Chromones serve as versatile heterocyclic scaffolds and are common core structural units in a variety of natural products and bioactive organic molecules.This area of research,at the forefront of organic synthesis,has...Chromones serve as versatile heterocyclic scaffolds and are common core structural units in a variety of natural products and bioactive organic molecules.This area of research,at the forefront of organic synthesis,has seen remarkable progress in recent years.Among the various synthetic methodologies for accessing chromone scaffolds,the tandem annulation of o-hydroxyaryl enaminones has emerged as a robust and practical strategy.This approach,through direct vinyl C-H bond functionalization of o-hydroxyaryl enaminones,enables the construction of structurally diverse chromones(including 3-substituted chromones,2-substituted chromones,and 2,3-disubstituted chromones)and their derivatives since mid-2019.In this review,we highlight recent advances in the synthesis of various types of chromones and their derivatives,achieved through tandem direct vinyl C-H activation and chromone annulation of o-hydroxyaryl enaminones.展开更多
A practical,metal-,and additive-free strategy for photo-and electro-induced perfluoroalkylation/cyclization of ohydroxyaryl enaminones with sodium perfluoroalkanesulfinates under mild conditions has been developed.Var...A practical,metal-,and additive-free strategy for photo-and electro-induced perfluoroalkylation/cyclization of ohydroxyaryl enaminones with sodium perfluoroalkanesulfinates under mild conditions has been developed.Various fluoroalkyl chromones were efficiently assembled in moderate to good yields.The scalability of this protocol and the assembling of diverse nitrogen-containing heterocycles from late-stage transformations of fluoroalkyl chromones greatly broaden the practical applications of this developed protocol.展开更多
A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides has been developed.The azaoxyallyl cation intermediates are employed as C^O 3-atom synthon to build oxa-heterocycles ...A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides has been developed.The azaoxyallyl cation intermediates are employed as C^O 3-atom synthon to build oxa-heterocycles via the selectivity of suitable cyclization partners.This transformation provides rapid access to highly functionalized 2-hydroxyaryl-oxazolines under mild conditions and excellent regioselectivity.展开更多
基金financially supported by National Natural Science Foundation of China(No.22161022).
文摘Chromones serve as versatile heterocyclic scaffolds and are common core structural units in a variety of natural products and bioactive organic molecules.This area of research,at the forefront of organic synthesis,has seen remarkable progress in recent years.Among the various synthetic methodologies for accessing chromone scaffolds,the tandem annulation of o-hydroxyaryl enaminones has emerged as a robust and practical strategy.This approach,through direct vinyl C-H bond functionalization of o-hydroxyaryl enaminones,enables the construction of structurally diverse chromones(including 3-substituted chromones,2-substituted chromones,and 2,3-disubstituted chromones)and their derivatives since mid-2019.In this review,we highlight recent advances in the synthesis of various types of chromones and their derivatives,achieved through tandem direct vinyl C-H activation and chromone annulation of o-hydroxyaryl enaminones.
基金the National Natural Science Foundation of China(No.22178314 and 21776254)the Zhejiang Provincial Key R&D Project(No.2021C03148)the Opening Project of Zhejiang Engineering Research Center of Fat-soluble Vitamin(2023)for financial help(No.202306).
文摘A practical,metal-,and additive-free strategy for photo-and electro-induced perfluoroalkylation/cyclization of ohydroxyaryl enaminones with sodium perfluoroalkanesulfinates under mild conditions has been developed.Various fluoroalkyl chromones were efficiently assembled in moderate to good yields.The scalability of this protocol and the assembling of diverse nitrogen-containing heterocycles from late-stage transformations of fluoroalkyl chromones greatly broaden the practical applications of this developed protocol.
基金partial financial support from the Ministry of Science and Technology of China(No.2016YFE0132600)Zhengzhou University。
文摘A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides has been developed.The azaoxyallyl cation intermediates are employed as C^O 3-atom synthon to build oxa-heterocycles via the selectivity of suitable cyclization partners.This transformation provides rapid access to highly functionalized 2-hydroxyaryl-oxazolines under mild conditions and excellent regioselectivity.
