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A single nucleotide substitution in the MATE transporter gene regulates plastochron and the many noded dwarf phenotype in barley(Hordeum vulgare L.) 被引量:1
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作者 GUO Bao-jian SUN Hong-wei +9 位作者 QI Jiang HUANG Xin-yu HONG Yi HOU Jian Lü Chao WANG Yu-lin WANG Fei-fei ZHU Juan GUO Gang-gang XU Ru-gen 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第8期2295-2305,共11页
In higher plants,the shoot apical meristem produces lateral organs in a regular spacing(phyllotaxy)and timing(plastochron).The molecular analysis of mutants associated with phyllotaxy and plastochron would increase ou... In higher plants,the shoot apical meristem produces lateral organs in a regular spacing(phyllotaxy)and timing(plastochron).The molecular analysis of mutants associated with phyllotaxy and plastochron would increase our understanding of the mechanism of shoot architecture formation.In this study,we identified mutant mnd8ynp5 that shows an increased rate of leaf emergence and a larger number of nodes in combination with a dwarfed growth habit from an EMS-treated population of the elite barley cultivar Yangnongpi 5.Using a map-based cloning strategy,the mnd8 gene was narrowed down to a 6.7-kb genomic interval on the long arm of chromosome 5H.Sequence analysis revealed that a C to T single-nucleotide mutation occurred at the first exon(position 953)of HORVU5Hr1G118820,leading to an alanine(Ala)to valine(Val)substitution at the 318th amino acid site.Next,HORVU5Hr1G118820 was defined as the candidate gene of MND8 encoding 514 amino acids and containing two multidrug and toxic compound extrusion(MATE)domains.It is highly homologous to maize Bige1and has a conserved function in the regulation of plant development by controlling the leaf initiation rate.Examination of modern barely varieties showed that Hap-1 was the dominant haplotype and was selected in barley breeding around the world.Collectively,our results indicated that mnd8ynp5 is a novel allele of the HORVU5Hr1G118820 gene that is possibly responsible for the shortened plastochron and many noded dwarf phenotype in barley. 展开更多
关键词 BARLEY EMS PLASTOCHRON many noded dwarf MATE transporter shoot architecture
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Coarse Graining Method Based on Noded Similarity in Complex Network
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作者 Yingying Wang Zhen Jia Lang Zeng 《Communications and Network》 2018年第3期51-64,共14页
Coarse graining of complex networks is an important method to study large-scale complex networks, and is also in the focus of network science today. This paper tries to develop a new coarse-graining method for complex... Coarse graining of complex networks is an important method to study large-scale complex networks, and is also in the focus of network science today. This paper tries to develop a new coarse-graining method for complex networks, which is based on the node similarity index. From the information structure of the network node similarity, the coarse-grained network is extracted by defining the local similarity and the global similarity index of nodes. A large number of simulation experiments show that the proposed method can effectively reduce the size of the network, while maintaining some statistical properties of the original network to some extent. Moreover, the proposed method has low computational complexity and allows people to freely choose the size of the reduced networks. 展开更多
关键词 COMPLEX Network Coarse GRAINING NODE SIMILARITY STATISTICAL PROPERTIES
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基于uni-app的旧物回收微信小程序的设计与实现
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作者 胡佳静 赵丙秀 《电脑编程技巧与维护》 2026年第2期65-68,共4页
为应对大学校园内闲置物品处置不便、资源浪费及环境污染等问题,研究以构建绿色循环校园为目标,设计并实现了一款旧物回收微信小程序。在技术实现上,该系统采用前后端分离架构。前端基于uni-app框架,实现了跨平台兼容的用户界面,包含用... 为应对大学校园内闲置物品处置不便、资源浪费及环境污染等问题,研究以构建绿色循环校园为目标,设计并实现了一款旧物回收微信小程序。在技术实现上,该系统采用前后端分离架构。前端基于uni-app框架,实现了跨平台兼容的用户界面,包含用户管理、回收交易及积分商城三大核心模块;后端利用Node.js及egg.js框架构建应用服务器,并通过MySQL、Redis与MongoDB的组合数据库方案,实现了关系型、缓存及非关系型数据的协同管理,确保了系统的高效与稳定。 展开更多
关键词 旧物回收 微信小程序 uni-app框架 Node.js 前后端分离
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Unusual recurrence of colon cancer with isolated axillary lymph node metastasis:A case report
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作者 Ali Toffaha Mahmood Al-Dhaheri +5 位作者 Mohammad AL.Zoubi Arwa Abdelrahim Mahir Petkar Ahmed Badr Mohamed Abunada Ayman Ahmed 《Laparoscopic, Endoscopic and Robotic Surgery》 2026年第1期58-61,共4页
The metastatic pattern of colon cancer is typically well characterized,with initial dissemination occurring through regional lymphatics,followed by hematogenous spread.The most frequent sites of metastasis in colorect... The metastatic pattern of colon cancer is typically well characterized,with initial dissemination occurring through regional lymphatics,followed by hematogenous spread.The most frequent sites of metastasis in colorectal cancer(CRC)include regional lymph nodes(50%–70%),liver(35%–50%),lungs(21%),peritoneum(15%),and ovaries(13%).1 Isolated distant lymph node metastasis,particularly in the absence of concurrent systemic disease,is exceedingly rare in CRC.To date,only six cases of isolated axillary lymph node metastasis(ALNM)from colorectal primaries have been documented in the literature.1–6 Even more uncommon is the incidental discovery of malignant cells in anastomotic doughnuts following stoma reversal procedures.Herein,we report a rare case involving both the incidental histopathological detection of tumor cells within doughnuts during stoma closure and the subsequent development of isolated ALNM after curative resection of sigmoid colon carcinoma. 展开更多
关键词 axillary lymph node hematogenous spreadthe axillary lymph node metastasis distant lymph node metastasisparticularly colon cancer regional lymph nodes liver lungs peritoneum colorectal cancer crc include regional lymphaticsfollowed
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PSMA PET/CT-guided pelvic lymph node dissection in patients with unfavorable intermediate-or high-risk prostate cancer
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作者 Eva Donck Sofie Verbeke +4 位作者 Pieter De Visschere Valérie Fonteyne Charles Van Praet Kathia De Man Nicolaas Lumen 《The Canadian Journal of Urology》 2026年第1期83-92,共10页
Objectives:PSMA PET/CT(Prostate-Specific MembraneAntigen Positron Emission Tomography/Computed Tomography)offers improved accuracy in detecting lymph node invasion(LNI)in prostate cancer(PC)patients,potentially reduci... Objectives:PSMA PET/CT(Prostate-Specific MembraneAntigen Positron Emission Tomography/Computed Tomography)offers improved accuracy in detecting lymph node invasion(LNI)in prostate cancer(PC)patients,potentially reducing the need for extended pelvic lymph node dissection(ePLND).This study aims to evaluate a patient-tailored care pathway in which ePLND is performed only in patients with unfavorable intermediate-or high-risk PC who are deemed at risk for LNI based on PSMA PET/CT findings.Methods:In this interventional cohort study,81 patients were managed according to the new care pathway.ePLND was omitted in cases of negative PSMA PET/CT findings(N0M0),while those with positive PSMA PET/CT findings(N1M0)underwent ePLND.A comparator group of 81 patients was selected from a prospectively generated database for comparison.Results:The intervention group experienced a 75% reduction in the number of ePLNDs performed compared to the comparator group(p<0.001).ePLND-related complications were significantly lower in the intervention group(p=0.008).No significant difference was observed in 3-year biochemical-recurrence free survival(BRFS)between the two groups(p=0.958).Conclusion:Omitting ePLND in patients with negative PSMA PET/CT findings(N0M0)leads to a substantial reduction in the number of ePLNDs performed,resulting in a decrease in morbidity,without compromising early oncological outcomes. 展开更多
关键词 prostate cancer PSMA PET/CT radical prostatectomy pelvic lymph node dissection lymph node invasion STAGING
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Optimizing 55 nm split-gate memory for compute-in-memory:a focus on floating-gate engineering
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作者 Wanyi Ling Ranran Liu +12 位作者 Kun Ren Dianyu Qi Yongyu Wu Guangji Li Miao Zhou Qingshuang Xu Zhenghui Xia Xuan Li Dertsyr Fan Ichun Chuang Tzung Wen Cheng Chenming Tsai Dawei Gao 《Journal of Semiconductors》 2026年第3期46-53,共8页
The escalating need for high-performance artificial intelligence(AI)computing intensifies the"memory bottleneck"of the von Neumann architecture,prompting extensive exploration of computation-in-memory(CIM)so... The escalating need for high-performance artificial intelligence(AI)computing intensifies the"memory bottleneck"of the von Neumann architecture,prompting extensive exploration of computation-in-memory(CIM)solutions.This study is cen-tered on the optimization of a high-efficiency,low-power"L"-shaped split-gate floating-gate(FG)memory for CIM applications.Fabricated on a 55 nm CMOS platform,the memory devices were systematically investigated through wafer acceptance test(WAT),Sentaurus^(TM)simulations and comprehensive evaluations with the DNN+NeuroSim Framework V2.0.Among devices with diverse FG lengths,the 95-nm FG variant exhibits outstanding performance:it achieves a 5.35 V memory window,reaches a maximum conductance of 16.7μS with excellent linearity under the varying voltage and width pulse scheme(VWPS),real-izes 32-state multi-level storage,and attains a 92%training accuracy on the CIFAR-10 dataset using the VGG8 neural network. 展开更多
关键词 SPLIT-GATE FLOATING-GATE 55 nm technology node computation-in-memory
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A Low-Cost Network Topology Obfuscation Method for Critical Node Protection
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作者 Yanming Chen Fuxiang Yuan Zekang Wang 《Computers, Materials & Continua》 2026年第5期1212-1231,共20页
Network topology obfuscation is a technique aimed at protecting critical nodes and links from disruptions such as Link Flooding Attack(LFA).Currently,there are limited topology obfuscation methods for protecting criti... Network topology obfuscation is a technique aimed at protecting critical nodes and links from disruptions such as Link Flooding Attack(LFA).Currently,there are limited topology obfuscation methods for protecting critical nodes,and the existing approaches mainly achieve obfuscation by extensivelymodifying network links,resulting in high costs.To address this issue,this paper proposes a low-cost network topology obfuscation method dedicated to critical node protection,with its core innovation lying in a lightweight obfuscation architecture based on Fake Node Clusters(FNCs).Firstly,the protected network is modeled as an undirected graph,and an adjacency matrix is constructed to quantify the network scale and structural characteristics.Then,a fake node cluster generation algorithm is designed to construct an FNC adapted to the target network.Finally,a heuristic obfuscated topology generation algorithm is proposed.By optimizing the deployment positions of Fake Nodes Clusters(FNCs)in the protected network,this algorithm effectively reduces the number of FNCs required to generate the obfuscated topology,further lowering the obfuscation cost.Extensive experiments were conducted on the public Topology Zoo dataset,categorizing network topologies by node count into small-scale([0,50)),medium-scale([50,100)),and large-scale([100,200))groups.The experimental results demonstrate that the proposed approach achieves excellent obfuscation performance,reducing the critical node recognition rate to 0%.Compared to the typical method,EigenObfu,the proposed approach also reduces obfuscation costs by an average of 97.9%,99.6%,and 99.3%for small,medium,and large-scale networks,respectively. 展开更多
关键词 Topology obfuscation critical node protection topology defense network topology cyberspace anti-mapping
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Predicting lymph node metastasis in colorectal cancer using caselevel multiple instance learning
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作者 Ling-Feng Zou Xuan-Bing Wang +4 位作者 Jing-Wen Li Xin Ouyang Yi-Ying Luo Yan Luo Cheng-Long Wang 《World Journal of Gastroenterology》 2026年第1期110-125,共16页
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte... BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation. 展开更多
关键词 Colorectal cancer Lymph node metastasis Deep learning Multiple instance learning HISTOPATHOLOGY
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Multi-Label Classification Model Using Graph Convolutional Neural Network for Social Network Nodes
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作者 Junmin Lyu Guangyu Xu +4 位作者 Feng Bao Yu Zhou Yuxin Liu Siyu Lu Wenfeng Zheng 《Computer Modeling in Engineering & Sciences》 2026年第2期1235-1256,共22页
Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relati... Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks. 展开更多
关键词 GNN social networks nodes multi-label classification model graphic convolution neural network coupling principle
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Combined multidetector computed tomography and gastrointestinal endoscopy for gastric cancer screening,preoperative staging,and lymph node metastasis detection
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作者 Le-Ping Ye Yan-Ping Zhang +4 位作者 Gang Chen Yi-Xian Wu Cheng-Long He Dong Wang Qiao Mei 《World Journal of Gastrointestinal Oncology》 2026年第1期200-210,共11页
BACKGROUND Early screening,preoperative staging,and diagnosis of lymph node metastasis are crucial for improving the prognosis of gastric cancer(GC).AIM To evaluate the diagnostic value of combined multidetector compu... BACKGROUND Early screening,preoperative staging,and diagnosis of lymph node metastasis are crucial for improving the prognosis of gastric cancer(GC).AIM To evaluate the diagnostic value of combined multidetector computed tomography(MDCT)and gastrointestinal endoscopy for GC screening,preoperative staging,and lymph node metastasis detection,thereby providing a reference for clinical diagnosis and treatment.METHODS In this retrospective study clinical and imaging data of 134 patients with suspected GC who were admitted between January 2023 and October 2024 were initially reviewed.According to the inclusion and exclusion criteria,102 patients were finally enrolled in the analysis.All enrolled patients had undergone both MDCT and gastrointestinal endoscopy examinations prior to surgical intervention.Preoperative clinical staging and lymph node metastasis findings were compared with pathological results.RESULTS The combined use of MDCT and gastrointestinal endoscopy demonstrated a sensitivity of 98.53%,specificity of 97.06%,accuracy of 98.04%,positive predictive value of 98.53%,and negative predictive value of 97.06%for diagnosing GC.These factors were all significantly higher than those of MDCT or endoscopy alone(P<0.05).The accuracy rates of the combined approach for detecting clinical T and N stages were 97.06%and 92.65%,respectively,outperforming MDCT alone(86.76% and 79.41%)and endoscopy alone(85.29% and 70.59%)(P<0.05).Among 68 patients with confirmed GC,50(73.53%)were pathologically diagnosed with lymph node metastasis.The accuracy for detecting lymph node metastasis was 66.00%with endoscopy,76.00%with MDCT,and 92.00% with the combined approach,all with statistically significant differences(P<0.05).CONCLUSION The combined application of MDCT and gastrointestinal endoscopy enhanced diagnostic accuracy for GC,provided greater consistency in preoperative staging,and improved the detection of lymph node metastasis,thereby demonstrating significant clinical utility. 展开更多
关键词 Multidetector computed tomography Gastrointestinal endoscopy Gastric cancer Preoperative staging Lymph node metastasis
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EARAS:An Efficient,Anonymous,and Robust Authentication Scheme for Smart Homes
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作者 Muntaham Inaam Hashmi Muhammad Ayaz Khan +3 位作者 Khwaja Mansoor ul Hassan Suliman A.Alsuhibany Ainur Abduvalova Asfandyar Khan 《Computers, Materials & Continua》 2026年第3期780-797,共18页
Cyber-criminals target smart connected devices for spyware distribution and security breaches,but existing Internet of Things(IoT)security standards are insufficient.Major IoT industry players prioritize market share ... Cyber-criminals target smart connected devices for spyware distribution and security breaches,but existing Internet of Things(IoT)security standards are insufficient.Major IoT industry players prioritize market share over security,leading to insecure smart products.Traditional host-based protection solutions are less effective due to limited resources.Overcoming these challenges and enhancing the security of IoT Devices requires a security design at the network level that uses lightweight cryptographic parameters.In order to handle control,administration,and security concerns in traditional networking,the Gateway Node offers a contemporary networking architecture.By managing all network-level computations and complexity,the Gateway Node relieves IoT devices of these responsibilities.In this study,we introduce a novel privacy-preserving security architecture for gateway-node smart homes.Subsequently,we develop Smart Homes,An Efficient,Anonymous,and Robust Authentication Scheme(EARAS)based on the foundational principles of this security architecture.Furthermore,we formally examine the security characteristics of our suggested protocol that makes use of methodology such as ProVerif,supplemented by an informal analysis of security.Lastly,we conduct performance evaluations and comparative analyses to assess the efficacy of our scheme.Performance analysis shows that EARAS achieves up to 30%to 54%more efficient than most protocols and lower computation cost compared to Banerjee et al.’s scheme,and significantly reduces communication overhead compared to other recent protocols,while ensuring comprehensive security.Our objective is to provide robust security measures for smart homes while addressing resource constraints and preserving user privacy. 展开更多
关键词 Smart home user authentication gateway node security IoT security privacy and security
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Dual Channel Graph Convolutional Networks via Personalized PageRank
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作者 Longlong Lin Xin Luo 《IEEE/CAA Journal of Automatica Sinica》 2026年第1期221-223,共3页
Dear Editor,D2This letter presents a node feature similarity preserving graph convolutional framework P G.Graph neural networks(GNNs)have garnered significant attention for their efficacy in learning graph representat... Dear Editor,D2This letter presents a node feature similarity preserving graph convolutional framework P G.Graph neural networks(GNNs)have garnered significant attention for their efficacy in learning graph representations across diverse real-world applications. 展开更多
关键词 convolutional node feature similarity graph convolutional framework learning graph representations neural networks gnns NETWORKS GRAPH PERSONALIZED
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Numerical calculation method of virtual nodes in complex structural composites: mechanical properties characterization and numerical simulation of combined Wbraid/Al/Epoxy functional structural materials
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作者 Zhenhui He Enling Tang +3 位作者 Zhe Zhai Wenjin Yao Ruizhi Wang Yafei Han 《Defence Technology(防务技术)》 2026年第3期149-165,共17页
Existing numerical methods for complex composites, such as multiscale simulation and neural network algorithms, face significant limitations. Multiscale techniques are often prohibitively expensive for large models, w... Existing numerical methods for complex composites, such as multiscale simulation and neural network algorithms, face significant limitations. Multiscale techniques are often prohibitively expensive for large models, while neural networks struggle to represent underlying microscopic material properties. To overcome these challenges, a meso-micro scale numerical method using a virtual node approach is developed in this study. A Wbraid/Al/Epoxy functional structural material is fabricated, and a representative periodic unit cell is identified based on its architecture. The complex structure is then discretized into nodes, and mechanical interactions are governed by pre-defined computation rules. This virtual node method is systematically compared against both multiscale simulation and a neural network algorithm, with validation provided through mechanical experiments. The results demonstrate that the nodal operation strategy significantly reduces computational resource requirements. By quantifying microscopic bonding with coefficients, explicit interface treatment is avoided, granting the method strong adaptability to lattice materials. The method can simulate extremely complex structures using parameters from simple tests and is suited for large systems. Compared to three-point bending experiments, errors for multiscale, virtual node, and neural network methods were 12.4%, 6.9%, and 34.5%, respectively. Under dynamic compression, the errors were 2.7%, 9.3%, and 15.43%. The virtual node method demonstrated superior accuracy under static conditions, enabling efficient prediction and auxiliary development of complex structural materials. 展开更多
关键词 Functional composites Complex structure Meso-micro scale Virtual node calculation method Numerical simulation
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ISTIRDA:An Efficient Data Availability Sampling Scheme for Lightweight Nodes in Blockchain
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作者 Jiaxi Wang Wenbo Sun +3 位作者 Ziyuan Zhou Shihua Wu Jiang Xu Shan Ji 《Computers, Materials & Continua》 2026年第4期685-700,共16页
Lightweight nodes are crucial for blockchain scalability,but verifying the availability of complete block data puts significant strain on bandwidth and latency.Existing data availability sampling(DAS)schemes either re... Lightweight nodes are crucial for blockchain scalability,but verifying the availability of complete block data puts significant strain on bandwidth and latency.Existing data availability sampling(DAS)schemes either require trusted setups or suffer from high communication overhead and low verification efficiency.This paper presents ISTIRDA,a DAS scheme that lets light clients certify availability by sampling small random codeword symbols.Built on ISTIR,an improved Reed–Solomon interactive oracle proof of proximity,ISTIRDA combines adaptive folding with dynamic code rate adjustment to preserve soundness while lowering communication.This paper formalizes opening consistency and prove security with bounded error in the random oracle model,giving polylogarithmic verifier queries and no trusted setup.In a prototype compared with FRIDA under equal soundness,ISTIRDA reduces communication by 40.65%to 80%.For data larger than 16 MB,ISTIRDA verifies faster and the advantage widens;at 128 MB,proofs are about 60%smaller and verification time is roughly 25%shorter,while prover overhead remains modest.In peer-to-peer emulation under injected latency and loss,ISTIRDA reaches confidence more quickly and is less sensitive to packet loss and load.These results indicate that ISTIRDA is a scalable and provably secure DAS scheme suitable for high-throughput,large-block public blockchains,substantially easing bandwidth and latency pressure on lightweight nodes. 展开更多
关键词 Blockchain scalability data availability sampling lightweight nodes
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Analysis of Long-term Prognosis and Cosmetic Outcomes of Breast-conserving Surgery Combined with Sentinel Lymph Node Biopsy for Early-stage Breast Cancer
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作者 Yuedong Zhang 《Proceedings of Anticancer Research》 2026年第1期101-108,共8页
Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a referen... Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology. 展开更多
关键词 Early-stage breast cancer Breast-conserving surgery Sentinel lymph node biopsy Long-term prognosis Cosmetic results
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Virtual histology imaging of lymph nodes via dynamic full-field optical coherence tomography and deep learning to differentiate metastasis
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作者 Shuwei Zhang Houpu Yang +8 位作者 Yiyin Zhang Xiaoxian Li Jin Zhao Yuanyuan Zhang Ping Xue Hua Kang Hongchuan Jiang Wenhui Ren Shu Wang 《Cancer Biology & Medicine》 2026年第3期418-429,共12页
Objective:The current pathological diagnosis of lymph node metastasis is time-consuming,labor-intensive,and dependent on sectioning of paraffin blocks.Herein,in a prospective cohort of patients with breast cancer,we v... Objective:The current pathological diagnosis of lymph node metastasis is time-consuming,labor-intensive,and dependent on sectioning of paraffin blocks.Herein,in a prospective cohort of patients with breast cancer,we validated dynamic full-field optical coherence tomography(D-FFOCT),a virtual pathology tool integrating deep learning for nodal metastasis detection,and offering rapid and label-free histologic approximations of fresh tissues.Methods:In a prospective dual-center cohort of 155 patients with breast cancer,747 freshly bisected lymph node slides were obtained via D-FFOCT.Surgeons interpreted each slide with histopathology as the gold standard.A deep learning model was trained on 28,911 patches(corresponding to 590 slides)and tested on 7,736 patches(corresponding to 157 slides).The results were mapped to the slide level for potential intraoperative evaluation.Results:D-FFOCT strongly correlated with hematoxylin and eosin(H&E)-stained histological images.Surgeons achieved 97.10%specificity in nodal diagnosis with D-FFOCT.The performance of the artificial intelligence(AI)model was not inferior to that of human experts and had a sensitivity/specificity of 87.88%/91.94%and an area under the receiver operating characteristic curve of 0.899 at the slide level.The human–AI collaborative system reduced labor requirements by 75%and increased the specificity by 6.5%,to 98.39%.Conclusions:D-FFOCT has excellent potential as a tool for assessing lymph node metastatic status without tissue preparation or consumption.The integration of D-FFOCT with deep learning decreases labor demands and maintains high accuracy,thereby enabling streamlined nodal prediction independent of routine pathology procedures. 展开更多
关键词 Breast cancer dynamic full field optical coherence tomography lymph nodes AI model metastatic status
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Expert consensus on multidisciplinary management of laparoscopic-endoscopic cooperative surgery combined with sentinel lymph node navigation surgery for early gastric cancer(2026 edition)
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作者 Zhi Zheng Yu Zhao +15 位作者 Rui Xu Zimeng Wang Jie Yin Fandong Meng Kuiliang Liu Guangyong Chen Jun Zhang Peng Li Lin Chen Zhongtao Zhang Shutian Zhang National Clinical Research Center for Digestive Diseases National Key Laboratory of Digestive Health Digestive Endoscopy Branch of Chinese Medical Association Gastroenterologist and Hepatologist Branch of Chinese Medical Doctor Association Chinese Gastric Cancer Association of China Anti-Cancer Association 《Chinese Journal of Cancer Research》 2026年第1期1-26,共26页
With the advancement of surgical techniques and enhanced management of early gastric cancer(EGC),minimally invasive function-preserving surgical approaches have emerged as a common goal for patients and clinicians.Lap... With the advancement of surgical techniques and enhanced management of early gastric cancer(EGC),minimally invasive function-preserving surgical approaches have emerged as a common goal for patients and clinicians.Laparoscopic-endoscopic cooperative surgery combined with sentinel lymph node navigation surgery(LECSSNNS)has drawn increasing interest because of its dual benefits of minimal invasiveness and organ function preservation.However,robust evidence-based support for guiding clinical implementation remains limited.To address this gap,we systematically evaluated available studies on the clinical application of LECS-SNNS in EGC and integrated expert insights to formulate 20 recommendations.These included preoperative assessment,surgical techniques,intraoperative endoscopic procedures,pathological evaluation,postoperative care,and follow-up.This consensus aimed to provide comprehensive guidance for the standardized application of LECS-SNNS,thereby advancing precise,minimally invasive,and function-preserving treatment for EGC. 展开更多
关键词 Sentinel lymph node laparoscopic-endoscopic cooperative surgery navigation surgery early gastric cancer multidisciplinary diagnosis and treatment CONSENSUS
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A systematic review of open versus robotic retroperitoneal lymph node dissection for testicular cancer:Comparative operative and oncological outcomes
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作者 Daniel Peter McNicholas Freddy Kattakayam +2 位作者 Joshua Hemmant Robin Weston Vishwanath Hanchanale 《Laparoscopic, Endoscopic and Robotic Surgery》 2026年第1期1-7,共7页
Objective:Open retroperitoneal lymph node dissection(RPLND)is the gold-standard surgical approach for the management of metastatic testicular cancer,but robotic RPLND is becoming increasingly popular.There is limited ... Objective:Open retroperitoneal lymph node dissection(RPLND)is the gold-standard surgical approach for the management of metastatic testicular cancer,but robotic RPLND is becoming increasingly popular.There is limited research directly comparing open and robotic RPLND.The objective of this systematic review is to identify all the literature with direct comparisons between the open and robotic techniques for RPLND and to compare the two techniques.The primary outcome was peri-operative outcomes,and the secondary outcomes included oncological outcomes and patient demographics.Methods:This systematic review was prospectively registered and was conducted in accordance with the PRISMA statement.The PubMed,Embase and MEDLINE databases were searched for relevant publication from January 2006 to August 2024.Results:Eight studies,totaling 3995 patients,are included in this systematic review,with 3521 patients who underwent open RPLND and 474 who underwent robotic RPLND.For open RPLND,the mean operative duration,blood loss and length of stay were 267.8 min,475 mL and 7.3 d,respectively.For robotic RPLND,the mean operative duration,blood loss and length of stay were 334.5 min,94.6 mL and 3.7 d,respectively.Teratoma was the most common RPLND specimen pathology from both open and robotic surgeries.For open RPLND,the specimens have 13–23 nodes(26–32 mm),whereas the robotic RPLND specimens have 13–28 nodes(18–20 mm).Conclusion:This systematic review suggests that the benefitsof robotic RPLND may be associated with reduced blood loss,shorter hospitalisation and an overall lower risk of minor and major complications while maintaining oncological safety. 展开更多
关键词 Retroperitoneal lymph node dissection Robotic surgery Testicular cancer
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Design and analysis of modular truss deployable antenna mechanism based on tetrahedral basic unit mechanism with dual height positioning nodes
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作者 Enbo LIU Yongsheng ZHAO +5 位作者 Tengfei CAO Shudan LI Bo CHEN Xinlu WEI Yundou XU Jiantao YAO 《Chinese Journal of Aeronautics》 2026年第2期593-608,共16页
Modular truss space deployable antennas are key for future large aperture,high precision antennas,already proven in various in-orbit applications globally.This paper introduces a design method for a tetrahedral basic ... Modular truss space deployable antennas are key for future large aperture,high precision antennas,already proven in various in-orbit applications globally.This paper introduces a design method for a tetrahedral basic unit mechanism with dual height positioning nodes.A parametric model is established,and its DOF are analyzed to confirm the mechanism's validity.The new tetrahedral basic unit mechanism constructed by this method is a single DOF mechanism and can locate different parabolic node heights.In order to further adapt to the parabolic and large aperture requirements of the deployable antenna of the truss,a combination unit and modular unit mechanism are developed based on this tetrahedral unit.The DOF and deployment characteristics of the modular unit mechanism are analyzed and validated through simulations.Various networking methods for the modular units are proposed,followed by a comprehensive performance comparison of different modular truss deployable antenna mechanisms.A prototype model of the modular unit mechanism is also developed,with deployment experiments demonstrating the mechanism's simplicity,low DOF,and large deployment ratio.The findings of this study provide a theoretical and technical basis for the future design and development of truss deployable antenna mechanisms. 展开更多
关键词 Degree of freedom(DOF) Deployable truss antenna Dual height node positioning Modularity Screw theory Tetrahedral unit
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Cascading failure modeling and survivability analysis of weak-communication underwater unmanned swarm networks
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作者 Yifan Yuan Xiaohong Shen +3 位作者 Lin Sun Ke He Yongsheng Yan Haiyan Wang 《Defence Technology(防务技术)》 2026年第2期66-82,共17页
Cascading failures pose a serious threat to the survivability of underwater unmanned swarm networks(UUSNs),significantly limiting their service ability in collaborative missions such as military reconnaissance and env... Cascading failures pose a serious threat to the survivability of underwater unmanned swarm networks(UUSNs),significantly limiting their service ability in collaborative missions such as military reconnaissance and environmental monitoring.Existing failure models primarily focus on power grids and traffic systems,and don't address the unique challenges of weak-communication UUSNs.In UUSNs,cascading failure present a complex and dynamic process driven by the coupling of unstable acoustic channels,passive node drift,adversarial attacks,and network heterogeneity.To address these challenges,a directed weighted graph model of UUSNs is first developed,in which node positions are updated according to ocean-current-driven drift and link weights reflect the probability of successful acoustic transmission.Building on this UUSNs graph model,a cascading failure model is proposed that integrates a normal-failure-recovery state-cycle mechanism,multiple attack strategies,and routingbased load redistribution.Finally,under a five-level connectivity UUSNs scheme,simulations are conducted to analyze how dynamic topology,network load,node recovery delay,and attack modes jointly affect network survivability.The main findings are:(1)moderate node drift can improve survivability by activating weak links;(2)based-energy routing(BER)outperform based-depth routing(BDR)in harsh conditions;(3)node self-recovery time is critical to network survivability;(4)traditional degree-based critical node metrics are inadequate for weak-communication UUSNs.These results provide a theoretical foundation for designing robust survivability mechanisms in weak-communication UUSNs. 展开更多
关键词 Weak communication Underwater unmanned swarm networks(UUSNs) Link success probability Cascading failure Node self-recovery Survivability analysis
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