This paper presents building one-parameter motion by complex numbers on a time scale. Firstly, we assumed that E and E′ were moving in a fixed time scale complex plane and {0, e1,e2} and {0', e'1,e'2} ?we...This paper presents building one-parameter motion by complex numbers on a time scale. Firstly, we assumed that E and E′ were moving in a fixed time scale complex plane and {0, e1,e2} and {0', e'1,e'2} ?were their orthonormal frames, respectively. By using complex numbers, we investigated the delta calculus equations of the motion on T. Secondly, we gave the velocities and their union rule on the time scale. Finally, by using the delta-derivative, we got interesting results and theorems for the instantaneous rotation pole and the pole curves (trajectory). In kinematics, investigating one-parameter motion by complex numbers is important for simplifying motion calculation. In this study, our aim is to obtain an equation of motion by using complex numbers on the time scale.展开更多
Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of ...Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of work breakdown structure and risk breakdown structure(WBS⁃RBS)is proposed to identify the project risks.In this paper,interval numbers are used to evaluate the risk levels,weights are assigned automatically based on the complexity and risk degree of WBS to distinguish three types of nodes in WBS,and a risk assessment algorithm is designed to assess safety risk at all layers of the project.A case study is conducted to demonstrate how to apply the method.The results show the practicality,robustness and efficiency of our new method,which can be applied to different kinds of large⁃scale complex projects in reality.展开更多
The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and cost-effectiveness.This paper inves...The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and cost-effectiveness.This paper investigates the potential applications of intuitionistic fuzzy sets(IFS)with rough sets in the context of sparse data.When it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy rough numbers(IFRNs)are superior to intuitionistic fuzzy sets and pythagorean fuzzy sets,respectively.We use rough sets in conjunction with IFSs to develop several fairly aggregation operators and analyze their underlying properties.We present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally within these principles.These operations lead to the development of the intuitionistic fuzzy rough weighted fairly aggregation operator(IFRWFA)and intuitionistic fuzzy rough ordered weighted fairly aggregation operator(IFRFOWA).These operators successfully adjust to membership and non-membership categories with fairness and subtlety.We highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making field.We use the intuitionistic fuzzy rough environment’s architecture to create a novel strategy in situation involving several decision-makers and non-weighted data.Additionally,we developed a novel technique by combining the IFSs with quaternion numbers.We establish a unique connection between alternatives and qualities by using intuitionistic fuzzy quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty in real-world situations and address a number of decision-making problems.Using the examples we have released,we offer a sophisticated and systematically constructed illustrative scenario that is intricately woven with the complexity ofmedical evaluation in order to thoroughly assess the relevance and efficacy of the suggested methodology.展开更多
Birds,a fascinating and diverse group occupying various habitats worldwide,exhibit a wide range of life-history traits,reproductive methods,and migratory behaviors,all of which influence their immune systems.The assoc...Birds,a fascinating and diverse group occupying various habitats worldwide,exhibit a wide range of life-history traits,reproductive methods,and migratory behaviors,all of which influence their immune systems.The association between major histocompatibility complex(MHC)genes and certain ecological factors in response to pathogen selection has been extensively studied;however,the role of the co-working molecule T cell receptor(TCR)remains poorly understood.This study aimed to analyze the copy numbers of TCR-V genes,the selection pressure(ωvalue)on MHC genes using available genomic data,and their potential ecological correlates across 93 species from 13 orders.The study was conducted using the publicly available genome data of birds.Our findings suggested that phylogeny influences the variability in TCR-V gene copy numbers and MHC selection pressure.The phylogenetic generalized least squares regression model revealed that TCR-Vαδcopy number and MHC-I selection pressure were positively associated with body mass.Clutch size was correlated with MHC selection pressure,and Migration was correlated with TCR-Vβcopy number.Further analyses revealed that the TCR-Vβcopy number was positively correlated with MHC-IIB selection pressure,while the TCR-Vγcopy number was negatively correlated with MHC-I peptide-binding region selection pressure.Our findings suggest that TCR-V diversity is significant in adaptive evolution and is related to species’life-history strategies and immunological defenses and provide valuable insights into the mechanisms underlying TCR-V gene duplication and MHC selection in avian species.展开更多
Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for mor...Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for more than 3y.She was diagnosed with ASs and choroiditis at a local hospital.She has a seven-year history of bilateral high myopia.A fundus examination confirmed the presence of ASs and myopic fundus changes in both eyes.Multimodal imaging revealed an AZOOR complex in the left eye.展开更多
In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random vari...In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random variables,and another is for sub-orthogonal random variables.Both extend the strong law of large numbers for independent random variables under sublinear expectations to the non-independent case.展开更多
Complex trimalleolar ankle fractures are a major orthopaedic challenge,with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars.This review synthesizes current ev...Complex trimalleolar ankle fractures are a major orthopaedic challenge,with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars.This review synthesizes current evidence on diagnostic protocols and management strategies,highlighting optimal approaches and emerging trends.Initial care emphasizes soft tissue assessment,often guided by the Tscherne classification,and fracture classification systems.External fixation may be required in open injuries,while early open reduction and internal fixation within six days is linked to improved outcomes.Minimally invasive techniques for the lateral malleolus,including intramedullary nailing and locking plates,are effective,while medial malleolus fractures are commonly managed with screw fixation or tension-band wiring.Posterior malleolus fragments involving more than 25%of the articular surface usually warrant fixation.Alternatives to syndesmotic screws,such as cortical buttons or high-strength sutures,reduce the need for secondary procedures.Arthroscopic-assisted open reduction and internal fixation benefits younger,active patients by enabling concurrent management of intra-articular and ligamentous injuries.Postoperative care prioritizes early weight-bearing and validated functional scores.Despite advances,complications remain common,and further research is needed to refine surgical strategies and improve outcomes.展开更多
We have found through calculations that the differences between the closest supposed prime numbers other than 2 and 3 defined in the articles are: 2;4: and 6. For those whose difference is equal to 6, we showed their ...We have found through calculations that the differences between the closest supposed prime numbers other than 2 and 3 defined in the articles are: 2;4: and 6. For those whose difference is equal to 6, we showed their origin then we classified them into two categories according to their classes, we showed in which context two prime numbers which differ from 6 are called sexy and in what context they are said real sexy prime. For those whose difference is equal to 4, we showed their origin then we showed that two prime numbers which differ from 4, that is to say two cousin prime numbers, are successive. We made an observation on the supposed prime numbers then we established two pairs of equations from this observation and deduced the origin of the Mersenne number and that of the Fermat number.展开更多
Microstructure topology evolution during severe plastic deformation(SPD)is crucial for understanding and optimising the mechanical properties of metallic materials,though its prediction remains challenging.Herein,we c...Microstructure topology evolution during severe plastic deformation(SPD)is crucial for understanding and optimising the mechanical properties of metallic materials,though its prediction remains challenging.Herein,we combine discrete cell complexes(DCC),a fully discrete algebraic topology model-with finite element analysis(FEA)to simulate and analyse the microstructure topology of pure copper under SPD.Using DCC,we model the evolution of microstructure topology characterised by Betti numbers(β_(0),β_(1),β_(2))and Euler characteristic(χ).This captures key changes in GBNs and topological features within representative volume elements(RVEs)containing several hundred grains during SPD-induced recrystallisation.As SPD cycles increase,high-angle grain boundaries(HAGBs)progressively form.Topological analysis reveals an overall decrease in β_(0)values,indicating fewer isolated HAGB substructures,while β_(2) values show a steady upward trend,highlighting new grain formation.Leveraging DCC-derived RVE topology and FEA-generated plastic strain data,we directly simulate the evolution and spatial distribution of microstructure topology and HAGB fraction in a copper tube undergoing cyclic parallel tube channel angular pressing(PTCAP),a representative SPD technique.Within the tube,the HAGB fraction continuously increases with PTCAP cycles,reflecting the microstructure’s gradual transition from subgrains to fully-formed grains.Analysis of Betti number distribution and evolution reveals the microstructural reconstruction mechanism underpinning this subgrain to grain transition during PTCAP.We further demonstrate the significant influence of spatially non-uniform plastic strain distribution on microstructure reconstruction kinetics.This study demonstrates a feasible approach for simulating microstructure topology evolution of metals processed by cyclic SPD via the integration of DCC and FEA.展开更多
The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals,coordinating physiological processes with the 24-hour day–night cycle.Comprising various cell types,the suprachiasmatic nucleus...The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals,coordinating physiological processes with the 24-hour day–night cycle.Comprising various cell types,the suprachiasmatic nucleus(SCN)integrates environmental signals to maintain complex and robust circadian rhythms.Understanding the complexity and synchrony within SCN neurons is essential for effective circadian clock function.Synchrony involves coordinated neuronal firing for robust rhythms,while complexity reflects diverse activity patterns and interactions,indicating adaptability.Interestingly,the SCN retains circadian rhythms in vitro,demonstrating intrinsic rhythmicity.This study introduces the multiscale structural complexity method to analyze changes in SCN neuronal activity and complexity at macro and micro levels,based on Bagrov et al.’s approach.By examining structural complexity and local complexities across scales,we aim to understand how tetrodotoxin,a neurotoxin that inhibits action potentials,affects SCN neurons.Our method captures critical scales in neuronal interactions that traditional methods may overlook.Validation with the Goodwin model confirms the reliability of our observations.By integrating experimental data with theoretical models,this study provides new insights into the effects of tetrodotoxin(TTX)on neuronal complexities,contributing to the understanding of circadian rhythms.展开更多
Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA)...Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA).However,the research on the uncertainty measure of complex evidence theory is still an open issue.Therefore,in this paper,first,the Fractal-based Complex Belief(FCB)entropy as a generalization of Fractal-based Belief(FB)entropy,which has superiority in uncertainty measurement of CBBA,is proposed.Second,on the basis of FCB entropy,we propose Fractal-based Supremum Complex Belief(FSCB)entropy and Fractal-based Infimum Complex Belief(FICB)entropy,with FSCB entropy as the upper bound and FICB entropy as the lower bound.They are collectively called the proposed FCB entropy.Furthermore,we analyze the properties,physical interpretation and numerical examples to prove the rationality of the proposed method.Finally,a practical information fusion application is proposed to prove that the proposed FCB entropy can reasonably measure the uncertainty of CBBA.The results show that,the proposed FCB entropy can handle the uncertainty measure of CBBA,which can be a reasonable way for uncertainty measure in complex evidence theory.展开更多
This study aims to validate the Object-Oriented User Interface Customization(OOUIC)framework by employing Use Case Analysis(UCA)to facilitate the development of adaptive User Interfaces(UIs).The OOUIC framework advoca...This study aims to validate the Object-Oriented User Interface Customization(OOUIC)framework by employing Use Case Analysis(UCA)to facilitate the development of adaptive User Interfaces(UIs).The OOUIC framework advocates for User-Centered Design(UCD)methodologies,including UCA,to systematically identify intricate user requirements and construct adaptive UIs tailored to diverse user needs.To operationalize this approach,thirty users of Product Lifecycle Management(PLM)systems were interviewed across six distinct use cases.Interview transcripts were subjected to deductive content analysis to classify UI objects systematically.Subsequently,adaptive UIs were developed for each use case,and their complexity was quantitatively compared against the original system UIs.The results demonstrated a significant reduction in complexity across all adaptive UIs(Mean Difference,MD=0.11,t(5)=8.26,p<0.001),confirming their superior efficiency.The findings validate the OOUIC framework,demonstrating that UCD effectively captures complex requirements for adaptive UI development,while adaptive UIs mitigate interface complexity through object reduction and optimized layout design.Furthermore,UCA and deductive content analysis serve as robust methodologies for object categorization in adaptive UI design.Beyond eliminating redundant elements and prioritizing object grouping,designers can further reduce complexity by adjusting object dimensions and window sizing.This study underscores the efficacy of UCA in developing adaptive UIs and streamlining complex interfaces.Ultimately,UCD proves instrumental in gathering intricate requirements,while adaptive UIs enhance usability by minimizing object clutter and refining spatial organization.展开更多
A novel double-stranded trinuclear bis(tridipyrrin)zinc(Ⅱ)complex,constructed from a linearπ-conjugated tridipyrrin ligand,was synthesized and characterized.The complex featuring six directly linked dipyrrin units e...A novel double-stranded trinuclear bis(tridipyrrin)zinc(Ⅱ)complex,constructed from a linearπ-conjugated tridipyrrin ligand,was synthesized and characterized.The complex featuring six directly linked dipyrrin units exhibits a stable double-helical structure with two non-superimposable P and M enantiomers,as confirmed by X-ray crystallography.Chirality was further demonstrated through HPLC separation and mirror-image circular dichroism(CD)spectra.The complex shows strong near-infrared(NIR)absorption and excellent solubility in various solvents,attributed to its sterically hindered structure.Spectroscopic,electrochemical,and theoretical studies revealed its unique electronic properties and redox behavior.This work advances the design of chiral NIR-active metallo-supramolecular systems and highlights potential applications in chiroptical mateials.展开更多
Sensitization of metal-centered forbidden transitions is of great significance.Solid MnII-based phosphors with d-d forbidden transition sensitized by CeIIIwith d-f allowed transition are promising light conversion mat...Sensitization of metal-centered forbidden transitions is of great significance.Solid MnII-based phosphors with d-d forbidden transition sensitized by CeIIIwith d-f allowed transition are promising light conversion materials,but the energy transfer mechanism in CeIII-MnIIis still in dispute for the uncertainty of distances between metal centers.Herein,for the first time,we explored the energy transfer mechanism in two well-designed luminescent heteronuclear complexes with clear crystal structures,i.e.,Ce-N8-Mn and Ce-N2O6-Mn(N8=1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosane;N2O6=4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane).Short distances between metal centers facilitate efficient energy transfer from CeIIIto MnIIin both complexes,resulting in high photoluminescence quantum yield up to unity.After systematic study of the two heteronuclear complexes as well as two reference complexes Ce(N8)Br3and Ce(N2O6)Br3,we concluded that dipole-quadrupole interaction is the dominant energy transfer mechanism in the heteronuclear complexes.展开更多
Objectives:Lung cancer represents a major global healthcare challenge,characterized by high annual incidence and mortality rates worldwide.Although targeted therapies for lung cancer have advanced,treatment outcomes f...Objectives:Lung cancer represents a major global healthcare challenge,characterized by high annual incidence and mortality rates worldwide.Although targeted therapies for lung cancer have advanced,treatment outcomes for advanced-stage patients remain suboptimal.This investigation examines the role of the translocase of the inner mitochondrial membrane(TIMM)8A-TIMM13 complex in lung cancer and evaluates its potential as a novel therapeutic target.Methods:A co-immunoprecipitation(Co-IP)assay was conducted to verify the interaction between TIMM8A and TIMM13.Differential gene expression analysis of TIMM8A or TIMM13 was executed using the TNMplot database,with survival estimates derived from the Kaplan-Meier plotter.Lung cancer cell proliferation was evaluated through Cell Counting Kit 8(CCK-8)and colony formation assays,while cell migration was assessed via Transwell assay.RNA sequencing identified the downstream effectors of TIMM13.RNAi technology facilitated the inhibition of TIMM8A or TIMM13 expression,which was measured through immunoblotting or qRT-PCR.Results:This investigation revealed that components of the TIMM8A-TIMM13 complex exhibited elevated expression in human lung cancer tissues,correlating with disease progression and poor overall survival rates among lung cancer patients.The suppression of either TIMM8A or TIMM13 inhibited cell proliferation and migration.Mechanistic studies through transcriptome analysis identified cell cycle-related pathways as potential key downstream effectors of the TIMM8A-TIMM13 complex.Subsequent experiments confirmed that the TIMM8A-TIMM13 complex significantly regulated the expression of cyclin D1(CCND1)and cyclin-dependent kinase 6(CDK6)complex.Conclusion:The elevated expression of TIMM8A-TIMM13 complex components plays a crucial role in lung cancer cell growth,suggesting its potential as a promising therapeutic target for lung cancer treatment.展开更多
Aim To present a quantitative method for structural complexity analysis and evaluation of information systems. Methods Based on Petri net modeling and analysis techniques and with the aid of mathematical tools in ge...Aim To present a quantitative method for structural complexity analysis and evaluation of information systems. Methods Based on Petri net modeling and analysis techniques and with the aid of mathematical tools in general net theory(GNT), a quantitative method for structure description and analysis of information systems was introduced. Results The structural complexity index and two related factors, i.e. element complexity factor and connection complexity factor were defined, and the relations between them and the parameters of the Petri net based model of the system were derived. Application example was presented. Conclusion The proposed method provides a theoretical basis for quantitative analysis and evaluation of the structural complexity and can be applied in the general planning and design processes of the information systems.展开更多
The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and ...The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment.展开更多
The dominant oxidation state for lanthanide ions is+3 due to the loss of 5d and 6s electrons from their shared configuration of[Xe]4f^(0-14)5d^(0-16)s(2).There are however several exceptions because of the completely ...The dominant oxidation state for lanthanide ions is+3 due to the loss of 5d and 6s electrons from their shared configuration of[Xe]4f^(0-14)5d^(0-16)s(2).There are however several exceptions because of the completely empty(Ce(Ⅳ)),half-filled(Eu(Ⅱ)),or fully filled(Yb(Ⅱ))4f subshell.As such,stable complexes are formed primarily with Ln(Ⅲ)ions[1].展开更多
Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-inje...Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-injective and Cartan-Eilenberg FP_(n)-flat complexes.As applications,we obtain that any complex admits Cartan-Eilenberg FP_(n)-injective(resp.,Cartan-Eilenberg FP_(n)-flat)cover and preenvelope and we characterize left n-coherent rings using these two classes of complexes.展开更多
文摘This paper presents building one-parameter motion by complex numbers on a time scale. Firstly, we assumed that E and E′ were moving in a fixed time scale complex plane and {0, e1,e2} and {0', e'1,e'2} ?were their orthonormal frames, respectively. By using complex numbers, we investigated the delta calculus equations of the motion on T. Secondly, we gave the velocities and their union rule on the time scale. Finally, by using the delta-derivative, we got interesting results and theorems for the instantaneous rotation pole and the pole curves (trajectory). In kinematics, investigating one-parameter motion by complex numbers is important for simplifying motion calculation. In this study, our aim is to obtain an equation of motion by using complex numbers on the time scale.
基金This paper was supported by National Social Science Foundation of China(2019⁃SKJJ⁃035)。
文摘Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of work breakdown structure and risk breakdown structure(WBS⁃RBS)is proposed to identify the project risks.In this paper,interval numbers are used to evaluate the risk levels,weights are assigned automatically based on the complexity and risk degree of WBS to distinguish three types of nodes in WBS,and a risk assessment algorithm is designed to assess safety risk at all layers of the project.A case study is conducted to demonstrate how to apply the method.The results show the practicality,robustness and efficiency of our new method,which can be applied to different kinds of large⁃scale complex projects in reality.
基金funded by King Khalid University through a large group research project under Grant Number R.G.P.2/449/44.
文摘The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and cost-effectiveness.This paper investigates the potential applications of intuitionistic fuzzy sets(IFS)with rough sets in the context of sparse data.When it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy rough numbers(IFRNs)are superior to intuitionistic fuzzy sets and pythagorean fuzzy sets,respectively.We use rough sets in conjunction with IFSs to develop several fairly aggregation operators and analyze their underlying properties.We present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally within these principles.These operations lead to the development of the intuitionistic fuzzy rough weighted fairly aggregation operator(IFRWFA)and intuitionistic fuzzy rough ordered weighted fairly aggregation operator(IFRFOWA).These operators successfully adjust to membership and non-membership categories with fairness and subtlety.We highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making field.We use the intuitionistic fuzzy rough environment’s architecture to create a novel strategy in situation involving several decision-makers and non-weighted data.Additionally,we developed a novel technique by combining the IFSs with quaternion numbers.We establish a unique connection between alternatives and qualities by using intuitionistic fuzzy quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty in real-world situations and address a number of decision-making problems.Using the examples we have released,we offer a sophisticated and systematically constructed illustrative scenario that is intricately woven with the complexity ofmedical evaluation in order to thoroughly assess the relevance and efficacy of the suggested methodology.
基金supported by the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(No.2022C04014)Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(No.2021C02068-10).
文摘Birds,a fascinating and diverse group occupying various habitats worldwide,exhibit a wide range of life-history traits,reproductive methods,and migratory behaviors,all of which influence their immune systems.The association between major histocompatibility complex(MHC)genes and certain ecological factors in response to pathogen selection has been extensively studied;however,the role of the co-working molecule T cell receptor(TCR)remains poorly understood.This study aimed to analyze the copy numbers of TCR-V genes,the selection pressure(ωvalue)on MHC genes using available genomic data,and their potential ecological correlates across 93 species from 13 orders.The study was conducted using the publicly available genome data of birds.Our findings suggested that phylogeny influences the variability in TCR-V gene copy numbers and MHC selection pressure.The phylogenetic generalized least squares regression model revealed that TCR-Vαδcopy number and MHC-I selection pressure were positively associated with body mass.Clutch size was correlated with MHC selection pressure,and Migration was correlated with TCR-Vβcopy number.Further analyses revealed that the TCR-Vβcopy number was positively correlated with MHC-IIB selection pressure,while the TCR-Vγcopy number was negatively correlated with MHC-I peptide-binding region selection pressure.Our findings suggest that TCR-V diversity is significant in adaptive evolution and is related to species’life-history strategies and immunological defenses and provide valuable insights into the mechanisms underlying TCR-V gene duplication and MHC selection in avian species.
基金Supported by the National Natural Science Foundation of China(No.82171073).
文摘Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for more than 3y.She was diagnosed with ASs and choroiditis at a local hospital.She has a seven-year history of bilateral high myopia.A fundus examination confirmed the presence of ASs and myopic fundus changes in both eyes.Multimodal imaging revealed an AZOOR complex in the left eye.
文摘In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random variables,and another is for sub-orthogonal random variables.Both extend the strong law of large numbers for independent random variables under sublinear expectations to the non-independent case.
文摘Complex trimalleolar ankle fractures are a major orthopaedic challenge,with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars.This review synthesizes current evidence on diagnostic protocols and management strategies,highlighting optimal approaches and emerging trends.Initial care emphasizes soft tissue assessment,often guided by the Tscherne classification,and fracture classification systems.External fixation may be required in open injuries,while early open reduction and internal fixation within six days is linked to improved outcomes.Minimally invasive techniques for the lateral malleolus,including intramedullary nailing and locking plates,are effective,while medial malleolus fractures are commonly managed with screw fixation or tension-band wiring.Posterior malleolus fragments involving more than 25%of the articular surface usually warrant fixation.Alternatives to syndesmotic screws,such as cortical buttons or high-strength sutures,reduce the need for secondary procedures.Arthroscopic-assisted open reduction and internal fixation benefits younger,active patients by enabling concurrent management of intra-articular and ligamentous injuries.Postoperative care prioritizes early weight-bearing and validated functional scores.Despite advances,complications remain common,and further research is needed to refine surgical strategies and improve outcomes.
文摘We have found through calculations that the differences between the closest supposed prime numbers other than 2 and 3 defined in the articles are: 2;4: and 6. For those whose difference is equal to 6, we showed their origin then we classified them into two categories according to their classes, we showed in which context two prime numbers which differ from 6 are called sexy and in what context they are said real sexy prime. For those whose difference is equal to 4, we showed their origin then we showed that two prime numbers which differ from 4, that is to say two cousin prime numbers, are successive. We made an observation on the supposed prime numbers then we established two pairs of equations from this observation and deduced the origin of the Mersenne number and that of the Fermat number.
基金support from Outstanding Youth Fund of Jiangsu Province(BK20240077)Key Project(Provincial-Municipal Joint)of Jiangsu Province(BK20243044)+2 种基金Fundamental Research Funds for the Central Universities(NE2024001)National Youth Talents Programof Chinaa project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Microstructure topology evolution during severe plastic deformation(SPD)is crucial for understanding and optimising the mechanical properties of metallic materials,though its prediction remains challenging.Herein,we combine discrete cell complexes(DCC),a fully discrete algebraic topology model-with finite element analysis(FEA)to simulate and analyse the microstructure topology of pure copper under SPD.Using DCC,we model the evolution of microstructure topology characterised by Betti numbers(β_(0),β_(1),β_(2))and Euler characteristic(χ).This captures key changes in GBNs and topological features within representative volume elements(RVEs)containing several hundred grains during SPD-induced recrystallisation.As SPD cycles increase,high-angle grain boundaries(HAGBs)progressively form.Topological analysis reveals an overall decrease in β_(0)values,indicating fewer isolated HAGB substructures,while β_(2) values show a steady upward trend,highlighting new grain formation.Leveraging DCC-derived RVE topology and FEA-generated plastic strain data,we directly simulate the evolution and spatial distribution of microstructure topology and HAGB fraction in a copper tube undergoing cyclic parallel tube channel angular pressing(PTCAP),a representative SPD technique.Within the tube,the HAGB fraction continuously increases with PTCAP cycles,reflecting the microstructure’s gradual transition from subgrains to fully-formed grains.Analysis of Betti number distribution and evolution reveals the microstructural reconstruction mechanism underpinning this subgrain to grain transition during PTCAP.We further demonstrate the significant influence of spatially non-uniform plastic strain distribution on microstructure reconstruction kinetics.This study demonstrates a feasible approach for simulating microstructure topology evolution of metals processed by cyclic SPD via the integration of DCC and FEA.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12275179,11875042,and 12150410309)the Natural Science Foundation of Shanghai(Grant No.21ZR1443900).
文摘The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals,coordinating physiological processes with the 24-hour day–night cycle.Comprising various cell types,the suprachiasmatic nucleus(SCN)integrates environmental signals to maintain complex and robust circadian rhythms.Understanding the complexity and synchrony within SCN neurons is essential for effective circadian clock function.Synchrony involves coordinated neuronal firing for robust rhythms,while complexity reflects diverse activity patterns and interactions,indicating adaptability.Interestingly,the SCN retains circadian rhythms in vitro,demonstrating intrinsic rhythmicity.This study introduces the multiscale structural complexity method to analyze changes in SCN neuronal activity and complexity at macro and micro levels,based on Bagrov et al.’s approach.By examining structural complexity and local complexities across scales,we aim to understand how tetrodotoxin,a neurotoxin that inhibits action potentials,affects SCN neurons.Our method captures critical scales in neuronal interactions that traditional methods may overlook.Validation with the Goodwin model confirms the reliability of our observations.By integrating experimental data with theoretical models,this study provides new insights into the effects of tetrodotoxin(TTX)on neuronal complexities,contributing to the understanding of circadian rhythms.
基金supported by the National Natural Science Foundation of China (No. 62473067)Chongqing Talents: Exceptional Young Talents Project, China (No. cstc2022ycjh-bgzxm0070)Chongqing Overseas Scholars Innovation Program, China (No. cx2022024)
文摘Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA).However,the research on the uncertainty measure of complex evidence theory is still an open issue.Therefore,in this paper,first,the Fractal-based Complex Belief(FCB)entropy as a generalization of Fractal-based Belief(FB)entropy,which has superiority in uncertainty measurement of CBBA,is proposed.Second,on the basis of FCB entropy,we propose Fractal-based Supremum Complex Belief(FSCB)entropy and Fractal-based Infimum Complex Belief(FICB)entropy,with FSCB entropy as the upper bound and FICB entropy as the lower bound.They are collectively called the proposed FCB entropy.Furthermore,we analyze the properties,physical interpretation and numerical examples to prove the rationality of the proposed method.Finally,a practical information fusion application is proposed to prove that the proposed FCB entropy can reasonably measure the uncertainty of CBBA.The results show that,the proposed FCB entropy can handle the uncertainty measure of CBBA,which can be a reasonable way for uncertainty measure in complex evidence theory.
基金supported by the National Natural Science Foundation of China(Grant No.72301061).
文摘This study aims to validate the Object-Oriented User Interface Customization(OOUIC)framework by employing Use Case Analysis(UCA)to facilitate the development of adaptive User Interfaces(UIs).The OOUIC framework advocates for User-Centered Design(UCD)methodologies,including UCA,to systematically identify intricate user requirements and construct adaptive UIs tailored to diverse user needs.To operationalize this approach,thirty users of Product Lifecycle Management(PLM)systems were interviewed across six distinct use cases.Interview transcripts were subjected to deductive content analysis to classify UI objects systematically.Subsequently,adaptive UIs were developed for each use case,and their complexity was quantitatively compared against the original system UIs.The results demonstrated a significant reduction in complexity across all adaptive UIs(Mean Difference,MD=0.11,t(5)=8.26,p<0.001),confirming their superior efficiency.The findings validate the OOUIC framework,demonstrating that UCD effectively captures complex requirements for adaptive UI development,while adaptive UIs mitigate interface complexity through object reduction and optimized layout design.Furthermore,UCA and deductive content analysis serve as robust methodologies for object categorization in adaptive UI design.Beyond eliminating redundant elements and prioritizing object grouping,designers can further reduce complexity by adjusting object dimensions and window sizing.This study underscores the efficacy of UCA in developing adaptive UIs and streamlining complex interfaces.Ultimately,UCD proves instrumental in gathering intricate requirements,while adaptive UIs enhance usability by minimizing object clutter and refining spatial organization.
基金supported by the National Natural Science Foundation of China(22478005,22578006 and 22271002)the Natural Science Foundation of Anhui Province(2308085J14)the Scientific Research Foundation of the Higher Education Institutions of Anhui Province(2022AH051142).
文摘A novel double-stranded trinuclear bis(tridipyrrin)zinc(Ⅱ)complex,constructed from a linearπ-conjugated tridipyrrin ligand,was synthesized and characterized.The complex featuring six directly linked dipyrrin units exhibits a stable double-helical structure with two non-superimposable P and M enantiomers,as confirmed by X-ray crystallography.Chirality was further demonstrated through HPLC separation and mirror-image circular dichroism(CD)spectra.The complex shows strong near-infrared(NIR)absorption and excellent solubility in various solvents,attributed to its sterically hindered structure.Spectroscopic,electrochemical,and theoretical studies revealed its unique electronic properties and redox behavior.This work advances the design of chiral NIR-active metallo-supramolecular systems and highlights potential applications in chiroptical mateials.
基金financial support from the National Key R&D Program of China(Nos.2022YFB3503702,2023YFB3506901,2021YFB3501800)the National Natural Science Foundation of China(Nos.92156016,62104013,22071003)。
文摘Sensitization of metal-centered forbidden transitions is of great significance.Solid MnII-based phosphors with d-d forbidden transition sensitized by CeIIIwith d-f allowed transition are promising light conversion materials,but the energy transfer mechanism in CeIII-MnIIis still in dispute for the uncertainty of distances between metal centers.Herein,for the first time,we explored the energy transfer mechanism in two well-designed luminescent heteronuclear complexes with clear crystal structures,i.e.,Ce-N8-Mn and Ce-N2O6-Mn(N8=1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosane;N2O6=4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane).Short distances between metal centers facilitate efficient energy transfer from CeIIIto MnIIin both complexes,resulting in high photoluminescence quantum yield up to unity.After systematic study of the two heteronuclear complexes as well as two reference complexes Ce(N8)Br3and Ce(N2O6)Br3,we concluded that dipole-quadrupole interaction is the dominant energy transfer mechanism in the heteronuclear complexes.
基金supported by Beijing Natural Science Foundation(7242268)Beijing Hospitals Authority Youth Programme(QML20230807)Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University(CCMU2023ZKYXZ007).
文摘Objectives:Lung cancer represents a major global healthcare challenge,characterized by high annual incidence and mortality rates worldwide.Although targeted therapies for lung cancer have advanced,treatment outcomes for advanced-stage patients remain suboptimal.This investigation examines the role of the translocase of the inner mitochondrial membrane(TIMM)8A-TIMM13 complex in lung cancer and evaluates its potential as a novel therapeutic target.Methods:A co-immunoprecipitation(Co-IP)assay was conducted to verify the interaction between TIMM8A and TIMM13.Differential gene expression analysis of TIMM8A or TIMM13 was executed using the TNMplot database,with survival estimates derived from the Kaplan-Meier plotter.Lung cancer cell proliferation was evaluated through Cell Counting Kit 8(CCK-8)and colony formation assays,while cell migration was assessed via Transwell assay.RNA sequencing identified the downstream effectors of TIMM13.RNAi technology facilitated the inhibition of TIMM8A or TIMM13 expression,which was measured through immunoblotting or qRT-PCR.Results:This investigation revealed that components of the TIMM8A-TIMM13 complex exhibited elevated expression in human lung cancer tissues,correlating with disease progression and poor overall survival rates among lung cancer patients.The suppression of either TIMM8A or TIMM13 inhibited cell proliferation and migration.Mechanistic studies through transcriptome analysis identified cell cycle-related pathways as potential key downstream effectors of the TIMM8A-TIMM13 complex.Subsequent experiments confirmed that the TIMM8A-TIMM13 complex significantly regulated the expression of cyclin D1(CCND1)and cyclin-dependent kinase 6(CDK6)complex.Conclusion:The elevated expression of TIMM8A-TIMM13 complex components plays a crucial role in lung cancer cell growth,suggesting its potential as a promising therapeutic target for lung cancer treatment.
文摘Aim To present a quantitative method for structural complexity analysis and evaluation of information systems. Methods Based on Petri net modeling and analysis techniques and with the aid of mathematical tools in general net theory(GNT), a quantitative method for structure description and analysis of information systems was introduced. Results The structural complexity index and two related factors, i.e. element complexity factor and connection complexity factor were defined, and the relations between them and the parameters of the Petri net based model of the system were derived. Application example was presented. Conclusion The proposed method provides a theoretical basis for quantitative analysis and evaluation of the structural complexity and can be applied in the general planning and design processes of the information systems.
文摘The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment.
基金supported by the National Natural Science Foundation of China(22101116,92261203,21971106)Shenzhen Fundamental Research Program(JCYJ20220530115001002 and JCYJ20220818100417037).
文摘The dominant oxidation state for lanthanide ions is+3 due to the loss of 5d and 6s electrons from their shared configuration of[Xe]4f^(0-14)5d^(0-16)s(2).There are however several exceptions because of the completely empty(Ce(Ⅳ)),half-filled(Eu(Ⅱ)),or fully filled(Yb(Ⅱ))4f subshell.As such,stable complexes are formed primarily with Ln(Ⅲ)ions[1].
基金Supported by the National Natural Science Foundation of China(Grant No.12061061)the Science and Technology Project of Gansu Province(Grant No.22JR5RA153).
文摘Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-injective and Cartan-Eilenberg FP_(n)-flat complexes.As applications,we obtain that any complex admits Cartan-Eilenberg FP_(n)-injective(resp.,Cartan-Eilenberg FP_(n)-flat)cover and preenvelope and we characterize left n-coherent rings using these two classes of complexes.
