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LPS与ATP共同诱导巨噬细胞中NLRP3炎症小体的激活 被引量:8
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作者 刘蓓桦 候梁 +4 位作者 罗伟珏 王豕辰 温炎佳 刘艺林 侯晓林 《北京农学院学报》 2018年第1期74-78,共5页
【目的】以脂多糖(LPS)为刺激源,探索小鼠巨噬细胞(RAW264.7)中NOD样受体家族pyrin结构域蛋白3(NLRP3)炎性小体激活的响应机制。【方法】试验分为对照组、LPS组、LPS与ATP共同刺激组。ELISA检测NLRP3源性白介素-1β(IL-1β)表达情况;RT-... 【目的】以脂多糖(LPS)为刺激源,探索小鼠巨噬细胞(RAW264.7)中NOD样受体家族pyrin结构域蛋白3(NLRP3)炎性小体激活的响应机制。【方法】试验分为对照组、LPS组、LPS与ATP共同刺激组。ELISA检测NLRP3源性白介素-1β(IL-1β)表达情况;RT-PCR检测NLRP3、Caspase-1、白介素-1β(IL-1β)的转录水平;ELISA检测LPS与NLRP3其他激动剂(MSU、CPPD、SiO2、Alum)共同作用后IL-1β的表达以及PI染色检测细胞焦亡。【结果】与对照组相比,LPS刺激组对IL-1β的表达无显著影响,LPS/ATP共同刺激组IL-1β的表达显著升高;LPS/ATP刺激组NLRP3、Caspase-1、IL-1βmRNA的表达显著升高且LPS/ATP刺激组发生明显的细胞焦亡。【结论】LPS与ATP共同作用能够显著提高NLRP3、Caspase-1、IL-1β的表达,说明LPS对NLRP3炎性小体的激活是LPS与ATP共同作用实现的。 展开更多
关键词 LPS RAW264.7细胞 nirp3炎性小体 ATP
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负利率环境下的货币政策溢出效应——来自欧元区和17个新兴经济体的证据 被引量:1
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作者 谭小芬 王欣康 《中国软科学》 CSSCI CSCD 北大核心 2022年第12期35-49,共15页
基于欧元区和17个新兴经济体2006年8月至2020年1月的日度高频数据,在识别欧洲央行非常规货币政策的基础上,实证检验负利率环境下欧元区货币政策对于新兴经济体的溢出效应,并比较其与正利率环境下的差异。结果发现,引入负利率后,欧央行... 基于欧元区和17个新兴经济体2006年8月至2020年1月的日度高频数据,在识别欧洲央行非常规货币政策的基础上,实证检验负利率环境下欧元区货币政策对于新兴经济体的溢出效应,并比较其与正利率环境下的差异。结果发现,引入负利率后,欧央行的货币政策对新兴经济体产生了广泛的溢出效应。具体表现为:利率下调和量化宽松政策的实施会显著推升新兴经济体的股票价格,造成新兴经济体货币相较于正利率环境下更大幅度的升值,同时还会导致新兴经济体长短期利差的收窄。进一步的研究表明,欧洲央行与美联储货币政策立场的分化可能是导致负利率环境下欧元区货币政策溢出效应增强的重要因素,本文的研究结论为负利率时代下的跨境金融风险防范提供了有益启示。 展开更多
关键词 负利率 货币政策溢出效应 新兴经济体 高频数据
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National Monitoring for Radioactivity in Drinking Water——China,2012–2024
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作者 Liangliang Yin Yuhan Xie +2 位作者 Yuxin Qian Cen Shi Yanqin Ji 《China CDC weekly》 2025年第36期1154-1159,共6页
Introduction:To establish baseline radioactivity levels and ensure the safety of drinking water quality in China,gross alpha and gross beta radioactivity levels in drinking water were surveyed from 2012 to 2024.Method... Introduction:To establish baseline radioactivity levels and ensure the safety of drinking water quality in China,gross alpha and gross beta radioactivity levels in drinking water were surveyed from 2012 to 2024.Methods:The surveillance was conducted through the national monitoring system for radioactivity in drinking water,organized by The National Institute for Radiological Protection(NIRP)during the period 2012–2024.Drinking water samples were collected and pretreated in accordance with a unified protocol,and radioactivity was determined using alpha/beta counting systems by local laboratories.Results:From 2012 to 2024,over 11,000 drinking water samples were collected and analyzed across 29 provinces,including areas surrounding nuclear power plants.The mean concentration ranges of gross alpha and gross beta radioactivity levels in all regions and various water bodies were 0.01–0.17 Bq/L and 0.05–0.38 Bq/L,respectively,all of which are below the guidance values specified in the national standard GB 5749(0.5 Bq/L for gross alpha and 1 Bq/L for gross beta).However,the gross alpha and gross beta activity levels in well water were higher than those in other water bodies.The results indicate that radioactivity in drinking water primarily originates from natural radionuclides.Conclusions:Drinking water in China maintains normal background levels of radioactivity.Nuclear power plant operations do not seem to have an impact on surrounding water sources. 展开更多
关键词 drinking waterorganized gross beta MONITORING national institute radiological protection nirp drinking water China establish baseline radioactivity levels RADIOACTIVITY
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海外负利率政策实施的效果及借鉴 被引量:18
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作者 吴秀波 《价格理论与实践》 CSSCI 北大核心 2016年第3期17-23,共7页
迄今有五家海外央行实行负利率政策,以迫使商业银行减少在央行的存款,将资金用于增加商业贷款,以实现提升物价水平、减少本币升值压力等多种政策目标。作为一项前所未有的金融创新,对负利率政策功效的客观评价尚需时日,短期内欧元区和... 迄今有五家海外央行实行负利率政策,以迫使商业银行减少在央行的存款,将资金用于增加商业贷款,以实现提升物价水平、减少本币升值压力等多种政策目标。作为一项前所未有的金融创新,对负利率政策功效的客观评价尚需时日,短期内欧元区和日本两大经济体的政策绩效不彰。借鉴海外负利率政策经验,在推出新的宏观调控措施时,我们不应过于迷信货币政策功效;不能机械照搬海外货币宽松做法;必须多管齐下,注重国内与国外监管机构之间、国内部门之间的沟通协调,否则效果将大打折扣。 展开更多
关键词 负利率 利率走廊 名义利率 消费物价水平
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Economic uncertainty,central bank digital currency,and negative interest rate policy 被引量:4
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作者 Baogui Xin Kai Jiang 《Journal of Management Science and Engineering》 CSCD 2023年第4期430-452,共23页
The covID-19 outbreak has brought unprecedented social attention to economic uncertainty and negative interest rate policy(NIRP).How does uncertainty affect economic activity,and how effective is a NIRP based on centr... The covID-19 outbreak has brought unprecedented social attention to economic uncertainty and negative interest rate policy(NIRP).How does uncertainty affect economic activity,and how effective is a NIRP based on central bank digital currency(CBDC)?To answer the two questions,we constructed a dynamic stochastic general equilibrium(DSGE)model that accommodates sticky prices and wages.The results indicated:(i)Economic uncertainty has substantially reduced investment,output,wage,and loans,which increases unemployment risk.In the short term,it has triggered impulsive consumption by households,while consumption has fallen into a slump in the long run.(ii)After suffering an uncertainty shock,the economy entered short-term stagflation and long-term deflation.The short-term stagflation was mainly caused by resident wage adjustment,and the long-term deflation was due to the decline in effective demand caused by unemployment risk.(ii)CBDC could eliminate the zero lower bound(ZLB)constraint,thereby improving the effectiveness of NIRP.Compared with traditional currency,CBDCbased NIRP could more effectively smooth macroeconomic fluctuations and alleviate the negative impact of an uncertainty shock,which is more conducive to restoring market confidence and promoting economic recovery. 展开更多
关键词 Economic uncertainty Zero lower bound(ZLB) Central bank digital currency(CBDC) Negative interest rate policy(nirp)
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