Non-O1/non-O139 Vibrio(V.)cholerae(NOVC)has emerged as a potential pathogen in patients with compromised health conditions[1].We report the whole genome sequencing(WGS)of a rare NOVC sepsis isolate(GenBank Accession:G...Non-O1/non-O139 Vibrio(V.)cholerae(NOVC)has emerged as a potential pathogen in patients with compromised health conditions[1].We report the whole genome sequencing(WGS)of a rare NOVC sepsis isolate(GenBank Accession:GCF_051906115.1)from an 89-year-old male admitted to the Intensive Care Unit(ICU)with septic shock(lactate 6.61 mmol/L)digestive illness.展开更多
Optical non-reciprocity is a fundamental phenomenon in photonics.It is crucial for developing devices that rely on directional signal control,such as optical isolators and circulators.However,most research in this fie...Optical non-reciprocity is a fundamental phenomenon in photonics.It is crucial for developing devices that rely on directional signal control,such as optical isolators and circulators.However,most research in this field has focused on systems in equilibrium or steady states.In this work,we demonstrate a room-temperature Rydberg atomic platform where the unidirectional propagation of light acts as a switch to mediate time-crystalline-like collective oscillations through atomic synchronization.展开更多
The weak and broken roof,explosive control and other problems seriously restrict the promotion of non coal pillar self-forming roadway technology.In order to solve such problems,a new method of non coal pillar self-fo...The weak and broken roof,explosive control and other problems seriously restrict the promotion of non coal pillar self-forming roadway technology.In order to solve such problems,a new method of non coal pillar self-forming roadway through non-blasting roof cutting and pressure relief was proposed in this study.A systematic research system of"theoretical analysis-physical experiment-engineering verification"was constructed with the 9103 working face of Longmenta Coal Mine as the research object.Firstly,the theoretical analysis was conducted to reveal the roof cutting mechanics mechanism of rock mass weakened by dense drilling,establish the design criteria for key drilling parameters,and obtain the key design parameters of dense drilling in the test working face.Secondly,the physical model test was conducted to make clear that the dense drilling method can directionally cut off the goaf roof along the set position,reducing the stress and deformation of the roadway surrounding rock.Finally,the field engineering tests were conducted,and monitoring results showed that the pressure relief effect of the dense drilling method was comparable to that of the directional blasting method,achieving non coal pillar self-forming roadway mining under non blasting conditions.展开更多
The published article titled“Long Noncoding RNA(lncRNA)HOTAIR Affects Tumorigenesis andMetastasis of Non-Small Cell Lung Cancer by Upregulating miR-613”has been retracted from Oncology Research,Vol.26,No.5,2018,pp....The published article titled“Long Noncoding RNA(lncRNA)HOTAIR Affects Tumorigenesis andMetastasis of Non-Small Cell Lung Cancer by Upregulating miR-613”has been retracted from Oncology Research,Vol.26,No.5,2018,pp.725–734.DOI:10.3727/096504017X15119467381615 URL:https://www.techscience.com/or/v26n5/56685 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
The published article titled“MicroRNA-138 Inhibits Cell Growth,Invasion,and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop”has been retracted fromOncology Research,Vol.26,No.3,2018,pp.385–400.DOI:10.3...The published article titled“MicroRNA-138 Inhibits Cell Growth,Invasion,and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop”has been retracted fromOncology Research,Vol.26,No.3,2018,pp.385–400.DOI:10.3727/096504017X14973124850905 URL:https://www.techscience.com/or/v26n3/56651 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Let A be a 3×3 singular or diagonalizable matrix,all solutions to the Yang-Baxter-like matrix equation have been determined.However,finding all solutions for full rank,non-diagonalizable matrices remains challeng...Let A be a 3×3 singular or diagonalizable matrix,all solutions to the Yang-Baxter-like matrix equation have been determined.However,finding all solutions for full rank,non-diagonalizable matrices remains challenging.By utilizing classification techniques,we establish all solutions of the Yang-Baxter-like matrix equation in this paper when the coefficient matrix A is similar to non-diagonalizable matrix diag(λ,J_(2)(λ))withλ̸=0.More specifically,we divide the non-diagonal elements of the solution into 10 different cases.By discussing each situation,we establish all solutions of the Yang-Baxter-like matrix equation.The results of this work enrich the existing ones.展开更多
Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has b...Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.展开更多
In non-independent and identically distributed(non-IID)data environments,model performance often degrades significantly.To address this issue,two improvement methods are proposed:FedReg and FedReg^(*).FedReg is a meth...In non-independent and identically distributed(non-IID)data environments,model performance often degrades significantly.To address this issue,two improvement methods are proposed:FedReg and FedReg^(*).FedReg is a method based on hybrid regularization aimed at enhancing federated learning in non-IID scenarios.It introduces hybrid regularization to replace traditional L2 regularization,combining the advantages of L1 and L2 regularization to enable feature selection while preventing overfitting.This method better adapts to the diverse data distributions of different clients,improving the overall model performance.FedReg^(*)combines hybrid regularization with weighted model aggregation.In addition to the benefits of hybrid regularization,FedReg^(*)applies a weighted averaging method in the model aggregation process,calculating weights based on the cosine similarity between each client gradient and the global gradient to more reasonably distribute client contributions.By considering variations in data quality and quantity among clients,FedReg^(*)highlights the importance of key clients and enhances the model’s generalization performance.These improvement methods enhance model accuracy and communication efficiency.展开更多
联邦学习因具有隐私保护的天然特性,已经逐渐成为一个被广泛认可的分布式机器学习框架。但由于参与方数据分布的差异性,特别是呈现非独立同分布(Non-Independent and Identically Distributed,Non-IID)时,其面临着泛化性能不足、收敛性...联邦学习因具有隐私保护的天然特性,已经逐渐成为一个被广泛认可的分布式机器学习框架。但由于参与方数据分布的差异性,特别是呈现非独立同分布(Non-Independent and Identically Distributed,Non-IID)时,其面临着泛化性能不足、收敛性能下降、数据倾斜等严峻挑战。用预训练基础模型缓解Non-IID问题作为一种新颖的方法,演变出了各种各样的解决方案。对此,从预训练基础模型的角度,对现有工作进行了综述。首先介绍了基础模型方法,对典型的基础模型编码结构进行对比分析。其次从修改输入、基础模型部分结构再训练,以及参数高效微调3个角度,提出了一种新的分类方法。最后探讨了该类工作的核心难题和未来研究方向。展开更多
Non-O1/non-O139 Vibrio cholerae(NOVC)has multiple pathogenic pathways in humans.The cause of disease in influenced by the virulence genes carried by the infecting strain and the health condition of the host.[1-2]When ...Non-O1/non-O139 Vibrio cholerae(NOVC)has multiple pathogenic pathways in humans.The cause of disease in influenced by the virulence genes carried by the infecting strain and the health condition of the host.[1-2]When seafood,food and water sources are contaminated with feces,people are prone to gastroenteritis,and direct exposure to contaminated water may cause wound infection.展开更多
Non-Abelian topological insulators are characterized by matrix-valued,non-commuting topological charges with regard to more than one energy gap.Their descriptions go beyond the conventional topological band theory,in ...Non-Abelian topological insulators are characterized by matrix-valued,non-commuting topological charges with regard to more than one energy gap.Their descriptions go beyond the conventional topological band theory,in which an additive integer like the winding or Chern number is endowed separately with each(degenerate group of)energy band(s).In this work,we reveal that Floquet(time-periodic)driving could not only enrich the topology and phase transitions of non-Abelian topological matter,but also induce bulk-edge correspondence unique to nonequilibrium setups.Using a one-dimensional,three-band model as an illustrative example,we demonstrate that Floquet driving could reshuffle the phase diagram of the non-driven system,yielding both gapped and gapless Floquet band structures with non-Abelian topological charges.Moreover,by dynamically tuning the anomalous Floquet π-quasienergy gap,non-Abelian topological transitions inaccessible to static systems could arise,leading to much more complicated relations between non-Abelian topological charges and Floquet edge states.These discoveries put forth periodic driving as a powerful scheme of engineering non-Abelian topological phases and incubating unique non-Abelian band topology beyond equilibrium.展开更多
This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and...This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and reproductive medicine.展开更多
Background:No clear evidence exists regarding the relationship between the systemic immune-inflammation index(SII)and the efficacy of first-line chemotherapy combined with immunotherapy in patients with advanced non-s...Background:No clear evidence exists regarding the relationship between the systemic immune-inflammation index(SII)and the efficacy of first-line chemotherapy combined with immunotherapy in patients with advanced non-small cell lung cancer(NSCLC).This study aimed to establish the relationship between the SII and survival of patients with advanced NSCLC.Methods:This study included 123 patients with advanced NSCLC.The cutoff value of the SII was determined to be 1172 using ROC curve analysis.We evaluated the relationship between the SII and progression-free survival(PFS)and overall survival(OS)using the Cox regression model and Kaplan-Meier(KM)curve analysis.We stratified patients into multiple subgroups based on covariates such as age,sex,and smoking history.Subgroup analysis was used to evaluate the relationship between high SII,disease progression,and mortality risk.Results:Univariate analysis indicated that no significant difference existed between SII and PFS,but univariate analysis showed a significant association between SII and OS(hazard ratio[HR]=1.93,95% confidence interval[CI]=1.14-3.29,p=0.015).The fully adjusted Cox regression analysis also showed a significant correlation between the SII and OS after adjustment for covariables(HR=1.76,95%CI=1.02-3.02,p=0.041).In some subgroups,a high SII positively correlated with the risk of disease progression,and the relationship between a high SII and the risk of mortality was consistent in almost all subgroups.Conclusions:These results indicate that pretreatment SII may be an independent predictivemarker for patients with advanced NSCLC undergoing first-line chemotherapy combined with immunotherapy.However,large-scale prospective studies are required to confirm our results.展开更多
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI...The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI:10.3727/096504016X14822800040451 URL:https://www.techscience.com/or/v25n6/56885 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.展开更多
BACKGROUND The use of apixaban in chronic hemodialysis(HD)patients for non-valvular atrial fibrillation(NVAF)is still controversial regarding benefit of stroke protection vs risk of bleeding.Rotational thromboelastome...BACKGROUND The use of apixaban in chronic hemodialysis(HD)patients for non-valvular atrial fibrillation(NVAF)is still controversial regarding benefit of stroke protection vs risk of bleeding.Rotational thromboelastometry(ROTEM)is a point of care method that evaluates clot formation in whole blood and has been used as an evaluation tool for bleeding risk assessment in non-HD apixaban users.AIM To determine whether bleeding risk can be predicted using ROTEM activated with tissue factor(EXTEM)in HD patients receiving apixaban for NVAF.METHODS Nineteen HD patients with NVAF treated with apixaban for at least 8 days were enrolled.Four dosing regimens were recorded as prescribed by their physician,from 2.5 mg once daily on a non-dialysis day to 5 mg twice daily.Standard coagulation tests,along with ROTEM and apixaban drug levels(using liquid anti-Xa assay)were performed once on a non-dialysis day before and two hours after apixaban morning pill administration.Patients were subsequently monitored for thrombotic/bleeding events and all-cause mortality.RESULTS Over a median follow-up period of 36 months,six patients experienced a bleeding event(group A)and 13 remained free of bleeding(group B).Six deaths were recorded:Three due to major bleeding,one from thrombotic stroke,and two unrelated to coagulopathy.EXTEM clotting time(CT)-post was the only parameter that significantly differed between group A and group B(P=0.013).Each 1-second increase in CT-post was linked to an 8%higher likelihood of a bleeding event(odds ratio=1.08,95%confidence interval:1.0-1.17;P=0.048).A significant progressive increase was observed with the drug’s trough and peak levels(P<0.05)across the four dosing regimens but no significant relationship was found between CT and apixaban dose groups.CONCLUSION Early detection of bleeding risk in HD patients with NVAF on Apixaban maybe be effectively achieved through frequent monitoring using ROTEM EXTEM post CT,thereby helping to reduce associated morbidity.展开更多
文摘Non-O1/non-O139 Vibrio(V.)cholerae(NOVC)has emerged as a potential pathogen in patients with compromised health conditions[1].We report the whole genome sequencing(WGS)of a rare NOVC sepsis isolate(GenBank Accession:GCF_051906115.1)from an 89-year-old male admitted to the Intensive Care Unit(ICU)with septic shock(lactate 6.61 mmol/L)digestive illness.
基金supported by the National Natural Science Foundation of China (Grant No.12274131)the Innovation Program for Quantum Science and Technology (Grant No.2024ZD0300101)。
文摘Optical non-reciprocity is a fundamental phenomenon in photonics.It is crucial for developing devices that rely on directional signal control,such as optical isolators and circulators.However,most research in this field has focused on systems in equilibrium or steady states.In this work,we demonstrate a room-temperature Rydberg atomic platform where the unidirectional propagation of light acts as a switch to mediate time-crystalline-like collective oscillations through atomic synchronization.
基金Project(2024YFC2909500)supported by the National Key Research and Development Program of ChinaProjects(42377148,52204164)supported by the National Natural Science Foundation of ChinaProject(2022XJSB03)supported by the Fundamental Research Funds for the Central Universities,China。
文摘The weak and broken roof,explosive control and other problems seriously restrict the promotion of non coal pillar self-forming roadway technology.In order to solve such problems,a new method of non coal pillar self-forming roadway through non-blasting roof cutting and pressure relief was proposed in this study.A systematic research system of"theoretical analysis-physical experiment-engineering verification"was constructed with the 9103 working face of Longmenta Coal Mine as the research object.Firstly,the theoretical analysis was conducted to reveal the roof cutting mechanics mechanism of rock mass weakened by dense drilling,establish the design criteria for key drilling parameters,and obtain the key design parameters of dense drilling in the test working face.Secondly,the physical model test was conducted to make clear that the dense drilling method can directionally cut off the goaf roof along the set position,reducing the stress and deformation of the roadway surrounding rock.Finally,the field engineering tests were conducted,and monitoring results showed that the pressure relief effect of the dense drilling method was comparable to that of the directional blasting method,achieving non coal pillar self-forming roadway mining under non blasting conditions.
文摘The published article titled“Long Noncoding RNA(lncRNA)HOTAIR Affects Tumorigenesis andMetastasis of Non-Small Cell Lung Cancer by Upregulating miR-613”has been retracted from Oncology Research,Vol.26,No.5,2018,pp.725–734.DOI:10.3727/096504017X15119467381615 URL:https://www.techscience.com/or/v26n5/56685 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘The published article titled“MicroRNA-138 Inhibits Cell Growth,Invasion,and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop”has been retracted fromOncology Research,Vol.26,No.3,2018,pp.385–400.DOI:10.3727/096504017X14973124850905 URL:https://www.techscience.com/or/v26n3/56651 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
基金Supported by National Natural Science Foundation of China(Grant No.62173161).
文摘Let A be a 3×3 singular or diagonalizable matrix,all solutions to the Yang-Baxter-like matrix equation have been determined.However,finding all solutions for full rank,non-diagonalizable matrices remains challenging.By utilizing classification techniques,we establish all solutions of the Yang-Baxter-like matrix equation in this paper when the coefficient matrix A is similar to non-diagonalizable matrix diag(λ,J_(2)(λ))withλ̸=0.More specifically,we divide the non-diagonal elements of the solution into 10 different cases.By discussing each situation,we establish all solutions of the Yang-Baxter-like matrix equation.The results of this work enrich the existing ones.
基金supported by grants from the National Natural Science Foundation of China(G.F.Wang,grant number 82204071)(P.Y.Su,grant numbers 81874268 and 82473655)the Research Funds of the Center for Big Data and Population Health of IHM(P.Y.Su,No.JKS2023016)Anhui Provincial Health Commission Scientific Research Project(Y.Zhou,No.AHWJ2023A30027)。
文摘Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.
文摘In non-independent and identically distributed(non-IID)data environments,model performance often degrades significantly.To address this issue,two improvement methods are proposed:FedReg and FedReg^(*).FedReg is a method based on hybrid regularization aimed at enhancing federated learning in non-IID scenarios.It introduces hybrid regularization to replace traditional L2 regularization,combining the advantages of L1 and L2 regularization to enable feature selection while preventing overfitting.This method better adapts to the diverse data distributions of different clients,improving the overall model performance.FedReg^(*)combines hybrid regularization with weighted model aggregation.In addition to the benefits of hybrid regularization,FedReg^(*)applies a weighted averaging method in the model aggregation process,calculating weights based on the cosine similarity between each client gradient and the global gradient to more reasonably distribute client contributions.By considering variations in data quality and quantity among clients,FedReg^(*)highlights the importance of key clients and enhances the model’s generalization performance.These improvement methods enhance model accuracy and communication efficiency.
文摘联邦学习因具有隐私保护的天然特性,已经逐渐成为一个被广泛认可的分布式机器学习框架。但由于参与方数据分布的差异性,特别是呈现非独立同分布(Non-Independent and Identically Distributed,Non-IID)时,其面临着泛化性能不足、收敛性能下降、数据倾斜等严峻挑战。用预训练基础模型缓解Non-IID问题作为一种新颖的方法,演变出了各种各样的解决方案。对此,从预训练基础模型的角度,对现有工作进行了综述。首先介绍了基础模型方法,对典型的基础模型编码结构进行对比分析。其次从修改输入、基础模型部分结构再训练,以及参数高效微调3个角度,提出了一种新的分类方法。最后探讨了该类工作的核心难题和未来研究方向。
基金supported by the National Natural Science Foundation(82372206)the Jiangsu Provincial Health Commission(H2023107)the project of basic and clinical research on cardiac arrest in the Emergency and Critical Care Department of the Second Affiliated Hospital of Soochow University(XKTJ-XK202408-2).
文摘Non-O1/non-O139 Vibrio cholerae(NOVC)has multiple pathogenic pathways in humans.The cause of disease in influenced by the virulence genes carried by the infecting strain and the health condition of the host.[1-2]When seafood,food and water sources are contaminated with feces,people are prone to gastroenteritis,and direct exposure to contaminated water may cause wound infection.
基金supported by the National Natural Science Foundation of China(Grant Nos.12275260 and 11905211)the Fundamental Research Funds for the Central Universities(Grant No.202364008)the Young Talents Project of Ocean University of China。
文摘Non-Abelian topological insulators are characterized by matrix-valued,non-commuting topological charges with regard to more than one energy gap.Their descriptions go beyond the conventional topological band theory,in which an additive integer like the winding or Chern number is endowed separately with each(degenerate group of)energy band(s).In this work,we reveal that Floquet(time-periodic)driving could not only enrich the topology and phase transitions of non-Abelian topological matter,but also induce bulk-edge correspondence unique to nonequilibrium setups.Using a one-dimensional,three-band model as an illustrative example,we demonstrate that Floquet driving could reshuffle the phase diagram of the non-driven system,yielding both gapped and gapless Floquet band structures with non-Abelian topological charges.Moreover,by dynamically tuning the anomalous Floquet π-quasienergy gap,non-Abelian topological transitions inaccessible to static systems could arise,leading to much more complicated relations between non-Abelian topological charges and Floquet edge states.These discoveries put forth periodic driving as a powerful scheme of engineering non-Abelian topological phases and incubating unique non-Abelian band topology beyond equilibrium.
文摘This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and reproductive medicine.
基金supported by grants from the“Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation”under Grant No.2023JJA141341the“Guangxi Medical and Health Key Discipline Construction Project.”。
文摘Background:No clear evidence exists regarding the relationship between the systemic immune-inflammation index(SII)and the efficacy of first-line chemotherapy combined with immunotherapy in patients with advanced non-small cell lung cancer(NSCLC).This study aimed to establish the relationship between the SII and survival of patients with advanced NSCLC.Methods:This study included 123 patients with advanced NSCLC.The cutoff value of the SII was determined to be 1172 using ROC curve analysis.We evaluated the relationship between the SII and progression-free survival(PFS)and overall survival(OS)using the Cox regression model and Kaplan-Meier(KM)curve analysis.We stratified patients into multiple subgroups based on covariates such as age,sex,and smoking history.Subgroup analysis was used to evaluate the relationship between high SII,disease progression,and mortality risk.Results:Univariate analysis indicated that no significant difference existed between SII and PFS,but univariate analysis showed a significant association between SII and OS(hazard ratio[HR]=1.93,95% confidence interval[CI]=1.14-3.29,p=0.015).The fully adjusted Cox regression analysis also showed a significant correlation between the SII and OS after adjustment for covariables(HR=1.76,95%CI=1.02-3.02,p=0.041).In some subgroups,a high SII positively correlated with the risk of disease progression,and the relationship between a high SII and the risk of mortality was consistent in almost all subgroups.Conclusions:These results indicate that pretreatment SII may be an independent predictivemarker for patients with advanced NSCLC undergoing first-line chemotherapy combined with immunotherapy.However,large-scale prospective studies are required to confirm our results.
文摘Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI:10.3727/096504016X14822800040451 URL:https://www.techscience.com/or/v25n6/56885 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.
文摘BACKGROUND The use of apixaban in chronic hemodialysis(HD)patients for non-valvular atrial fibrillation(NVAF)is still controversial regarding benefit of stroke protection vs risk of bleeding.Rotational thromboelastometry(ROTEM)is a point of care method that evaluates clot formation in whole blood and has been used as an evaluation tool for bleeding risk assessment in non-HD apixaban users.AIM To determine whether bleeding risk can be predicted using ROTEM activated with tissue factor(EXTEM)in HD patients receiving apixaban for NVAF.METHODS Nineteen HD patients with NVAF treated with apixaban for at least 8 days were enrolled.Four dosing regimens were recorded as prescribed by their physician,from 2.5 mg once daily on a non-dialysis day to 5 mg twice daily.Standard coagulation tests,along with ROTEM and apixaban drug levels(using liquid anti-Xa assay)were performed once on a non-dialysis day before and two hours after apixaban morning pill administration.Patients were subsequently monitored for thrombotic/bleeding events and all-cause mortality.RESULTS Over a median follow-up period of 36 months,six patients experienced a bleeding event(group A)and 13 remained free of bleeding(group B).Six deaths were recorded:Three due to major bleeding,one from thrombotic stroke,and two unrelated to coagulopathy.EXTEM clotting time(CT)-post was the only parameter that significantly differed between group A and group B(P=0.013).Each 1-second increase in CT-post was linked to an 8%higher likelihood of a bleeding event(odds ratio=1.08,95%confidence interval:1.0-1.17;P=0.048).A significant progressive increase was observed with the drug’s trough and peak levels(P<0.05)across the four dosing regimens but no significant relationship was found between CT and apixaban dose groups.CONCLUSION Early detection of bleeding risk in HD patients with NVAF on Apixaban maybe be effectively achieved through frequent monitoring using ROTEM EXTEM post CT,thereby helping to reduce associated morbidity.
