Polydeoxyribonucleotide(PDRN)has been utilized in clinical practice for an extended period;however,its application in the cosmetics is relatively recent.This study aims to explore the research progress of PDRN regardi...Polydeoxyribonucleotide(PDRN)has been utilized in clinical practice for an extended period;however,its application in the cosmetics is relatively recent.This study aims to explore the research progress of PDRN regarding its skin repair and anti-aging properties.To evaluate the potential skin repair,soothing,anti-wrinkle and firming effects of PDRN essence via both in vitro and in vivo test method.This study employed in vitro and in vivo test to assess the skin repair and anti-wrinkle effects.The 3D skin model(FulKutis®)was utilized to verify the effects of the PDRN essence on anti-inflammation,barrier repair,and anti-aging.In human test,a randomized,half-face comparison test with PDRN essence and the placebo was conducted with 33 Chinese subjects who met the test criteria.During the test,the skin conditions in terms of the a*value,facial red area ratio,and Transepidermal Water Loss(TEWL)were evaluated at 30 min,4 h,1 day,and 3 days;the skin conditions in terms of skin elasticity and firmness,skin wrinkles were evaluated at 42 days.Subjects’self-assessments were collected at 3 days and 42 days.The FulKutis■experiments demonstrated that the PDRN essence significantly decreased the levels of IL-1α,TNF-α,and PGE2,and improved the protein levels of Filaggrin,Loricrin,Collagen I,Collagen IV,and the thickness of the epidermal living cell layer.In the human study,the a*value,red area ratio,TEWL,and skin-related parameters(R2,R5,R7,F4,and skin wrinkles)on the test face side exhibited greater improvement compared to the control face side with statistically significant differences.Additionally,subject selfassessments revealed high satisfaction with the PDRN essence.The PDRN essence applied after non-ablative fractional laser treatment promotes barrier repair and soothing effects,shortens the recovery period,and enhances facial firmness and wrinkle improvement at the crow’s feet and undereye regions.No adverse events related to the tested cosmetics were observed.展开更多
In this paper, a Non-Ablative Thermal Protection System(NATPS) with the spiked body and the opposing jet combined configuration is proposed to reduce the aerodynamic heating of the hypersonic vehicle, and the coupled ...In this paper, a Non-Ablative Thermal Protection System(NATPS) with the spiked body and the opposing jet combined configuration is proposed to reduce the aerodynamic heating of the hypersonic vehicle, and the coupled fluid-thermal numerical analysis is performed to study the thermal control performance of the NATPS. The results show that the spiked body pushes the bow shock away from the protected structure and thus reduces the shock intensity and the wall heat flux. In addition, the low temperature gas of the opposing jet separates the high temperature gas behind the shock from the nose cone of the spiked body, ensuring the non-ablative property of the spiked body. Therefore, the NATPS reduces the aerodynamic heating by the reconfiguration of the flow field, and the thermal control efficiency of the system is better than the Thermal Protection System(TPS) with the single spiked body and the single opposing jet. The influencing factors of the NATPS are analyzed. Both increasing the length of the spiked body and reducing the total temperature of the opposing jet can improve the thermal control performance of the NATPS and the nonablative property of the spiked body. However, increasing the heat conductivity coefficient of the spiked body can enhance benefit the non-ablative property of the spiked body, but has little influence on the thermal control performance of the NATPS.展开更多
Cutaneous warts are common skin diseases caused by human papillomavirus （HPV） infection. The prevalence of cutaneous warts varied from 2.4%-12.9%, with common warts, planta warts and genital warts being the most com...Cutaneous warts are common skin diseases caused by human papillomavirus （HPV） infection. The prevalence of cutaneous warts varied from 2.4%-12.9%, with common warts, planta warts and genital warts being the most common ones. About 67% of patients with warts might resolve spontaneously within 2 years, while in some patients warts persist for years. A cellular immune response is essential for the clearance of HPV. Treatment modalities are usually ablative.展开更多
Demand for non-invasive techniques to treat oculofacial pathology has allowed for the growth and development of several new laser and light therapy modalities. These modalities include the use of intense pulsed light(...Demand for non-invasive techniques to treat oculofacial pathology has allowed for the growth and development of several new laser and light therapy modalities. These modalities include the use of intense pulsed light(IPL) and photodynamic therapy(PDT), light-emitting diode devices, as well as ablative and non-ablative lasers. Therapeutic applications in the periorbital area may involve the treatment of vascular lesions, telangiectasias, dyspigmentation, photodamage, hypertrichosis, rhytids, and scars. Laser and light-based technology offers patients treatment options that range from conservative to aggressive, allowing for choices between subtle results with little downtime or dramatic results with longer downtime. Advantages of laser treatments, as compared to traditional medical and surgical treatments, include a longer lasting effect than some of the conservative therapies and the ability to serve as a happy medium between non-invasive topical medicine and invasive surgical techniques. For patients seekingnon-invasive alternatives, these modalities confer a major advantage over incisional surgery. Understanding appropriate usage, side effects, and outcomes is before treating functional and cosmetic issues. Here we present a review of current treatment modalities, their use, side effects, and outcomes.展开更多
Skin laxity is an unavoidable consequence of aging and chronic sun exposure.Patients are increasingly turning to non-surgical skin tightening measures for a more youthful look.Non-surgical methods can be effective in ...Skin laxity is an unavoidable consequence of aging and chronic sun exposure.Patients are increasingly turning to non-surgical skin tightening measures for a more youthful look.Non-surgical methods can be effective in treating mild to moderate skin laxity,while offering decreased downtimes and fewer serious complications than surgical interventions.This article reviews the major non-surgical interventions for skin laxity:ablative and non-ablative lasers,radiofrequency,and microfocused ultrasound,noting their physiologic mechanism of actions,clinical benefits,and side effects.Regardless of the procedure,patient selection and expectation setting are crucial to achieving desired results and ensuring patient satisfaction.展开更多
文摘Polydeoxyribonucleotide(PDRN)has been utilized in clinical practice for an extended period;however,its application in the cosmetics is relatively recent.This study aims to explore the research progress of PDRN regarding its skin repair and anti-aging properties.To evaluate the potential skin repair,soothing,anti-wrinkle and firming effects of PDRN essence via both in vitro and in vivo test method.This study employed in vitro and in vivo test to assess the skin repair and anti-wrinkle effects.The 3D skin model(FulKutis®)was utilized to verify the effects of the PDRN essence on anti-inflammation,barrier repair,and anti-aging.In human test,a randomized,half-face comparison test with PDRN essence and the placebo was conducted with 33 Chinese subjects who met the test criteria.During the test,the skin conditions in terms of the a*value,facial red area ratio,and Transepidermal Water Loss(TEWL)were evaluated at 30 min,4 h,1 day,and 3 days;the skin conditions in terms of skin elasticity and firmness,skin wrinkles were evaluated at 42 days.Subjects’self-assessments were collected at 3 days and 42 days.The FulKutis■experiments demonstrated that the PDRN essence significantly decreased the levels of IL-1α,TNF-α,and PGE2,and improved the protein levels of Filaggrin,Loricrin,Collagen I,Collagen IV,and the thickness of the epidermal living cell layer.In the human study,the a*value,red area ratio,TEWL,and skin-related parameters(R2,R5,R7,F4,and skin wrinkles)on the test face side exhibited greater improvement compared to the control face side with statistically significant differences.Additionally,subject selfassessments revealed high satisfaction with the PDRN essence.The PDRN essence applied after non-ablative fractional laser treatment promotes barrier repair and soothing effects,shortens the recovery period,and enhances facial firmness and wrinkle improvement at the crow’s feet and undereye regions.No adverse events related to the tested cosmetics were observed.
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘In this paper, a Non-Ablative Thermal Protection System(NATPS) with the spiked body and the opposing jet combined configuration is proposed to reduce the aerodynamic heating of the hypersonic vehicle, and the coupled fluid-thermal numerical analysis is performed to study the thermal control performance of the NATPS. The results show that the spiked body pushes the bow shock away from the protected structure and thus reduces the shock intensity and the wall heat flux. In addition, the low temperature gas of the opposing jet separates the high temperature gas behind the shock from the nose cone of the spiked body, ensuring the non-ablative property of the spiked body. Therefore, the NATPS reduces the aerodynamic heating by the reconfiguration of the flow field, and the thermal control efficiency of the system is better than the Thermal Protection System(TPS) with the single spiked body and the single opposing jet. The influencing factors of the NATPS are analyzed. Both increasing the length of the spiked body and reducing the total temperature of the opposing jet can improve the thermal control performance of the NATPS and the nonablative property of the spiked body. However, increasing the heat conductivity coefficient of the spiked body can enhance benefit the non-ablative property of the spiked body, but has little influence on the thermal control performance of the NATPS.
基金This study was supported in part by grants from Program for Changjiang Scholars and Innovative Research Team in University （No. IRT0760）, National Natural Science Foundation （No. 30740082）, Program for postdoctoral training （No. 20070159020） and Liaoning BaiQianWan Talents Program.
文摘Cutaneous warts are common skin diseases caused by human papillomavirus （HPV） infection. The prevalence of cutaneous warts varied from 2.4%-12.9%, with common warts, planta warts and genital warts being the most common ones. About 67% of patients with warts might resolve spontaneously within 2 years, while in some patients warts persist for years. A cellular immune response is essential for the clearance of HPV. Treatment modalities are usually ablative.
文摘Demand for non-invasive techniques to treat oculofacial pathology has allowed for the growth and development of several new laser and light therapy modalities. These modalities include the use of intense pulsed light(IPL) and photodynamic therapy(PDT), light-emitting diode devices, as well as ablative and non-ablative lasers. Therapeutic applications in the periorbital area may involve the treatment of vascular lesions, telangiectasias, dyspigmentation, photodamage, hypertrichosis, rhytids, and scars. Laser and light-based technology offers patients treatment options that range from conservative to aggressive, allowing for choices between subtle results with little downtime or dramatic results with longer downtime. Advantages of laser treatments, as compared to traditional medical and surgical treatments, include a longer lasting effect than some of the conservative therapies and the ability to serve as a happy medium between non-invasive topical medicine and invasive surgical techniques. For patients seekingnon-invasive alternatives, these modalities confer a major advantage over incisional surgery. Understanding appropriate usage, side effects, and outcomes is before treating functional and cosmetic issues. Here we present a review of current treatment modalities, their use, side effects, and outcomes.
文摘Skin laxity is an unavoidable consequence of aging and chronic sun exposure.Patients are increasingly turning to non-surgical skin tightening measures for a more youthful look.Non-surgical methods can be effective in treating mild to moderate skin laxity,while offering decreased downtimes and fewer serious complications than surgical interventions.This article reviews the major non-surgical interventions for skin laxity:ablative and non-ablative lasers,radiofrequency,and microfocused ultrasound,noting their physiologic mechanism of actions,clinical benefits,and side effects.Regardless of the procedure,patient selection and expectation setting are crucial to achieving desired results and ensuring patient satisfaction.
