A minimal system-plus-reservoir model yielding a nonergodic Langevin equation is proposed, which originates from the cubic-spectral density of environmental oscillators and momentum-dependent coupling. This model allo...A minimal system-plus-reservoir model yielding a nonergodic Langevin equation is proposed, which originates from the cubic-spectral density of environmental oscillators and momentum-dependent coupling. This model allows ballistic diffusion and classical localization simultaneously, in which the fluctuation-dissipation relation is still satisfied but the Khinchin theorem is broken. The asymptotical equilibrium for a nonergodic system requires the initial thermal equilibrium, however, when the system starts from nonthermal conditions, it does not approach the equilibration even though a nonlinear potential is used to bound the particle, this can be confirmed by the zerotb law of thermodynamics. In the dynamics of Brownian localization, due to the memory damping function inducing a constant term, our results show that the stationary distribution of the system depends on its initial preparation of coordinate rather than momentum. The coupled oscillator chain with a fixed end boundary acts as a heat bath, which has long been used in studies of collinear atom/solid-surface scattering and lattice vibration, we investigate this problem from the viewpoint of nonergodicity.展开更多
Objective To study the function of focal adhesion kinase （FAK） in the formation of hypertrophic scar and its interrelationship with integrin α1. Methods Original fibroblasts from human hypertrophic scar and human n...Objective To study the function of focal adhesion kinase （FAK） in the formation of hypertrophic scar and its interrelationship with integrin α1. Methods Original fibroblasts from human hypertrophic scar and human normal dermis were cultured, and immunocytochemistry was applied to detect localization of expres- sion of FAK and integrin α1 in hypertrophic scar and human normal skin fibroblasts. The expression of integrin α1 was detected before and after FAK antibody blocking hypertrophic scar fibroblasts （HSFB） 48 h later. Meanwhile the collagen synthesis was evaluated by [^3 H]-proline incorporation and HSFB cell proliferation was measured by MTT method. Results The expression of FAK and integrin aI of hypertrophic scar fibroblasts was higher than that of the normal skin fibroblasts significantly （ P 〈 0.01 ）. The expression of integrin α1 was reduced after FAK being blocked （ P 〈 0.01 ）. Meanwhile the collagen synthesis of human scar-derived fibroblasts by [^3H] -proline incor- poration was depressed respectively （ P 〈 0. 01 ）. The cell proliferation was inhibited by using 1：100 and 1：200 FAK antibody with MTI＂ method （ P 〈 0. 01 ）. Conclusion FAK is the key point of signal transmission pathway mediated by integrin α1 , which regulates protein synthesis of integrin α1 , it may play an important role in the proliferation and constriction of hypertrophic scar. FAK antibody can inhibit the collagen synthesis and cell proliferation of hypertrophic scar fibroblasts.展开更多
An algorithm for face description and recognition based on multi-resolution with multi-scale local binary pattern （multi-LBP） features is proposed. The facial image pyramid is constructed and each facial image is di...An algorithm for face description and recognition based on multi-resolution with multi-scale local binary pattern （multi-LBP） features is proposed. The facial image pyramid is constructed and each facial image is divided into various regions from which partial and holistic local binary patter （LBP） histograms are extracted. All LBP features of each image are concatenated to a single LBP eigenvector with different resolutions. The dimensionaUty of LBP features is then reduced by a local margin alignment （LMA） algorithm based on manifold, which can preserve the between-class variance. Support vector machine （SVM） is applied to classify facial images. Extensive experiments on ORL and CMU face databases clearly show the superiority of the proposed scheme over some existed algorithms, especially on the robustness of the method against different facial expressions and postures of the subjects.展开更多
Effects of two important factors on earthquake response of high arch dams are considered and combined into one program.These tactors are:effects of radiation damping of the infinite canyon and local non-linearity of t...Effects of two important factors on earthquake response of high arch dams are considered and combined into one program.These tactors are:effects of radiation damping of the infinite canyon and local non-linearity of the contraction joint opening between the dam monoliths.For modeling of rock canyon,the discrete parameters are obtained based on a curve fitting, thus allowing the nonlinear dam system to be solved in the time domain.The earthquake uniform tree-field input at the dam-canyon interface is used.An engineering example is given to demonstrate the significant effects of the radiation damping on the structure response.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 11175021)
文摘A minimal system-plus-reservoir model yielding a nonergodic Langevin equation is proposed, which originates from the cubic-spectral density of environmental oscillators and momentum-dependent coupling. This model allows ballistic diffusion and classical localization simultaneously, in which the fluctuation-dissipation relation is still satisfied but the Khinchin theorem is broken. The asymptotical equilibrium for a nonergodic system requires the initial thermal equilibrium, however, when the system starts from nonthermal conditions, it does not approach the equilibration even though a nonlinear potential is used to bound the particle, this can be confirmed by the zerotb law of thermodynamics. In the dynamics of Brownian localization, due to the memory damping function inducing a constant term, our results show that the stationary distribution of the system depends on its initial preparation of coordinate rather than momentum. The coupled oscillator chain with a fixed end boundary acts as a heat bath, which has long been used in studies of collinear atom/solid-surface scattering and lattice vibration, we investigate this problem from the viewpoint of nonergodicity.
基金Supported by Shanghai Science Committee Project Fund, China (04JC14085)shanghai Health Burean Project Fund, CHina(054042)
文摘Objective To study the function of focal adhesion kinase （FAK） in the formation of hypertrophic scar and its interrelationship with integrin α1. Methods Original fibroblasts from human hypertrophic scar and human normal dermis were cultured, and immunocytochemistry was applied to detect localization of expres- sion of FAK and integrin α1 in hypertrophic scar and human normal skin fibroblasts. The expression of integrin α1 was detected before and after FAK antibody blocking hypertrophic scar fibroblasts （HSFB） 48 h later. Meanwhile the collagen synthesis was evaluated by [^3 H]-proline incorporation and HSFB cell proliferation was measured by MTT method. Results The expression of FAK and integrin aI of hypertrophic scar fibroblasts was higher than that of the normal skin fibroblasts significantly （ P 〈 0.01 ）. The expression of integrin α1 was reduced after FAK being blocked （ P 〈 0.01 ）. Meanwhile the collagen synthesis of human scar-derived fibroblasts by [^3H] -proline incor- poration was depressed respectively （ P 〈 0. 01 ）. The cell proliferation was inhibited by using 1：100 and 1：200 FAK antibody with MTI＂ method （ P 〈 0. 01 ）. Conclusion FAK is the key point of signal transmission pathway mediated by integrin α1 , which regulates protein synthesis of integrin α1 , it may play an important role in the proliferation and constriction of hypertrophic scar. FAK antibody can inhibit the collagen synthesis and cell proliferation of hypertrophic scar fibroblasts.
基金supported by the National Natural Science Foundation of China under Grant No. 60973070
文摘An algorithm for face description and recognition based on multi-resolution with multi-scale local binary pattern （multi-LBP） features is proposed. The facial image pyramid is constructed and each facial image is divided into various regions from which partial and holistic local binary patter （LBP） histograms are extracted. All LBP features of each image are concatenated to a single LBP eigenvector with different resolutions. The dimensionaUty of LBP features is then reduced by a local margin alignment （LMA） algorithm based on manifold, which can preserve the between-class variance. Support vector machine （SVM） is applied to classify facial images. Extensive experiments on ORL and CMU face databases clearly show the superiority of the proposed scheme over some existed algorithms, especially on the robustness of the method against different facial expressions and postures of the subjects.
文摘Effects of two important factors on earthquake response of high arch dams are considered and combined into one program.These tactors are:effects of radiation damping of the infinite canyon and local non-linearity of the contraction joint opening between the dam monoliths.For modeling of rock canyon,the discrete parameters are obtained based on a curve fitting, thus allowing the nonlinear dam system to be solved in the time domain.The earthquake uniform tree-field input at the dam-canyon interface is used.An engineering example is given to demonstrate the significant effects of the radiation damping on the structure response.
