parameters and provide guidance for surgical procedures.
基金Supported by the National Natural Science Foundation of China(No.81400428)Self-selected Projects of Shanghai Children’s Hospital(No.2020R124)Shanghai Children’s Hospital Hospital-level Project Clinical Research Cultivation Special Focus Project(No.2021YLYZ03).
文摘AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python technology.METHODS:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes respectively.The corresponding photo pixels-actual length ratio was acquired by a proportional scale.The edge coordinates were identified artificially by ginput function.Circle and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal view.The curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric principles.Next,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in vitro.The results were compared between in vivo and in vitro.RESULTS:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the keratometer.The horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°respectively.For the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical planes.CONCLUSION:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in Matlab.There are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of binoculus.This study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.
文摘AIM:To compare relative peripheral refractive errors(RPREs)in Chinese children with and without myopic anisometropia(MAI)and to explore the relationship between RPRE and myopia.METHODS:This observational cross-sectional study included 160 children divided into two groups according to the interocular spherical equivalent refraction(SER)difference≥1.0 D in the MAI group(n=80)and<1.0 D in the non-MAI group(n=80).The MAI group was further divided into two subgroups:ΔSER<2.0 D group and ΔSER≥2.0 D group.Basic ocular biometric parameters of axial length(AL),average keratometry(Ave K),cylinder(CYL),surface regularity index(SRI),and surface asymmetry index(SAI)were recorded.In addition,multispectral refraction topography was performed to measure RPRE,and the parameters were recorded as total refraction difference value(TRDV),refraction difference value(RDV)0-10,RDV10-20,RDV20-30,RDV30-40,RDV40-53,RDV-superior(RDV-S),RDV-inferior(RDV-I),RDV-temporal(RDV-T)and RDV-nasal(RDV-N).RESULTS:In the non-MAI group,the interocular differences of all parameters of RPRE were not significant.In the MAI group,the interocular differences of TRDV,RDV10-53,RDV-S,RDV-I,RDV-T,and RDV-N were significant.In subgroup analysis,the interocular differences of TRDV,RDV30-53,RDV-I,and RDV-T were significant in ΔSER<2.0 D group and ΔSER≥2.0 D group,but the interocular differences of RDV10-30,RDV-S and RDV-N were only significant in the ΔSER≥2.0 D group.In correlation analysis,ΔTRDV,ΔRDV 10-53,ΔRDV-S,and ΔRDV-N were negatively correlated with ΔSER but positively correlated with ΔAL.CONCLUSION:The more myopic eyes have larger hyperopic RPRE in Chinese children with MAI in certain retinal range,and partialΔRPRE is closely associated with ΔSER and ΔAL.
基金supported by the Science and Technology Innovation Program of Socialization Investment of Hunan Province(No.2020SKC2002).
文摘To the Editor:The prevalence of high myopia(HM)has been increasing globally,particularly in the young Chinese population.[1]Most early investigations on ocular biometric parameters in myopic individuals focused primarily on children,adolescents,and elderly individuals with cataracts,leaving a dearth of research on ocular biometric parameters among young adults with HM.Additionally,the associations between ocular biometric parameters and axial length(AL)in individuals with HM are unclear.[2,3]Therefore,understanding the ocular biometric characteristics of young Chinese individuals with HM and their correlations with AL is crucial.
基金the National Key Research and Development Program(Grant 2023YFF0613001)the Presidential Foundation of China National Institute of Standardization(Grant 512024Y-11446)+1 种基金the National Natural Science Foundation of China(Grant 62074072,Grant 62031011,Grant 62264009)the Key Research and Development Program in Jiangxi Province(Grant 20224BBC31004).
文摘Despite an increasing number of researches focused on the photo-biological effects of lighting on visual and nonvisual health,insights into the phosphor-free white LED lamps with different spectral power distributions remain unclear.In this study,human factors experiments were conducted with 30 participants.Variations in ocular physiological parameters and melatonin circadian rhythms were assessed for participants in an ordinary lamp,a fullspectrum lamp,and four phosphor-free white LED lamps rich in the 535–589 nm yellow-green light.It was observed that ocular functions exhibited significantly higher improvements under the four phosphor-free LED lamps compared to the ordinary and full-spectrum lamps,indicating the advantageous effects of phosphor-free lamps rich in the 535–589 nm yellow-green light on both visual and non-visual health.
