The hemolysis of human red blood cells was initiated by a water soluble free radical initiator, 2,2′ azobis (2 amidinopropane hydrochloride)(AAPH), at 37 ℃ in phosphate buffered saline(pH=7.4). The respective additi...The hemolysis of human red blood cells was initiated by a water soluble free radical initiator, 2,2′ azobis (2 amidinopropane hydrochloride)(AAPH), at 37 ℃ in phosphate buffered saline(pH=7.4). The respective addition of 1 [ N (o hydroxybenzylidene)amino]tetradecane(TDCA), 1,2 di[ N (o hydroxybenzylidene)amino]cyclohexane(DACH), 4 [ N (o hydroxybenzylidene)amino]benzoic acid(PABA), 4 nitro[ N (o hydroxybenzylidene)]aniline(APNA) or N (o hydroxybenzylidene)aniline(APA) can all prolong the inhibition period of hemolysis, indicating that the above Schiff bases play an antioxidative role in free radical induced hemolysis. It can be concluded that Schiff base with an alkyl group or a conjugated system in the molecule protect red blood cells against free radical induced hemolysis efficiently. This information may be useful for antioxidant drug design.展开更多
To further advance the development of the fluorescent dyes for latent fingerprint imaging,two triphenylamine-based Schiff base compounds containing a benzimidazole group(TPA-BZI)and a phenyl unit(TPA-Ph)were designed ...To further advance the development of the fluorescent dyes for latent fingerprint imaging,two triphenylamine-based Schiff base compounds containing a benzimidazole group(TPA-BZI)and a phenyl unit(TPA-Ph)were designed and synthesized.Photoluminescence experiments revealed that both compounds exhibited solvatochromism and intramolecular charge transfer(ICT)characteristics in six organic solvents.Additionally,they showed aggregation-induced emission(AIE)in CH_(3)OH/water mixtures and solid-state fluorescence.These phenomena were further elucidated through time-dependent density functional theory(TD-DFT)calculations.It was also found that the two compounds could be used for latent fingerprints imaging,and could easily distinguish the details of fingerprints from Ⅰ to Ⅲ levels,which could provide the preliminary evidence to match personal identification.展开更多
Two new complexes,[Zn_(2)(L1)(HL1)(NO_(3))]·CH_(3)OH(1)and[Zn_(3)(L2)(L3)_(3)Cl]·CH_(3)OH(2),were successfully synthesized by‘one-pot’method based on cinnoline-3-ylhydrazine ligand and zinc with 2-hydroxy-...Two new complexes,[Zn_(2)(L1)(HL1)(NO_(3))]·CH_(3)OH(1)and[Zn_(3)(L2)(L3)_(3)Cl]·CH_(3)OH(2),were successfully synthesized by‘one-pot’method based on cinnoline-3-ylhydrazine ligand and zinc with 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-3-methoxybenzaldehyde ligands,respectively,where H_(2)L1=5-methoxy-2-(phthalazin-1-ylhydrazonomethyl)-phenol,H_(2)L2=2-methoxy-6-(phthalazin-1-yl-hydrazonomethyl)-phenol,HL3=2-(1,8-dihydro-[1,2,4]triazolo[3,4-α]phthalazin-3-yl)-6-methoxy-phenol.Complexes 1 and 2 were characterized by infrared spectroscopy,elemental analysis,single-crystal X-ray diffraction,powder X-ray diffraction,etc.It is worth noting that the cinnolin-3-yl-hydrazine ligand and 2-hydroxy-3-methoxybenzaldehyde form two types of Schiff bases(H_(2)L2 and HL3)when in situ reacting and coordinating with Zn(Ⅱ),and HL3 also has two coordination modes.In addition,the fluorescence performance showed that complex 1 can achieve selective and sensitive sensing of Al^(3+)in water with a detection limit of 6.37μmol·L^(-1).CCDC:2413978,1;2413979,2.展开更多
Two Gd_(2)complexes,namely[Gd_(2)(dbm)_(2)(HL_(1))_(2)(CH_(3)OH)_(2)]·4CH_(3)OH(1)and[Gd_(2)(dbm)_(2)(L_(2))_(2)(CH_(3)OH)_(2)]·2CH_(3)OH(2),where H_(3)L_(1)=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene...Two Gd_(2)complexes,namely[Gd_(2)(dbm)_(2)(HL_(1))_(2)(CH_(3)OH)_(2)]·4CH_(3)OH(1)and[Gd_(2)(dbm)_(2)(L_(2))_(2)(CH_(3)OH)_(2)]·2CH_(3)OH(2),where H_(3)L_(1)=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxyacetohydrazide,H_(2)L_(2)=(E)-N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)nicotinohydrazide,Hdbm=dibenzoylmethane,have been constructed by adopting the solvothermal method.Structural characterization unveils that both complexes 1 and 2 are constituted by two Gd^(3+)ions,two dbm-ions,two CH_(3)OH molecules,and two polydentate Schiff-base ligands(HL_(1)^(2-)or L_(2)^(2-)).In addition,complex 1 contains four free methanol molecules,whereas complex 2 harbors two free methanol molecules.By investigating the interactions between complexes 1 and 2 and four types of bacteria(Bacillus subtilis,Escherichia coli,Staphylococcus aureus,Candida albicans),it was found that both complexes 1 and 2 exhibited potent antibacte-rial activities.The interaction mechanisms between the ligands H_(3)L_(1),H_(2)L_(2),complexes 1 and 2,and calf thymus DNA(CT-DNA)were studied using ultraviolet-visible spectroscopy,fluorescence titration,and cyclic voltammetry.The results demonstrated that both complexes 1 and 2 can intercalate into CT-DNA molecules,thereby inhibiting bacterial proliferation to achieve the antibacterial effects.CCDC:2401116,1;2401117,2.展开更多
A[3+4]annulation of α-substituted allenes and Schiff bases is reported.This methodology serves as a conduit for the construction of a series of biologically important benzazepine derivatives in good to excellent yiel...A[3+4]annulation of α-substituted allenes and Schiff bases is reported.This methodology serves as a conduit for the construction of a series of biologically important benzazepine derivatives in good to excellent yields under mild conditions by an unprecedented mode involving β’-carbon of α-substituted allenes and the proposed mechanism is supported by capturing the intermediate.Moreover,this class of benzazepine derivatives exhibited potential ability of cytotoxicity toward cancer cells.展开更多
Since their discovery by Hugo Schiff in 1864,Schiff bases and their metal complexes have gained recognition for their catalytic and biological properties.These compounds exhibit diverse functionalities,serving as cata...Since their discovery by Hugo Schiff in 1864,Schiff bases and their metal complexes have gained recognition for their catalytic and biological properties.These compounds exhibit diverse functionalities,serving as catalysts in synthetic processes and displaying notable biological activities such as antifungal,antibacterial,anti-malarial,and antiviral effects.In various applications,Schiff bases serve as versatile tools,particularly in sensing appli-cations.Through coordination with various metal ions,they form stable complexes.They are utilized as fluo-rescent turn-on/turn-off sensors for detecting a wide range of analytes.The coordination ability makes them valuable as chemosensor for detecting environmentally and biologically important analytes.This review provides a thorough overview of Schiff base chemosensors designed for the detection of environmental and biological significance including metal cations,anions,and neutral analytes.It is structured into four focused sections.The first section addresses the use of Schiff base chemosensor for the selective detection of various metal cations,including Ca^(2+),Al^(3+),Cr^(3+),Mn^(2+),Fe^(3+),Ni^(2+),Cu^(2+),Zn^(2+),Cd^(2+),Hg^(2+),and Pb^(2+);The second section examines the application of fluorescent Schiff base sensors in detecting diverse anions such as F^(-),CN^(-),I^(-),and HSO_(4)^(-);The third section investigates the use of Schiff base fluorescent probes for accurate pH detection and determination;and the fourth section explores the utilization of Schiff base sensors for detecting environmentally and biolog-ically important neutral analytes,including insecticides,pesticides,and others.Additionally,the Schiff base chemosensors for metal cations and anions section are concluded with a table,summarizing the reviewed fluorescent Schiff base sensors for enhanced clarity.展开更多
以L-酪氨酸甲酯盐酸盐为原料,通过格氏反应合成了一种手性β-氨基醇;以水杨醛为原料,通过溴代反应合成了3,5-二溴水杨醛和5-溴水杨醛;将手性β-氨基醇和溴代水杨醛在乙醇中缩合,制备了两种手性三齿Schiff-base配体.产物的结构经IR,1 H N...以L-酪氨酸甲酯盐酸盐为原料,通过格氏反应合成了一种手性β-氨基醇;以水杨醛为原料,通过溴代反应合成了3,5-二溴水杨醛和5-溴水杨醛;将手性β-氨基醇和溴代水杨醛在乙醇中缩合,制备了两种手性三齿Schiff-base配体.产物的结构经IR,1 H NMR,13C NMR和MS表征确定.将配体应用于催化不对称Henry反应中,考察其在不同反应条件下的催化性能,在最优化的反应条件下,不同底物均获得了较好的催化效果,产率最高达95%,ee值最高达90%.展开更多
文摘The hemolysis of human red blood cells was initiated by a water soluble free radical initiator, 2,2′ azobis (2 amidinopropane hydrochloride)(AAPH), at 37 ℃ in phosphate buffered saline(pH=7.4). The respective addition of 1 [ N (o hydroxybenzylidene)amino]tetradecane(TDCA), 1,2 di[ N (o hydroxybenzylidene)amino]cyclohexane(DACH), 4 [ N (o hydroxybenzylidene)amino]benzoic acid(PABA), 4 nitro[ N (o hydroxybenzylidene)]aniline(APNA) or N (o hydroxybenzylidene)aniline(APA) can all prolong the inhibition period of hemolysis, indicating that the above Schiff bases play an antioxidative role in free radical induced hemolysis. It can be concluded that Schiff base with an alkyl group or a conjugated system in the molecule protect red blood cells against free radical induced hemolysis efficiently. This information may be useful for antioxidant drug design.
文摘To further advance the development of the fluorescent dyes for latent fingerprint imaging,two triphenylamine-based Schiff base compounds containing a benzimidazole group(TPA-BZI)and a phenyl unit(TPA-Ph)were designed and synthesized.Photoluminescence experiments revealed that both compounds exhibited solvatochromism and intramolecular charge transfer(ICT)characteristics in six organic solvents.Additionally,they showed aggregation-induced emission(AIE)in CH_(3)OH/water mixtures and solid-state fluorescence.These phenomena were further elucidated through time-dependent density functional theory(TD-DFT)calculations.It was also found that the two compounds could be used for latent fingerprints imaging,and could easily distinguish the details of fingerprints from Ⅰ to Ⅲ levels,which could provide the preliminary evidence to match personal identification.
文摘Two new complexes,[Zn_(2)(L1)(HL1)(NO_(3))]·CH_(3)OH(1)and[Zn_(3)(L2)(L3)_(3)Cl]·CH_(3)OH(2),were successfully synthesized by‘one-pot’method based on cinnoline-3-ylhydrazine ligand and zinc with 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-3-methoxybenzaldehyde ligands,respectively,where H_(2)L1=5-methoxy-2-(phthalazin-1-ylhydrazonomethyl)-phenol,H_(2)L2=2-methoxy-6-(phthalazin-1-yl-hydrazonomethyl)-phenol,HL3=2-(1,8-dihydro-[1,2,4]triazolo[3,4-α]phthalazin-3-yl)-6-methoxy-phenol.Complexes 1 and 2 were characterized by infrared spectroscopy,elemental analysis,single-crystal X-ray diffraction,powder X-ray diffraction,etc.It is worth noting that the cinnolin-3-yl-hydrazine ligand and 2-hydroxy-3-methoxybenzaldehyde form two types of Schiff bases(H_(2)L2 and HL3)when in situ reacting and coordinating with Zn(Ⅱ),and HL3 also has two coordination modes.In addition,the fluorescence performance showed that complex 1 can achieve selective and sensitive sensing of Al^(3+)in water with a detection limit of 6.37μmol·L^(-1).CCDC:2413978,1;2413979,2.
文摘Two Gd_(2)complexes,namely[Gd_(2)(dbm)_(2)(HL_(1))_(2)(CH_(3)OH)_(2)]·4CH_(3)OH(1)and[Gd_(2)(dbm)_(2)(L_(2))_(2)(CH_(3)OH)_(2)]·2CH_(3)OH(2),where H_(3)L_(1)=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxyacetohydrazide,H_(2)L_(2)=(E)-N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)nicotinohydrazide,Hdbm=dibenzoylmethane,have been constructed by adopting the solvothermal method.Structural characterization unveils that both complexes 1 and 2 are constituted by two Gd^(3+)ions,two dbm-ions,two CH_(3)OH molecules,and two polydentate Schiff-base ligands(HL_(1)^(2-)or L_(2)^(2-)).In addition,complex 1 contains four free methanol molecules,whereas complex 2 harbors two free methanol molecules.By investigating the interactions between complexes 1 and 2 and four types of bacteria(Bacillus subtilis,Escherichia coli,Staphylococcus aureus,Candida albicans),it was found that both complexes 1 and 2 exhibited potent antibacte-rial activities.The interaction mechanisms between the ligands H_(3)L_(1),H_(2)L_(2),complexes 1 and 2,and calf thymus DNA(CT-DNA)were studied using ultraviolet-visible spectroscopy,fluorescence titration,and cyclic voltammetry.The results demonstrated that both complexes 1 and 2 can intercalate into CT-DNA molecules,thereby inhibiting bacterial proliferation to achieve the antibacterial effects.CCDC:2401116,1;2401117,2.
基金financially supported by the National Natural Science Foundation of China(No.21572271).
文摘A[3+4]annulation of α-substituted allenes and Schiff bases is reported.This methodology serves as a conduit for the construction of a series of biologically important benzazepine derivatives in good to excellent yields under mild conditions by an unprecedented mode involving β’-carbon of α-substituted allenes and the proposed mechanism is supported by capturing the intermediate.Moreover,this class of benzazepine derivatives exhibited potential ability of cytotoxicity toward cancer cells.
文摘Since their discovery by Hugo Schiff in 1864,Schiff bases and their metal complexes have gained recognition for their catalytic and biological properties.These compounds exhibit diverse functionalities,serving as catalysts in synthetic processes and displaying notable biological activities such as antifungal,antibacterial,anti-malarial,and antiviral effects.In various applications,Schiff bases serve as versatile tools,particularly in sensing appli-cations.Through coordination with various metal ions,they form stable complexes.They are utilized as fluo-rescent turn-on/turn-off sensors for detecting a wide range of analytes.The coordination ability makes them valuable as chemosensor for detecting environmentally and biologically important analytes.This review provides a thorough overview of Schiff base chemosensors designed for the detection of environmental and biological significance including metal cations,anions,and neutral analytes.It is structured into four focused sections.The first section addresses the use of Schiff base chemosensor for the selective detection of various metal cations,including Ca^(2+),Al^(3+),Cr^(3+),Mn^(2+),Fe^(3+),Ni^(2+),Cu^(2+),Zn^(2+),Cd^(2+),Hg^(2+),and Pb^(2+);The second section examines the application of fluorescent Schiff base sensors in detecting diverse anions such as F^(-),CN^(-),I^(-),and HSO_(4)^(-);The third section investigates the use of Schiff base fluorescent probes for accurate pH detection and determination;and the fourth section explores the utilization of Schiff base sensors for detecting environmentally and biolog-ically important neutral analytes,including insecticides,pesticides,and others.Additionally,the Schiff base chemosensors for metal cations and anions section are concluded with a table,summarizing the reviewed fluorescent Schiff base sensors for enhanced clarity.
文摘以L-酪氨酸甲酯盐酸盐为原料,通过格氏反应合成了一种手性β-氨基醇;以水杨醛为原料,通过溴代反应合成了3,5-二溴水杨醛和5-溴水杨醛;将手性β-氨基醇和溴代水杨醛在乙醇中缩合,制备了两种手性三齿Schiff-base配体.产物的结构经IR,1 H NMR,13C NMR和MS表征确定.将配体应用于催化不对称Henry反应中,考察其在不同反应条件下的催化性能,在最优化的反应条件下,不同底物均获得了较好的催化效果,产率最高达95%,ee值最高达90%.
