The Directory of China’s Foreign Trade,compiled by China Council for the Promotionof International Trade (CCPIT) and ChinaChamber of International Commerce(CCOIC), is always well received by friendsfrom foreign trade...The Directory of China’s Foreign Trade,compiled by China Council for the Promotionof International Trade (CCPIT) and ChinaChamber of International Commerce(CCOIC), is always well received by friendsfrom foreign trade companies and industrialenterprises both at home and abroad, and reprinted for several times.展开更多
South Sudan faces ongoing hurdles as it struggles to deal with growing pains ON July 9,South Sudanese who live as refugees in neighboring countries celebrated with their fellow countrymen back home to mark the second ...South Sudan faces ongoing hurdles as it struggles to deal with growing pains ON July 9,South Sudanese who live as refugees in neighboring countries celebrated with their fellow countrymen back home to mark the second anniversary of the world＇s newest country. But news from home including stories of political rivalry between the Dinka and Luo Nuer,South Sudan＇s leading ethnic groups,coupled with allegations of graft and human rights abuses perpetrated by the government against dissenters and a gridlocked state of war with the northern neighbor in Khartoum have continued to give thousands of refugees in Uganda,Ethiopia,Kenya and a host of other countries reasons not to return to their war-torn,hungerstricken homeland.展开更多
In this paper, an efficient and easy-to-implement coarsening algorithm is proposed for adaptive grids obtained using the newest vertex bisection method in two dimemsions. The new coarsening algorithm does not require ...In this paper, an efficient and easy-to-implement coarsening algorithm is proposed for adaptive grids obtained using the newest vertex bisection method in two dimemsions. The new coarsening algorithm does not require storing the binary refinement tree explicitly. Instead, the structure is implicitly contained in a special ordering of triangular elements. Numerical experiments demonstrate that the proposed coarsening algorithm is efficient when applied for multilevel preconditioners and mesh adaptivity for time-dependent problems.展开更多
WANG Haizhen might have been a shy,quiet college student from Hebei Province,but all that changed when she recently wonthe "New Silk Road" Cup Chinese ModelContest held in Chengdu. Her previous pre-occupatio...WANG Haizhen might have been a shy,quiet college student from Hebei Province,but all that changed when she recently wonthe "New Silk Road" Cup Chinese ModelContest held in Chengdu. Her previous pre-occupation with designing ideal apartmentsfor the next century, while studying interiordesign has had to be put on hold as thecharming young mannequin navigates therunways that this win has opened up for her.展开更多
The 87-foot-high doors of the world’s largest building opened on April 9, and out of a cavernous bay rolled the first Boeing 777.Scheduled to make its maiden flight this month, the 777 is the biggest twin-engine jetl...The 87-foot-high doors of the world’s largest building opened on April 9, and out of a cavernous bay rolled the first Boeing 777.Scheduled to make its maiden flight this month, the 777 is the biggest twin-engine jetliner made,and it sports the most powerful jet engines ever built.展开更多
Revolutionary breakthroughs in tumor treatment have been achieved through the rapid progress of cancer immunotherapy,notably through the clinical promise shown by chimeric antigen receptor(CAR)–modified immune cell th...Revolutionary breakthroughs in tumor treatment have been achieved through the rapid progress of cancer immunotherapy,notably through the clinical promise shown by chimeric antigen receptor(CAR)–modified immune cell therapies.Compared with traditional CAR-T cell therapy,CAR-natural killer(NK)cell therapy has become an emergingfield in tumor immunotherapy due to its unique innate immune advantages:(1)it can kill tumors through natural cytotoxicity mechanisms without major histocompatibility com-plexes restricted recognition,(2)the rich activating receptors provide multiple tumor recognition pathways,and(3)the lower risk of cytokine release syndrome endows it with better safety characteristics.Efforts include refining target antigens such as CD19 and natural killer group 2D ligands,designing novel costimulatory domains like DNAX accessory molecule-1 and 2B4,and developing universal allogeneic treatment platforms.However,the technology still faces key challenges:insufficient in vivo persistence,sup-pression by the tumor microenvironment,low transduction efficiency,and the standardization of large-scale production processes are urgent problems to be solved.This review aims to systematically examine how CAR-NK cells exert their effects,summarize the latest breakthroughs in clinical and technicalfields,and explore existing scientific challenges as well as potential approaches to address them.The insights offered aim to inform future directions in CAR-NK cell research and development.展开更多
文摘The Directory of China’s Foreign Trade,compiled by China Council for the Promotionof International Trade (CCPIT) and ChinaChamber of International Commerce(CCOIC), is always well received by friendsfrom foreign trade companies and industrialenterprises both at home and abroad, and reprinted for several times.
文摘South Sudan faces ongoing hurdles as it struggles to deal with growing pains ON July 9,South Sudanese who live as refugees in neighboring countries celebrated with their fellow countrymen back home to mark the second anniversary of the world＇s newest country. But news from home including stories of political rivalry between the Dinka and Luo Nuer,South Sudan＇s leading ethnic groups,coupled with allegations of graft and human rights abuses perpetrated by the government against dissenters and a gridlocked state of war with the northern neighbor in Khartoum have continued to give thousands of refugees in Uganda,Ethiopia,Kenya and a host of other countries reasons not to return to their war-torn,hungerstricken homeland.
基金supported in part by NSF Grant DMS-0811272in part by NIH Grant P50GM76516 and R01GM75309supported by NSF Grant DMS-0915153
文摘In this paper, an efficient and easy-to-implement coarsening algorithm is proposed for adaptive grids obtained using the newest vertex bisection method in two dimemsions. The new coarsening algorithm does not require storing the binary refinement tree explicitly. Instead, the structure is implicitly contained in a special ordering of triangular elements. Numerical experiments demonstrate that the proposed coarsening algorithm is efficient when applied for multilevel preconditioners and mesh adaptivity for time-dependent problems.
文摘WANG Haizhen might have been a shy,quiet college student from Hebei Province,but all that changed when she recently wonthe "New Silk Road" Cup Chinese ModelContest held in Chengdu. Her previous pre-occupation with designing ideal apartmentsfor the next century, while studying interiordesign has had to be put on hold as thecharming young mannequin navigates therunways that this win has opened up for her.
文摘The 87-foot-high doors of the world’s largest building opened on April 9, and out of a cavernous bay rolled the first Boeing 777.Scheduled to make its maiden flight this month, the 777 is the biggest twin-engine jetliner made,and it sports the most powerful jet engines ever built.
基金supported by grants from the Graduate Research-Innovation Project in Jiangsu province(No.SJCX22_1816).
文摘Revolutionary breakthroughs in tumor treatment have been achieved through the rapid progress of cancer immunotherapy,notably through the clinical promise shown by chimeric antigen receptor(CAR)–modified immune cell therapies.Compared with traditional CAR-T cell therapy,CAR-natural killer(NK)cell therapy has become an emergingfield in tumor immunotherapy due to its unique innate immune advantages:(1)it can kill tumors through natural cytotoxicity mechanisms without major histocompatibility com-plexes restricted recognition,(2)the rich activating receptors provide multiple tumor recognition pathways,and(3)the lower risk of cytokine release syndrome endows it with better safety characteristics.Efforts include refining target antigens such as CD19 and natural killer group 2D ligands,designing novel costimulatory domains like DNAX accessory molecule-1 and 2B4,and developing universal allogeneic treatment platforms.However,the technology still faces key challenges:insufficient in vivo persistence,sup-pression by the tumor microenvironment,low transduction efficiency,and the standardization of large-scale production processes are urgent problems to be solved.This review aims to systematically examine how CAR-NK cells exert their effects,summarize the latest breakthroughs in clinical and technicalfields,and explore existing scientific challenges as well as potential approaches to address them.The insights offered aim to inform future directions in CAR-NK cell research and development.
