AIM To evaluate whether implant design, glenoid positioning, and other factors influenced instability and scapular notching in reverse total shoulder arthroplasty.METHODS We retrospectively reviewed records of patient...AIM To evaluate whether implant design, glenoid positioning, and other factors influenced instability and scapular notching in reverse total shoulder arthroplasty.METHODS We retrospectively reviewed records of patients who had undergone reverse total shoulder arthroplasty by the senior author from July 2004 through October 2011 and who had at least 24 mo of follow-up. The 58 patients who met the criteria had 65 arthroplasties: 18 with a Grammont-type prosthesis(Grammont group) and 47 with a lateral-based prosthesis(lateral-design group). We compared the groups by rates of scapular notching and instability and by radiographic markers of glenoid position and tilt. We also compared glenoid sphere sizes and the number of subscapularis tendon repairs between the groups. Rates were compared using the Fisher exact test. Notching severity distribution was compared using the χ2 test of association. Significance was set at P < 0.05.RESULTS The Grammont group had a higher incidence of scapular notching(13 of 18; 72%) than the lateral-design group(11 of 47; 23%)(P < 0.001) and a higher incidence of instability(3 of 18; 17%) than the lateral-design group(0 of 47; 0%)(P = 0.019). Glenoid position, glenoid sphere size, and subscapularis tendon repair were not predictive of scapular notching or instability, independent of implantdesign. With the lateral-based prosthesis, each degree of inferior tilt of the baseplate was associated with a 7.3% reduction in the odds of developing notching(odds ratio 0.937, 95%CI: 0.894-0.983). CONCLUSION The lateral-based prosthesis was associated with less instability and notching compared with the Grammonttype prosthesis. Prosthesis design appears to be more important than glenoid positioning.展开更多
According to federal communication commission (FCC) rules, the 3.1 - 10.6 GHz band is allocated to the amateur ultra wideband (UWB) applications. On the other hand, the 5.15 - 5.825 GHz band is associated with the wir...According to federal communication commission (FCC) rules, the 3.1 - 10.6 GHz band is allocated to the amateur ultra wideband (UWB) applications. On the other hand, the 5.15 - 5.825 GHz band is associated with the wireless LAN (WLAN) applications according to IEEE 802.11 and HIPERLAN/2 standards. Therefore, an unwanted intrusion will be expected between these two frequency requests. In This paper a comprehensive review will be done over a wide range of UWB microstrip antennas which all have the band notching property over the WLAN band to effectively avoid this interference. All the band notching techniques in the recent papers will be categorized in 4 distinct methods including the tuning stub, the shaped slot, the parasitic element, and the fractal geometry. A few typical papers will be introduced and evaluated in each category for declaration purposes. At last, a comparison will be done between these methods and the relative papers.展开更多
We examine Qin Dynasty(221 to 207 BCE)wood bookkeeping slips from 217 to 210 BCE unearthed in Hunan province,China.While purely written slips were unearthed before,these slips are unique in that they contain written r...We examine Qin Dynasty(221 to 207 BCE)wood bookkeeping slips from 217 to 210 BCE unearthed in Hunan province,China.While purely written slips were unearthed before,these slips are unique in that they contain written records of details oftransactions as well as notches on their sides that represent the quantities of money or measures of commodities involved.Scholars have speculated that ancient engraving,notching or tokening before the development of written language could be bookkeeping/accounting.We show a form of bookkeeping combining notching with written records that emerged at a point in Chinese history where a region saw a temporary dip in local literacy.Notching reappeared to compensate for the loss in literacy to prevent fraud and reduce bookkeepers’risk of being accused of fraud.This for of dualmethod bookkeeping adds credence to the conjecture that prehistorical,prelanguage notching,engraving or tokening was likely bookkee ping/accounting.展开更多
Background:The development of gastric cancer(GC)encompasses precancerous conditions like chronic atrophic gastritis(CAG)and premalignant lesions of gastric cancer(PLGC).In these situations,abnormal Notch signaling res...Background:The development of gastric cancer(GC)encompasses precancerous conditions like chronic atrophic gastritis(CAG)and premalignant lesions of gastric cancer(PLGC).In these situations,abnormal Notch signaling results in mucosal impairment and the initiation of cancer.Banxia Xiexin Decoction(BXD),a well-known formula in traditional Chinese medicine(TCM),shows promise in treating gastric disorders,but its mechanisms in gastric restoration remain unclear.Methods:Using MNNG-induced CAG and PLGC rat models,BXD was administered for 12 weeks.Gastric mucosal pathology was assessed via hematoxylin-eosin staining.Proliferation(Ki-67)and angiogenesis(VEGFA)markers were evaluated by immunohistochemistry.Network pharmacology identified BXD’s targets and pathways.Notch pathway components(Notch1,Jagged1,Dll4,Hes1)were analyzed via qPCR,Western blot,and immunohistochemistry.Results:BXD significantly ameliorated mucosal atrophy,glandular structural disorder,and dysplasia in CAG and PLGC rats.Network pharmacology revealed 323 overlapping targets between BXD and PLGC,with Notch signaling as a central pathway.BXD downregulated Notch1,Jagged1,Dll4,and Hes1 expression at transcriptional and protein levels,suppressed Ki-67(proliferation)and VEGFA(angiogenesis)overexpression,and restored gastric mucosal integrity.Conclusion:BXD inhibits Notch signaling,reduces aberrant proliferation and angiogenesis,and interrupts Correa’s gastric carcinogenesis cascade.This study provides mechanistic evidence supporting BXD as a TCM-based intervention for gastric precancerous lesions.展开更多
文摘AIM To evaluate whether implant design, glenoid positioning, and other factors influenced instability and scapular notching in reverse total shoulder arthroplasty.METHODS We retrospectively reviewed records of patients who had undergone reverse total shoulder arthroplasty by the senior author from July 2004 through October 2011 and who had at least 24 mo of follow-up. The 58 patients who met the criteria had 65 arthroplasties: 18 with a Grammont-type prosthesis(Grammont group) and 47 with a lateral-based prosthesis(lateral-design group). We compared the groups by rates of scapular notching and instability and by radiographic markers of glenoid position and tilt. We also compared glenoid sphere sizes and the number of subscapularis tendon repairs between the groups. Rates were compared using the Fisher exact test. Notching severity distribution was compared using the χ2 test of association. Significance was set at P < 0.05.RESULTS The Grammont group had a higher incidence of scapular notching(13 of 18; 72%) than the lateral-design group(11 of 47; 23%)(P < 0.001) and a higher incidence of instability(3 of 18; 17%) than the lateral-design group(0 of 47; 0%)(P = 0.019). Glenoid position, glenoid sphere size, and subscapularis tendon repair were not predictive of scapular notching or instability, independent of implantdesign. With the lateral-based prosthesis, each degree of inferior tilt of the baseplate was associated with a 7.3% reduction in the odds of developing notching(odds ratio 0.937, 95%CI: 0.894-0.983). CONCLUSION The lateral-based prosthesis was associated with less instability and notching compared with the Grammonttype prosthesis. Prosthesis design appears to be more important than glenoid positioning.
文摘According to federal communication commission (FCC) rules, the 3.1 - 10.6 GHz band is allocated to the amateur ultra wideband (UWB) applications. On the other hand, the 5.15 - 5.825 GHz band is associated with the wireless LAN (WLAN) applications according to IEEE 802.11 and HIPERLAN/2 standards. Therefore, an unwanted intrusion will be expected between these two frequency requests. In This paper a comprehensive review will be done over a wide range of UWB microstrip antennas which all have the band notching property over the WLAN band to effectively avoid this interference. All the band notching techniques in the recent papers will be categorized in 4 distinct methods including the tuning stub, the shaped slot, the parasitic element, and the fractal geometry. A few typical papers will be introduced and evaluated in each category for declaration purposes. At last, a comparison will be done between these methods and the relative papers.
基金the National Social Science Foundation of China:“Research on Historical Materials of Accounting Books in Unearthed Bamboo and Wooden Slips”(Project Approval No.:22FJYB056).
文摘We examine Qin Dynasty(221 to 207 BCE)wood bookkeeping slips from 217 to 210 BCE unearthed in Hunan province,China.While purely written slips were unearthed before,these slips are unique in that they contain written records of details oftransactions as well as notches on their sides that represent the quantities of money or measures of commodities involved.Scholars have speculated that ancient engraving,notching or tokening before the development of written language could be bookkeeping/accounting.We show a form of bookkeeping combining notching with written records that emerged at a point in Chinese history where a region saw a temporary dip in local literacy.Notching reappeared to compensate for the loss in literacy to prevent fraud and reduce bookkeepers’risk of being accused of fraud.This for of dualmethod bookkeeping adds credence to the conjecture that prehistorical,prelanguage notching,engraving or tokening was likely bookkee ping/accounting.
基金supported by the National Natural Science Foundation of China(Grant No.82274442)the Key Research Project in Traditional Chinese Medicine of Tianjin Municipal Health Commission(Grant No.202007)the Integrated Traditional Chinese and Western Medicine Research Project of Tianjin Municipal Health Commission(Grant No.2023134).
文摘Background:The development of gastric cancer(GC)encompasses precancerous conditions like chronic atrophic gastritis(CAG)and premalignant lesions of gastric cancer(PLGC).In these situations,abnormal Notch signaling results in mucosal impairment and the initiation of cancer.Banxia Xiexin Decoction(BXD),a well-known formula in traditional Chinese medicine(TCM),shows promise in treating gastric disorders,but its mechanisms in gastric restoration remain unclear.Methods:Using MNNG-induced CAG and PLGC rat models,BXD was administered for 12 weeks.Gastric mucosal pathology was assessed via hematoxylin-eosin staining.Proliferation(Ki-67)and angiogenesis(VEGFA)markers were evaluated by immunohistochemistry.Network pharmacology identified BXD’s targets and pathways.Notch pathway components(Notch1,Jagged1,Dll4,Hes1)were analyzed via qPCR,Western blot,and immunohistochemistry.Results:BXD significantly ameliorated mucosal atrophy,glandular structural disorder,and dysplasia in CAG and PLGC rats.Network pharmacology revealed 323 overlapping targets between BXD and PLGC,with Notch signaling as a central pathway.BXD downregulated Notch1,Jagged1,Dll4,and Hes1 expression at transcriptional and protein levels,suppressed Ki-67(proliferation)and VEGFA(angiogenesis)overexpression,and restored gastric mucosal integrity.Conclusion:BXD inhibits Notch signaling,reduces aberrant proliferation and angiogenesis,and interrupts Correa’s gastric carcinogenesis cascade.This study provides mechanistic evidence supporting BXD as a TCM-based intervention for gastric precancerous lesions.
