Objective:Cetuximab combined with chemotherapy has been used to treat non-small cell lung cancer (NSCLC) in recent years, most of them were first line setting.This study was to summarize our experiences in treating NS...Objective:Cetuximab combined with chemotherapy has been used to treat non-small cell lung cancer (NSCLC) in recent years, most of them were first line setting.This study was to summarize our experiences in treating NSCLC patients with cetuximab in the non-first line setting.Methods:From October 1st 2006 to December 31st 2009, six NSCLC patients were treated with cetuximab combined standard chemotherapy as non-first line setting in Sun Yat-sen University Cancer Center, China.The short-term efficacies and safeties were analyzed.Results:1.A total of 18 cycles of cetuximab treatment, with a median of two cycles in the whole group.2.There were 6 patients treated as non-first line setting, overall response rate (ORR) was 33.3% (2/6), disease control rate (DCR) was 33.3% (2/6), median time to progression (TTP) was 3.5 (3-4) months, and median OS was 18 (4-28) months.3.There were 50% (3/6) patients occurred acne-like rash within three weeks, their ORR was 66.7% (2/3), and DCR was 66.7% (2/3), however, both of ORR and DCR in patients who didn't occurred acne-like rash were 0% (0/3), the differences of ORR, DCR between two groups were in significant different (P=0.143).4.There was no treatment-associated death and no cetuximab-associated discontinuation.The incidence of acne-like rash was 50% occurred within three weeks, there were two patients suffered side effects associated with chemotherapy.Conclusion:The data of cetuximab application in non-first line setting for patients with NSCLC were rare, and the addition of cetuximab in those population was safe.展开更多
随着柔性直流电网的发展,其边界结构将发生改变,从“有边界电网”转变为“无边界电网”。如果在配置保护时,能够在原理上尽量适用于两种边界结构,则可以大大降低电网结构变化时保护验证的繁复性、提升保护应用的经济性。为提升线路行波...随着柔性直流电网的发展,其边界结构将发生改变,从“有边界电网”转变为“无边界电网”。如果在配置保护时,能够在原理上尽量适用于两种边界结构,则可以大大降低电网结构变化时保护验证的繁复性、提升保护应用的经济性。为提升线路行波保护对不同边界结构的适用性,该文提出一种新型的行波保护方案。该保护方案主要通过非故障极电流首行波积分(first current integration of non-fault pole,FCINP)实现。基于FCINP在不同边界结构电网下的距离特性和边界特性,可有效地提升保护在有边界电网和无边界电网下的故障识别性能,从而提升保护适用性。所提保护在基于PSCAD/EMTDC直流电网仿真模型中进行了性能验证。展开更多
基金Supported by a grant of Major Science and Technology Project of "National Significant New Drug Creation" (No.2008ZX09312-002)
文摘Objective:Cetuximab combined with chemotherapy has been used to treat non-small cell lung cancer (NSCLC) in recent years, most of them were first line setting.This study was to summarize our experiences in treating NSCLC patients with cetuximab in the non-first line setting.Methods:From October 1st 2006 to December 31st 2009, six NSCLC patients were treated with cetuximab combined standard chemotherapy as non-first line setting in Sun Yat-sen University Cancer Center, China.The short-term efficacies and safeties were analyzed.Results:1.A total of 18 cycles of cetuximab treatment, with a median of two cycles in the whole group.2.There were 6 patients treated as non-first line setting, overall response rate (ORR) was 33.3% (2/6), disease control rate (DCR) was 33.3% (2/6), median time to progression (TTP) was 3.5 (3-4) months, and median OS was 18 (4-28) months.3.There were 50% (3/6) patients occurred acne-like rash within three weeks, their ORR was 66.7% (2/3), and DCR was 66.7% (2/3), however, both of ORR and DCR in patients who didn't occurred acne-like rash were 0% (0/3), the differences of ORR, DCR between two groups were in significant different (P=0.143).4.There was no treatment-associated death and no cetuximab-associated discontinuation.The incidence of acne-like rash was 50% occurred within three weeks, there were two patients suffered side effects associated with chemotherapy.Conclusion:The data of cetuximab application in non-first line setting for patients with NSCLC were rare, and the addition of cetuximab in those population was safe.
文摘随着柔性直流电网的发展,其边界结构将发生改变,从“有边界电网”转变为“无边界电网”。如果在配置保护时,能够在原理上尽量适用于两种边界结构,则可以大大降低电网结构变化时保护验证的繁复性、提升保护应用的经济性。为提升线路行波保护对不同边界结构的适用性,该文提出一种新型的行波保护方案。该保护方案主要通过非故障极电流首行波积分(first current integration of non-fault pole,FCINP)实现。基于FCINP在不同边界结构电网下的距离特性和边界特性,可有效地提升保护在有边界电网和无边界电网下的故障识别性能,从而提升保护适用性。所提保护在基于PSCAD/EMTDC直流电网仿真模型中进行了性能验证。
