Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipien...Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use of these scores will help early identify PNF, standardize grading of EAF and reasonably select clinical endpoints in relative studies.展开更多
OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment o...OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment outcome of patients, and to identify prognostic factors affecting progression-free survival （PFS）. METHODS Data of 55 patients macroadenoma presented to the with non-functioning pituitary Clinical Oncology and Nuclear Medicine department between 1998 and 2009 were investigated. RESULTS The most common symptom was visual disturbance （38.2%） followed by headache （27.3%）. The presence of male predominance was observed （1.4：1）. Ten patients received radio-therapy （RT） only. Extrasellar extension was the more common treatment. The overall response rate was 72.8% with completed response at 16.4%. Memory and intellectual sequelae were the most common late complications of treatment （14%）. The ten-year PFS was at 84.6%. PFS was found to be significantly better with higher dose of RT （up to 54 Gy）, treatment by both surgery and RT, absence of visual field defect, and tumor localized to sella, whereas it was not significantly affected by age and sex. CONCLUSION The data confirmed that the prevalence of mass effect and hypopituitarism in patients with non-functioning pituitary macroadenoma is elevated. Conventional external RT up to 54 Gy is safe and effective in controlling non-functioning pituitary macro- adenoma with tolerable and acceptable morbidity.展开更多
Introduction: Despite the fact that non-functioning pituitary adenomas do not overproduce hormones, many will stain positive for a particular pituitary hormone, which can be used to differentiate these adenomas into s...Introduction: Despite the fact that non-functioning pituitary adenomas do not overproduce hormones, many will stain positive for a particular pituitary hormone, which can be used to differentiate these adenomas into subgroups. If these different sub-groups behave differently in terms of post surgical progression of disease (PSPD) rates or other clinical variables, then better treatment and prognosis could be predicted. Methods: This was a retrospective cohort study. Patients who have undergone surgery for removal of a non-functioning pituitary adenoma at Emory University Hospital served as the source for all data used in this study (n = 184). Data were collected from a database of electronic medical records (EMRs) for these patients in 2010 documenting clinical and demographic variables including treatment and PSPD. Results: Risk for PSPD did not differ by adenoma subtypes: follicle-stimulating hormone (FSH+), luteinizing hormone (LH+), or those that do not stain positive for any hormone (non-functioning, or NF?) (p = 0.971). There were two clinical characteristics statistically related to adenoma subtype: altered mental status and the anterior-posterior (AP) dimension of pre-operative adenomas. PSPD was related to several clinical characteristics, including gender, previous adenoma, post-operative residual, and follow-up time.展开更多
NFMAs are benign tumors that do not produce any biologically active hormones and exceed 10 mm (0.39 in) in size. Although NFMAs are benign in origin, mass effects may lead to serious clinical symptoms such as visual i...NFMAs are benign tumors that do not produce any biologically active hormones and exceed 10 mm (0.39 in) in size. Although NFMAs are benign in origin, mass effects may lead to serious clinical symptoms such as visual impairments, chronic headache, and pituitary insufficiency. The authors describe a 51-year-old woman who had a NFMA (35 × 24 × 25 mm). The vision was reduced to 7/10 in the both eyes. A transnasal transsphenoidal surgery was performed and the tumor was successfully resected. Postoperatively, the patient had visual (9/10) and headache improvement. This case highlights a rare presentation of non-functioning pituitary macroadenoma.展开更多
Requirements elicitation step is of paramount importance in the requirements engineering process. In the distributed environment of so-called inter-company cooperative information system, this step is a thorny issue. ...Requirements elicitation step is of paramount importance in the requirements engineering process. In the distributed environment of so-called inter-company cooperative information system, this step is a thorny issue. To elicit require-ments for an inter-company cooperative information system, we early proposed a methodology called MAMIE (from MAcro to MIcro level requirements Elicitation) with an accompanied tool. In MAMIE methodology, requirements are the result of composing functional and non-functional concerns. Before non-functional concerns composition, it’s primary to identify relationships between them. According to the most existing approaches, a non-functional concern may have a negative, positive or null contribution on the other non-functional concerns. In this paper, we argue that using only these three contributions types is not sufficient to express relationships which may exist between non-functional concerns. Thus, we propose a process which aims to identify non-functional concerns’ relationships and model them using a fuzzy cognitive map. The resulting model is composed of non-functional concerns, relationships between them and the weight of these relationships expressed with linguistics fuzzy values. Using fuzzy cognitive maps to model non-functional concerns relationships allows moving from the conventional modelling toward developing a computer based model. An example from the textile industry is used to illustrate the applicability of our process.展开更多
In the process of oxidative phosphorylation, protons are pumped into the intermembrane space to establish the mitochondrial membrane potential (MMP). Relying on the electrochemical gradient, protons can return to the ...In the process of oxidative phosphorylation, protons are pumped into the intermembrane space to establish the mitochondrial membrane potential (MMP). Relying on the electrochemical gradient, protons can return to the matrix through the ATP synthase complex with ATP generation. MitoQ, a lipophilic cation drug, can be bsorbed to the inner mitochondrial membrane with the cationic moiety staying at the intermembrane space[1].展开更多
In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and tr...In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects.展开更多
目的:大量研究表明,非侵入性神经调控技术能够有效改善脑卒中后非流畅性失语的症状,然而,针对该类技术的最优刺激方案仍有待深入验证与探究。此次研究借助网状Meta分析方法,系统评价不同非侵入性神经调控技术改善脑卒中后非流畅性失语...目的:大量研究表明,非侵入性神经调控技术能够有效改善脑卒中后非流畅性失语的症状,然而,针对该类技术的最优刺激方案仍有待深入验证与探究。此次研究借助网状Meta分析方法,系统评价不同非侵入性神经调控技术改善脑卒中后非流畅性失语患者言语功能的效应。方法:检索CNKI、万方、维普、CBM、PubMed、Cochrane图书馆、Embase和Web of Science数据库,筛选有关非侵入性神经调控技术治疗脑卒中后非流畅性失语的随机对照试验,检索时限截至2025-06-01。对照组采用常规治疗或假刺激,试验组在对照组治疗的基础上加入非侵入性神经调控技术,结局指标为西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表。采用Stata 17.0软件对结局指标进行传统Meta分析和网状Meta分析,采用GRADE对结局指标进行证据等级评价。结果:共纳入33篇随机对照试验,涉及10种非侵入性神经调控方式。①传统Meta分析结果显示,低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、经颅直流电刺激左侧Broca区可改善患者西方失语成套测验评分(P<0.001),低频重复经颅磁刺激右侧Broca区、低频重复经颅磁刺激颞上回后部、低频重复经颅磁刺激右侧Broca区联合高频重复经颅磁刺激左侧Broca区可改善患者汉语失语成套测验评分(P<0.05),低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、连续性θ爆发刺激右侧Broca区联合间歇性θ爆发刺激左侧Broca区、高频重复经颅磁刺激刺激右侧Broca区、低频重复经颅磁刺激右侧Broca区联合高频刺激左侧Broca区可改善患者日常生活交流能力评定量表评分(P<0.05)。②网状Meta分析结果显示,低频重复经颅磁刺激右侧Broca区改善患者西方失语成套测验评分和汉语失语成套测验评分的疗效更佳[SMD=1.13,95%CI(0.59,1.67),P<0.05;SMD=4.73,95%CI(1.28,8.18),P<0.05],经颅直流电刺激双侧Broca区在改善患者日常生活交流能力评定量表评分的疗效更佳[SMD=1.81,95%CI(0.51,2.12),P<0.05]。③GRADE证据等级评价结果显示,西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表结局指标的证据等级均为低级。结论:不同非侵入性神经调控方式均能改善脑卒中后非流畅性失语患者的言语功能,低频重复经颅磁刺激右侧Broca区在改善多维度言语功能方面,尤其在自发言语连贯性、听觉理解准确性及命名流畅性等方面疗效显著;经颅直流电刺激双侧Broca区更侧重改善患者的日常生活交流能力,但研究结果受纳入研究的数量及质量影响,证据等级较低,仍需更多高质量的研究进一步验证。展开更多
目的研究基于近红外脑功能成像探讨针刺结合重复经颅磁刺激治疗卒中后非流利性失语的临床效应机制。方法选取2022年6月—2024年3月天津中医药大学第一附属医院收治的104例被诊断为脑卒中并伴有非流利性失语的患者作为研究对象,采取随机...目的研究基于近红外脑功能成像探讨针刺结合重复经颅磁刺激治疗卒中后非流利性失语的临床效应机制。方法选取2022年6月—2024年3月天津中医药大学第一附属医院收治的104例被诊断为脑卒中并伴有非流利性失语的患者作为研究对象,采取随机数字表法分为观察组和对照组,每组52例,所有患者均基于近红外脑功能成像技术进行探讨。对照组采用重复经颅磁刺激治疗,观察组采用针刺结合重复经颅磁刺激治疗。比较两组患者的临床效果、言语功能、声学水平以及失语症评分情况,并采取近红外脑功能成像技术检测其脑活动情况。结果观察组总有效率为98.00%(49/50),明显高于对照组的70.00%(35/50)(P<0.05)。治疗后,两组言语功能评分均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组语言交流能力检查量表(Communicative abilities in daily living,CADL)、非语言认知评估量表(Non-linguistic cognitive assessment,NLCA)均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组预运动皮质(Pre-motor cortex,PMC)、感觉运动皮质(Sensory motor cortex,SMC)、运动补充区(Supplementary motor area,SMA)均低于/高于治疗前,且观察组低于/高于对照组,差异有统计学意义(P<0.05)。结论卒中后非流利性失语患者采取针刺结合重复经颅磁刺激治疗,并予以近红外脑功能成像技术监测大脑后,可有效提升治疗效果,改善患者的语言功能,促进患者恢复,具有较高的临床应用价值。展开更多
基金supported by grants from the National Nat-ural Science Foundation of China (81570587 and 81700557)the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007 and 2017B030314018)+3 种基金Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010)Science and Technology Program of Guangzhou (201704020150)the Natural Science Foundations of Guangdong province (2016A030310141 and 2020A1515010091)Young Teachers Training Project of Sun Yat-sen University (K0401068) and the Guangdong Science and Technology Innovation Strategy (pdjh2022b0010 and pdjh2023a0002)。
文摘Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use of these scores will help early identify PNF, standardize grading of EAF and reasonably select clinical endpoints in relative studies.
文摘OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment outcome of patients, and to identify prognostic factors affecting progression-free survival （PFS）. METHODS Data of 55 patients macroadenoma presented to the with non-functioning pituitary Clinical Oncology and Nuclear Medicine department between 1998 and 2009 were investigated. RESULTS The most common symptom was visual disturbance （38.2%） followed by headache （27.3%）. The presence of male predominance was observed （1.4：1）. Ten patients received radio-therapy （RT） only. Extrasellar extension was the more common treatment. The overall response rate was 72.8% with completed response at 16.4%. Memory and intellectual sequelae were the most common late complications of treatment （14%）. The ten-year PFS was at 84.6%. PFS was found to be significantly better with higher dose of RT （up to 54 Gy）, treatment by both surgery and RT, absence of visual field defect, and tumor localized to sella, whereas it was not significantly affected by age and sex. CONCLUSION The data confirmed that the prevalence of mass effect and hypopituitarism in patients with non-functioning pituitary macroadenoma is elevated. Conventional external RT up to 54 Gy is safe and effective in controlling non-functioning pituitary macro- adenoma with tolerable and acceptable morbidity.
文摘Introduction: Despite the fact that non-functioning pituitary adenomas do not overproduce hormones, many will stain positive for a particular pituitary hormone, which can be used to differentiate these adenomas into subgroups. If these different sub-groups behave differently in terms of post surgical progression of disease (PSPD) rates or other clinical variables, then better treatment and prognosis could be predicted. Methods: This was a retrospective cohort study. Patients who have undergone surgery for removal of a non-functioning pituitary adenoma at Emory University Hospital served as the source for all data used in this study (n = 184). Data were collected from a database of electronic medical records (EMRs) for these patients in 2010 documenting clinical and demographic variables including treatment and PSPD. Results: Risk for PSPD did not differ by adenoma subtypes: follicle-stimulating hormone (FSH+), luteinizing hormone (LH+), or those that do not stain positive for any hormone (non-functioning, or NF?) (p = 0.971). There were two clinical characteristics statistically related to adenoma subtype: altered mental status and the anterior-posterior (AP) dimension of pre-operative adenomas. PSPD was related to several clinical characteristics, including gender, previous adenoma, post-operative residual, and follow-up time.
文摘NFMAs are benign tumors that do not produce any biologically active hormones and exceed 10 mm (0.39 in) in size. Although NFMAs are benign in origin, mass effects may lead to serious clinical symptoms such as visual impairments, chronic headache, and pituitary insufficiency. The authors describe a 51-year-old woman who had a NFMA (35 × 24 × 25 mm). The vision was reduced to 7/10 in the both eyes. A transnasal transsphenoidal surgery was performed and the tumor was successfully resected. Postoperatively, the patient had visual (9/10) and headache improvement. This case highlights a rare presentation of non-functioning pituitary macroadenoma.
文摘Requirements elicitation step is of paramount importance in the requirements engineering process. In the distributed environment of so-called inter-company cooperative information system, this step is a thorny issue. To elicit require-ments for an inter-company cooperative information system, we early proposed a methodology called MAMIE (from MAcro to MIcro level requirements Elicitation) with an accompanied tool. In MAMIE methodology, requirements are the result of composing functional and non-functional concerns. Before non-functional concerns composition, it’s primary to identify relationships between them. According to the most existing approaches, a non-functional concern may have a negative, positive or null contribution on the other non-functional concerns. In this paper, we argue that using only these three contributions types is not sufficient to express relationships which may exist between non-functional concerns. Thus, we propose a process which aims to identify non-functional concerns’ relationships and model them using a fuzzy cognitive map. The resulting model is composed of non-functional concerns, relationships between them and the weight of these relationships expressed with linguistics fuzzy values. Using fuzzy cognitive maps to model non-functional concerns relationships allows moving from the conventional modelling toward developing a computer based model. An example from the textile industry is used to illustrate the applicability of our process.
基金Key Program of National Natural Science Foundation of China (U1432248), National Natural Science Foundation of China (11505245), Western Talent Program of Chinese Academy of Sciences (Y460040XB0)
文摘In the process of oxidative phosphorylation, protons are pumped into the intermembrane space to establish the mitochondrial membrane potential (MMP). Relying on the electrochemical gradient, protons can return to the matrix through the ATP synthase complex with ATP generation. MitoQ, a lipophilic cation drug, can be bsorbed to the inner mitochondrial membrane with the cationic moiety staying at the intermembrane space[1].
基金supported by the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS)2021-I2M-1-002.
文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects.
文摘目的:大量研究表明,非侵入性神经调控技术能够有效改善脑卒中后非流畅性失语的症状,然而,针对该类技术的最优刺激方案仍有待深入验证与探究。此次研究借助网状Meta分析方法,系统评价不同非侵入性神经调控技术改善脑卒中后非流畅性失语患者言语功能的效应。方法:检索CNKI、万方、维普、CBM、PubMed、Cochrane图书馆、Embase和Web of Science数据库,筛选有关非侵入性神经调控技术治疗脑卒中后非流畅性失语的随机对照试验,检索时限截至2025-06-01。对照组采用常规治疗或假刺激,试验组在对照组治疗的基础上加入非侵入性神经调控技术,结局指标为西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表。采用Stata 17.0软件对结局指标进行传统Meta分析和网状Meta分析,采用GRADE对结局指标进行证据等级评价。结果:共纳入33篇随机对照试验,涉及10种非侵入性神经调控方式。①传统Meta分析结果显示,低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、经颅直流电刺激左侧Broca区可改善患者西方失语成套测验评分(P<0.001),低频重复经颅磁刺激右侧Broca区、低频重复经颅磁刺激颞上回后部、低频重复经颅磁刺激右侧Broca区联合高频重复经颅磁刺激左侧Broca区可改善患者汉语失语成套测验评分(P<0.05),低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、连续性θ爆发刺激右侧Broca区联合间歇性θ爆发刺激左侧Broca区、高频重复经颅磁刺激刺激右侧Broca区、低频重复经颅磁刺激右侧Broca区联合高频刺激左侧Broca区可改善患者日常生活交流能力评定量表评分(P<0.05)。②网状Meta分析结果显示,低频重复经颅磁刺激右侧Broca区改善患者西方失语成套测验评分和汉语失语成套测验评分的疗效更佳[SMD=1.13,95%CI(0.59,1.67),P<0.05;SMD=4.73,95%CI(1.28,8.18),P<0.05],经颅直流电刺激双侧Broca区在改善患者日常生活交流能力评定量表评分的疗效更佳[SMD=1.81,95%CI(0.51,2.12),P<0.05]。③GRADE证据等级评价结果显示,西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表结局指标的证据等级均为低级。结论:不同非侵入性神经调控方式均能改善脑卒中后非流畅性失语患者的言语功能,低频重复经颅磁刺激右侧Broca区在改善多维度言语功能方面,尤其在自发言语连贯性、听觉理解准确性及命名流畅性等方面疗效显著;经颅直流电刺激双侧Broca区更侧重改善患者的日常生活交流能力,但研究结果受纳入研究的数量及质量影响,证据等级较低,仍需更多高质量的研究进一步验证。
文摘目的研究基于近红外脑功能成像探讨针刺结合重复经颅磁刺激治疗卒中后非流利性失语的临床效应机制。方法选取2022年6月—2024年3月天津中医药大学第一附属医院收治的104例被诊断为脑卒中并伴有非流利性失语的患者作为研究对象,采取随机数字表法分为观察组和对照组,每组52例,所有患者均基于近红外脑功能成像技术进行探讨。对照组采用重复经颅磁刺激治疗,观察组采用针刺结合重复经颅磁刺激治疗。比较两组患者的临床效果、言语功能、声学水平以及失语症评分情况,并采取近红外脑功能成像技术检测其脑活动情况。结果观察组总有效率为98.00%(49/50),明显高于对照组的70.00%(35/50)(P<0.05)。治疗后,两组言语功能评分均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组语言交流能力检查量表(Communicative abilities in daily living,CADL)、非语言认知评估量表(Non-linguistic cognitive assessment,NLCA)均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组预运动皮质(Pre-motor cortex,PMC)、感觉运动皮质(Sensory motor cortex,SMC)、运动补充区(Supplementary motor area,SMA)均低于/高于治疗前,且观察组低于/高于对照组,差异有统计学意义(P<0.05)。结论卒中后非流利性失语患者采取针刺结合重复经颅磁刺激治疗,并予以近红外脑功能成像技术监测大脑后,可有效提升治疗效果,改善患者的语言功能,促进患者恢复,具有较高的临床应用价值。
