Dear Editor,Choroidal vascular occlusion is a rare finding. Choroidal perfusion disorders may range from focal infarction of the choriocapillaris to fibrinoid arteriolar necrosis. Vascular occlusion due to microemboli...Dear Editor,Choroidal vascular occlusion is a rare finding. Choroidal perfusion disorders may range from focal infarction of the choriocapillaris to fibrinoid arteriolar necrosis. Vascular occlusion due to microembolism is more common in choroidal than in retinal vasculature. Due to its unique hemodynamic characteristics, which involve one of the highest rates of blood flow in the body and the fact that it is functionally an end artery system, the choroidal circulation is prone to platelet emboli associated with cardiovascular disease and other pathologies with increased risk of microembolismt.展开更多
AIM：To determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys.METHODS：One or two temporal vortex veins were occluded in 8 cynomolgus monkeys.Fluorescein angiography（FA）,indoc...AIM：To determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys.METHODS：One or two temporal vortex veins were occluded in 8 cynomolgus monkeys.Fluorescein angiography（FA）,indocyanine green angiogram（ICGA）,and enhanced-depth imaging optical coherence tomography（EDI-OCT）were performed preoperatively and at 1d,1,4,8 and 12wk after occlusion.EDI-OCT images were binarized to calculate the choroid vascular index（CVI）.RESULTS：ICGA showed delayed filling of choroidal arteries in occluded quadrants in eyes with two occluded temporal vortex veins within 1wk.The thickness of the superotemporal choroid increased 1d and 4wk after occlusion,the thickness of the superonasal and inferonasal choroid increased 12wk after occlusion,and the CVI of the superonasal quadrant increased 8wk after occlusion in eyes with 2 occluded vortex veins. CONCLUSION：Occlusion of two vortex veins leads to hemodynamic and structural changes in choroidal layers in the acute phase,while autoregulation may play the main role in the long term.Occlusion of one vortex vein has little influence on the hemodynamic and structural status of the choroid.展开更多
文摘Dear Editor,Choroidal vascular occlusion is a rare finding. Choroidal perfusion disorders may range from focal infarction of the choriocapillaris to fibrinoid arteriolar necrosis. Vascular occlusion due to microembolism is more common in choroidal than in retinal vasculature. Due to its unique hemodynamic characteristics, which involve one of the highest rates of blood flow in the body and the fact that it is functionally an end artery system, the choroidal circulation is prone to platelet emboli associated with cardiovascular disease and other pathologies with increased risk of microembolismt.
基金Supported by National Natural Science Foundation of China(No.81670879)
文摘AIM：To determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys.METHODS：One or two temporal vortex veins were occluded in 8 cynomolgus monkeys.Fluorescein angiography（FA）,indocyanine green angiogram（ICGA）,and enhanced-depth imaging optical coherence tomography（EDI-OCT）were performed preoperatively and at 1d,1,4,8 and 12wk after occlusion.EDI-OCT images were binarized to calculate the choroid vascular index（CVI）.RESULTS：ICGA showed delayed filling of choroidal arteries in occluded quadrants in eyes with two occluded temporal vortex veins within 1wk.The thickness of the superotemporal choroid increased 1d and 4wk after occlusion,the thickness of the superonasal and inferonasal choroid increased 12wk after occlusion,and the CVI of the superonasal quadrant increased 8wk after occlusion in eyes with 2 occluded vortex veins. CONCLUSION：Occlusion of two vortex veins leads to hemodynamic and structural changes in choroidal layers in the acute phase,while autoregulation may play the main role in the long term.Occlusion of one vortex vein has little influence on the hemodynamic and structural status of the choroid.
