Objectives This study aimed to explore the lagged and cumulative effects of risk factors on disability in older adults using distributed lag non-linear models(DLNMs).Methods We utilized data from the China Health and ...Objectives This study aimed to explore the lagged and cumulative effects of risk factors on disability in older adults using distributed lag non-linear models(DLNMs).Methods We utilized data from the China Health and Retirement Longitudinal Study(CHARLS).After feature selection via Elastic Net Regularization,we applied DLNMs to evaluate the lagged effects of risk factors.Disability was defined as the presence of any difficulties in basic activities of daily living(BADL).The cumulative relative risk(CRR)was calculated by summing the lag-specific risk estimates,representing the cumulative disability risk over the specified lag period.Effect modifications and sensitivity analyses were also performed.Results This study included a total of 2,318 participants.Early-phase lag factors,such as the difficulty in stooping(CRR=3.58;95%CI:2.31-5.55;P<0.001)and walking(CRR=2.77;95%CI:1.39-5.55;P<0.001),exerted the strongest effects immediately upon occurrence.Mid-phase lag factors,such as arthritis(CRR=1.51;95%CI:1.10-2.06;P=0.001),showed a resurgence in disability risk within 2-3 years.Late-phase lag factors,including depressive symptoms(CRR=2.38;95%CI:1.30-4.35;P<0.001)and elevated systolic blood pressure(CRR=1.64;95%CI:1.06-2.79;P=0.02),exhibited significant long-term cumulative risks.Conversely,grip strength(CRR=0.80;95%CI:0.54-0.95;P=0.02)and social participation(CRR=0.89;95%CI:0.73-0.99;P=0.04)were significant protective factors.Conclusions The findings underscore the importance of tailored interventions that account for various lag characteristics of different factors to effectively mitigate disability risk.Future studies should explore the underlying biological and sociological mechanisms of these lagged effects,identify intervention strategies that target risk factors with different lagged patterns,and evaluate their effectiveness.展开更多
BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidec...BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidectomy vestibular approach and trans-areolar approaches(TAA)are the two most commonly used remote approaches.No previous meta-analysis has compared postoperative infections and swallowing difficulties among the two procedures.AIM To compared the same among patients undergoing lobectomy for unilateral thyroid carcinoma/benign thyroid nodule.METHODS We searched PubMed MEDLINE,Google Scholar,and Cochrane Library from the date of the first published article up to August 2025.The term used were transoral thyroidectomy vestibular approach,trans areolar thyroidectomy,scarless thyroidectomy,remote thyroidectomy,infections,postoperative,inflammation,dysphagia,and swallowing difficulties.We identified 130 studies,of them,30 full texts were screened and only six studies were included in the final meta-analysis.RESULTS Postoperative infections were not different between the two approaches,odd ratio=1.33,95%confidence interval:0.50-3.53,theχ2 was 1.92 and the P-value for overall effect of 0.57.Similarly,transient swallowing difficulty was not different between the two forms of surgery,with odd ratio=0.91,95%confidence interval:0.35-2.40;theχ2 was 1.32,and the P-value for overall effect of 0.85.CONCLUSION No significant statistical differences were evident between trans-oral endoscopic Mirghani H.Infections and swallowing difficulty in scarless thyroidectomy WJCC https://www.wjgnet.com 2 January 6,2026 Volume 14 Issue 1 thyroidectomy vestibular approach and trans-areolar approach regarding postoperative infection and transient swallowing difficulties.Further longer randomized trials are needed.展开更多
This paper addresses the three-dimensional(3-D)approach angle constrained cooperative guidance problem for speed-varying missiles against maneuvering targets.First,the guidance problem is formulated in a relative refe...This paper addresses the three-dimensional(3-D)approach angle constrained cooperative guidance problem for speed-varying missiles against maneuvering targets.First,the guidance problem is formulated in a relative reference frame and a virtual control input is selected.Then,the cooperative guidance law is designed on the basis of a prediction-correction framework.The time-to-go under the baseline command is estimated by an efficient prediction method with a realistic aerodynamic model and a biased command is developed by utilizing the time-to-go predictions for synchronizing different missiles'impact times.The design of the biased command is decoupled into the individual design of its direction and magnitude.It is proved that the designed cooperative guidance law can make the time-to-go consensus error converge to zero before interception.Finally,the designed guidance law is validated through a series of numerical simulations.展开更多
A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was syst...A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was systematically investigated.The strengthening mechanism and electrical conductivity of the alloy were discussed in detail.The optimal thermomechanical treatment process was as follows:solid solution→80%cold rolling→(450℃,4 h)aging→50%cold rolling→(400℃,4 h)aging.The designed alloy achieved excellent comprehensive properties with a microhardness of HV 260,a yield strength of 843 MPa,a tensile strength of 884 MPa,and an electrical conductivity of 42.6%(IACS).Compared to direct aging treatment,the designed alloy subjected to multi-stage thermomechanical treatment had refined grains,high density of dislocations,and accelerated of precipitation of(Ni,Co)_(2)Si precipitates.High strength was mainly attributed to the combined effect of dislocation strengthening,work hardening and sub-grain strengthening,while good electrical conductivity was maintained through the precipitation of the large number of nanoparticles.展开更多
The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-effic...The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-efficiency excitation and detection elements may improve the imaging sensitivity to a certain extent,the application of the elements is inevitably subject to various limitations in practical applications,particularly during in vivo imaging and endoscopic imaging.In this study,we propose a multi-combinatorial approach to enhance the sensitivity of lipid photoacoustic imaging.The approach involves wavelet transform processing of one-dimensional A-line signals,gradient-based denoising of two-dimensional B-scan images,and finally,threedimensional spatial weighted averaging of the data processed by the previous two steps.This method not only significantly improves the signal-to-noise ratio(SNR)in distinguished feature regions of the image by around 10 dB,but also efficiently extracts weak signals with no distinct features in the original image.After processing with this method,the images acquired under single scanning were compared with those obtained under multiple scanning.The results showed highly consistent image features,with the structural similarity index increasing from 0.2 to 0.8,confirming the accuracy and reliability of the multi-combinatorial approach.展开更多
This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data e...This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets.展开更多
With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper pro...With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper proposes an intelligent path planning framework based on grid map modeling.First,an improved Safe and Smooth A*(SSA*)algorithm is employed for global path planning.By incorporating obstacle expansion and cornerpoint optimization,the proposed SSA*enhances the safety and smoothness of the planned path.Then,a Partitioned Dynamic Window Approach(PDWA)is integrated for local planning,which is triggered when dynamic or sudden static obstacles appear,enabling real-time obstacle avoidance and path adjustment.A unified objective function is constructed,considering path length,safety,and smoothness comprehensively.Multiple simulation experiments are conducted on typical port grid maps.The results demonstrate that the improved SSA*significantly reduces the number of expanded nodes and computation time in static environmentswhile generating smoother and safer paths.Meanwhile,the PDWA exhibits strong real-time performance and robustness in dynamic scenarios,achieving shorter paths and lower planning times compared to other graph search algorithms.The proposedmethodmaintains stable performance across maps of different scales and various port scenarios,verifying its practicality and potential for wider application.展开更多
This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the ...This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the design process,we transform the studied system into the form of a fully actuated system through a state transformation.Then,to address the unknown nonlinear functions and actuator fault parameters,we employ neural networks and adaptive estimation techniques,respectively.Moreover,to reduce the control cost and improve the control efficiency,we introduce event-triggered inputs into the control strategy.It is proved by the Lyapunov stability analysis that all signals of the closed-loop system are bounded and the output of system eventually converge to a bounded region.The efficacy of the control approach is ultimately demonstrated via the simulation of an actual machine feeding system.展开更多
The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are havi...The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are having a significant impact,particularly on global poverty governance.As a platform for dialogue,exchange and technical cooperation,the 2025 International Seminar on Global Poverty Reduction Partnerships was held in Beijing on 10 December 2025.展开更多
The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring suffi...The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring sufficient count accumulation for evaluation,thereby limiting response time.The sequential Bayesian approach,which utilizes prior information and considers both photon energies and interarrival times,can significantly enhance the performance of radionuclides identification.This study proposes a theoretical optimization method for the traditional sequential Bayesian approach.Each photon is processed sequentially,and the corresponding posterior probability is updated in real time using a noninformative prior from the Bayesian theory.By comparing the posterior probabilities of the background and radionuclides based on the energy variance and time interval,the type of γ-rays can be identified(background characteristic γ-rays,Compton plateaus γ-rays,or radionuclide-specific characteristic γ-rays).By integrating the information from these multiple characteristic γ-rays,the presence and type of radionuclides were determined based on the final decision function and a set threshold.Based on theoretical research,verification experiments were conducted using a LaBr_(3)(Ce)detector in both low-and natural background radiation environments with typical radionuclides(^(137)Cs,^(60)Co,and ^(133)Ba).The results show that this approach can identify ^(137)Cs in 7.9 s and 8.5 s(source dose rate contribution:approximately 6.5×10^(−3)μGy/h),^(60)Co in 8.1 s and 9.8 s(approximately 4.8×10^(−2)μGy/h),and ^(133)Ba in 4.05 s and 5.99 s(approximately 3.4×10^(−2)μGy/h)under low and natural background radiation,respectively,with a miss rate below 0.01%.This demonstrates the effectiveness of the proposed approach for fast radionuclides identification,even at low activity levels and highlights its potential for enhancing public safety in diverse radiation environments.展开更多
Disorders of consciousness(DoC),including coma,vegetative state,and minimally conscious state,present a spectrum of conditions characterized by impaired awareness and responsiveness due to severe brain injury.Conventi...Disorders of consciousness(DoC),including coma,vegetative state,and minimally conscious state,present a spectrum of conditions characterized by impaired awareness and responsiveness due to severe brain injury.Conventional interventions for DoC primarily focus on promoting conditions conducive to spontaneous neurological recovery including pharmacological treatments such as dopaminergic agents(e.g.,amantadine)and rehabilitative strategies including sensory stimulation programs and physical therapy.展开更多
Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in a...Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in an algebra,then the solution(and also the control gain in many cases)is also in the same algebra.The main result is verified by a numerical simulation.展开更多
In this work, the transient free surface of con- tainer filling with non-linear constitutive equation＇s fluids is numerically investigated by the smoothed particle hydrody- namics （SPH） method. Specifically, the fi...In this work, the transient free surface of con- tainer filling with non-linear constitutive equation＇s fluids is numerically investigated by the smoothed particle hydrody- namics （SPH） method. Specifically, the filling process of a square container is considered for non-linear polymer fluids based on the Cross model. The validity of the presented SPH is first verified by solving the Newtonian fluid and Oldroyd- B fluid jet. Various phenomena in the filling process are shown, including the jet buckling, jet thinning, splashing or spluttering, steady filling. Moreover, a new phenomenon of vortex whirling is more evidently observed for the Cross model fluid compared with the Newtonian fluid case.展开更多
We study the relationship between energy consumption and economic growth in the case of USA by using an asymmetric ARDL bounds test approach to achieve the actual model. The quarterly data set covers the period of 197...We study the relationship between energy consumption and economic growth in the case of USA by using an asymmetric ARDL bounds test approach to achieve the actual model. The quarterly data set covers the period of 1973:1- 2013:4. The findings indicate that the effect of energy consumption is asymmetric in the long term but not in the short term. In the long run, the effect of negative component of energy consumption on economic growth is small and statistically insignificant. The coefficient of the positive component of energy consumption is found about 0.9 and statistically significant at 1% level. We conclude that energy saving policies such as technological progress and organizational rearrangements may have the dimmer effect for the impact of a negative component of energy consumption and the booster effect for impact of the positive component of energy consumption. Thus, energy saving policy should be tightly followed by the goal of high economic growth.展开更多
This paper investigates the mathematic features of non-linear models and discusses the processing way of non-linear factors which contributes to the non-linearity of a non-linear model. On the basis of the error defin...This paper investigates the mathematic features of non-linear models and discusses the processing way of non-linear factors which contributes to the non-linearity of a non-linear model. On the basis of the error definition,this paper puts forward a new adjustment criterion, SGPE.Last,this paper investigates the solution of a non-linear regression model in the non-linear model space and makes the comparison between the estimated values in non-linear model space and those in linear model space.展开更多
The following article has been retracted due to the investigation of complaints received against it. Mr. Mohammadali Ghorbani (corresponding author and also the last author) cheated the authors’ name: Alireza Heidari...The following article has been retracted due to the investigation of complaints received against it. Mr. Mohammadali Ghorbani (corresponding author and also the last author) cheated the authors’ name: Alireza Heidari and Seyedali Vedad. The scientific community takes a very strong view on this matter and we treat all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No.5 420-429, 2012, has been removed from this site.展开更多
This paper deals with a new higher order compact difference scheme, which is, O(h4) using coupled approach on the 19-point 3D stencil for the solution of three dimensional nonlinear biharmonic equations. At each inter...This paper deals with a new higher order compact difference scheme, which is, O(h4) using coupled approach on the 19-point 3D stencil for the solution of three dimensional nonlinear biharmonic equations. At each internal grid point, the solution u(x,y,z) and its Laplacian Δ4u are obtained. The resulting stencil algo-rithm is presented and hence this new algorithm can be easily incorporated to solve many problems. The present discretization allows us to use the Dirichlet boundary conditions only and there is no need to discretize the derivative boundary conditions near the boundary. We also show that special treatment is required to handle the boundary conditions. Convergence analysis for a model problem is briefly discussed. The method is tested on three problems and compares very favourably with the corresponding second order approximation which we also discuss using coupled approach.展开更多
Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponi...Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponin,and natriuretic peptides play crucial roles in CVD management,yet they are often limited by sensitivity and specificity constraints.This narrative review critically examines the emerging landscape of cardiac biomarkers and advocates for a multiple-marker approach to enhance early detection,prognosis,and risk stratification of CVD.In recent years,several novel biomarkers have shown promise in revolutionizing CVD diagnostics.Gamma-glutamyltransferase,microRNAs,endothelial microparticles,placental growth factor,trimethylamine N-oxide,retinol-binding protein 4,copeptin,heart-type fatty acid-binding protein,galectin-3,growth differentiation factor-15,soluble suppression of tumorigenicity 2,fibroblast growth factor 23,and adrenomedullin have emerged as significant indicators of CV health.These biomarkers provide insights into various pathophysiological processes,such as oxidative stress,endothelial dysfunction,inflammation,metabolic disturbances,and myocardial injury.The integration of these novel biomarkers with traditional ones offers a more comprehensive understanding of CVD mechanisms.This multiple-marker approach can improve diagnostic accuracy,allowing for better risk stratification and more personalized treatment strategies.This review underscores the need for continued research to validate the clinical utility of these biomarkers and their potential incorporation into routine clinical practice.By leveraging the strengths of both traditional and novel biomarkers,precise therapeutic plans can be developed,thereby improving the management and prognosis of patients with CVDs.The ongoing exploration and validation of these biomarkers are crucial for advancing CV care and addressing the limitations of current diagnostic tools.展开更多
BACKGROUND The surgical treatment of pelvic fractures is challenging,particularly after lum-bosacral plexus injuries.Such impairments affect a patient's physiological function and can cause significant mental heal...BACKGROUND The surgical treatment of pelvic fractures is challenging,particularly after lum-bosacral plexus injuries.Such impairments affect a patient's physiological function and can cause significant mental health problems.In recent years,the new transrectus lateral approach has favorably treated pelvic fractures and possibly preserved patients'physiological and psychological conditions.There-fore,investigating its clinical efficacy for treating pelvic fractures plus lum-bosacral plexus injuries is of great clinical significance.AIM To investigate the clinical effect of the transrectus lateral approach on pelvic fractures complicated by lumbosacral plexus injuries as well as anxiety and depression.METHODS Data of 136 patients with pelvic fractures complicated by lumbosacral plexus injuries treated by the transrectus lateral approach(January 2011 to May 2024)were retrospectively analyzed.The patients'general data were collected via questionnaire.The Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to assess anxiety and depression,respectively.We adopted a numerical rating scale(NRS)to evaluate pain degree,the Pittsburgh Sleep Quality Index(PSQI)to assess sleep quality,and Medical Research Council(MRC)Scale for Muscle Strength to evaluate treatment efficacy and complications.RESULTS The 136 included patients(92 male,44 female)were a mean 48.02±15.72 years old.The mean SAS score was 66.36±5.15 preoperatively vs 42.15±4.36 postoperatively,while the mean SDS score was 65.61±5.02 preoperatively vs 43.83±4.54 postoperatively,showing statistically significant differences(P<0.05).The mean NRS and PSQI scores were significantly lower pre-vs postoperatively(P<0.05).Postoperatively,67 patients with fresh pelvic fractures plus nerve injuries achieved an MRC of M5,22 achieved an M1-M4,and four achieved an M0.Postoperative motor function improved by a mean 4.20 grades(scale,0-5).Among the patients with old pelvic fractures and nerve injuries,19 achieved an M5,16 achieved an M1-M4,and eight achieved an M0.Motor function improved significantly by a mean 3.30 grades(scale,0-5;P<0.05).No serious postoperative complications occurred.CONCLUSION The transrectus lateral approach to treating pelvic fractures plus lumbosacral plexus injuries can safely alleviate anxiety and depression,relieve pain,improve sleep quality,reduce intraoperative blood loss,and improve postoperative recovery.展开更多
For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies ...For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies bionic analytical framework based on the partial differential equation-ordinary differential equation(PDE-ODE)approach.Specifically,by designing a specialized network communication protocol and employing the spatial continuum method for densely distributed agents,this paper models the tracking errors of densely distributed agents as a PDE equivalent to a human disease transmission model,and that of sparsely distributed agents as several ODEs equivalent to the predator population models.The coupling relationship between the PDE and ODE models is established through boundary conditions of the PDE,thereby forming a PDE-ODE-based tracking error model for the considered MASs.Furthermore,by integrating adaptive neural control scheme with the aforementioned biological models,a“Flexible Neural Network”endowed with adaptive and self-stabilized capabilities is constructed,which acts upon the considered MASs,enabling their practical finite-time deployment.Finally,effectiveness of the developed approach is illustrated through a numerical example.展开更多
基金supported by ScientificResearch Fund of National Health Commission of the People’s Republic of China-Major Science and Technology Program for Medicine and Health in Zhejiang Province(WKJ-ZJ-2406).
文摘Objectives This study aimed to explore the lagged and cumulative effects of risk factors on disability in older adults using distributed lag non-linear models(DLNMs).Methods We utilized data from the China Health and Retirement Longitudinal Study(CHARLS).After feature selection via Elastic Net Regularization,we applied DLNMs to evaluate the lagged effects of risk factors.Disability was defined as the presence of any difficulties in basic activities of daily living(BADL).The cumulative relative risk(CRR)was calculated by summing the lag-specific risk estimates,representing the cumulative disability risk over the specified lag period.Effect modifications and sensitivity analyses were also performed.Results This study included a total of 2,318 participants.Early-phase lag factors,such as the difficulty in stooping(CRR=3.58;95%CI:2.31-5.55;P<0.001)and walking(CRR=2.77;95%CI:1.39-5.55;P<0.001),exerted the strongest effects immediately upon occurrence.Mid-phase lag factors,such as arthritis(CRR=1.51;95%CI:1.10-2.06;P=0.001),showed a resurgence in disability risk within 2-3 years.Late-phase lag factors,including depressive symptoms(CRR=2.38;95%CI:1.30-4.35;P<0.001)and elevated systolic blood pressure(CRR=1.64;95%CI:1.06-2.79;P=0.02),exhibited significant long-term cumulative risks.Conversely,grip strength(CRR=0.80;95%CI:0.54-0.95;P=0.02)and social participation(CRR=0.89;95%CI:0.73-0.99;P=0.04)were significant protective factors.Conclusions The findings underscore the importance of tailored interventions that account for various lag characteristics of different factors to effectively mitigate disability risk.Future studies should explore the underlying biological and sociological mechanisms of these lagged effects,identify intervention strategies that target risk factors with different lagged patterns,and evaluate their effectiveness.
文摘BACKGROUND Due to the increasing rate of thyroid nodules diagnosis,and the desire to avoid the unsightly cervical scar,remote thyroidectomies were invented and are increasingly performed.Transoral endoscopic thyroidectomy vestibular approach and trans-areolar approaches(TAA)are the two most commonly used remote approaches.No previous meta-analysis has compared postoperative infections and swallowing difficulties among the two procedures.AIM To compared the same among patients undergoing lobectomy for unilateral thyroid carcinoma/benign thyroid nodule.METHODS We searched PubMed MEDLINE,Google Scholar,and Cochrane Library from the date of the first published article up to August 2025.The term used were transoral thyroidectomy vestibular approach,trans areolar thyroidectomy,scarless thyroidectomy,remote thyroidectomy,infections,postoperative,inflammation,dysphagia,and swallowing difficulties.We identified 130 studies,of them,30 full texts were screened and only six studies were included in the final meta-analysis.RESULTS Postoperative infections were not different between the two approaches,odd ratio=1.33,95%confidence interval:0.50-3.53,theχ2 was 1.92 and the P-value for overall effect of 0.57.Similarly,transient swallowing difficulty was not different between the two forms of surgery,with odd ratio=0.91,95%confidence interval:0.35-2.40;theχ2 was 1.32,and the P-value for overall effect of 0.85.CONCLUSION No significant statistical differences were evident between trans-oral endoscopic Mirghani H.Infections and swallowing difficulty in scarless thyroidectomy WJCC https://www.wjgnet.com 2 January 6,2026 Volume 14 Issue 1 thyroidectomy vestibular approach and trans-areolar approach regarding postoperative infection and transient swallowing difficulties.Further longer randomized trials are needed.
基金supported by Key R&D Program(Soft Science Project)of Shandong Province,China(No.2020CXGC011502)National Natural Science Foundation of China(Nos.62273043 and 62103049).
文摘This paper addresses the three-dimensional(3-D)approach angle constrained cooperative guidance problem for speed-varying missiles against maneuvering targets.First,the guidance problem is formulated in a relative reference frame and a virtual control input is selected.Then,the cooperative guidance law is designed on the basis of a prediction-correction framework.The time-to-go under the baseline command is estimated by an efficient prediction method with a realistic aerodynamic model and a biased command is developed by utilizing the time-to-go predictions for synchronizing different missiles'impact times.The design of the biased command is decoupled into the individual design of its direction and magnitude.It is proved that the designed cooperative guidance law can make the time-to-go consensus error converge to zero before interception.Finally,the designed guidance law is validated through a series of numerical simulations.
基金the financial support by the National Natural Science Foundation of China(No.U2202255)the Hunan Provincial Natural Science Foundation of China(No.2024JJ2076)the Key Research and Development Program of Ningbo,China(No.2023Z092)。
文摘A Cu-1.9Ni-1.9Co-0.9Si(mass fraction,%)alloy with high strength and electrical conductivity was designed by cluster formula approach.The microstructure evolution of the alloy during thermomechanical treatment was systematically investigated.The strengthening mechanism and electrical conductivity of the alloy were discussed in detail.The optimal thermomechanical treatment process was as follows:solid solution→80%cold rolling→(450℃,4 h)aging→50%cold rolling→(400℃,4 h)aging.The designed alloy achieved excellent comprehensive properties with a microhardness of HV 260,a yield strength of 843 MPa,a tensile strength of 884 MPa,and an electrical conductivity of 42.6%(IACS).Compared to direct aging treatment,the designed alloy subjected to multi-stage thermomechanical treatment had refined grains,high density of dislocations,and accelerated of precipitation of(Ni,Co)_(2)Si precipitates.High strength was mainly attributed to the combined effect of dislocation strengthening,work hardening and sub-grain strengthening,while good electrical conductivity was maintained through the precipitation of the large number of nanoparticles.
基金supported by the National Key Research and Development Program of China(2022YFC2402400)the National Natural Science Foundation of China(82027803,62275062)+7 种基金the Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology(2020B121201010)the Shenzhen Science and Technology Innovation Committee under Grant(JCYJ20220818101417039)the Shenzhen Key Laboratory for Molecular lmaging(ZDSY20130401165820357)the Shenzhen Medical Research Fund(D2404002)the Project of Shandong Innovation and Startup Community of High-end Medical Apparatus and Instruments(2023-SGTTXM-002 and 2024-SGTTXM-005)the Shandong Province Technology Innovation Guidance Plan(Central Leading Local Science and Technology Development Fund)(YDZX2023115)the Taishan Scholar Special Funding Project of Shandong Provinceand the Shandong Laboratory of Advanced Biomaterials and Medical Devices in Weihai(ZL202402).
文摘The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-efficiency excitation and detection elements may improve the imaging sensitivity to a certain extent,the application of the elements is inevitably subject to various limitations in practical applications,particularly during in vivo imaging and endoscopic imaging.In this study,we propose a multi-combinatorial approach to enhance the sensitivity of lipid photoacoustic imaging.The approach involves wavelet transform processing of one-dimensional A-line signals,gradient-based denoising of two-dimensional B-scan images,and finally,threedimensional spatial weighted averaging of the data processed by the previous two steps.This method not only significantly improves the signal-to-noise ratio(SNR)in distinguished feature regions of the image by around 10 dB,but also efficiently extracts weak signals with no distinct features in the original image.After processing with this method,the images acquired under single scanning were compared with those obtained under multiple scanning.The results showed highly consistent image features,with the structural similarity index increasing from 0.2 to 0.8,confirming the accuracy and reliability of the multi-combinatorial approach.
基金supported by the National Natural Science Foundation of China[grant numbers 12171158,12371474 and 12571510]Fundamental Research Funds for the Central Universities[grant number 2025ECNU-WLJC006].
文摘This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets.
文摘With the rapid development of intelligent navigation technology,efficient and safe path planning for mobile robots has become a core requirement.To address the challenges of complex dynamic environments,this paper proposes an intelligent path planning framework based on grid map modeling.First,an improved Safe and Smooth A*(SSA*)algorithm is employed for global path planning.By incorporating obstacle expansion and cornerpoint optimization,the proposed SSA*enhances the safety and smoothness of the planned path.Then,a Partitioned Dynamic Window Approach(PDWA)is integrated for local planning,which is triggered when dynamic or sudden static obstacles appear,enabling real-time obstacle avoidance and path adjustment.A unified objective function is constructed,considering path length,safety,and smoothness comprehensively.Multiple simulation experiments are conducted on typical port grid maps.The results demonstrate that the improved SSA*significantly reduces the number of expanded nodes and computation time in static environmentswhile generating smoother and safer paths.Meanwhile,the PDWA exhibits strong real-time performance and robustness in dynamic scenarios,achieving shorter paths and lower planning times compared to other graph search algorithms.The proposedmethodmaintains stable performance across maps of different scales and various port scenarios,verifying its practicality and potential for wider application.
基金supported by the Science Center Program of National Natural Science Foundation of China under Grant 62188101the National Natural Science Foundation of China under Grant 62573265.
文摘This study develops an event-triggered control strategy utilizing the fully actuated system approach for nonlinear interconnected large-scale systems containing actuator failures.First,to reduce the complexity of the design process,we transform the studied system into the form of a fully actuated system through a state transformation.Then,to address the unknown nonlinear functions and actuator fault parameters,we employ neural networks and adaptive estimation techniques,respectively.Moreover,to reduce the control cost and improve the control efficiency,we introduce event-triggered inputs into the control strategy.It is proved by the Lyapunov stability analysis that all signals of the closed-loop system are bounded and the output of system eventually converge to a bounded region.The efficacy of the control approach is ultimately demonstrated via the simulation of an actual machine feeding system.
文摘The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are having a significant impact,particularly on global poverty governance.As a platform for dialogue,exchange and technical cooperation,the 2025 International Seminar on Global Poverty Reduction Partnerships was held in Beijing on 10 December 2025.
基金supported by the Program for NIM-Basic Research Business Expenses Key Field Program,China(No.AKYCX2315).
文摘The rapid identification of γ-emitting radionuclides with low activity levels in public areas is crucial for nuclear safety.However,classical methods rely on full-energy peaks in the integral spectrum,requiring sufficient count accumulation for evaluation,thereby limiting response time.The sequential Bayesian approach,which utilizes prior information and considers both photon energies and interarrival times,can significantly enhance the performance of radionuclides identification.This study proposes a theoretical optimization method for the traditional sequential Bayesian approach.Each photon is processed sequentially,and the corresponding posterior probability is updated in real time using a noninformative prior from the Bayesian theory.By comparing the posterior probabilities of the background and radionuclides based on the energy variance and time interval,the type of γ-rays can be identified(background characteristic γ-rays,Compton plateaus γ-rays,or radionuclide-specific characteristic γ-rays).By integrating the information from these multiple characteristic γ-rays,the presence and type of radionuclides were determined based on the final decision function and a set threshold.Based on theoretical research,verification experiments were conducted using a LaBr_(3)(Ce)detector in both low-and natural background radiation environments with typical radionuclides(^(137)Cs,^(60)Co,and ^(133)Ba).The results show that this approach can identify ^(137)Cs in 7.9 s and 8.5 s(source dose rate contribution:approximately 6.5×10^(−3)μGy/h),^(60)Co in 8.1 s and 9.8 s(approximately 4.8×10^(−2)μGy/h),and ^(133)Ba in 4.05 s and 5.99 s(approximately 3.4×10^(−2)μGy/h)under low and natural background radiation,respectively,with a miss rate below 0.01%.This demonstrates the effectiveness of the proposed approach for fast radionuclides identification,even at low activity levels and highlights its potential for enhancing public safety in diverse radiation environments.
文摘Disorders of consciousness(DoC),including coma,vegetative state,and minimally conscious state,present a spectrum of conditions characterized by impaired awareness and responsiveness due to severe brain injury.Conventional interventions for DoC primarily focus on promoting conditions conducive to spontaneous neurological recovery including pharmacological treatments such as dopaminergic agents(e.g.,amantadine)and rehabilitative strategies including sensory stimulation programs and physical therapy.
文摘Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in an algebra,then the solution(and also the control gain in many cases)is also in the same algebra.The main result is verified by a numerical simulation.
基金support by the National Basic Research Program of China (973) (2012CB025903)the National Natural Science Foundation of China (10871159)Basic Research Program of China(2005CB321704)
文摘In this work, the transient free surface of con- tainer filling with non-linear constitutive equation＇s fluids is numerically investigated by the smoothed particle hydrody- namics （SPH） method. Specifically, the filling process of a square container is considered for non-linear polymer fluids based on the Cross model. The validity of the presented SPH is first verified by solving the Newtonian fluid and Oldroyd- B fluid jet. Various phenomena in the filling process are shown, including the jet buckling, jet thinning, splashing or spluttering, steady filling. Moreover, a new phenomenon of vortex whirling is more evidently observed for the Cross model fluid compared with the Newtonian fluid case.
文摘We study the relationship between energy consumption and economic growth in the case of USA by using an asymmetric ARDL bounds test approach to achieve the actual model. The quarterly data set covers the period of 1973:1- 2013:4. The findings indicate that the effect of energy consumption is asymmetric in the long term but not in the short term. In the long run, the effect of negative component of energy consumption on economic growth is small and statistically insignificant. The coefficient of the positive component of energy consumption is found about 0.9 and statistically significant at 1% level. We conclude that energy saving policies such as technological progress and organizational rearrangements may have the dimmer effect for the impact of a negative component of energy consumption and the booster effect for impact of the positive component of energy consumption. Thus, energy saving policy should be tightly followed by the goal of high economic growth.
文摘This paper investigates the mathematic features of non-linear models and discusses the processing way of non-linear factors which contributes to the non-linearity of a non-linear model. On the basis of the error definition,this paper puts forward a new adjustment criterion, SGPE.Last,this paper investigates the solution of a non-linear regression model in the non-linear model space and makes the comparison between the estimated values in non-linear model space and those in linear model space.
文摘The following article has been retracted due to the investigation of complaints received against it. Mr. Mohammadali Ghorbani (corresponding author and also the last author) cheated the authors’ name: Alireza Heidari and Seyedali Vedad. The scientific community takes a very strong view on this matter and we treat all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No.5 420-429, 2012, has been removed from this site.
文摘This paper deals with a new higher order compact difference scheme, which is, O(h4) using coupled approach on the 19-point 3D stencil for the solution of three dimensional nonlinear biharmonic equations. At each internal grid point, the solution u(x,y,z) and its Laplacian Δ4u are obtained. The resulting stencil algo-rithm is presented and hence this new algorithm can be easily incorporated to solve many problems. The present discretization allows us to use the Dirichlet boundary conditions only and there is no need to discretize the derivative boundary conditions near the boundary. We also show that special treatment is required to handle the boundary conditions. Convergence analysis for a model problem is briefly discussed. The method is tested on three problems and compares very favourably with the corresponding second order approximation which we also discuss using coupled approach.
文摘Cardiovascular diseases(CVDs)remain the leading cause of morbidity and mortality worldwide,necessitating innovative diagnostic and prognostic strategies.Traditional biomarkers like C-reactive protein,uric acid,troponin,and natriuretic peptides play crucial roles in CVD management,yet they are often limited by sensitivity and specificity constraints.This narrative review critically examines the emerging landscape of cardiac biomarkers and advocates for a multiple-marker approach to enhance early detection,prognosis,and risk stratification of CVD.In recent years,several novel biomarkers have shown promise in revolutionizing CVD diagnostics.Gamma-glutamyltransferase,microRNAs,endothelial microparticles,placental growth factor,trimethylamine N-oxide,retinol-binding protein 4,copeptin,heart-type fatty acid-binding protein,galectin-3,growth differentiation factor-15,soluble suppression of tumorigenicity 2,fibroblast growth factor 23,and adrenomedullin have emerged as significant indicators of CV health.These biomarkers provide insights into various pathophysiological processes,such as oxidative stress,endothelial dysfunction,inflammation,metabolic disturbances,and myocardial injury.The integration of these novel biomarkers with traditional ones offers a more comprehensive understanding of CVD mechanisms.This multiple-marker approach can improve diagnostic accuracy,allowing for better risk stratification and more personalized treatment strategies.This review underscores the need for continued research to validate the clinical utility of these biomarkers and their potential incorporation into routine clinical practice.By leveraging the strengths of both traditional and novel biomarkers,precise therapeutic plans can be developed,thereby improving the management and prognosis of patients with CVDs.The ongoing exploration and validation of these biomarkers are crucial for advancing CV care and addressing the limitations of current diagnostic tools.
基金Supported by National Key Research and Development Plan,No.2022YFC2504303National Natural Science Foundation of China,No.82072411+1 种基金Guangzhou Area Clinical High-tech and Major Technology Projects,No.2024PL-GX11Internal Medicine Research Fund Project of Huadu District People's Hospital,Guangzhou(Excellent Youth Project),No.2020B06.
文摘BACKGROUND The surgical treatment of pelvic fractures is challenging,particularly after lum-bosacral plexus injuries.Such impairments affect a patient's physiological function and can cause significant mental health problems.In recent years,the new transrectus lateral approach has favorably treated pelvic fractures and possibly preserved patients'physiological and psychological conditions.There-fore,investigating its clinical efficacy for treating pelvic fractures plus lum-bosacral plexus injuries is of great clinical significance.AIM To investigate the clinical effect of the transrectus lateral approach on pelvic fractures complicated by lumbosacral plexus injuries as well as anxiety and depression.METHODS Data of 136 patients with pelvic fractures complicated by lumbosacral plexus injuries treated by the transrectus lateral approach(January 2011 to May 2024)were retrospectively analyzed.The patients'general data were collected via questionnaire.The Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to assess anxiety and depression,respectively.We adopted a numerical rating scale(NRS)to evaluate pain degree,the Pittsburgh Sleep Quality Index(PSQI)to assess sleep quality,and Medical Research Council(MRC)Scale for Muscle Strength to evaluate treatment efficacy and complications.RESULTS The 136 included patients(92 male,44 female)were a mean 48.02±15.72 years old.The mean SAS score was 66.36±5.15 preoperatively vs 42.15±4.36 postoperatively,while the mean SDS score was 65.61±5.02 preoperatively vs 43.83±4.54 postoperatively,showing statistically significant differences(P<0.05).The mean NRS and PSQI scores were significantly lower pre-vs postoperatively(P<0.05).Postoperatively,67 patients with fresh pelvic fractures plus nerve injuries achieved an MRC of M5,22 achieved an M1-M4,and four achieved an M0.Postoperative motor function improved by a mean 4.20 grades(scale,0-5).Among the patients with old pelvic fractures and nerve injuries,19 achieved an M5,16 achieved an M1-M4,and eight achieved an M0.Motor function improved significantly by a mean 3.30 grades(scale,0-5;P<0.05).No serious postoperative complications occurred.CONCLUSION The transrectus lateral approach to treating pelvic fractures plus lumbosacral plexus injuries can safely alleviate anxiety and depression,relieve pain,improve sleep quality,reduce intraoperative blood loss,and improve postoperative recovery.
基金The National Key R&D Program of China(2021ZD0201300)the National Natural Science Foundation of China(624B2058,U1913602 and 61936004)+1 种基金the Innovation Group Project of the National Natural Science Foundation of China(61821003)the 111 Project on Computational Intelligence and Intelligent Control(B18024).
文摘For large-scale heterogeneous multi-agent systems(MASs)with characteristics of dense-sparse mixed distribution,this paper investigates the practical finite-time deployment problem by establishing a novel crossspecies bionic analytical framework based on the partial differential equation-ordinary differential equation(PDE-ODE)approach.Specifically,by designing a specialized network communication protocol and employing the spatial continuum method for densely distributed agents,this paper models the tracking errors of densely distributed agents as a PDE equivalent to a human disease transmission model,and that of sparsely distributed agents as several ODEs equivalent to the predator population models.The coupling relationship between the PDE and ODE models is established through boundary conditions of the PDE,thereby forming a PDE-ODE-based tracking error model for the considered MASs.Furthermore,by integrating adaptive neural control scheme with the aforementioned biological models,a“Flexible Neural Network”endowed with adaptive and self-stabilized capabilities is constructed,which acts upon the considered MASs,enabling their practical finite-time deployment.Finally,effectiveness of the developed approach is illustrated through a numerical example.
