Satellite swarm coordinated flight(SSCF)technology has promising applications,but its complex nature poses significant challenges for control implementation.In response,this paper proposes an easily solvable adaptive ...Satellite swarm coordinated flight(SSCF)technology has promising applications,but its complex nature poses significant challenges for control implementation.In response,this paper proposes an easily solvable adaptive control scheme to achieve high-performance trajectory tracking of the SSCF system subject to actuator efficiency losses and external disturbances.Most existing adaptive controllers based on the certaintyequivalent(CE)principle show unpredictability and nonconvergence in their online parameter estimations.To overcome the above vulnerabilities and the difficulties caused by input failures of SSCF,this paper proposes an adaptive estimator based on scaling immersion and invariance(I&I),which reduces the computational complexity while improving the performance of the parameter estimator.Besides,a barrier Lyapunov function(BLF)is applied to satisfy both the boundedness of the system states and the singularity avoidance of the computation.It is proved that the estimator error becomes sufficiently small to converge to a specified attractive invariant manifold and the closed-loop SSCF system can obtain asymptotic stability under full-state constraints.Finally,numerical simulations are performed for comparison and analysis to verify the effectiveness and superiority of the proposed method.展开更多
Objective： To compare the clinical characteristics and prognosis between hepatitis virus-related hepatocellular carcinoma（viral HCC） and non-B, non-C HCC（NBC-HCC） among Uyghur patients in Xinjiang province, China...Objective： To compare the clinical characteristics and prognosis between hepatitis virus-related hepatocellular carcinoma（viral HCC） and non-B, non-C HCC（NBC-HCC） among Uyghur patients in Xinjiang province, China. Methods： Between 01/01/2000 and 31/12/2012, 319 Uyghur HCC patients were treated at the Cancer Centre of The First Affiliated Hospital of Xinjiang Medical University. The data for the patients were obtained from a retrospective review of the patients＇ medical records. A total of 18 patients were excluded from the study because of incomplete information. The patients were classified into two groups： viral HCC and NBC-HCC. The clinical characteristics and prognostic factors were statistically analysed.Results： For all 301 patients, gender（P=0.000）, area of residence（P=0.002）, diabetes mellitus（P=0.009）, BMI（P=0.000）, cirrhosis（P=0.000）, tumour stage（P=0.004）, Child-Pugh class（P=0.000）, the TBIL level（P=0.000）, and the alpha-fetoprotein（AFP） level（P=0.000） were significantly different between the NBC-HCC and viral HCC groups. The NBC-HCC patients tended to be diagnosed at advanced stages; however, the NBC-HCC patients exhibited lower Child-Pugh scores than the viral HCC patients. In all patients examined, the 0.5-, 1-, 3- and 5-year overall survival（OS） rates were 35.6%, 20.3%, 12.6% and 4.5%, respectively. No significant difference in OS was observed between the two groups（P=0.124）. Cox multivariate analysis revealed that age（RR =1.539, P=0.001）, TNM stage（RR =12.708, P=0.000）, portal vein tumour thrombus（PVTT）（RR =2.003, P=0.000）, Child-Pugh class（RR =1.715, P=0.000）, and TACE ＋ radiotherapy/RFA（RR =0.567, P=0.000） were significant independent prognostic factors for HCC patients. Conclusions： The clinical characteristics differ between Uyghur patients with NBC-HCC and viral HCC. HCC in the Xinjiang region displays specific regional characteristics. Age, TNM stage, PVTT, Child-Pugh class and TACE ＋ radiotherapy/RFA are significant risk factors that influence patient survival.展开更多
There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a seque...There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a sequence analysis of the entire HBV region in a case of non-B non-C chronic hepatitis in a 46-yearold female.A diagnosis of non-B non-C chronic hepatitis was made.Although HBV markers,such as HBs antibody(anti-HBs),anti-HBc,HBeAg and anti-HBe,were negative,HBV-DNA was positive.Nested PCR was performed to amplify the precore region of HBV-DNA and all remaining regions by long nested PCR.Sequence analysis of the two obtained bands was conducted by direct sequencing.Compared with the control strains,the ATG(Methionine)start codon in the X region had mut ated to GTG(Valine).It is assumed that a mutation at the start codon in the X region may be the reason why HBV markers are negative in some cases of hepatitis that involve occult HBV infection.展开更多
AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS Th...AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical outcomes.CONCLUSION Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors.展开更多
To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC), and we investigated the patients’ clinicopathological characteristics accordi...To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC), and we investigated the patients’ clinicopathological characteristics according to smoking status.METHODSWe retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of non-alcoholic steatohepatitis (NASH) was based on both clinical information and pathological confirmation.RESULTSAlcohol abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival (P = 0.0058) and disease-specific survival (P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery (P = 0.0002) and more likely to abuse alcohol (P = 0.0188) and to have multiple tumors (P = 0.023).CONCLUSIONCurrent smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients.展开更多
设计了一款基于ARM & Windows CE及FFT算法的锚杆无损检测系统,介绍了硬件电路设计方法,包括信号采集模块、A/D转换模块、液晶显示模块、电源模块;在软件设计中,完成了Windows CE操作系统的定制以及应用程序设计,并对设计方法和数据...设计了一款基于ARM & Windows CE及FFT算法的锚杆无损检测系统,介绍了硬件电路设计方法,包括信号采集模块、A/D转换模块、液晶显示模块、电源模块;在软件设计中,完成了Windows CE操作系统的定制以及应用程序设计,并对设计方法和数据FFT分析方法进行了阐述。展开更多
采用自制线管式介质阻挡放电反应器,针对非热等离子体协同Mn-Ce/La/γ-Al_2O_3催化剂对低浓度甲苯的去除开展研究。研究中制备了Mn/γ-Al_2O_3、Mn-Ce/γ-Al_2O_3、Mn-La/γ-Al_2O_3催化剂,从甲苯去除率、产物O_3生成、CO_x选择性及其...采用自制线管式介质阻挡放电反应器,针对非热等离子体协同Mn-Ce/La/γ-Al_2O_3催化剂对低浓度甲苯的去除开展研究。研究中制备了Mn/γ-Al_2O_3、Mn-Ce/γ-Al_2O_3、Mn-La/γ-Al_2O_3催化剂,从甲苯去除率、产物O_3生成、CO_x选择性及其他副产物生成情况考察比较了空管放电、协同催化剂放电时催化降解甲苯性能,并对催化剂进行了BET、SEM、H2-TPR和ICP-OES表征研究。结果表明:稀土助剂的加入有助于提高甲苯去除率及降低程度,且La催化性能优于Ce.,当外加电压22 k V、气量6 L·min-1、甲苯初始浓度600 mg·m-3时,Mn-La/γ-Al_2O_3催化剂对甲苯去除率达到72.74%。H2-TPR结果表明,稀土助剂的加入提高了催化剂低温活性及储氧能力,添加La的效果优于Ce。催化剂有助于抑制副产物O_3生成,提高CO_2和COx选择性。展开更多
基金supported by the Natural Science Foundation of Shaanxi Province(2020JQ-132)China Postdoctoral Science Foundation(2020M683571)+1 种基金National Natural Science Foundation of China(62103336,11972026,U2013206)Funds for the Central Universities(3102019HTQD007)。
文摘Satellite swarm coordinated flight(SSCF)technology has promising applications,but its complex nature poses significant challenges for control implementation.In response,this paper proposes an easily solvable adaptive control scheme to achieve high-performance trajectory tracking of the SSCF system subject to actuator efficiency losses and external disturbances.Most existing adaptive controllers based on the certaintyequivalent(CE)principle show unpredictability and nonconvergence in their online parameter estimations.To overcome the above vulnerabilities and the difficulties caused by input failures of SSCF,this paper proposes an adaptive estimator based on scaling immersion and invariance(I&I),which reduces the computational complexity while improving the performance of the parameter estimator.Besides,a barrier Lyapunov function(BLF)is applied to satisfy both the boundedness of the system states and the singularity avoidance of the computation.It is proved that the estimator error becomes sufficiently small to converge to a specified attractive invariant manifold and the closed-loop SSCF system can obtain asymptotic stability under full-state constraints.Finally,numerical simulations are performed for comparison and analysis to verify the effectiveness and superiority of the proposed method.
基金supported by a grant from the Urumqi Science and Technology Project Foundation of China(No.H111313001)
文摘Objective： To compare the clinical characteristics and prognosis between hepatitis virus-related hepatocellular carcinoma（viral HCC） and non-B, non-C HCC（NBC-HCC） among Uyghur patients in Xinjiang province, China. Methods： Between 01/01/2000 and 31/12/2012, 319 Uyghur HCC patients were treated at the Cancer Centre of The First Affiliated Hospital of Xinjiang Medical University. The data for the patients were obtained from a retrospective review of the patients＇ medical records. A total of 18 patients were excluded from the study because of incomplete information. The patients were classified into two groups： viral HCC and NBC-HCC. The clinical characteristics and prognostic factors were statistically analysed.Results： For all 301 patients, gender（P=0.000）, area of residence（P=0.002）, diabetes mellitus（P=0.009）, BMI（P=0.000）, cirrhosis（P=0.000）, tumour stage（P=0.004）, Child-Pugh class（P=0.000）, the TBIL level（P=0.000）, and the alpha-fetoprotein（AFP） level（P=0.000） were significantly different between the NBC-HCC and viral HCC groups. The NBC-HCC patients tended to be diagnosed at advanced stages; however, the NBC-HCC patients exhibited lower Child-Pugh scores than the viral HCC patients. In all patients examined, the 0.5-, 1-, 3- and 5-year overall survival（OS） rates were 35.6%, 20.3%, 12.6% and 4.5%, respectively. No significant difference in OS was observed between the two groups（P=0.124）. Cox multivariate analysis revealed that age（RR =1.539, P=0.001）, TNM stage（RR =12.708, P=0.000）, portal vein tumour thrombus（PVTT）（RR =2.003, P=0.000）, Child-Pugh class（RR =1.715, P=0.000）, and TACE ＋ radiotherapy/RFA（RR =0.567, P=0.000） were significant independent prognostic factors for HCC patients. Conclusions： The clinical characteristics differ between Uyghur patients with NBC-HCC and viral HCC. HCC in the Xinjiang region displays specific regional characteristics. Age, TNM stage, PVTT, Child-Pugh class and TACE ＋ radiotherapy/RFA are significant risk factors that influence patient survival.
文摘There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a sequence analysis of the entire HBV region in a case of non-B non-C chronic hepatitis in a 46-yearold female.A diagnosis of non-B non-C chronic hepatitis was made.Although HBV markers,such as HBs antibody(anti-HBs),anti-HBc,HBeAg and anti-HBe,were negative,HBV-DNA was positive.Nested PCR was performed to amplify the precore region of HBV-DNA and all remaining regions by long nested PCR.Sequence analysis of the two obtained bands was conducted by direct sequencing.Compared with the control strains,the ATG(Methionine)start codon in the X region had mut ated to GTG(Valine).It is assumed that a mutation at the start codon in the X region may be the reason why HBV markers are negative in some cases of hepatitis that involve occult HBV infection.
文摘AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical outcomes.CONCLUSION Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors.
文摘To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC), and we investigated the patients’ clinicopathological characteristics according to smoking status.METHODSWe retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of non-alcoholic steatohepatitis (NASH) was based on both clinical information and pathological confirmation.RESULTSAlcohol abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival (P = 0.0058) and disease-specific survival (P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery (P = 0.0002) and more likely to abuse alcohol (P = 0.0188) and to have multiple tumors (P = 0.023).CONCLUSIONCurrent smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients.
文摘采用自制线管式介质阻挡放电反应器,针对非热等离子体协同Mn-Ce/La/γ-Al_2O_3催化剂对低浓度甲苯的去除开展研究。研究中制备了Mn/γ-Al_2O_3、Mn-Ce/γ-Al_2O_3、Mn-La/γ-Al_2O_3催化剂,从甲苯去除率、产物O_3生成、CO_x选择性及其他副产物生成情况考察比较了空管放电、协同催化剂放电时催化降解甲苯性能,并对催化剂进行了BET、SEM、H2-TPR和ICP-OES表征研究。结果表明:稀土助剂的加入有助于提高甲苯去除率及降低程度,且La催化性能优于Ce.,当外加电压22 k V、气量6 L·min-1、甲苯初始浓度600 mg·m-3时,Mn-La/γ-Al_2O_3催化剂对甲苯去除率达到72.74%。H2-TPR结果表明,稀土助剂的加入提高了催化剂低温活性及储氧能力,添加La的效果优于Ce。催化剂有助于抑制副产物O_3生成,提高CO_2和COx选择性。
