Current pharmacotherapy for neurodegenerative diseases is limited to providing symptomatic relief,instead of slowing or reversing disease progression.As a form of neuromodulation surgery,deep brain stimulation deliver...Current pharmacotherapy for neurodegenerative diseases is limited to providing symptomatic relief,instead of slowing or reversing disease progression.As a form of neuromodulation surgery,deep brain stimulation delivers electrical pulses thro ugh implanted electrodes in targeted brain regions and has been used to alleviate symptoms in neurodegenerative diseases.Depending on the precise targeting of neural modulation,deep brain stimulation is being explo red for its potential to manage symptoms and improve overall quality of life in neurodegenerative diseases associated with cognitive impairment,such as Alzheimer's disease and dementia in Parkinson's disease.The nucleus basalis of Meynert,a critical component of the cerebral cholinergic system and the Papez circuit,is considered as a promising target for treating cognitive dysfunction in neurodegenerative diseases due to its essential role in regulating cognition,memory,and attention.However,the comprehensive mechanisms by which deep brain stimulation of nucleus basalis of Meynert affects neurodegenerative diseases with cognitive impairment remain largely unchara cterized.Nonetheless,various hypotheses and evidence from animal and clinical studies suggest mechanisms such as the modeulation of the choline rgic system,increased glucose metabolism and regional cerebral blood flow,neuroprotective effects,and the modulation of neural networks.In this review,we update the advances in research rega rding the therapeutic effects and potential mechanisms of deep brain stimulation of nucleus basalis of Meynert on cognitive impairment in neurodegenerative diseases.Additionally,we examine the anatomy,connectivity,and physiological functions of the nucleus basalis of M eynert.Deep brain stimulation of nucleus basalis of Meynert may improve cognitive impairment in neurodegenerative diseases through multiple mechanisms;howeve r,further larger-scale,multi-center clinical trials conducted at earlier disease stages are necessary to fully confirm its efficacy and safety.展开更多
基金National Key Project of Common and Frequently Occurring Diseases,No.2022YFC25038001the National Natural Science Foundation of China,Nos.82472100,81974279the Natural Science Foundation of Hubei Province,No.2022CFB279(all to HK)。
文摘Current pharmacotherapy for neurodegenerative diseases is limited to providing symptomatic relief,instead of slowing or reversing disease progression.As a form of neuromodulation surgery,deep brain stimulation delivers electrical pulses thro ugh implanted electrodes in targeted brain regions and has been used to alleviate symptoms in neurodegenerative diseases.Depending on the precise targeting of neural modulation,deep brain stimulation is being explo red for its potential to manage symptoms and improve overall quality of life in neurodegenerative diseases associated with cognitive impairment,such as Alzheimer's disease and dementia in Parkinson's disease.The nucleus basalis of Meynert,a critical component of the cerebral cholinergic system and the Papez circuit,is considered as a promising target for treating cognitive dysfunction in neurodegenerative diseases due to its essential role in regulating cognition,memory,and attention.However,the comprehensive mechanisms by which deep brain stimulation of nucleus basalis of Meynert affects neurodegenerative diseases with cognitive impairment remain largely unchara cterized.Nonetheless,various hypotheses and evidence from animal and clinical studies suggest mechanisms such as the modeulation of the choline rgic system,increased glucose metabolism and regional cerebral blood flow,neuroprotective effects,and the modulation of neural networks.In this review,we update the advances in research rega rding the therapeutic effects and potential mechanisms of deep brain stimulation of nucleus basalis of Meynert on cognitive impairment in neurodegenerative diseases.Additionally,we examine the anatomy,connectivity,and physiological functions of the nucleus basalis of M eynert.Deep brain stimulation of nucleus basalis of Meynert may improve cognitive impairment in neurodegenerative diseases through multiple mechanisms;howeve r,further larger-scale,multi-center clinical trials conducted at earlier disease stages are necessary to fully confirm its efficacy and safety.
