P-N and P=N bonds play important roles in the design and synthesis of functional molecules such as bioactive compounds and organic ligands for catalysis.Existing methods for P-N coupling mostly rely on Staudinger cond...P-N and P=N bonds play important roles in the design and synthesis of functional molecules such as bioactive compounds and organic ligands for catalysis.Existing methods for P-N coupling mostly rely on Staudinger condensation or nucleophilic substitution between phosphorus electrophiles and amine nucleo philes.Herein,we report a nitrene-mediated intermolecular P-N coupling reaction between various phos phorus nucleophiles and dioxazolones under simp le iron-catalyzed conditions.These reactions offer an efficient,versatile,and broadly applicable method for synthesis of a range of N-P compounds,including amidophosphines,iminophosphonamides,phosphinamides,aminophosphines,and iminophospho ranes,from readily available precursors under mild conditions.展开更多
基金the Natural Science Foundation of China(nos.21421062 and 21901127)the China Postdoctoral Science Foundation(nos.2018M640225 and 2019T120179)Nankai-Cangzhou Green Chemistry Institute(no.NCC2020FH02)for financial support of this work.
文摘P-N and P=N bonds play important roles in the design and synthesis of functional molecules such as bioactive compounds and organic ligands for catalysis.Existing methods for P-N coupling mostly rely on Staudinger condensation or nucleophilic substitution between phosphorus electrophiles and amine nucleo philes.Herein,we report a nitrene-mediated intermolecular P-N coupling reaction between various phos phorus nucleophiles and dioxazolones under simp le iron-catalyzed conditions.These reactions offer an efficient,versatile,and broadly applicable method for synthesis of a range of N-P compounds,including amidophosphines,iminophosphonamides,phosphinamides,aminophosphines,and iminophospho ranes,from readily available precursors under mild conditions.
