The emergence and development of sequencing and DNA synthesis techniques have empowered us with the ability to read and write genomes,thereby enhancing our understanding and manipulation of biological processes.Over t...The emergence and development of sequencing and DNA synthesis techniques have empowered us with the ability to read and write genomes,thereby enhancing our understanding and manipulation of biological processes.Over the past two decades,numerous genomes ranging from kilobase-sized viruses to megabase-sized bacteria and yeast chromosomes have been artificially synthesized[1].Notably,the Synthetic Yeast Genome Project(Sc2.0)has successfully constructed all the chromosomes of Saccharomyces cerevisiae,with a strain containing 7.5 synthetic chromosomes also being generated[2–11].It is anticipated that collaborative efforts among scientists worldwide will soon lead to the creation of the first eukaryotic cell harboring a fully synthesized genome.Furthermore,synthetic genomes for higher eukaryotes are also emerging,as exemplified by the ongoing initial phase of the Synthetic Moss Genome Project(Syn-Moss)[12].展开更多
基金Elite Young Scientists Program of CAASNational Natural Science Foundation of China,Grant/Award Numbers:32150025,31725002+7 种基金Guangdong Provincial Key Laboratory of Synthetic Genomics,Grant/Award Number:2023B1212060054Shenzhen Outstanding Talents Training FundScience and Technology Planning Project of Guangdong Province,Grant/Award Number:2022A0505090009Bureau of International Cooperation,Chinese Academy of Sciences,Grant/Award Number:172644KYSB20180022Innovation Program of Chinese Academy of Agricultural SciencesShenzhen Science and Technology Program,Grant/Award Number:KQTD20180413181837372National Key Research and Development Program of China,Grant/Award Number:2022YFF1201800Shenzhen Key Laboratory of Synthetic Genomics,Grant/Award Number:ZDSYS201802061806209。
文摘The emergence and development of sequencing and DNA synthesis techniques have empowered us with the ability to read and write genomes,thereby enhancing our understanding and manipulation of biological processes.Over the past two decades,numerous genomes ranging from kilobase-sized viruses to megabase-sized bacteria and yeast chromosomes have been artificially synthesized[1].Notably,the Synthetic Yeast Genome Project(Sc2.0)has successfully constructed all the chromosomes of Saccharomyces cerevisiae,with a strain containing 7.5 synthetic chromosomes also being generated[2–11].It is anticipated that collaborative efforts among scientists worldwide will soon lead to the creation of the first eukaryotic cell harboring a fully synthesized genome.Furthermore,synthetic genomes for higher eukaryotes are also emerging,as exemplified by the ongoing initial phase of the Synthetic Moss Genome Project(Syn-Moss)[12].
