To investigate the influence of magnitude and distribution of the transverse normal pressure on deformation behavior of sheet metal,viscous pressure bulge test (VPB) of overlapping sheet metals is proposed,where the o...To investigate the influence of magnitude and distribution of the transverse normal pressure on deformation behavior of sheet metal,viscous pressure bulge test (VPB) of overlapping sheet metals is proposed,where the overlapped sheet metal is deformed under the dual-sided normal pressure provided by viscous medium and the overlapping sheet.The transverse normal pressure loading features provided by overlapping sheet metals are first simulated by DEFORM-2D.It shows that the magnitude and space distribution of transverse normal pressure are dependent on strain hardening exponent n-,strength coefficient K-and thickness t-values of the overlapping sheet metal.Based on the stress,deviator stress and strain distribution resulted from the finite element simulation,it indicated that the uniform transverse normal pressure has no effect on deviator stress,the figure and strain distribution of bulge specimens have no change.The non-uniform transverse normal pressure can remarkably change the figure and metal flow of specimens,and the formability of sheet metal can be improved by controlling the transverse normal pressure distribution.展开更多
Idiopathic normal pressure hydrocephalus(iNPH)is a significant cause of the severe cognitive decline in the elderly population.There is no cure for iNPH,but cognitive symptoms can be partially alleviated through cereb...Idiopathic normal pressure hydrocephalus(iNPH)is a significant cause of the severe cognitive decline in the elderly population.There is no cure for iNPH,but cognitive symptoms can be partially alleviated through cerebrospinal fluid(CSF)diversion.In the early stages of iNPH,cognitive deficits occur primarily in the executive functions and working memory supported by frontostriatal circuits.As the disease progresses,cognition declines continuously and globally,leading to poor quality of life and daily functioning.In this review,we present recent advances in understanding the neurobiological mechanisms of cognitive impairment in iNPH,focusing on(1)abnormal CSF dynamics,(2)dysfunction of frontostriatal and entorhinal-hippocampal circuits and the default mode network,(3)abnormal neuromodulation,and(4)the presence of amyloid-βand tau pathologies.展开更多
As a kind of multi-physics imaging approach integrating the advantages of electrical impedance tomography and ul- trasound imaging with the improved spatial resolution and image contrast, magneto-acoustic tomography w...As a kind of multi-physics imaging approach integrating the advantages of electrical impedance tomography and ul- trasound imaging with the improved spatial resolution and image contrast, magneto-acoustic tomography with magnetic induction （MAT-MI） is demonstrated to have the capability of electrical impedance contrast imaging for biological tissues with conductivity differences. By being detected with a strong directional transducer, abrupt pressure change is proved to be generated by the gradient of the induced Lorentz force along the force direction at conductivity boundary. A simplified boundary normal pressure （BNP）-based conductivity reconstruction algorithm is proposed and the formula for conductivity distribution inside the object with the clear physical meaning of pressure derivative, is derived. Numerical simulations of acoustic pressure and conductivity reconstruction are conducted based on a 2-layer eccentric cylindrical phantom model using Hilbert transform. The reconstructed two-dimensional conductivity images accord well with the model, thus success- fully making up the deficiency of only imaging conductivity boundary in traditional MAT-MI. The proposed method is also demonstrated to have a spatial resolution of one wavelength. This study provides a new method of reconstructing accurate electrical conductivity and suggests the potential applications of MAT-MI in imaging biological tissues with conductivity difference.展开更多
Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by semiconductors.However,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) pr...Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by semiconductors.However,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) production at the same time.Herein,we illustrate that carbon dots(CDs)/Bi_(2)WO_(6) photocatalyst with compensatory photo-electronic effect has enhanced activity for overall water photo-splitting without any sacrificial agent.In this complex photocatalytic system,the photo-potential provided by CDs makes the CDs/Bi2WO6(C-BWO)composite could satisfy the band structure conditions for overall water photo-splitting.The C-BWO composite(3 wt%CDs content)exhibits optimized hydrogen evolution(oxygen evolution)of 0.28μmol/h(0.12μmol/h)with an approximate 2:1(H_(2):O_(2))stoichiometry at normal pressure.We further employed the in-situ transient photovoltage(TPV)technique to study the photoelectron extraction and the interface charge transfer kinetics of this composite catalyst.展开更多
Idiopathic normal pressure hydrocephalus(iNPH)is caused by impaired cerebrospinal fluid absorption in the elderly;it is a surgically treatable form of dementia.Gait disturbance,dementia,and urinary incontinence are th...Idiopathic normal pressure hydrocephalus(iNPH)is caused by impaired cerebrospinal fluid absorption in the elderly;it is a surgically treatable form of dementia.Gait disturbance,dementia,and urinary incontinence are the triad of signs for iNPH.In addition to these clinical findings,imaging studies show characteristic ventricular enlargement.High Evans Index and‘disproportionately enlarged subarachnoid hydrocephalus’are other well-known imaging findings of iNPH.If the tap test shows improved symptoms,shunt surgery is performed.The disease was first described by Hakim and Adams in 1965,followed by the publication of the first,second,and third editions of the guidelines in 2004,2012,and 2020,respectively.Recent studies signal the glymphatic system and classical cerebrospinal fluid(CSF)absorption from the dural lymphatics as aetiological mechanisms of CSF retention.Research is also underway on imaging test and biomarker developments for more precise diagnosis,shunting technique options with fewer sequelae and complications,and the influence of genetics.Particularly,the newly introduced‘suspected iNPH’in the third edition of the guidelines may be useful for earlier diagnosis.However,less well-studied areas remain,such as pharmacotherapy in non-operative indications and neurological findings other than the triadic signs.This review briefly presents previous research on these and future issues.展开更多
This paper seeks to investigate nonlinear out-of-plane mechanical behaviours of woven composite flexible skin(WCFS)through experimental and theoretical methods.Firstly,quasi-static experiments are carried out on recta...This paper seeks to investigate nonlinear out-of-plane mechanical behaviours of woven composite flexible skin(WCFS)through experimental and theoretical methods.Firstly,quasi-static experiments are carried out on rectangular WCFSs with different aspect ratios under uniform normal pressure to measure out-of-plane deformation and failure loads.Afterwards,a new three-parameter geometric model is presented to describe 3D geometry of pressurized WCFS,and thus,a nonlinear mechanical model is deduced for depicting the relationship between pressure and out-of-plane displacement.The application of the aforementioned models for experimental results shows that the new models have adequately and logically depicted deformation geometry and nonlinear mechanical characteristics.展开更多
In normal pressure of reservoir, formation pressure and depth can not fully reflect the linear relationship between the formation pressure with depth, the change rule of reservoir measured formation pressure and often...In normal pressure of reservoir, formation pressure and depth can not fully reflect the linear relationship between the formation pressure with depth, the change rule of reservoir measured formation pressure and often reduced pressure, understanding unclear cause fluid properties. By introducing basic principles of hydrostatics. The relationship between pressure coefficient and mathematical depth is discussed by mathematical induction analysis of measured pressure data of nearly 50 normal pressure reservoirs in Bohai Oilfield. The results show that the reservoir pressure data is linearly distributed with depth, and the pressure coefficient is inversely proportional to depth. When the depth becomes shallower, the pressure coefficient increases and approaches the reservoir level. As the depth increases, the pressure coefficient decreases and approaches the hydrostatic pressure coefficient infinitely. The study can more accurately analyze the reservoir pressure changes, which is helpful to study the oil and water distribution, reservoir connectivity and fluid properties of atmospheric pressure reservoirs.展开更多
Background and need for the research:High-normal blood pressure(i.e.,130–139/85–89 mmHg)hashazardous ratio for both coronary heart disease and stroke,because of day to day variations in blood pressure;consequently,p...Background and need for the research:High-normal blood pressure(i.e.,130–139/85–89 mmHg)hashazardous ratio for both coronary heart disease and stroke,because of day to day variations in blood pressure;consequently,prevention through lifestyle modification is essential.Although numerous studies have examined stretching and myo-fascial release to lower blood pressure,no consensus has been reached regarding which technique is superior for immediate lowering blood pressure.The aim of this study was to evaluate and compare the immediate effects of self-performed foam rolling and active-stretching on blood pressure and myocardial oxygen demand.Methods:A total of 98 patients with high normal blood pressure(20–40 years of age)meeting the inclusion criteria were randomly divided into two groups.Group 1(n=49)performed foam rolling,and group 2(n=49)performed TheraBand-assisted active stretching of the calf muscle.The pre and post blood pressure,heart rate,and the rate pres-sure product were assessed.Statistical analysis was conducted in SPSS software(version 20.0).Results:Systolic and diastolic blood pressure significantly decreased in both groups(P<0.05),and the decrease was greater in the active stretching group than the foam rolling group.In the foam rolling group,the heart rate signifi-cantly increased,whereas no changes were observed in the active stretching group.The Rate Pressure Product was notsignificant within and between two groups.Conclusion and clinical implications:Active stretching as part of a self-performed daily exercise routineappears safer for immediate lowering blood pressure,without affecting myocardial oxygen demand.Ethics committee approval:Reference No.:EC/Approval/08/Physio/21/06/2023.展开更多
The normal pressure decomposition of CF 2Cl 2 and CF 2ClBr in air by non equilibrium plasma was studied. The pressure of CF 2Cl 2 and CF 2ClBr was 2.67×10 3Pa, added the dry air to 1.01×10 5 Pa, dis...The normal pressure decomposition of CF 2Cl 2 and CF 2ClBr in air by non equilibrium plasma was studied. The pressure of CF 2Cl 2 and CF 2ClBr was 2.67×10 3Pa, added the dry air to 1.01×10 5 Pa, discharged by corona or DBD, 11.5% of CF 2ClBr was decomposed by corona after 120s discharge, more than 85% of CF 2Cl 2 and 95% of CF 2ClBr were decomposed by DBD after 10s discharge respectively. The main products were CF 2O, Cl 2 and Br 2.展开更多
Objective： The management of se- condary normal pressure hydrocephalus （sNPH） is controversial. Many factors may affect the surgery effect. The purpose of this study was to identify the possible fac- tors influenci...Objective： The management of se- condary normal pressure hydrocephalus （sNPH） is controversial. Many factors may affect the surgery effect. The purpose of this study was to identify the possible fac- tors influencing prognosis and provide theoretical basis for clinical treatment of sNPH. Methods： A retrospective study was carried out to investigate the results of 31 patients with sNPH who under- went ventriculoperitoneal shunt surgery from January 2007 to December 2011. We processed the potential influencing factors by univariate analysis and the result further by mul- tivariate logistic regression analysis. Results： Factors including age, disease duration and Glasgow coma scale （GCS） score before surgery significantly influenced the prognosis of sNPH （P〈0.05）. Further logistic regression analysis showed that all the three factors are independent influencing factors. Conclusion： Age, disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH.展开更多
Surface modality of coalbed methane hydrate and fractal-like kinetic characteristics of the hydrate dissociation at normal pressure have been studied by using fractal geometry theory. The results show that the surface...Surface modality of coalbed methane hydrate and fractal-like kinetic characteristics of the hydrate dissociation at normal pressure have been studied by using fractal geometry theory. The results show that the surface modality of coalbed methane hydrate has fractal characteristic, and the dissociation kinetics of coalbed methane hydrate is fractal-like. Moreover, a new kinetic model for coalbed methane hydrate dissociation was proposed, and its reliability was validated.展开更多
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by abnormal cerebrospinal fluid (CSF) flow and consequent cerebral ventricular enlargement due to imbalance of CSF production and absorption. The typica...Idiopathic normal pressure hydrocephalus (iNPH) is characterized by abnormal cerebrospinal fluid (CSF) flow and consequent cerebral ventricular enlargement due to imbalance of CSF production and absorption. The typical triad symptoms, namely cognitive decline, gait disturbance, and urinary incontinence, are thought to be caused by disruption of CSF circulation. However, some patients may still experience symptomatic progression after functional shunting, suggesting that iNPH is far more complicated than a simple disorder of CSF circulation. Moreover, the diagnostic workup of iNPH can be challenging due to symptomatic and neuroimaging overlaps with other neurological disorders, such as Alzheimer's disease. Furthermore, accumulating studies indicate that the pathogenesis of iNPH might relate to multiple mechanisms, including abnormalities of brain development, brain extracellular matrix, synaptic function, blood flow, and cerebral metabolism. Therefore, iNPH is not an isolated entity in occurrence and development. Nevertheless, different pathogeneses may result in protein content changes in CSF, and the biomarkers in CSF may reflect the possible mechanisms involving the etiology of iNPH and are potentially useful in assisting the diagnosis and treatment selection. In this review, we summarize the main findings of CSF biomarkers and aim to outline a possible synthetic profile in assisting iNPH diagnosis and therapeutic options.展开更多
Idiopathic normal pressure hydrocephalus(iNPH)is a clinical syndrome characterized by cognitive decline,gait disturbance,and urinary incontinence.As iNPH often occurs in elderly individuals prone tomany types of comor...Idiopathic normal pressure hydrocephalus(iNPH)is a clinical syndrome characterized by cognitive decline,gait disturbance,and urinary incontinence.As iNPH often occurs in elderly individuals prone tomany types of comorbidity,a differential diagnosis with other neurodegenerative diseases is crucial,especially Alzheimer’s disease(AD).A growing body of published work provides evidence of radiological methods,including multimodal magnetic resonance imaging and positron emission tomography,which may help noninvasively differentiate iNPH from AD or reveal concurrent AD pathology in vivo.Imaging methods detecting morphological changes,white matter microstructural changes,cerebrospinal fluid circulation,and molecular imaging have been widely applied in iNPH patients.Here,we review radiological biomarkers using different methods in evaluating iNPH pathophysiology and differentiating or detecting concomitant AD,to noninvasively predict the possible outcome postshunt and select candidates for shunt surgery.展开更多
Catalytic oxidation of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA,an alternative bioplastic monomer to petroleum-derived terephthalic acid),has been identified as an important bioma...Catalytic oxidation of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA,an alternative bioplastic monomer to petroleum-derived terephthalic acid),has been identified as an important biomass conversion reaction in bio-based polyester industry.However,it is still challenging to acquire a high FDCA yield from the selective oxidation of HMF at low temperatures.Herein,a ternary metal-based catalyst was prepared by loading AuPdPt noble metal nanoparticles on the oxygen-rich vacancy titanium dioxide layer deposited on natural clay mineral halloysite nanotubes(HNTs),and the catalytic activity was examined for air-oxidation of HMF to FDCA in water at ambient temperature(30℃).By adjusting the Au/Pd/Pt ratio,a 93.6%FDCA yield was achieved with the optimal Au_(0.5)Pd_(0.2)Pt_(0.3)/TiO_(2)@HNTs catalyst,which revealed an impressive FDCA formation rate of 67.58 mmol g^(-1)h^(-1)and an excellent TOF value of 17.54 h^(-1)under normal air pressure at 30℃,surpassing the performance of mono-and bimetallic-based catalysts.Theoretical calculation and catalytic performance study clarified the structure-activity relationship.It was found that the ternary metal and oxygen vacancies revealing synergistic enhancement of ambient temperature catalyzed HMF air-oxidation via electronic structure tuning and adsorption intensification.DFT and kinetics study demonstrated that the presence of ternary metal significantly improved the adsorption capacity of substrate and enhanced the rate-determining step of the key intermediate 5-hydroxymethyl-2-furanocarboxylic acid(HMFCA)oxidation when compared to mono-and bimetal.Additionally,the TiO_(2)@HNTs support with high oxygen vacancy concentration facilitated the adsorption of oxygen,synergistically working with the ternary metal to activate and low the energy barriers for the generation of superoxide radical,thus enhancing the FDCA formation.This work offers a novel strategy for designing ternary metal-based catalysts for low-energy catalytic oxidation reactions.展开更多
In soil dynamics,cyclic tests on sands have been extensively studied over the past several decades.Among the natural materials most susceptible to strength loss due to earthquakes,sands are commonly tested under varyi...In soil dynamics,cyclic tests on sands have been extensively studied over the past several decades.Among the natural materials most susceptible to strength loss due to earthquakes,sands are commonly tested under varying loading,frequency,and drainage conditions.Traditionally,it has been assumed that pore pressure increases with constant strength loss once the threshold for pore pressure build-up is reached.However,recent studies have revealed that at small strains,the material initially hardens despite the generation of pore pressure.This paper presents the response and degradation of uniformly graded Drava River sand(DrOS018),similar to well-known sands such as Toyoura,Nevada or Ottawa sands,and the initial hardening phenomena that occur around threshold strains.Tests were conducted using a triaxial cyclic device at three relative densities and cell pressures(100 kPa,200 kPa,and 400 kPa)under undrained conditions.Strain-controlled tests were conducted at 0.1 Hz and 0.05 Hz using sinusoidal loading,with samples prepared by under-compaction.After crossing the threshold,the sand initially shows hardening(degradation index greater than 1)with up to a 35%increase in pore pressure,followed by strength degradation at higher strains.This study is critical for seismic design and safety,particularly for fully saturated sands in coastal and high water table areas.The findings enhance our understanding of liquefaction potential and site response,aiding more informed engineering practices by contributing to enhanced knowledge in soil dynamics and improved predictive models.The results support effective mitigation strategies and infrastructure resilience in earthquake-prone regions such as Croatia.展开更多
AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients ...AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients with well-controlled Goldmann applanation tonometer（GAT） who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled.GAT and ORA parameters including corneal compensated intraocular pressure（lOPcc）,Goldmann estimated intraocular pressure（lOPg）,corneal hysteresis（CH）,corneal resistance factor（CRF） were recorded.VF was tested by Swedish interactive threshold algorithm（SITA）-standard 30-2 fields.All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up.Patients were divided into four groups according to VF change over 3y,and ORA findings were compared between the upper 25th percentile group（slow progression group） and the lower 25th percentile group（rapid progression group）.RESULTS：Eighty-two eyes of 56 patients were studied.There were 21 eyes（21 patients） each in rapid and slow progression groups respectively.GAT,lOPcc,lOPg,CH,CRF were 12.1＋1.4 mm Hg,15.8±1.8 mm Hg,12.8±2.0 mm Hg,8.4±1.1 mm Hg,7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg,13.5±2.1 mm Hg,11.2±1.6 mm Hg,9.3±1.1 mm Hg,8.2±0.9 mm Hg respectively in slow progression group（P=0.214,〈0.001,0.007,0.017,0.413,respectively）.In bivariate correlation analysis,lOPcc,lOPcc-GAT and CH were significant correlated with m△MD（r =-0.292,-0.312,0.228 respectively,P =0.008,0.004,0.039 respectively）.CONCLUSION：Relatively rapid VF progression occurred in NTG patients whose lOPcc are rather high,CH are rather low and the difference between lOPcc and GAT are relatively large.Higher lOPcc and lower CH are associated with VF progression in NTG patients.This study suggests that GAT measures might underestimate the IOP in such patients.展开更多
Objective To evaluate the variations of intraocular pressure （lOP） in suspected open-angle glaucoma （OAG） patients. Methods The variations of lOP were measured in 216 eyes of suspected OAG patients at 4-hour inter...Objective To evaluate the variations of intraocular pressure （lOP） in suspected open-angle glaucoma （OAG） patients. Methods The variations of lOP were measured in 216 eyes of suspected OAG patients at 4-hour intervals for 48 h. Based on the results of the serial lOP measurements, optic disc changed and visual field defected, the patients were diagnosed as primary OAG （ POAG ）, normal tension glaucoma （NTG）, ocular hypertension （ OHT） , or physiologic cup （PC）. Results After the serial lOP measurements, 16. 7% of the suspected OAG patients were diagnosed as POAG, 32. 4% as NTG, 24. 5% as OHT, and 26. 4% as PC. The highest percentages of the POAG group had peak lOP at 8 AM （19. 4% ） and their trough lOP at 10 PM （27. 8% ） ; the NTG group had peak lOP at 12 AM （18. 6% ） and their trough lOP at 12 PM （22. 9% ） ; the OHT group had peak lOP at 4 AM （22. 6% ） and their trough lOP at 10 PM （26. 4% ） ; and the PC group had peak lOP at 4 AM （ 21. 1% ） and their trough lOP at 12 PM （ 21. 1% ）. The percentages of peak lOP outside clinic （ 8 AM - 4 PM） in the POAG, NTG, OHT and PC groups were 55. 6%, 50. 0%, 58. 4% and 45. 7%, respectively. The mean magnitude of variance was 5. 1 - 6. 7 mmHg in those suspected OAG patients. There was a strong positive correlation in lOP between both eyes at each time point of measurement and the variation curves of the right and left eyes had parallel profiles in those suspected OAG patients. Conclusion Serial measurement of lOP is still needed, in order not to miss the peak and the trough lOP readings in suspected OAG patients, which helps in better management of glaucoma.展开更多
Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases.Thrombin,a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor,activated pr...Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases.Thrombin,a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor,activated protein C(aPC),is considered neuroprotective.While levels of thrombin and aPC activity are readily measured in the blood,similar assays in the cerebrospinal fluid(CSF)have not been described.The aim of this study was to establish a specific and sensitive enzymatic assay to measure both thrombin and aPC activity in the CSF.CSF was collected from 14 patients with suspected normal pressure hydrocephalus served as a control group,while seven patients with central nervous system infections served as an acute neuro-inflammatory study group and one sample of CSF following traumatic lumbar puncture served as a positive control.Thrombin and aPC activities were measured by fluorescence released by specific proteolytic cleavage in the presence of endopeptidase and amino-peptidase inhibitors to ensure specificity.Specificity of the method was verified by thrombin and serine-protease inhibitors N-alpha-((2-naphthylsulfinyl)glycyl)-DL-p-amidinophenylalanylpiperidine and phenylmethanesulfonyl fluoride.Inhibition of thrombin activity by CSF samples and levels of specific thrombin inhibitors were also assessed.Thrombin and aPC activities were reliably measured and were significantly higher in the CSF of patients with central nervous system infections compared to normal pressure hydrocephalus controls,suggesting the involvement of these factors in neuro-inflammation.CSF thrombin activity levels in the presence of known thrombin concentration were high in patients with central nervous system infections,and low in normal pressure hydrocephalus patients.Quantification of endogenous thrombin inhibitors protease nexin 1,amyloid precursor protein and anti-thrombin III in CSF by western blot indicated a significant elevation of amyloid precursor protein in infectious CSF.In conclusion,this study describes a novel and sensitive assay aimed at the detection of thrombin and aPC activity in CSF.This method may be useful for measuring these factors that reflect degenerative and protective influences of coagulation on neurological disorders.The study procedure was approved by the Ethics Committee of the Chaim Sheba Medical Center(approval No.4245-17-SMC)on October 18,2018.展开更多
The pullout testing of geosynthetics is essential for studying interface interaction in the soil-reinforcement system. In this paper, a new method for testing interface properties of geotextiles is proposed. The inter...The pullout testing of geosynthetics is essential for studying interface interaction in the soil-reinforcement system. In this paper, a new method for testing interface properties of geotextiles is proposed. The interface frictional characters of two kinds of geotextiles (woven and needle-punched nonwoven) are investigated through pullout test. Nonwoven specimen has more wide variety of displacement along length than that of woven under the same pressure because of their different extensibility. The greater the elongation and deformation of specimens, the more evident the variations of displacement along reinforcement from front to pullout end. The greater the normal pressure, the smaller the displacement of every position along length with the same pullout load. The study focuses on the effects of the tensile modulus and the difference of pullout response between woven and nonwoven geotextiles.展开更多
Normal pressure hydrocephalus (NPH) secondary to syphilis is an atypical form of neurosyphilis with an unusual clinical presentation and uncommon neuroimaging findings. A case of Syndrome de Hakim-Adams occurring in a...Normal pressure hydrocephalus (NPH) secondary to syphilis is an atypical form of neurosyphilis with an unusual clinical presentation and uncommon neuroimaging findings. A case of Syndrome de Hakim-Adams occurring in a 79-year-old male was admitted for investigation of a dementia syndrome. The patient presented with clinical features and neuroimaging compatible with NPH. Syphilis serology was reactive and compatible with active disease. The patient was treated with crystalline penicillin (4 million units every 4 hours for 21 days) and was assessed again after three months, when his cognition and gait had improved and the urinary incontinence had resolved. According to this information, we describe a case of syphilis mimicking normal pressure hydrocephalus, making clear the importance of the investigation of sexually transmitted diseases in the differential diagnosis of dementia, even in patients without established risk supposedly.展开更多
文摘To investigate the influence of magnitude and distribution of the transverse normal pressure on deformation behavior of sheet metal,viscous pressure bulge test (VPB) of overlapping sheet metals is proposed,where the overlapped sheet metal is deformed under the dual-sided normal pressure provided by viscous medium and the overlapping sheet.The transverse normal pressure loading features provided by overlapping sheet metals are first simulated by DEFORM-2D.It shows that the magnitude and space distribution of transverse normal pressure are dependent on strain hardening exponent n-,strength coefficient K-and thickness t-values of the overlapping sheet metal.Based on the stress,deviator stress and strain distribution resulted from the finite element simulation,it indicated that the uniform transverse normal pressure has no effect on deviator stress,the figure and strain distribution of bulge specimens have no change.The non-uniform transverse normal pressure can remarkably change the figure and metal flow of specimens,and the formability of sheet metal can be improved by controlling the transverse normal pressure distribution.
基金supported by the National Natural Science Foundation of China(31961133025).
文摘Idiopathic normal pressure hydrocephalus(iNPH)is a significant cause of the severe cognitive decline in the elderly population.There is no cure for iNPH,but cognitive symptoms can be partially alleviated through cerebrospinal fluid(CSF)diversion.In the early stages of iNPH,cognitive deficits occur primarily in the executive functions and working memory supported by frontostriatal circuits.As the disease progresses,cognition declines continuously and globally,leading to poor quality of life and daily functioning.In this review,we present recent advances in understanding the neurobiological mechanisms of cognitive impairment in iNPH,focusing on(1)abnormal CSF dynamics,(2)dysfunction of frontostriatal and entorhinal-hippocampal circuits and the default mode network,(3)abnormal neuromodulation,and(4)the presence of amyloid-βand tau pathologies.
基金supported by the National Natural Science Foundation of China(Grant Nos.11474166 and 11604156)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20161013)+1 种基金the Postdoctoral Science Foundation of China(Grant No.2016M591874)the Priority Academic Program Development of Jiangsu Provincial Higher Education Institutions,China
文摘As a kind of multi-physics imaging approach integrating the advantages of electrical impedance tomography and ul- trasound imaging with the improved spatial resolution and image contrast, magneto-acoustic tomography with magnetic induction （MAT-MI） is demonstrated to have the capability of electrical impedance contrast imaging for biological tissues with conductivity differences. By being detected with a strong directional transducer, abrupt pressure change is proved to be generated by the gradient of the induced Lorentz force along the force direction at conductivity boundary. A simplified boundary normal pressure （BNP）-based conductivity reconstruction algorithm is proposed and the formula for conductivity distribution inside the object with the clear physical meaning of pressure derivative, is derived. Numerical simulations of acoustic pressure and conductivity reconstruction are conducted based on a 2-layer eccentric cylindrical phantom model using Hilbert transform. The reconstructed two-dimensional conductivity images accord well with the model, thus success- fully making up the deficiency of only imaging conductivity boundary in traditional MAT-MI. The proposed method is also demonstrated to have a spatial resolution of one wavelength. This study provides a new method of reconstructing accurate electrical conductivity and suggests the potential applications of MAT-MI in imaging biological tissues with conductivity difference.
基金supported by National MCF Energy R&D Program(No.2018YFE0306105)National Key Research and Development Project of China(No.2020YFA0406104)+5 种基金Innovative Research Group Project of the National Natural Science Foundation of China(No.51821002)National Natural Science Foundation of China(Nos.51725204,21771132,51972216,52041202)Natural Science Foundation of Jiangsu Province(No.BK20190041)Collaborative Innovation Center of Suzhou Nano Science&Technologythe Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the 111 Project。
文摘Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by semiconductors.However,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) production at the same time.Herein,we illustrate that carbon dots(CDs)/Bi_(2)WO_(6) photocatalyst with compensatory photo-electronic effect has enhanced activity for overall water photo-splitting without any sacrificial agent.In this complex photocatalytic system,the photo-potential provided by CDs makes the CDs/Bi2WO6(C-BWO)composite could satisfy the band structure conditions for overall water photo-splitting.The C-BWO composite(3 wt%CDs content)exhibits optimized hydrogen evolution(oxygen evolution)of 0.28μmol/h(0.12μmol/h)with an approximate 2:1(H_(2):O_(2))stoichiometry at normal pressure.We further employed the in-situ transient photovoltage(TPV)technique to study the photoelectron extraction and the interface charge transfer kinetics of this composite catalyst.
文摘Idiopathic normal pressure hydrocephalus(iNPH)is caused by impaired cerebrospinal fluid absorption in the elderly;it is a surgically treatable form of dementia.Gait disturbance,dementia,and urinary incontinence are the triad of signs for iNPH.In addition to these clinical findings,imaging studies show characteristic ventricular enlargement.High Evans Index and‘disproportionately enlarged subarachnoid hydrocephalus’are other well-known imaging findings of iNPH.If the tap test shows improved symptoms,shunt surgery is performed.The disease was first described by Hakim and Adams in 1965,followed by the publication of the first,second,and third editions of the guidelines in 2004,2012,and 2020,respectively.Recent studies signal the glymphatic system and classical cerebrospinal fluid(CSF)absorption from the dural lymphatics as aetiological mechanisms of CSF retention.Research is also underway on imaging test and biomarker developments for more precise diagnosis,shunting technique options with fewer sequelae and complications,and the influence of genetics.Particularly,the newly introduced‘suspected iNPH’in the third edition of the guidelines may be useful for earlier diagnosis.However,less well-studied areas remain,such as pharmacotherapy in non-operative indications and neurological findings other than the triadic signs.This review briefly presents previous research on these and future issues.
基金supported by the National Natural Science Foundation of China(Grant No.51875021)China Postdoctoral Science Foundation(Grant No.2022M720348).
文摘This paper seeks to investigate nonlinear out-of-plane mechanical behaviours of woven composite flexible skin(WCFS)through experimental and theoretical methods.Firstly,quasi-static experiments are carried out on rectangular WCFSs with different aspect ratios under uniform normal pressure to measure out-of-plane deformation and failure loads.Afterwards,a new three-parameter geometric model is presented to describe 3D geometry of pressurized WCFS,and thus,a nonlinear mechanical model is deduced for depicting the relationship between pressure and out-of-plane displacement.The application of the aforementioned models for experimental results shows that the new models have adequately and logically depicted deformation geometry and nonlinear mechanical characteristics.
文摘In normal pressure of reservoir, formation pressure and depth can not fully reflect the linear relationship between the formation pressure with depth, the change rule of reservoir measured formation pressure and often reduced pressure, understanding unclear cause fluid properties. By introducing basic principles of hydrostatics. The relationship between pressure coefficient and mathematical depth is discussed by mathematical induction analysis of measured pressure data of nearly 50 normal pressure reservoirs in Bohai Oilfield. The results show that the reservoir pressure data is linearly distributed with depth, and the pressure coefficient is inversely proportional to depth. When the depth becomes shallower, the pressure coefficient increases and approaches the reservoir level. As the depth increases, the pressure coefficient decreases and approaches the hydrostatic pressure coefficient infinitely. The study can more accurately analyze the reservoir pressure changes, which is helpful to study the oil and water distribution, reservoir connectivity and fluid properties of atmospheric pressure reservoirs.
文摘Background and need for the research:High-normal blood pressure(i.e.,130–139/85–89 mmHg)hashazardous ratio for both coronary heart disease and stroke,because of day to day variations in blood pressure;consequently,prevention through lifestyle modification is essential.Although numerous studies have examined stretching and myo-fascial release to lower blood pressure,no consensus has been reached regarding which technique is superior for immediate lowering blood pressure.The aim of this study was to evaluate and compare the immediate effects of self-performed foam rolling and active-stretching on blood pressure and myocardial oxygen demand.Methods:A total of 98 patients with high normal blood pressure(20–40 years of age)meeting the inclusion criteria were randomly divided into two groups.Group 1(n=49)performed foam rolling,and group 2(n=49)performed TheraBand-assisted active stretching of the calf muscle.The pre and post blood pressure,heart rate,and the rate pres-sure product were assessed.Statistical analysis was conducted in SPSS software(version 20.0).Results:Systolic and diastolic blood pressure significantly decreased in both groups(P<0.05),and the decrease was greater in the active stretching group than the foam rolling group.In the foam rolling group,the heart rate signifi-cantly increased,whereas no changes were observed in the active stretching group.The Rate Pressure Product was notsignificant within and between two groups.Conclusion and clinical implications:Active stretching as part of a self-performed daily exercise routineappears safer for immediate lowering blood pressure,without affecting myocardial oxygen demand.Ethics committee approval:Reference No.:EC/Approval/08/Physio/21/06/2023.
文摘The normal pressure decomposition of CF 2Cl 2 and CF 2ClBr in air by non equilibrium plasma was studied. The pressure of CF 2Cl 2 and CF 2ClBr was 2.67×10 3Pa, added the dry air to 1.01×10 5 Pa, discharged by corona or DBD, 11.5% of CF 2ClBr was decomposed by corona after 120s discharge, more than 85% of CF 2Cl 2 and 95% of CF 2ClBr were decomposed by DBD after 10s discharge respectively. The main products were CF 2O, Cl 2 and Br 2.
文摘Objective： The management of se- condary normal pressure hydrocephalus （sNPH） is controversial. Many factors may affect the surgery effect. The purpose of this study was to identify the possible fac- tors influencing prognosis and provide theoretical basis for clinical treatment of sNPH. Methods： A retrospective study was carried out to investigate the results of 31 patients with sNPH who under- went ventriculoperitoneal shunt surgery from January 2007 to December 2011. We processed the potential influencing factors by univariate analysis and the result further by mul- tivariate logistic regression analysis. Results： Factors including age, disease duration and Glasgow coma scale （GCS） score before surgery significantly influenced the prognosis of sNPH （P〈0.05）. Further logistic regression analysis showed that all the three factors are independent influencing factors. Conclusion： Age, disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH.
基金Project supported by the National Natural Science Foundation of China （Nos. 50874040, 51004045） and the Scientific Research Foundation for the Recruited Talents, Heilongjiang Institute of Science ＆ Technology.
文摘Surface modality of coalbed methane hydrate and fractal-like kinetic characteristics of the hydrate dissociation at normal pressure have been studied by using fractal geometry theory. The results show that the surface modality of coalbed methane hydrate has fractal characteristic, and the dissociation kinetics of coalbed methane hydrate is fractal-like. Moreover, a new kinetic model for coalbed methane hydrate dissociation was proposed, and its reliability was validated.
文摘Idiopathic normal pressure hydrocephalus (iNPH) is characterized by abnormal cerebrospinal fluid (CSF) flow and consequent cerebral ventricular enlargement due to imbalance of CSF production and absorption. The typical triad symptoms, namely cognitive decline, gait disturbance, and urinary incontinence, are thought to be caused by disruption of CSF circulation. However, some patients may still experience symptomatic progression after functional shunting, suggesting that iNPH is far more complicated than a simple disorder of CSF circulation. Moreover, the diagnostic workup of iNPH can be challenging due to symptomatic and neuroimaging overlaps with other neurological disorders, such as Alzheimer's disease. Furthermore, accumulating studies indicate that the pathogenesis of iNPH might relate to multiple mechanisms, including abnormalities of brain development, brain extracellular matrix, synaptic function, blood flow, and cerebral metabolism. Therefore, iNPH is not an isolated entity in occurrence and development. Nevertheless, different pathogeneses may result in protein content changes in CSF, and the biomarkers in CSF may reflect the possible mechanisms involving the etiology of iNPH and are potentially useful in assisting the diagnosis and treatment selection. In this review, we summarize the main findings of CSF biomarkers and aim to outline a possible synthetic profile in assisting iNPH diagnosis and therapeutic options.
基金Thisworkwas supported by the National Natural Science Foundation of China(no.82071203)Science and Technology Innovation 2030“Brain Science and Brain-inspired Research”Youth Scientist Program(no.2022ZD0213600)+1 种基金Natural Science Foundation of Sichuan(no.2022NSFSC1325)Chengdu Science and technology Bureau Program(no.2019-YF09-00215-SN)。
文摘Idiopathic normal pressure hydrocephalus(iNPH)is a clinical syndrome characterized by cognitive decline,gait disturbance,and urinary incontinence.As iNPH often occurs in elderly individuals prone tomany types of comorbidity,a differential diagnosis with other neurodegenerative diseases is crucial,especially Alzheimer’s disease(AD).A growing body of published work provides evidence of radiological methods,including multimodal magnetic resonance imaging and positron emission tomography,which may help noninvasively differentiate iNPH from AD or reveal concurrent AD pathology in vivo.Imaging methods detecting morphological changes,white matter microstructural changes,cerebrospinal fluid circulation,and molecular imaging have been widely applied in iNPH patients.Here,we review radiological biomarkers using different methods in evaluating iNPH pathophysiology and differentiating or detecting concomitant AD,to noninvasively predict the possible outcome postshunt and select candidates for shunt surgery.
基金supported by the National Natural Science Foundation of China(22478167,22278419)the College Students Innovative Practice Plan of Jiangsu University(202410299160Y)+2 种基金the Youth Talent Cultivation Plan of Jiangsu Universitythe Key Core Technology Research(Social Development)Foundation of Suzhou(2023ss06)Collaborative Innovation Center for Water Treatment Technology and Materials and the Special Fund of Henan Key Laboratory of Water Pollution Control and Rehabilitation Technology(CJSZ2024010).
文摘Catalytic oxidation of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-furandicarboxylic acid(FDCA,an alternative bioplastic monomer to petroleum-derived terephthalic acid),has been identified as an important biomass conversion reaction in bio-based polyester industry.However,it is still challenging to acquire a high FDCA yield from the selective oxidation of HMF at low temperatures.Herein,a ternary metal-based catalyst was prepared by loading AuPdPt noble metal nanoparticles on the oxygen-rich vacancy titanium dioxide layer deposited on natural clay mineral halloysite nanotubes(HNTs),and the catalytic activity was examined for air-oxidation of HMF to FDCA in water at ambient temperature(30℃).By adjusting the Au/Pd/Pt ratio,a 93.6%FDCA yield was achieved with the optimal Au_(0.5)Pd_(0.2)Pt_(0.3)/TiO_(2)@HNTs catalyst,which revealed an impressive FDCA formation rate of 67.58 mmol g^(-1)h^(-1)and an excellent TOF value of 17.54 h^(-1)under normal air pressure at 30℃,surpassing the performance of mono-and bimetallic-based catalysts.Theoretical calculation and catalytic performance study clarified the structure-activity relationship.It was found that the ternary metal and oxygen vacancies revealing synergistic enhancement of ambient temperature catalyzed HMF air-oxidation via electronic structure tuning and adsorption intensification.DFT and kinetics study demonstrated that the presence of ternary metal significantly improved the adsorption capacity of substrate and enhanced the rate-determining step of the key intermediate 5-hydroxymethyl-2-furanocarboxylic acid(HMFCA)oxidation when compared to mono-and bimetal.Additionally,the TiO_(2)@HNTs support with high oxygen vacancy concentration facilitated the adsorption of oxygen,synergistically working with the ternary metal to activate and low the energy barriers for the generation of superoxide radical,thus enhancing the FDCA formation.This work offers a novel strategy for designing ternary metal-based catalysts for low-energy catalytic oxidation reactions.
基金Project Research Infrastructure for Campus-based Laboratories at the University of Rijeka(RC.2.2.06-0001)funded by the Ministry of Science,EducationSports of the Republic of Croatia.This project has been co-funded by the European Fund for Regional Development(ERDF)The support is gratefully acknowledged.This research was partially supported by the project“Laboratory Research of Static and Cyclic Behavior at Landslide Activation”(uniri-tehnic-18-113)funded by the University of Rijeka,Croatia.
文摘In soil dynamics,cyclic tests on sands have been extensively studied over the past several decades.Among the natural materials most susceptible to strength loss due to earthquakes,sands are commonly tested under varying loading,frequency,and drainage conditions.Traditionally,it has been assumed that pore pressure increases with constant strength loss once the threshold for pore pressure build-up is reached.However,recent studies have revealed that at small strains,the material initially hardens despite the generation of pore pressure.This paper presents the response and degradation of uniformly graded Drava River sand(DrOS018),similar to well-known sands such as Toyoura,Nevada or Ottawa sands,and the initial hardening phenomena that occur around threshold strains.Tests were conducted using a triaxial cyclic device at three relative densities and cell pressures(100 kPa,200 kPa,and 400 kPa)under undrained conditions.Strain-controlled tests were conducted at 0.1 Hz and 0.05 Hz using sinusoidal loading,with samples prepared by under-compaction.After crossing the threshold,the sand initially shows hardening(degradation index greater than 1)with up to a 35%increase in pore pressure,followed by strength degradation at higher strains.This study is critical for seismic design and safety,particularly for fully saturated sands in coastal and high water table areas.The findings enhance our understanding of liquefaction potential and site response,aiding more informed engineering practices by contributing to enhanced knowledge in soil dynamics and improved predictive models.The results support effective mitigation strategies and infrastructure resilience in earthquake-prone regions such as Croatia.
文摘AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients with well-controlled Goldmann applanation tonometer（GAT） who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled.GAT and ORA parameters including corneal compensated intraocular pressure（lOPcc）,Goldmann estimated intraocular pressure（lOPg）,corneal hysteresis（CH）,corneal resistance factor（CRF） were recorded.VF was tested by Swedish interactive threshold algorithm（SITA）-standard 30-2 fields.All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up.Patients were divided into four groups according to VF change over 3y,and ORA findings were compared between the upper 25th percentile group（slow progression group） and the lower 25th percentile group（rapid progression group）.RESULTS：Eighty-two eyes of 56 patients were studied.There were 21 eyes（21 patients） each in rapid and slow progression groups respectively.GAT,lOPcc,lOPg,CH,CRF were 12.1＋1.4 mm Hg,15.8±1.8 mm Hg,12.8±2.0 mm Hg,8.4±1.1 mm Hg,7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg,13.5±2.1 mm Hg,11.2±1.6 mm Hg,9.3±1.1 mm Hg,8.2±0.9 mm Hg respectively in slow progression group（P=0.214,〈0.001,0.007,0.017,0.413,respectively）.In bivariate correlation analysis,lOPcc,lOPcc-GAT and CH were significant correlated with m△MD（r =-0.292,-0.312,0.228 respectively,P =0.008,0.004,0.039 respectively）.CONCLUSION：Relatively rapid VF progression occurred in NTG patients whose lOPcc are rather high,CH are rather low and the difference between lOPcc and GAT are relatively large.Higher lOPcc and lower CH are associated with VF progression in NTG patients.This study suggests that GAT measures might underestimate the IOP in such patients.
文摘Objective To evaluate the variations of intraocular pressure （lOP） in suspected open-angle glaucoma （OAG） patients. Methods The variations of lOP were measured in 216 eyes of suspected OAG patients at 4-hour intervals for 48 h. Based on the results of the serial lOP measurements, optic disc changed and visual field defected, the patients were diagnosed as primary OAG （ POAG ）, normal tension glaucoma （NTG）, ocular hypertension （ OHT） , or physiologic cup （PC）. Results After the serial lOP measurements, 16. 7% of the suspected OAG patients were diagnosed as POAG, 32. 4% as NTG, 24. 5% as OHT, and 26. 4% as PC. The highest percentages of the POAG group had peak lOP at 8 AM （19. 4% ） and their trough lOP at 10 PM （27. 8% ） ; the NTG group had peak lOP at 12 AM （18. 6% ） and their trough lOP at 12 PM （22. 9% ） ; the OHT group had peak lOP at 4 AM （22. 6% ） and their trough lOP at 10 PM （26. 4% ） ; and the PC group had peak lOP at 4 AM （ 21. 1% ） and their trough lOP at 12 PM （ 21. 1% ）. The percentages of peak lOP outside clinic （ 8 AM - 4 PM） in the POAG, NTG, OHT and PC groups were 55. 6%, 50. 0%, 58. 4% and 45. 7%, respectively. The mean magnitude of variance was 5. 1 - 6. 7 mmHg in those suspected OAG patients. There was a strong positive correlation in lOP between both eyes at each time point of measurement and the variation curves of the right and left eyes had parallel profiles in those suspected OAG patients. Conclusion Serial measurement of lOP is still needed, in order not to miss the peak and the trough lOP readings in suspected OAG patients, which helps in better management of glaucoma.
文摘Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases.Thrombin,a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor,activated protein C(aPC),is considered neuroprotective.While levels of thrombin and aPC activity are readily measured in the blood,similar assays in the cerebrospinal fluid(CSF)have not been described.The aim of this study was to establish a specific and sensitive enzymatic assay to measure both thrombin and aPC activity in the CSF.CSF was collected from 14 patients with suspected normal pressure hydrocephalus served as a control group,while seven patients with central nervous system infections served as an acute neuro-inflammatory study group and one sample of CSF following traumatic lumbar puncture served as a positive control.Thrombin and aPC activities were measured by fluorescence released by specific proteolytic cleavage in the presence of endopeptidase and amino-peptidase inhibitors to ensure specificity.Specificity of the method was verified by thrombin and serine-protease inhibitors N-alpha-((2-naphthylsulfinyl)glycyl)-DL-p-amidinophenylalanylpiperidine and phenylmethanesulfonyl fluoride.Inhibition of thrombin activity by CSF samples and levels of specific thrombin inhibitors were also assessed.Thrombin and aPC activities were reliably measured and were significantly higher in the CSF of patients with central nervous system infections compared to normal pressure hydrocephalus controls,suggesting the involvement of these factors in neuro-inflammation.CSF thrombin activity levels in the presence of known thrombin concentration were high in patients with central nervous system infections,and low in normal pressure hydrocephalus patients.Quantification of endogenous thrombin inhibitors protease nexin 1,amyloid precursor protein and anti-thrombin III in CSF by western blot indicated a significant elevation of amyloid precursor protein in infectious CSF.In conclusion,this study describes a novel and sensitive assay aimed at the detection of thrombin and aPC activity in CSF.This method may be useful for measuring these factors that reflect degenerative and protective influences of coagulation on neurological disorders.The study procedure was approved by the Ethics Committee of the Chaim Sheba Medical Center(approval No.4245-17-SMC)on October 18,2018.
文摘The pullout testing of geosynthetics is essential for studying interface interaction in the soil-reinforcement system. In this paper, a new method for testing interface properties of geotextiles is proposed. The interface frictional characters of two kinds of geotextiles (woven and needle-punched nonwoven) are investigated through pullout test. Nonwoven specimen has more wide variety of displacement along length than that of woven under the same pressure because of their different extensibility. The greater the elongation and deformation of specimens, the more evident the variations of displacement along reinforcement from front to pullout end. The greater the normal pressure, the smaller the displacement of every position along length with the same pullout load. The study focuses on the effects of the tensile modulus and the difference of pullout response between woven and nonwoven geotextiles.
文摘Normal pressure hydrocephalus (NPH) secondary to syphilis is an atypical form of neurosyphilis with an unusual clinical presentation and uncommon neuroimaging findings. A case of Syndrome de Hakim-Adams occurring in a 79-year-old male was admitted for investigation of a dementia syndrome. The patient presented with clinical features and neuroimaging compatible with NPH. Syphilis serology was reactive and compatible with active disease. The patient was treated with crystalline penicillin (4 million units every 4 hours for 21 days) and was assessed again after three months, when his cognition and gait had improved and the urinary incontinence had resolved. According to this information, we describe a case of syphilis mimicking normal pressure hydrocephalus, making clear the importance of the investigation of sexually transmitted diseases in the differential diagnosis of dementia, even in patients without established risk supposedly.
