Here, we administered repeated-pulse transcranial magnetic stimulation to healthy people at the left Guangming （GB37） and a mock point, and calculated the sample entropy of electroencephalo- gram signals using nonli...Here, we administered repeated-pulse transcranial magnetic stimulation to healthy people at the left Guangming （GB37） and a mock point, and calculated the sample entropy of electroencephalo- gram signals using nonlinear dynamics. Additionally, we compared electroencephalogram sample entropy of signals in response to visual stimulation before, during, and after repeated-pulse tran- scranial magnetic stimulation at the Guangming. Results showed that electroencephalogram sample entropy at left （F3） and right （FP2） frontal electrodes were significantly different depending on where the magnetic stimulation was administered. Additionally, compared with the mock point, electroencephalogram sample entropy was higher after stimulating the Guangming point. When visual stimulation at Guangming was given before repeated-pulse transcranial magnetic stimula- tion, significant differences in sample entropy were found at five electrodes （C3, Cz, C4, P3, T8） in parietal cortex, the central gyrus, and the right temporal region compared with when it was given after repeated-pulse transcranial magnetic stimulation, indicating that repeated-pulse transcranial magnetic stimulation at Guangming can affect visual function. Analysis of electroencephalogram revealed that when visual stimulation preceded repeated pulse transcranial magnetic stimulation, sample entropy values were higher at the C3, C4, and P3 electrodes and lower at the Cz and T8 electrodes than visual stimulation followed preceded repeated pulse transcranial magnetic stimula- tion. The findings indicate that repeated-pulse transcranial magnetic stimulation at the Guangming evokes different patterns of electroencephalogram signals than repeated-pulse transcranial mag- netic stimulation at other nearby points on the body surface, and that repeated-pulse transcranial magnetic stimulation at the Guangrning is associated with changes in the complexity of visually evoked electroencephalogram signals in parietal regions, central gyrus, and temporal regions.展开更多
目的:本研究旨在探讨NT联合NIPT、早期唐氏筛查及四维超声检查在胎儿染色体疾病筛查中的临床应用价值,评估不同检测方法单独及联合使用时的检出率和诊断效能,为优化胎儿染色体异常的早期筛查策略提供依据。方法:回顾性分析2018年1月至2...目的:本研究旨在探讨NT联合NIPT、早期唐氏筛查及四维超声检查在胎儿染色体疾病筛查中的临床应用价值,评估不同检测方法单独及联合使用时的检出率和诊断效能,为优化胎儿染色体异常的早期筛查策略提供依据。方法:回顾性分析2018年1月至2024年10月于青海红十字医院行产前诊断的532例孕妇的临床数据,所有病例均行NT、NIPT、早期唐氏筛查、四维超声检查及羊水穿刺。分别计算各检测方法单独及联合筛查的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值及准确率,同时对多种检测联合方案的诊断效能进行ROC曲线分析。结果:两组孕妇的年龄、孕周、孕前BMI、居住地与文化程度均无统计学差异(P > 0.05)。单独检测中,相比NT、早期唐氏筛查及四维超声检查,NIPT具有较高的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值、准确率及AUC (P Objective: The aim of this study was to investigate the clinical application value of NT combined with NIPT, early Down’s screening, and four-dimensional ultrasonography in the screening of fetal chromosomal disorders, to assess the detection rate and diagnostic efficacy of different testing methods when used individually and in combination, and to provide a basis for optimising the early screening strategy for fetal chromosomal abnormalities. Methods: Clinical data of 532 pregnant women who underwent prenatal diagnosis in Qinghai Red Cross Hospital from January 2018 to October 2024 were retrospectively analysed, and all cases underwent NT, NIPT, early Down’s syndrome screening, four-dimensional ultrasonography, and amniocentesis. The positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of each test alone and in combination were calculated, and the diagnostic efficacy of the combination of multiple tests was analysed by ROC curve. Results: There were no statistically significant differences in age, gestational week, pre-pregnancy BMI, place of residence, and education between the two groups (P > 0.05). Among individual tests, compared with NT, early Down’s screening, and 4D ultrasound, NIPT alone had a higher positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Compared to individual screening, NT combined with early Down syndrome screening, and NT combined with four dimensional ultrasound examination, NT combined with NIPT had higher sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Conclusion: NT combined with NIPT, early Down’s syndrome screening, and four-dimensional ultrasound can significantly improve the detection rate and diagnostic accuracy of individual screening, especially the combined NT + NIPT program has high clinical value in the screening of fetal chromosomal abnormalities, which provides a scientific basis for optimizing the screening strategy for high-risk pregnant women.展开更多
分析急性生理与慢性健康评分(APACHE-Ⅱ评分)、红细胞体积分布宽度(red cell volume distribution width,RDW)及氨基末端脑利钠肽前体(NT-proBNP)与脓毒症患者预后的相关性。选取72例脓毒症患者作为研究对象,患者的入院时间为2022年1月...分析急性生理与慢性健康评分(APACHE-Ⅱ评分)、红细胞体积分布宽度(red cell volume distribution width,RDW)及氨基末端脑利钠肽前体(NT-proBNP)与脓毒症患者预后的相关性。选取72例脓毒症患者作为研究对象,患者的入院时间为2022年1月—2023年12月,按照存活与否将患者分为存活组(n=58)和病亡组(n=14),对比存活组与病亡组患者的APACHE-Ⅱ评分、RDW及NT-proBNP指标。结果显示,存活组与病亡组脓毒症患者的APACHE-Ⅱ评分、RDW及NT-proBNP差异显著,存活组脓毒症患者的APACHE-Ⅱ评分、RDW及NT-proBNP更优,差异有统计学意义(P<0.05)。BNP浓度越高,APACHE-Ⅱ评分越高,BNP浓度与APACHE-Ⅱ评分成正比。研究发现,APACHE-Ⅱ评分、RDW及NT-proB-NP与脓毒症患者的预后具有相关性。展开更多
目的探讨血清Clara细胞分泌蛋白16(Clara cell secretory protein 16,CC-16)、肺表面活性蛋白A(pulmonary surfactant protein A,SP-A)及氨基末端脑钠肽前体(N-terminal pro-B type natriuretic peptide,NT-proBNP)、白细胞介素17(inter...目的探讨血清Clara细胞分泌蛋白16(Clara cell secretory protein 16,CC-16)、肺表面活性蛋白A(pulmonary surfactant protein A,SP-A)及氨基末端脑钠肽前体(N-terminal pro-B type natriuretic peptide,NT-proBNP)、白细胞介素17(interleukin-17,IL-17)在新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)中的表达及意义。方法将2021年1月—2023年2月湖北省汉川市人民医院收治的NRDS患儿98例纳为NRDS组,其中轻度38例,中度33例,重度27例,另将同时期在我院出生的健康新生儿50例纳为健康组。比较2组CC-16、SP-A、NT-proBNP、IL-17水平;通过受试者工作特征曲线分析CC-16、SP-A、NT-proBNP、IL-17单独及各项联合评估NRDS的价值。比较不同病情严重程度NRDS患儿基线资料与CC-16、SP-A、NT-proBNP、IL-17水平;通过Spearman秩相关分析检验CC-16、SP-A、NT-proBNP、IL-17水平与NRDS病情严重程度的相关性。结果NRDS组CC-16、SP-A、NT-proBNP、IL-17水平[(60.21±3.85)mg/L、(74.96±6.35)mg/L、(5063.44±992.65)ng/L、(99.75±30.42)ng/L]明显高于健康组[(12.09±1.27)mg/L、(17.88±2.76)mg/L、(1872.49±502.51)ng/L、(58.82±15.73)ng/L],差异有统计学意义(P<0.05)。ROC曲线分析结果显示,CC-16、SP-A、NT-proBNP、IL-17评估NRDS的曲线下面积为0.845、0.870、0.846、0.885,各项联合评估NRDS的曲线下面积为0.927,敏感度为0.980。轻度组CC-16、SP-A、NT-proBNP、IL-17水平[(37.69±10.52)mg/L、(46.85±7.36)mg/L、(3472.57±295.14)ng/L、(39.86±12.45)ng/L]低于中度组[(52.37±16.24)mg/L、(72.81±8.06)mg/L、(4886.29±334.72)ng/L、(101.49±32.13)ng/L]和重度组[(85.13±14.44)mg/L、(97.23±12.37)mg/L、(6379.36±362.47)ng/L、(146.52±35.08)ng/L],中度组CC-16、SP-A、NT-proBNP、IL-17水平低于重度组,差异有统计学意义(P<0.05)。CC-16、SP-A、NT-proBNP、IL-17与NRDS病情严重程度之间呈正相关关系(r=0.549、0.574、0.607、0.563,均P<0.05)。结论CC-16、SP-A、NT-proBNP、IL-17在NRDS中表达水平升高,均可用于NRDS诊断,且联合诊断敏感度更高,以上指标与NRDS病情严重程度呈正相关关系。展开更多
新型混凝土扩盘桩(New type concrete expanded-plate pile,简称NT-CEP桩)作为变截面桩在工程领域应用渐广,与传统直孔桩相比,它具有承载能力高、沉降小及承力盘设计灵活等优势。运用ANSYS软件对NT-CEP桩群桩的桩身及桩周土体应力进行分...新型混凝土扩盘桩(New type concrete expanded-plate pile,简称NT-CEP桩)作为变截面桩在工程领域应用渐广,与传统直孔桩相比,它具有承载能力高、沉降小及承力盘设计灵活等优势。运用ANSYS软件对NT-CEP桩群桩的桩身及桩周土体应力进行分析,在不考虑上部承台对桩顶约束的情况下,研究NT-CEP桩抗压群桩在达到破坏时,桩身应力和桩周土体应力的变化规律,揭示竖向压力作用下NT-CEP桩群桩的破坏机理,进而确定合理盘端净间距(以下简称桩间距)。研究表明,竖向压力下NT-CEP群桩承载能力随桩间距增大而提高,但不是线性增长,桩间距超4倍盘悬挑径时,承载力提升效率开始降低,故工程设计中的桩间距控制在3~4倍盘悬挑径较为合理。完善NT-CEP桩群桩在竖向荷载作用下的理论体系,为其设计应用和技术推广提供了重要技术支撑。展开更多
基金supported by the National Natural Science Foundation of China,No.31100711,51377045,31300818the Natural Science Foundation of Hebei Province,No.H2013202176
文摘Here, we administered repeated-pulse transcranial magnetic stimulation to healthy people at the left Guangming （GB37） and a mock point, and calculated the sample entropy of electroencephalo- gram signals using nonlinear dynamics. Additionally, we compared electroencephalogram sample entropy of signals in response to visual stimulation before, during, and after repeated-pulse tran- scranial magnetic stimulation at the Guangming. Results showed that electroencephalogram sample entropy at left （F3） and right （FP2） frontal electrodes were significantly different depending on where the magnetic stimulation was administered. Additionally, compared with the mock point, electroencephalogram sample entropy was higher after stimulating the Guangming point. When visual stimulation at Guangming was given before repeated-pulse transcranial magnetic stimula- tion, significant differences in sample entropy were found at five electrodes （C3, Cz, C4, P3, T8） in parietal cortex, the central gyrus, and the right temporal region compared with when it was given after repeated-pulse transcranial magnetic stimulation, indicating that repeated-pulse transcranial magnetic stimulation at Guangming can affect visual function. Analysis of electroencephalogram revealed that when visual stimulation preceded repeated pulse transcranial magnetic stimulation, sample entropy values were higher at the C3, C4, and P3 electrodes and lower at the Cz and T8 electrodes than visual stimulation followed preceded repeated pulse transcranial magnetic stimula- tion. The findings indicate that repeated-pulse transcranial magnetic stimulation at the Guangming evokes different patterns of electroencephalogram signals than repeated-pulse transcranial mag- netic stimulation at other nearby points on the body surface, and that repeated-pulse transcranial magnetic stimulation at the Guangrning is associated with changes in the complexity of visually evoked electroencephalogram signals in parietal regions, central gyrus, and temporal regions.
文摘目的:本研究旨在探讨NT联合NIPT、早期唐氏筛查及四维超声检查在胎儿染色体疾病筛查中的临床应用价值,评估不同检测方法单独及联合使用时的检出率和诊断效能,为优化胎儿染色体异常的早期筛查策略提供依据。方法:回顾性分析2018年1月至2024年10月于青海红十字医院行产前诊断的532例孕妇的临床数据,所有病例均行NT、NIPT、早期唐氏筛查、四维超声检查及羊水穿刺。分别计算各检测方法单独及联合筛查的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值及准确率,同时对多种检测联合方案的诊断效能进行ROC曲线分析。结果:两组孕妇的年龄、孕周、孕前BMI、居住地与文化程度均无统计学差异(P > 0.05)。单独检测中,相比NT、早期唐氏筛查及四维超声检查,NIPT具有较高的阳性检出率、灵敏度、特异度、阳性预测值、阴性预测值、准确率及AUC (P Objective: The aim of this study was to investigate the clinical application value of NT combined with NIPT, early Down’s screening, and four-dimensional ultrasonography in the screening of fetal chromosomal disorders, to assess the detection rate and diagnostic efficacy of different testing methods when used individually and in combination, and to provide a basis for optimising the early screening strategy for fetal chromosomal abnormalities. Methods: Clinical data of 532 pregnant women who underwent prenatal diagnosis in Qinghai Red Cross Hospital from January 2018 to October 2024 were retrospectively analysed, and all cases underwent NT, NIPT, early Down’s syndrome screening, four-dimensional ultrasonography, and amniocentesis. The positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of each test alone and in combination were calculated, and the diagnostic efficacy of the combination of multiple tests was analysed by ROC curve. Results: There were no statistically significant differences in age, gestational week, pre-pregnancy BMI, place of residence, and education between the two groups (P > 0.05). Among individual tests, compared with NT, early Down’s screening, and 4D ultrasound, NIPT alone had a higher positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Compared to individual screening, NT combined with early Down syndrome screening, and NT combined with four dimensional ultrasound examination, NT combined with NIPT had higher sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and AUC (P < 0.05). Conclusion: NT combined with NIPT, early Down’s syndrome screening, and four-dimensional ultrasound can significantly improve the detection rate and diagnostic accuracy of individual screening, especially the combined NT + NIPT program has high clinical value in the screening of fetal chromosomal abnormalities, which provides a scientific basis for optimizing the screening strategy for high-risk pregnant women.
文摘分析急性生理与慢性健康评分(APACHE-Ⅱ评分)、红细胞体积分布宽度(red cell volume distribution width,RDW)及氨基末端脑利钠肽前体(NT-proBNP)与脓毒症患者预后的相关性。选取72例脓毒症患者作为研究对象,患者的入院时间为2022年1月—2023年12月,按照存活与否将患者分为存活组(n=58)和病亡组(n=14),对比存活组与病亡组患者的APACHE-Ⅱ评分、RDW及NT-proBNP指标。结果显示,存活组与病亡组脓毒症患者的APACHE-Ⅱ评分、RDW及NT-proBNP差异显著,存活组脓毒症患者的APACHE-Ⅱ评分、RDW及NT-proBNP更优,差异有统计学意义(P<0.05)。BNP浓度越高,APACHE-Ⅱ评分越高,BNP浓度与APACHE-Ⅱ评分成正比。研究发现,APACHE-Ⅱ评分、RDW及NT-proB-NP与脓毒症患者的预后具有相关性。
文摘目的探讨血清Clara细胞分泌蛋白16(Clara cell secretory protein 16,CC-16)、肺表面活性蛋白A(pulmonary surfactant protein A,SP-A)及氨基末端脑钠肽前体(N-terminal pro-B type natriuretic peptide,NT-proBNP)、白细胞介素17(interleukin-17,IL-17)在新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)中的表达及意义。方法将2021年1月—2023年2月湖北省汉川市人民医院收治的NRDS患儿98例纳为NRDS组,其中轻度38例,中度33例,重度27例,另将同时期在我院出生的健康新生儿50例纳为健康组。比较2组CC-16、SP-A、NT-proBNP、IL-17水平;通过受试者工作特征曲线分析CC-16、SP-A、NT-proBNP、IL-17单独及各项联合评估NRDS的价值。比较不同病情严重程度NRDS患儿基线资料与CC-16、SP-A、NT-proBNP、IL-17水平;通过Spearman秩相关分析检验CC-16、SP-A、NT-proBNP、IL-17水平与NRDS病情严重程度的相关性。结果NRDS组CC-16、SP-A、NT-proBNP、IL-17水平[(60.21±3.85)mg/L、(74.96±6.35)mg/L、(5063.44±992.65)ng/L、(99.75±30.42)ng/L]明显高于健康组[(12.09±1.27)mg/L、(17.88±2.76)mg/L、(1872.49±502.51)ng/L、(58.82±15.73)ng/L],差异有统计学意义(P<0.05)。ROC曲线分析结果显示,CC-16、SP-A、NT-proBNP、IL-17评估NRDS的曲线下面积为0.845、0.870、0.846、0.885,各项联合评估NRDS的曲线下面积为0.927,敏感度为0.980。轻度组CC-16、SP-A、NT-proBNP、IL-17水平[(37.69±10.52)mg/L、(46.85±7.36)mg/L、(3472.57±295.14)ng/L、(39.86±12.45)ng/L]低于中度组[(52.37±16.24)mg/L、(72.81±8.06)mg/L、(4886.29±334.72)ng/L、(101.49±32.13)ng/L]和重度组[(85.13±14.44)mg/L、(97.23±12.37)mg/L、(6379.36±362.47)ng/L、(146.52±35.08)ng/L],中度组CC-16、SP-A、NT-proBNP、IL-17水平低于重度组,差异有统计学意义(P<0.05)。CC-16、SP-A、NT-proBNP、IL-17与NRDS病情严重程度之间呈正相关关系(r=0.549、0.574、0.607、0.563,均P<0.05)。结论CC-16、SP-A、NT-proBNP、IL-17在NRDS中表达水平升高,均可用于NRDS诊断,且联合诊断敏感度更高,以上指标与NRDS病情严重程度呈正相关关系。
文摘新型混凝土扩盘桩(New type concrete expanded-plate pile,简称NT-CEP桩)作为变截面桩在工程领域应用渐广,与传统直孔桩相比,它具有承载能力高、沉降小及承力盘设计灵活等优势。运用ANSYS软件对NT-CEP桩群桩的桩身及桩周土体应力进行分析,在不考虑上部承台对桩顶约束的情况下,研究NT-CEP桩抗压群桩在达到破坏时,桩身应力和桩周土体应力的变化规律,揭示竖向压力作用下NT-CEP桩群桩的破坏机理,进而确定合理盘端净间距(以下简称桩间距)。研究表明,竖向压力下NT-CEP群桩承载能力随桩间距增大而提高,但不是线性增长,桩间距超4倍盘悬挑径时,承载力提升效率开始降低,故工程设计中的桩间距控制在3~4倍盘悬挑径较为合理。完善NT-CEP桩群桩在竖向荷载作用下的理论体系,为其设计应用和技术推广提供了重要技术支撑。
