In order to save manpower and time costs,and to achieve simultaneous detection of multiple animal-derived components in meat and meat products,this study used multiple nucleotide polymorphism(MNP)marker technology bas...In order to save manpower and time costs,and to achieve simultaneous detection of multiple animal-derived components in meat and meat products,this study used multiple nucleotide polymorphism(MNP)marker technology based on the principle of high-throughput sequencing,and established a multi-locus 10 animalderived components identification method of cattle,goat,sheep,donkey,horse,chicken,duck,goose,pigeon,quail in meat and meat products.The specific loci of each species could be detected and the species could be accurately identified,including 5 loci for cattle and duck,3 loci for sheep,9 loci for chicken and horse,10 loci for goose and pigeon,6 loci for quail and 1 locus for donkey and goat,and an adulteration model was established to simulate commercially available samples.The results showed that the method established in this study had high throughput,good repeatability and accuracy,and was able to identify 10 animalderived components simultaneously with 100%repeatability accuracy.The detection limit was 0.1%(m/m)in simulated samples of chicken,duck and horse.Using the method established in this study to test commercially available samples,4 samples from 14 commercially available samples were detected to be inconsistent with the labels,of which 2 did not contain the target ingredient and 2 were adulterated with small amounts of other ingredients.展开更多
As the study of vascular anomalies progresses,it is imperative for plastic surgeons to individualize their in-depth research and practice to develop more effective and personalized treatment plans.Recent advancements ...As the study of vascular anomalies progresses,it is imperative for plastic surgeons to individualize their in-depth research and practice to develop more effective and personalized treatment plans.Recent advancements in genome sequencing technology have highlighted the importance of vascular endothelial growth factor(VEGF)and its receptor(VEGFR)in the formation and alteration of vascularity.However,definitive reports regarding mutations associated with this locus and treatment experiences remain scarce.Herein,we report a clinical case of multiple venous malformations with mutations in VEGFR3(FLT4).We implemented a comprehensive approach,including local lesion excision of the left foot and trunk,oral propranolol administration,and local physiotherapy.After two years of follow-up,the patient’s left foot venous malformation did not recur,and he expressed satisfaction with the outcomes of the combined therapy.This case offers valuable insights into the clinical management of this mutant type and similar presentations of multiple venous malformations.展开更多
This study provides insights into the distillation sequence optimization of refinery system in a methanol to propylene plant with extractive distillation under multiple conditions. The simulated annealing algorithm(SA...This study provides insights into the distillation sequence optimization of refinery system in a methanol to propylene plant with extractive distillation under multiple conditions. The simulated annealing algorithm(SA) with relative cost function was used to solve a meaningful optimization problem. It was observed that different conditions had differed on the flowsheet. Case study shows the effectiveness of the proposed method.展开更多
In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS associated and 6 others known). The alignment mo...In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS associated and 6 others known). The alignment model was based on the profile HMM (Hidden Markov Model), and the model training was implemented through the SAHMM (Self Adapting Hidden Markov Model) software developed by the authors.展开更多
Let X be a Banach space and be a sequence in X. The author shows that is a basic sequence if and only if converges for every j≥1 and holds for every choice of scalar variables {αnj} such that converges for each n≥ ...Let X be a Banach space and be a sequence in X. The author shows that is a basic sequence if and only if converges for every j≥1 and holds for every choice of scalar variables {αnj} such that converges for each n≥ 1 and any choice of scalar variables {rn} such that converges. Moreover, some applications about the result are given.展开更多
In this letter, we briefly describe a program of self adapting hidden Markov model (SA HMM) and its application in multiple sequences alignment. Program consists of two stage optimisation algorithm.
The boundary value problem of plate bending problem on two_parameter foundation was discussed.Using two series of the high_order fundamental solution sequences, namely, the fundamental solution sequences for the multi...The boundary value problem of plate bending problem on two_parameter foundation was discussed.Using two series of the high_order fundamental solution sequences, namely, the fundamental solution sequences for the multi_harmonic operator and Laplace operator, applying the multiple reciprocity method(MRM), the MRM boundary integral equation for plate bending problem was constructed. It proves that the boundary integral equation derived from MRM is essentially identical to the conventional boundary integral equation. Hence the convergence analysis of MRM for plate bending problem can be obtained by the error estimation for the conventional boundary integral equation. In addition, this method can extend to the case of more series of the high_order fundamental solution sequences.展开更多
Multiple sequence alignment （MSA） is the alignment among more than two molecular biological sequences, which is a fundamental method to analyze evolutionary events such as mutations, insertions, deletions, and re-ar...Multiple sequence alignment （MSA） is the alignment among more than two molecular biological sequences, which is a fundamental method to analyze evolutionary events such as mutations, insertions, deletions, and re-arrangements. In theory, a dynamic programming algorithm can be employed to produce the optimal MSA. However, this leads to an explosive increase in computing time and memory consumption as the number of sequences increases （Taylor, 1990）. So far, MSA is still regarded as one of the most challenging problems in bioinformatics and computational biology （Chatzou et al., 2016）.展开更多
The purpose of this study was to analyze the lesion brightness (image contrast) in multiple MRI sequences in patients with relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS),...The purpose of this study was to analyze the lesion brightness (image contrast) in multiple MRI sequences in patients with relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and clinically isolated syndrome (CIS);and to correlate the lesion contrast with lesion volumes and neurological disability. MRI ex- amination at 1.5 T was performed on 80 patients with RRMS, SPMS, PPMS, or CIS. The protocol included T1- and T2-weighted spin echo (SE), fluid attenuated inversion recovery (FLAIR), T1-weighted SE with magnetization transfer preparation, and diffusion weighted imaging (DWI). Contrast was measured between MS lesions and normal appearing white matter. Lesion volume was calculated in T1-weighted- and FLAIR-images. All patients were examined neurologically including evaluation of expanded disability status scale (EDSS) score. Lesion contrast correlated with total brain lesion volume (p = 0.000 - 0.040). In patients with low EDSS, three sequences were able to differentiate between CIS and RRMS. SPMS and PPMS were separated by DWI. Lesion contrast correlated with EDSS score on T1-weighted imaging, with or without magnetization transfer preparation. Patient age correlated with lesion contrasts. Contrast measurements seem limited in radiological and clinical diagnosis of MS in reference to disease course, its activity and progression. The differentiation between MS subgroups might improve at 3 T and could help in leading to earlier treatment of the disease.展开更多
This paper proposes how to learn and generate multiple action sequences of a humanoid robot. At first, all the basic action sequences, also called primitive behaviors, are learned by a recurrent neural network with pa...This paper proposes how to learn and generate multiple action sequences of a humanoid robot. At first, all the basic action sequences, also called primitive behaviors, are learned by a recurrent neural network with parametric bias (RNNPB) and the value of the internal nodes which are parametric bias (PB) determining the output with different primitive behaviors are obtained. The training of the RNN uses back propagation through time (BPTT) method. After that, to generate the learned behaviors, or a more complex behavior which is the combination of the primitive behaviors, a reinforcement learning algorithm: Q-learning (QL) is adopt to determine which PB value is adaptive for the generation. Finally, using a real humanoid robot, the proposed method was confirmed its effectiveness by the results of experiment.展开更多
By the function transformation and the first integral of the ordinary differential equations, the problem of solving the solutions of the double sine-Gordon equation and the treble sine-Gordon equation is researched, ...By the function transformation and the first integral of the ordinary differential equations, the problem of solving the solutions of the double sine-Gordon equation and the treble sine-Gordon equation is researched, and the new solutions are obtained. First, the problem of solving the solutions of the double sine-Gordon equation and the treble sine-Gordon equation is changed to the problem of solving the solutions of the nonlinear ordinary differential equation. Second, with the help of the B?cklund transformation and the nonlinear superposition formula of solutions of the first kind of elliptic equation and the Riccati equation, the new infinite sequence soliton-like solutions of two kinds of sine-Gordon equations are constructed.展开更多
Although the Cramer-Rao Bound(CRB) can be used as the benchmark of estimation algorithm performance,it's too complicated for joint training sequence(TS) design for multiple input multiple output(MIMO) orthogonal f...Although the Cramer-Rao Bound(CRB) can be used as the benchmark of estimation algorithm performance,it's too complicated for joint training sequence(TS) design for multiple input multiple output(MIMO) orthogonal frequency division multiplexing(OFDM) coordination on multiple point(CoMP) systems.So a minimum mean square error(MSE) based sub-optimal sequence design criterion was proposed,including ideal sequence correlation property and sequence length constraint.The simulation results verify the theory analysis.展开更多
Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response v...Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among individuals.Genetic factor may play an important role in BIPN.Methods:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy.mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM patients.BIPN is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.展开更多
The threat sequencing of multiple unmanned combat air vehicles(UCAVs) is a multi-attribute decision-making(MADM)problem. In the threat sequencing process of multiple UCAVs,due to the strong confrontation and high dyna...The threat sequencing of multiple unmanned combat air vehicles(UCAVs) is a multi-attribute decision-making(MADM)problem. In the threat sequencing process of multiple UCAVs,due to the strong confrontation and high dynamics of the air combat environment, the weight coefficients of the threat indicators are usually time-varying. Moreover, the air combat data is difficult to be obtained accurately. In this study, a threat sequencing method of multiple UCAVs is proposed based on game theory by considering the incomplete information. Firstly, a zero-sum game model of decision maker( D) and nature(N)with fuzzy payoffs is established to obtain the uncertain parameters which are the weight coefficient parameters of the threat indicators and the interval parameters of the threat matrix. Then,the established zero-sum game with fuzzy payoffs is transformed into a zero-sum game with crisp payoffs(matrix game) to solve. Moreover, a decision rule is addressed for the threat sequencing problem of multiple UCAVs based on the obtained uncertain parameters. Finally, numerical simulation results are presented to show the effectiveness of the proposed approach.展开更多
Two new families of finite binary sequences are constructed using multiplicative inverse. The sequences are shown to have strong pseudorandom properties by using some estimates of certain exponential sums over finite ...Two new families of finite binary sequences are constructed using multiplicative inverse. The sequences are shown to have strong pseudorandom properties by using some estimates of certain exponential sums over finite fields. The constructions can be implemented fast since multiplicative inverse over finite fields can be computed in polynomial time.展开更多
Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later tr...Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later transitions to secondary progressive MS. Currently available disease-modifying therapies（DMTs） for relapsing MS have been demonstrated to reduce disease activity, however most patients require a change in therapy over the course of their disease. Treatment goals include the prevention of relapses and disability accumulation and to achieve this objective requires careful planning. Sequencing of DMTs for individual patients should be designed in such a way to maximize disease control and minimize risk based on the mechanism of action, pharmacokinetic and pharmacodynamic properties of each therapy. This includes the DMT patients are being switched from to those they are being switched to. The reversibility of immune system effects should be a key consideration for DMT sequence selection. This feature varies across DMTs and should factor more prominently in decision making as newer treatments become available for the prevention of disability accumulation in patients with progressive MS. In this short review, we discuss the landscape of existing therapies with an eye to the future when planning for optimal DMT sequencing. While no cure exists for MS, efforts are being directed toward research in neuroregeneration with the hope for positive outcomes.展开更多
The main purpose of this paper is to introduce the general Smarandache mul- tiplicative sequence based on the Smarandache multiplicative sequence, and calculate the value of some infinite series involving these sequen...The main purpose of this paper is to introduce the general Smarandache mul- tiplicative sequence based on the Smarandache multiplicative sequence, and calculate the value of some infinite series involving these sequences.展开更多
A novel kind of multidimension symbol/sequence trellis coded modulation (TCM) based on TCM of lower coding rate has been constructed. The redundancy of this new kind of TCM is provided not only by the modulated symbo...A novel kind of multidimension symbol/sequence trellis coded modulation (TCM) based on TCM of lower coding rate has been constructed. The redundancy of this new kind of TCM is provided not only by the modulated symbol sequence but also by the PN sequences for spreading spectrum as well. The performance of direct sequence spread spectrum multiple access (DS/SSMA) system with this symbol/sequence TCM over flat Rayleigh fading channel has been investigated by theoretical analysis and numerical simulation. The results obtained in this research demonstrate the performance improvements of this system in comparison with that of the DS/SSMA system with conventional TCM under the same conditions.展开更多
Room-and-pillar mining with pillar recovery has historically been associated with more than 25% of all ground fall fatalities in underground coal mines in the United States.The risk of ground falls during pillar recov...Room-and-pillar mining with pillar recovery has historically been associated with more than 25% of all ground fall fatalities in underground coal mines in the United States.The risk of ground falls during pillar recovery increases in multiple-seam mining conditions.The hazards associated with pillar recovery in multiple-seam mining include roof cutters, roof falls, rib rolls, coal outbursts, and floor heave.When pillar recovery is planned in multiple seams, it is critical to properly design the mining sequence and panel layout to minimize potential seam interaction.This paper addresses geotechnical considerations for concurrent pillar recovery in two coal seams with 21 m of interburden under about 305 m of depth of cover.The study finds that, for interburden thickness of 21 m, the multiple-seam mining influence zone in the lower seam is directly under the barrier pillar within about 30 m from the gob edge of the upper seam.The peak stress in the interburden transfers down at an angle of approximately 20°away from the gob, and the entries and crosscuts in the influence zone are subjected to elevated stress during development and retreat.The study also suggests that, for full pillar recovery in close-distance multiple-seam scenarios,it is optimal to superimpose the gobs in both seams, but it is not necessary to superimpose the pillars.If the entries and/or crosscuts in the lower seam are developed outside the gob line of the upper seam,additional roof and rib support needs to be considered to account for the elevated stress in the multiple-seam influence zone.展开更多
Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple organs.However, cellular and molecular understanding of SARS-CoV-2 infe...Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple organs.However, cellular and molecular understanding of SARS-CoV-2 infection-associated pathology and immune defense features in different organs remains incomplete. Here, we profiled approximately 77 000single-nucleus transcriptomes of the lung, liver,kidney, and cerebral cortex in rhesus macaques(Macaca mulatta) infected with SARS-CoV-2 and healthy controls. Integrated analysis of the multiorgan dataset suggested that the liver harbored the strongest global transcriptional alterations. We observed prominent impairment in lung epithelial cells, especially in AT2 and ciliated cells, and evident signs of fibrosis in fibroblasts. These lung injury characteristics are similar to those reported in patients with coronavirus disease 2019(COVID-19).Furthermore, we found suppressed MHC class I/II molecular activity in the lung, inflammatory response in the liver, and activation of the kynurenine pathway,which induced the development of an immunosuppressive microenvironment. Analysis of the kidney dataset highlighted tropism of tubule cells to SARS-CoV-2, and we found membranous nephropathy(an autoimmune disease) caused by podocyte dysregulation. In addition, we identified the pathological states of astrocytes and oligodendrocytes in the cerebral cortex, providing molecular insights into COVID-19-related neurological implications. Overall, our multi-organ single-nucleus transcriptomic survey of SARS-CoV-2-infected rhesus macaques broadens our understanding of disease features and antiviral immune defects caused by SARS-CoV-2 infection,which may facilitate the development of therapeutic interventions for COVID-19.展开更多
基金financially supported by National Key R&D Program(2021YFF0701905)。
文摘In order to save manpower and time costs,and to achieve simultaneous detection of multiple animal-derived components in meat and meat products,this study used multiple nucleotide polymorphism(MNP)marker technology based on the principle of high-throughput sequencing,and established a multi-locus 10 animalderived components identification method of cattle,goat,sheep,donkey,horse,chicken,duck,goose,pigeon,quail in meat and meat products.The specific loci of each species could be detected and the species could be accurately identified,including 5 loci for cattle and duck,3 loci for sheep,9 loci for chicken and horse,10 loci for goose and pigeon,6 loci for quail and 1 locus for donkey and goat,and an adulteration model was established to simulate commercially available samples.The results showed that the method established in this study had high throughput,good repeatability and accuracy,and was able to identify 10 animalderived components simultaneously with 100%repeatability accuracy.The detection limit was 0.1%(m/m)in simulated samples of chicken,duck and horse.Using the method established in this study to test commercially available samples,4 samples from 14 commercially available samples were detected to be inconsistent with the labels,of which 2 did not contain the target ingredient and 2 were adulterated with small amounts of other ingredients.
基金supported by the National Natural Science Foundation of China(grant no.82272891).
文摘As the study of vascular anomalies progresses,it is imperative for plastic surgeons to individualize their in-depth research and practice to develop more effective and personalized treatment plans.Recent advancements in genome sequencing technology have highlighted the importance of vascular endothelial growth factor(VEGF)and its receptor(VEGFR)in the formation and alteration of vascularity.However,definitive reports regarding mutations associated with this locus and treatment experiences remain scarce.Herein,we report a clinical case of multiple venous malformations with mutations in VEGFR3(FLT4).We implemented a comprehensive approach,including local lesion excision of the left foot and trunk,oral propranolol administration,and local physiotherapy.After two years of follow-up,the patient’s left foot venous malformation did not recur,and he expressed satisfaction with the outcomes of the combined therapy.This case offers valuable insights into the clinical management of this mutant type and similar presentations of multiple venous malformations.
文摘This study provides insights into the distillation sequence optimization of refinery system in a methanol to propylene plant with extractive distillation under multiple conditions. The simulated annealing algorithm(SA) with relative cost function was used to solve a meaningful optimization problem. It was observed that different conditions had differed on the flowsheet. Case study shows the effectiveness of the proposed method.
文摘In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS associated and 6 others known). The alignment model was based on the profile HMM (Hidden Markov Model), and the model training was implemented through the SAHMM (Self Adapting Hidden Markov Model) software developed by the authors.
基金Natural Science and Education Foundationof Henan Province and Young Fundation of Henan Normal University
文摘Let X be a Banach space and be a sequence in X. The author shows that is a basic sequence if and only if converges for every j≥1 and holds for every choice of scalar variables {αnj} such that converges for each n≥ 1 and any choice of scalar variables {rn} such that converges. Moreover, some applications about the result are given.
文摘In this letter, we briefly describe a program of self adapting hidden Markov model (SA HMM) and its application in multiple sequences alignment. Program consists of two stage optimisation algorithm.
文摘The boundary value problem of plate bending problem on two_parameter foundation was discussed.Using two series of the high_order fundamental solution sequences, namely, the fundamental solution sequences for the multi_harmonic operator and Laplace operator, applying the multiple reciprocity method(MRM), the MRM boundary integral equation for plate bending problem was constructed. It proves that the boundary integral equation derived from MRM is essentially identical to the conventional boundary integral equation. Hence the convergence analysis of MRM for plate bending problem can be obtained by the error estimation for the conventional boundary integral equation. In addition, this method can extend to the case of more series of the high_order fundamental solution sequences.
基金supported by the National Key R&D Program of China (Nos. 2017YFB0202600, 2016YFC1302500, 2016YFB0200400 and 2017YFB0202104)the National Natural Science Foundation of China (Nos. 61772543, U1435222, 61625202, 61272056 and 61771331)Guangdong Provincial Department of Science and Technology (No. 2016B090918122)
文摘Multiple sequence alignment （MSA） is the alignment among more than two molecular biological sequences, which is a fundamental method to analyze evolutionary events such as mutations, insertions, deletions, and re-arrangements. In theory, a dynamic programming algorithm can be employed to produce the optimal MSA. However, this leads to an explosive increase in computing time and memory consumption as the number of sequences increases （Taylor, 1990）. So far, MSA is still regarded as one of the most challenging problems in bioinformatics and computational biology （Chatzou et al., 2016）.
文摘The purpose of this study was to analyze the lesion brightness (image contrast) in multiple MRI sequences in patients with relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and clinically isolated syndrome (CIS);and to correlate the lesion contrast with lesion volumes and neurological disability. MRI ex- amination at 1.5 T was performed on 80 patients with RRMS, SPMS, PPMS, or CIS. The protocol included T1- and T2-weighted spin echo (SE), fluid attenuated inversion recovery (FLAIR), T1-weighted SE with magnetization transfer preparation, and diffusion weighted imaging (DWI). Contrast was measured between MS lesions and normal appearing white matter. Lesion volume was calculated in T1-weighted- and FLAIR-images. All patients were examined neurologically including evaluation of expanded disability status scale (EDSS) score. Lesion contrast correlated with total brain lesion volume (p = 0.000 - 0.040). In patients with low EDSS, three sequences were able to differentiate between CIS and RRMS. SPMS and PPMS were separated by DWI. Lesion contrast correlated with EDSS score on T1-weighted imaging, with or without magnetization transfer preparation. Patient age correlated with lesion contrasts. Contrast measurements seem limited in radiological and clinical diagnosis of MS in reference to disease course, its activity and progression. The differentiation between MS subgroups might improve at 3 T and could help in leading to earlier treatment of the disease.
文摘This paper proposes how to learn and generate multiple action sequences of a humanoid robot. At first, all the basic action sequences, also called primitive behaviors, are learned by a recurrent neural network with parametric bias (RNNPB) and the value of the internal nodes which are parametric bias (PB) determining the output with different primitive behaviors are obtained. The training of the RNN uses back propagation through time (BPTT) method. After that, to generate the learned behaviors, or a more complex behavior which is the combination of the primitive behaviors, a reinforcement learning algorithm: Q-learning (QL) is adopt to determine which PB value is adaptive for the generation. Finally, using a real humanoid robot, the proposed method was confirmed its effectiveness by the results of experiment.
文摘By the function transformation and the first integral of the ordinary differential equations, the problem of solving the solutions of the double sine-Gordon equation and the treble sine-Gordon equation is researched, and the new solutions are obtained. First, the problem of solving the solutions of the double sine-Gordon equation and the treble sine-Gordon equation is changed to the problem of solving the solutions of the nonlinear ordinary differential equation. Second, with the help of the B?cklund transformation and the nonlinear superposition formula of solutions of the first kind of elliptic equation and the Riccati equation, the new infinite sequence soliton-like solutions of two kinds of sine-Gordon equations are constructed.
基金International Science&Technology Cooperation Projects of Qinghai,China(Nos.2013-H-811,2014-HZ-821)Chunhui Plan Projects,China(Nos.Z2014013,Z2014014)
文摘Although the Cramer-Rao Bound(CRB) can be used as the benchmark of estimation algorithm performance,it's too complicated for joint training sequence(TS) design for multiple input multiple output(MIMO) orthogonal frequency division multiplexing(OFDM) coordination on multiple point(CoMP) systems.So a minimum mean square error(MSE) based sub-optimal sequence design criterion was proposed,including ideal sequence correlation property and sequence length constraint.The simulation results verify the theory analysis.
基金supported by the“GZ Hematologic Malignancy MARKER GHROMOS of Education Department of Liaoning Province”Grant(Grant Number:07102).
文摘Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among individuals.Genetic factor may play an important role in BIPN.Methods:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy.mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM patients.BIPN is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.
基金supported by the Major Projects for Science and Technology Innovation 2030 (2018AAA0100805)。
文摘The threat sequencing of multiple unmanned combat air vehicles(UCAVs) is a multi-attribute decision-making(MADM)problem. In the threat sequencing process of multiple UCAVs,due to the strong confrontation and high dynamics of the air combat environment, the weight coefficients of the threat indicators are usually time-varying. Moreover, the air combat data is difficult to be obtained accurately. In this study, a threat sequencing method of multiple UCAVs is proposed based on game theory by considering the incomplete information. Firstly, a zero-sum game model of decision maker( D) and nature(N)with fuzzy payoffs is established to obtain the uncertain parameters which are the weight coefficient parameters of the threat indicators and the interval parameters of the threat matrix. Then,the established zero-sum game with fuzzy payoffs is transformed into a zero-sum game with crisp payoffs(matrix game) to solve. Moreover, a decision rule is addressed for the threat sequencing problem of multiple UCAVs based on the obtained uncertain parameters. Finally, numerical simulation results are presented to show the effectiveness of the proposed approach.
基金Supported by the Open Funds of Key Lab of Fujian Province University Network Security and Cryptology (07B005)the Funds of the Education Department of Fujian Province (JA07164)the Natural Science Foundation of Fujian Province of China (2007F3086)
文摘Two new families of finite binary sequences are constructed using multiplicative inverse. The sequences are shown to have strong pseudorandom properties by using some estimates of certain exponential sums over finite fields. The constructions can be implemented fast since multiplicative inverse over finite fields can be computed in polynomial time.
文摘Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later transitions to secondary progressive MS. Currently available disease-modifying therapies（DMTs） for relapsing MS have been demonstrated to reduce disease activity, however most patients require a change in therapy over the course of their disease. Treatment goals include the prevention of relapses and disability accumulation and to achieve this objective requires careful planning. Sequencing of DMTs for individual patients should be designed in such a way to maximize disease control and minimize risk based on the mechanism of action, pharmacokinetic and pharmacodynamic properties of each therapy. This includes the DMT patients are being switched from to those they are being switched to. The reversibility of immune system effects should be a key consideration for DMT sequence selection. This feature varies across DMTs and should factor more prominently in decision making as newer treatments become available for the prevention of disability accumulation in patients with progressive MS. In this short review, we discuss the landscape of existing therapies with an eye to the future when planning for optimal DMT sequencing. While no cure exists for MS, efforts are being directed toward research in neuroregeneration with the hope for positive outcomes.
文摘The main purpose of this paper is to introduce the general Smarandache mul- tiplicative sequence based on the Smarandache multiplicative sequence, and calculate the value of some infinite series involving these sequences.
文摘A novel kind of multidimension symbol/sequence trellis coded modulation (TCM) based on TCM of lower coding rate has been constructed. The redundancy of this new kind of TCM is provided not only by the modulated symbol sequence but also by the PN sequences for spreading spectrum as well. The performance of direct sequence spread spectrum multiple access (DS/SSMA) system with this symbol/sequence TCM over flat Rayleigh fading channel has been investigated by theoretical analysis and numerical simulation. The results obtained in this research demonstrate the performance improvements of this system in comparison with that of the DS/SSMA system with conventional TCM under the same conditions.
文摘Room-and-pillar mining with pillar recovery has historically been associated with more than 25% of all ground fall fatalities in underground coal mines in the United States.The risk of ground falls during pillar recovery increases in multiple-seam mining conditions.The hazards associated with pillar recovery in multiple-seam mining include roof cutters, roof falls, rib rolls, coal outbursts, and floor heave.When pillar recovery is planned in multiple seams, it is critical to properly design the mining sequence and panel layout to minimize potential seam interaction.This paper addresses geotechnical considerations for concurrent pillar recovery in two coal seams with 21 m of interburden under about 305 m of depth of cover.The study finds that, for interburden thickness of 21 m, the multiple-seam mining influence zone in the lower seam is directly under the barrier pillar within about 30 m from the gob edge of the upper seam.The peak stress in the interburden transfers down at an angle of approximately 20°away from the gob, and the entries and crosscuts in the influence zone are subjected to elevated stress during development and retreat.The study also suggests that, for full pillar recovery in close-distance multiple-seam scenarios,it is optimal to superimpose the gobs in both seams, but it is not necessary to superimpose the pillars.If the entries and/or crosscuts in the lower seam are developed outside the gob line of the upper seam,additional roof and rib support needs to be considered to account for the elevated stress in the multiple-seam influence zone.
基金supported by the National Basic Research Program of China(2020YFA0804000,2020YFC0842000,2020YFA0112200,2021YFC2301703)Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010100)+6 种基金Special Associate Research Program of the Chinese Academy of Sciences(E1290601)National Natural Science Foundation of China(32122037,81891001,32192411,32100512,U1902215)Collaborative Research Fund of the Chinese Institute for Brain Research,Beijing(2020-NKX-PT-03)CAS Project for Young Scientists in Basic Research(YSBR-013)Young Elite Scientist Sponsorship Program by the China Association for Science and Technology(2020QNRC001)National Resource Center for Non-Human Primates。
文摘Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple organs.However, cellular and molecular understanding of SARS-CoV-2 infection-associated pathology and immune defense features in different organs remains incomplete. Here, we profiled approximately 77 000single-nucleus transcriptomes of the lung, liver,kidney, and cerebral cortex in rhesus macaques(Macaca mulatta) infected with SARS-CoV-2 and healthy controls. Integrated analysis of the multiorgan dataset suggested that the liver harbored the strongest global transcriptional alterations. We observed prominent impairment in lung epithelial cells, especially in AT2 and ciliated cells, and evident signs of fibrosis in fibroblasts. These lung injury characteristics are similar to those reported in patients with coronavirus disease 2019(COVID-19).Furthermore, we found suppressed MHC class I/II molecular activity in the lung, inflammatory response in the liver, and activation of the kynurenine pathway,which induced the development of an immunosuppressive microenvironment. Analysis of the kidney dataset highlighted tropism of tubule cells to SARS-CoV-2, and we found membranous nephropathy(an autoimmune disease) caused by podocyte dysregulation. In addition, we identified the pathological states of astrocytes and oligodendrocytes in the cerebral cortex, providing molecular insights into COVID-19-related neurological implications. Overall, our multi-organ single-nucleus transcriptomic survey of SARS-CoV-2-infected rhesus macaques broadens our understanding of disease features and antiviral immune defects caused by SARS-CoV-2 infection,which may facilitate the development of therapeutic interventions for COVID-19.
