Objective This study aimed to investigate the effect of penile selective dorsal neurectomy(SDN)on erectile function in rats.Methods Twelve adult male Sprague-Dawley rats(15 weeks old)were divided into three groups(n=4...Objective This study aimed to investigate the effect of penile selective dorsal neurectomy(SDN)on erectile function in rats.Methods Twelve adult male Sprague-Dawley rats(15 weeks old)were divided into three groups(n=4 per group):in control group,rats received no treatment;in sham group,rats underwent a sham operation;in SDN group,rats underwent SDN with half of the dorsal penile nerve severed.The mating test was performed,and the intracavernous pressure(ICP)assessed six weeks after the surgical treatment.Results At postoperative six weeks,the mating test revealed no significant difference in mounting latency and mounting frequency among the three groups(P>0.05),while the ejaculation latency(EL)was significantly longer and ejaculation frequency(EF)lower in the SDN group than in the control and sham groups(P<0.05).There were no significant differences in preoperative and postoperative ICP and ICP/mean arterial blood pressure(MAP)among the three groups(P>0.05).Conclusion SDN does not adversely affect the erectile function and sexual desire of rats,and at the same time it can reduce EL and EF,providing an application basis for SDN in the clinical treatment of premature ejaculation.展开更多
Objectives:Allergic rhinitis(AR)has a significant effect on the quality of life and accounts for unproductive times at work and school,causes disturbed sleep patterns and can lead to daytime somnolence.It is fairly pr...Objectives:Allergic rhinitis(AR)has a significant effect on the quality of life and accounts for unproductive times at work and school,causes disturbed sleep patterns and can lead to daytime somnolence.It is fairly prevalent in the world with medical management still being the mainstay of treatment.Patients suffer for a significant number of years before they undergo surgical management for their intractable rhinitis.Thus,this prospective observational study was conducted to reinforce the proficiency of posterior nasal neurectomy in being an effective method for ending this suffering.Methods:Thirty patients with troublesome intractable rhinitis underwent posterior nasal neurectomy.Pre-and postoperative Visual Analogue Scale(VAS)and Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)scores were compared to study the improvement in nasal and ocular symptoms.Each domain of these scores was studied separately.Results:The mean reduction in the VAS was from 6.76±0.884 preoperatively to a mean of 5.33±0.675 at 1 month,3.81±0.462 at 3 months and 2.53±0.405 at 6 months postoperatively.The mean RQLQ score was reduced from preoperative 4.22±1.091 to a mean of 3.82±1.072 at 1 month,3.55±1.063 at 3 months and 3.18±1.173 at 6 months postoperatively.Thus,a statistically significant improvement was seen in both mean VAS and RQLQ scores(P<0.001),and also when each domain was compared separately.Conclusion:Endoscopic posterior nasal neurectomy may be an effective way of improving symptoms in patients with intractable AR and freeing them from long-term medical regimes,thereby improving their quality of life.展开更多
Inguinodynia(chronic groin pain) is one of the recognised complications of the commonly performed Lichtenstein mesh inguinal hernia repair.This has major impact on quality of life in a significant proportion of patien...Inguinodynia(chronic groin pain) is one of the recognised complications of the commonly performed Lichtenstein mesh inguinal hernia repair.This has major impact on quality of life in a significant proportion of patients.The pain is classif ied as neuropathic and nonneuropathic related to nerve damage and to the mesh,respectively.Correct diagnosis of this problem is relatively difficult.A thorough history and clinical examination are essential,as is a good knowledge of the groin nerve distribution.In spite of the common nature of the problem,the literature evidence is limited.In this paper we discuss the diagnostic tools and treatment options,both non-surgical and surgical.In addition,we discuss the criteria for surgical intervention and its optimal timing.展开更多
Spasmodic dysphonia is a laryngeal dystonia that can present as adductor,abductor,or mixed types,with or without tremor.The etiology is not understood fully.Comprehensive evaluation is required to establish the diagno...Spasmodic dysphonia is a laryngeal dystonia that can present as adductor,abductor,or mixed types,with or without tremor.The etiology is not understood fully.Comprehensive evaluation is required to establish the diagnosis.Treatments include voice therapy,medications,botulinum toxin injection,laryngeal surgery,deep brain stimulation,and others.In most patients,it is possible to improve fluency.展开更多
基金study was supported by Wuhan Application Foundation Frontier Project(No.2019020701011428).
文摘Objective This study aimed to investigate the effect of penile selective dorsal neurectomy(SDN)on erectile function in rats.Methods Twelve adult male Sprague-Dawley rats(15 weeks old)were divided into three groups(n=4 per group):in control group,rats received no treatment;in sham group,rats underwent a sham operation;in SDN group,rats underwent SDN with half of the dorsal penile nerve severed.The mating test was performed,and the intracavernous pressure(ICP)assessed six weeks after the surgical treatment.Results At postoperative six weeks,the mating test revealed no significant difference in mounting latency and mounting frequency among the three groups(P>0.05),while the ejaculation latency(EL)was significantly longer and ejaculation frequency(EF)lower in the SDN group than in the control and sham groups(P<0.05).There were no significant differences in preoperative and postoperative ICP and ICP/mean arterial blood pressure(MAP)among the three groups(P>0.05).Conclusion SDN does not adversely affect the erectile function and sexual desire of rats,and at the same time it can reduce EL and EF,providing an application basis for SDN in the clinical treatment of premature ejaculation.
文摘Objectives:Allergic rhinitis(AR)has a significant effect on the quality of life and accounts for unproductive times at work and school,causes disturbed sleep patterns and can lead to daytime somnolence.It is fairly prevalent in the world with medical management still being the mainstay of treatment.Patients suffer for a significant number of years before they undergo surgical management for their intractable rhinitis.Thus,this prospective observational study was conducted to reinforce the proficiency of posterior nasal neurectomy in being an effective method for ending this suffering.Methods:Thirty patients with troublesome intractable rhinitis underwent posterior nasal neurectomy.Pre-and postoperative Visual Analogue Scale(VAS)and Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)scores were compared to study the improvement in nasal and ocular symptoms.Each domain of these scores was studied separately.Results:The mean reduction in the VAS was from 6.76±0.884 preoperatively to a mean of 5.33±0.675 at 1 month,3.81±0.462 at 3 months and 2.53±0.405 at 6 months postoperatively.The mean RQLQ score was reduced from preoperative 4.22±1.091 to a mean of 3.82±1.072 at 1 month,3.55±1.063 at 3 months and 3.18±1.173 at 6 months postoperatively.Thus,a statistically significant improvement was seen in both mean VAS and RQLQ scores(P<0.001),and also when each domain was compared separately.Conclusion:Endoscopic posterior nasal neurectomy may be an effective way of improving symptoms in patients with intractable AR and freeing them from long-term medical regimes,thereby improving their quality of life.
文摘Inguinodynia(chronic groin pain) is one of the recognised complications of the commonly performed Lichtenstein mesh inguinal hernia repair.This has major impact on quality of life in a significant proportion of patients.The pain is classif ied as neuropathic and nonneuropathic related to nerve damage and to the mesh,respectively.Correct diagnosis of this problem is relatively difficult.A thorough history and clinical examination are essential,as is a good knowledge of the groin nerve distribution.In spite of the common nature of the problem,the literature evidence is limited.In this paper we discuss the diagnostic tools and treatment options,both non-surgical and surgical.In addition,we discuss the criteria for surgical intervention and its optimal timing.
文摘Spasmodic dysphonia is a laryngeal dystonia that can present as adductor,abductor,or mixed types,with or without tremor.The etiology is not understood fully.Comprehensive evaluation is required to establish the diagnosis.Treatments include voice therapy,medications,botulinum toxin injection,laryngeal surgery,deep brain stimulation,and others.In most patients,it is possible to improve fluency.
