Retinal diseases are a serious threat to human visual health and their early diagnosis is crucial.Currently,most of the retinal disease diagnostic algorithms are based on a single imaging modality of fundus color phot...Retinal diseases are a serious threat to human visual health and their early diagnosis is crucial.Currently,most of the retinal disease diagnostic algorithms are based on a single imaging modality of fundus color photography(FCP)or optical coherence tomography(OCT).These methods can only reflect retinal diseases to a certain extent,ignoring the speci ficity of modalities between different imaging modalities.In this research,a newmulti-scale feature fusion network(MSFF-Net)model for multi-modal retinal image diagnosis is proposed.The MSFF-Net model employs a dualbranch architecture design,enabling efficient learning and extraction of multi-modal feature information related to retinal diseases from CFP and OCT images.MSFF-Net improves disease diagnosis by combining multi-scale features of CFP and OCT images.When evaluated on challenging datasets,the model achieved an accuracy of 95.00%and an F1-score of 95.24%for retinal disease diagnosis.Even under low-quality dataset conditions,it maintained robust performance,with diagnostic accuracy and F1-scores of 71.50%and 71.73%,respectively.In addition,the MSFFNet model outperformed eight state-of-the-art single and multi-modal models in the comparison experiments.The proposed MSFF-Net model provides ophthalmologists with a more accurate and efficient diagnostic pathway that helps them detect and treat retinal diseases earlier.展开更多
Strained bridged rings bicyclo[3.2.1]octane and tricyclo[3.2.1.0^(2,7)]octane are prevalent in natural products known for their significant biological activities.However,strategies for efficiently synthesizing these c...Strained bridged rings bicyclo[3.2.1]octane and tricyclo[3.2.1.0^(2,7)]octane are prevalent in natural products known for their significant biological activities.However,strategies for efficiently synthesizing these complex frameworks from simple starting materials via de novo synthesis remain underexplored.This article presents an efficient strategy that combines phosphine catalysis and photocatalysis to execute a stepwise tandem reaction involving allenoates and α-cyano cinnamaldehydes,including[3+2]cyclization,[5+2]cyclization,acyl transfer,and decarboxylation reactions,synthesizing a series of functional bicyclo[3.2.1]octa-2,6-diene and tricyclo[3.2.1.0^(2,7)]oct-3-ene skeleton derivatives with excellent chemoselectivity demonstrated throughout the process.Meanwhile,the reaction can also be performed via a onepot,scalable phosphine/photocatalytic cascade process,efficiently yielding the bridged products which can serve as versatile intermediates for further applications.展开更多
目的:研究康柏西普对视网膜静脉阻塞性黄斑水肿(RVO-ME)患者不同光学相干断层扫描(OCT)生物标记物的影响,并分析其变化与视力预后的关系。方法:回顾性研究,收集2023年1月至2024年12月我院收治的RVO-ME患者57例57眼,其中视网膜中央静脉阻...目的:研究康柏西普对视网膜静脉阻塞性黄斑水肿(RVO-ME)患者不同光学相干断层扫描(OCT)生物标记物的影响,并分析其变化与视力预后的关系。方法:回顾性研究,收集2023年1月至2024年12月我院收治的RVO-ME患者57例57眼,其中视网膜中央静脉阻塞(CRVO)组25例25眼,视网膜分支静脉阻塞(BRVO)组32例32眼,所有患者均接受玻璃体腔注射康柏西普治疗(每月1次,共3次)。比较手术前后最佳矫正视力(BCVA),不同OCT生物标记物的变化包括中央黄斑厚度(CMT)、视网膜内层结构紊乱(DRIL)的长度、高反射点(HRD)数量、视网膜内积液(IRF)、视网膜下积液(SRF)面积、椭圆体带(EZ)断裂的长度,并分析不同OCT生物标记物的变化与BCVA的关系。结果:与术前相比,术后3 mo BCVA(LogMAR)改善、CMT下降、DRIL长度缩短、HRD数量减少、IRF面积下降、SRF面积降低、EZ中断长度缩短(均P<0.05)。Spearman相关性分析表明:手术前后CMT、DRIL长度、HRD数量、IRF面积、SRF面积变化与BCVA变化均无相关性(P>0.05),但EZ中断长度的变化与BCVA变化呈正相关(rs=0.34,P=0.011),EZ断裂长度的变化与BCVA变化的拟合曲线R^(2)=0.113,P=0.011。CRVO组和BRVO组患者手术前后BCVA、DRIL长度、HRD数量、IRF面积、SRF面积、EZ中断长度变化量比较均无差异(均P>0.05),CMT变化量比较有差异(P=0.002)。结论:康柏西普可有效改善RVO-ME患者的多种OCT生物标记物,其中EZ中断修复是视力恢复的关键驱动因素,其稳定性可作为抗血管内皮生长因子治疗个体化决策的新指标。展开更多
基金supported by the National Natural Science Foundation of China(Nos.82472104 and U24B2053)the Natural Science Basic Research Program of Shaanxi(No.2025JC-JCQN-023)+2 种基金the Key Core Technology Research and Development of Shaanxi(No.2024QY2-GJHX-03)the Innovation Capability Support Program of Shaanxi(Program No.2023-CX-TD-54)the Xidian University Specially Funded Project for Interdisciplinary Exploration(No.TZJHF202510).
文摘Retinal diseases are a serious threat to human visual health and their early diagnosis is crucial.Currently,most of the retinal disease diagnostic algorithms are based on a single imaging modality of fundus color photography(FCP)or optical coherence tomography(OCT).These methods can only reflect retinal diseases to a certain extent,ignoring the speci ficity of modalities between different imaging modalities.In this research,a newmulti-scale feature fusion network(MSFF-Net)model for multi-modal retinal image diagnosis is proposed.The MSFF-Net model employs a dualbranch architecture design,enabling efficient learning and extraction of multi-modal feature information related to retinal diseases from CFP and OCT images.MSFF-Net improves disease diagnosis by combining multi-scale features of CFP and OCT images.When evaluated on challenging datasets,the model achieved an accuracy of 95.00%and an F1-score of 95.24%for retinal disease diagnosis.Even under low-quality dataset conditions,it maintained robust performance,with diagnostic accuracy and F1-scores of 71.50%and 71.73%,respectively.In addition,the MSFFNet model outperformed eight state-of-the-art single and multi-modal models in the comparison experiments.The proposed MSFF-Net model provides ophthalmologists with a more accurate and efficient diagnostic pathway that helps them detect and treat retinal diseases earlier.
基金financial support from National Natural Science Foundation of China(Nos.82374020 and 22401025)Science&Technology Department of Sichuan Province(No.2024NSFTD0023)Xinglin Scholar Research Promotion Project of Chengdu University of TCM。
文摘Strained bridged rings bicyclo[3.2.1]octane and tricyclo[3.2.1.0^(2,7)]octane are prevalent in natural products known for their significant biological activities.However,strategies for efficiently synthesizing these complex frameworks from simple starting materials via de novo synthesis remain underexplored.This article presents an efficient strategy that combines phosphine catalysis and photocatalysis to execute a stepwise tandem reaction involving allenoates and α-cyano cinnamaldehydes,including[3+2]cyclization,[5+2]cyclization,acyl transfer,and decarboxylation reactions,synthesizing a series of functional bicyclo[3.2.1]octa-2,6-diene and tricyclo[3.2.1.0^(2,7)]oct-3-ene skeleton derivatives with excellent chemoselectivity demonstrated throughout the process.Meanwhile,the reaction can also be performed via a onepot,scalable phosphine/photocatalytic cascade process,efficiently yielding the bridged products which can serve as versatile intermediates for further applications.
文摘目的:研究康柏西普对视网膜静脉阻塞性黄斑水肿(RVO-ME)患者不同光学相干断层扫描(OCT)生物标记物的影响,并分析其变化与视力预后的关系。方法:回顾性研究,收集2023年1月至2024年12月我院收治的RVO-ME患者57例57眼,其中视网膜中央静脉阻塞(CRVO)组25例25眼,视网膜分支静脉阻塞(BRVO)组32例32眼,所有患者均接受玻璃体腔注射康柏西普治疗(每月1次,共3次)。比较手术前后最佳矫正视力(BCVA),不同OCT生物标记物的变化包括中央黄斑厚度(CMT)、视网膜内层结构紊乱(DRIL)的长度、高反射点(HRD)数量、视网膜内积液(IRF)、视网膜下积液(SRF)面积、椭圆体带(EZ)断裂的长度,并分析不同OCT生物标记物的变化与BCVA的关系。结果:与术前相比,术后3 mo BCVA(LogMAR)改善、CMT下降、DRIL长度缩短、HRD数量减少、IRF面积下降、SRF面积降低、EZ中断长度缩短(均P<0.05)。Spearman相关性分析表明:手术前后CMT、DRIL长度、HRD数量、IRF面积、SRF面积变化与BCVA变化均无相关性(P>0.05),但EZ中断长度的变化与BCVA变化呈正相关(rs=0.34,P=0.011),EZ断裂长度的变化与BCVA变化的拟合曲线R^(2)=0.113,P=0.011。CRVO组和BRVO组患者手术前后BCVA、DRIL长度、HRD数量、IRF面积、SRF面积、EZ中断长度变化量比较均无差异(均P>0.05),CMT变化量比较有差异(P=0.002)。结论:康柏西普可有效改善RVO-ME患者的多种OCT生物标记物,其中EZ中断修复是视力恢复的关键驱动因素,其稳定性可作为抗血管内皮生长因子治疗个体化决策的新指标。
