Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combinin...Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.展开更多
The key parameters that characterize the morphological quality of multi-layer and multi-pass metal laser deposited parts are the surface roughness and the error between the actual printing height and the theoretical m...The key parameters that characterize the morphological quality of multi-layer and multi-pass metal laser deposited parts are the surface roughness and the error between the actual printing height and the theoretical model height.The Taguchi method was employed to establish the correlations between process parameter combinations and multi-objective characterization of metal deposition morphology(height error and roughness).Results show that using the signal-to-noise ratio and grey relational analysis,the optimal parameter combination for multi-layer and multi-pass deposition is determined as follows:laser power of 800 W,powder feeding rate of 0.3 r/min,step distance of 1.6 mm,and scanning speed of 20 mm/s.Subsequently,a Genetic Bayesian-back propagation(GB-BP)network is constructed to predict multi-objective responses.Compared with the traditional back propagation network,the GB-back propagation network improves the prediction accuracy of height error and surface roughness by 43.14%and 71.43%,respectively.This network can accurately predict the multi-objective characterization of morphological quality of multi-layer and multi-pass metal deposited parts.展开更多
In modern ZnO varistors,traditional aging mechanisms based on increased power consumption are no longer relevant due to reduced power consumption during DC aging.Prolonged exposure to both AC and DC voltages results i...In modern ZnO varistors,traditional aging mechanisms based on increased power consumption are no longer relevant due to reduced power consumption during DC aging.Prolonged exposure to both AC and DC voltages results in increased leakage current,decreased breakdown voltage,and lower nonlinearity,ultimately compromising their protective performance.To investigate the evolution in electrical properties during DC aging,this work developed a finite element model based on Voronoi networks and conducted accelerated aging tests on commercial varistors.Throughout the aging process,current-voltage characteristics and Schottky barrier parameters were measured and analyzed.The results indicate that when subjected to constant voltage,current flows through regions with larger grain sizes,forming discharge channels.As aging progresses,the current focus increases on these channels,leading to a decline in the varistor’s overall performance.Furthermore,analysis of the Schottky barrier parameters shows that the changes in electrical performance during aging are non-monotonic.These findings offer theoretical support for understanding the aging mechanisms and condition assessment of modern stable ZnO varistors.展开更多
BACKGROUND:Breast hyperplasia is a common benign breast disease mainly caused by endocrine disorders,manifested as abnormal hyperplasia of breast tissue.In recent years,traditional Chinese medicine compounds and probi...BACKGROUND:Breast hyperplasia is a common benign breast disease mainly caused by endocrine disorders,manifested as abnormal hyperplasia of breast tissue.In recent years,traditional Chinese medicine compounds and probiotics have shown good potential in regulating the endocrine system and improving the intestinal microecology,providing new ideas for the treatment of breast hyperplasia.OBJECTIVE:To explore the effects and mechanisms of traditional Chinese medicine compounds and fermented probiotic compounds on breast hyperplasia in mice,providing new theoretical and experimental bases for the clinical treatment and prevention of breast hyperplasia.METHODS:(1)Network pharmacology tools were used to predict the anti-breast-hyperplasia activity of Herba Gueldenstaedtiae(Euphorbia humifusa),as well as its potential targets and signaling pathways.The databases included:TCMSP,OMIM,GeneCards database,UniProt website,Venny2.1.0 website,Metascape,HERB website,and STRING database,all of which are open-access databases.Network pharmacology can predict and screen key information such as the targets corresponding to the active ingredients of traditional Chinese medicine,disease targets,and action pathways through network analysis and computer-system analysis.Therefore,it has been increasingly widely used in the research of traditional Chinese medicine.(2)A breast hyperplasia model was induced in mice by injecting estrogen and progesterone.Mice in the normal blank group were injected intraperitoneally with normal saline every day.Mice in the model group and drugadministration groups were injected intraperitoneally with estradiol benzoate injection at a concentration of 0.5 mg/kg every day for 25 days.From the 26th day,the injection of estradiol benzoate injection was stopped.Mice in the normal blank group were injected intramuscularly with normal saline every day,and mice in the model group and drug-administration groups were injected intramuscularly with progesterone injection at a concentration of 5 mg/kg for 5 days.After the model was established,each group was given drugs respectively.The normal blank group and the model group were gavaged with 0.2 mL/d of normal saline;the positive blank group(Xiaozheng Pill group)was gavaged with an aqueous solution of Xiaozheng Pill at 0.9 mg/g;the low-,medium-and high-dose groups of Compound Herba Gueldenstaedtiae were gavaged with an aqueous solution of the compound medicine at 0.75,1.5,and 3.0 mg/(g·d)respectively;the low-,medium-and high-dose groups of traditional Chinese medicine-bacteria fermentation were gavaged with an aqueous solution of the compound medicine at 0.75,1.5,and 3.0 mg/(g·d)respectively.The administration was continuous for 30 days.RESULTS AND CONCLUSION:(1)The results of network pharmacology research showed that the Compound Herba Gueldenstaedtiae(Euphorbia humifusa)contained 46 active ingredients,which were related to 1213 potential targets.After comparison with 588 known breast-hyperplasia targets,it was speculated that 50 of these targets might be related to the direct effect of the compound on breast hyperplasia.(2)After drug intervention,there was no significant change in the high-dose group of Compound Herba Gueldenstaedtiae compared with the normal blank group.The liver indicators of the other intervention groups all significantly decreased(P<0.05).(3)In terms of kidney and uterine indicators,the medium-dose group of Compound Herba Gueldenstaedtiae decreased significantly compared with the normal blank group(P<0.05).In terms of the uterine index,the model group increased significantly compared with the normal blank group(P<0.01).(4)After 1-month drug treatment,the number of lobules and acini in the breast tissue of the Xiaozheng Pill group,the low,medium,and high-dose group of Compound Herba Gueldenstaedtiae,the low,medium,and highdose groups of traditional Chinese medicine-bacteria fermentation decreased,and the duct openings narrowed.With the increase of drug dose,diffuse hyperplasia of breast tissue was significantly improved.(5)The ELISA results showed that compared with the model group,the estrogen level was lower in the medium-dose group of traditional Chinese medicine-bacteria fermentation after the intervention(P<0.05).In addition,the follicle-stimulating hormone level in the low-dose group of Compound Herba Gueldenstaedtiae was lower than that of the model group(P<0.05).(6)The intervention in the mouse model led to changes in the abundance of short chain fatty acids and intestinal flora in all groups.To conclude,the Compound Herba Gueldenstaedtiae and its probiotic fermentation products significantly improved mammary gland hyperplasia in mice by regulating hormone levels,improving the structure of the gut microbiota,and increasing the content of shortchain fatty acids,providing new ideas and potential sources of drugs for the treatment of breast hyperplasia.展开更多
Network attacks have become a critical issue in the internet security domain.Artificial intelligence technology-based detection methodologies have attracted attention;however,recent studies have struggled to adapt to ...Network attacks have become a critical issue in the internet security domain.Artificial intelligence technology-based detection methodologies have attracted attention;however,recent studies have struggled to adapt to changing attack patterns and complex network environments.In addition,it is difficult to explain the detection results logically using artificial intelligence.We propose a method for classifying network attacks using graph models to explain the detection results.First,we reconstruct the network packet data into a graphical structure.We then use a graph model to predict network attacks using edge classification.To explain the prediction results,we observed numerical changes by randomly masking and calculating the importance of neighbors,allowing us to extract significant subgraphs.Our experiments on six public datasets demonstrate superior performance with an average F1-score of 0.960 and accuracy of 0.964,outperforming traditional machine learning and other graph models.The visual representation of the extracted subgraphs highlights the neighboring nodes that have the greatest impact on the results,thus explaining detection.In conclusion,this study demonstrates that graph-based models are suitable for network attack detection in complex environments,and the importance of graph neighbors can be calculated to efficiently analyze the results.This approach can contribute to real-world network security analyses and provide a new direction in the field.展开更多
The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they ...The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they exhibit dense interconnectivity(Braitenburg and Schüz,1998;Campagnola et al.,2022).The strength and probability of connectivity depend on cell type,inter-neuronal distance,and species.Still,every cortical neuron receives input from thousands of other neurons while transmitting output to a similar number of neurons.Second,communication between neurons occurs primarily via chemical or electrical synapses.展开更多
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener...The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment.展开更多
With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a ...With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a promising Deep Learning(DL)approach,has proven to be highly effective in identifying intricate patterns in graph⁃structured data and has already found wide applications in the field of network security.In this paper,we propose a hybrid Graph Convolutional Network(GCN)⁃GraphSAGE model for Anomaly Traffic Detection,namely HGS⁃ATD,which aims to improve the accuracy of anomaly traffic detection by leveraging edge feature learning to better capture the relationships between network entities.We validate the HGS⁃ATD model on four publicly available datasets,including NF⁃UNSW⁃NB15⁃v2.The experimental results show that the enhanced hybrid model is 5.71%to 10.25%higher than the baseline model in terms of accuracy,and the F1⁃score is 5.53%to 11.63%higher than the baseline model,proving that the model can effectively distinguish normal traffic from attack traffic and accurately classify various types of attacks.展开更多
Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of...Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of user preferences.To address this,we propose a Conditional Generative Adversarial Network(CGAN)that generates diverse and highly relevant itineraries.Our approach begins by constructing a conditional vector that encapsulates a user’s profile.This vector uniquely fuses embeddings from a Heterogeneous Information Network(HIN)to model complex user-place-route relationships,a Recurrent Neural Network(RNN)to capture sequential path dynamics,and Neural Collaborative Filtering(NCF)to incorporate collaborative signals from the wider user base.This comprehensive condition,further enhanced with features representing user interaction confidence and uncertainty,steers a CGAN stabilized by spectral normalization to generate high-fidelity latent route representations,effectively mitigating the data sparsity problem.Recommendations are then formulated using an Anchor-and-Expand algorithm,which selects relevant starting Points of Interest(POI)based on user history,then expands routes through latent similarity matching and geographic coherence optimization,culminating in Traveling Salesman Problem(TSP)-based route optimization for practical travel distances.Experiments on a real-world check-in dataset validate our model’s unique generative capability,achieving F1 scores ranging from 0.163 to 0.305,and near-zero pairs−F1 scores between 0.002 and 0.022.These results confirm the model’s success in generating novel travel routes by recommending new locations and sequences rather than replicating users’past itineraries.This work provides a robust solution for personalized travel planning,capable of generating novel and compelling routes for both new and existing users by learning from collective travel intelligence.展开更多
Photonic neural networks(PNNs)of sufficiently large physical dimensions and high operation accuracies are envisaged as ideal candidates for breaking the major bottlenecks in the current artificial intelligence archite...Photonic neural networks(PNNs)of sufficiently large physical dimensions and high operation accuracies are envisaged as ideal candidates for breaking the major bottlenecks in the current artificial intelligence architectures in terms of latency,energy efficiency,and computational power.To achieve this vision,it is of vital importance to scale up the PNNs while simultaneously reducing the high demand on the dimensions required by them.The underlying cause of this strategy is the enormous gap between the scales of photonic and electronic integrated circuits.Here,we demonstrate monolithically integrated optical convolutional processors on thin film lithium niobate(TFLN)that harness inherent parallelism in photonics to enable large-scale programmable convolution kernels and,in turn,greatly reduce the dimensions required by subsequent fully connected layers.Experimental validation achieves high classification accuracies of 96%(86%)on the MNIST(Fashion-MNIST)dataset and 84.6%on the AG News dataset while dramatically reducing the required subsequent fully connected layer dimensions to 196×10(from 784×10)and 175×4(from 800×4),respectively.Furthermore,our devices can be driven by commercial field-programmable gate array systems;a unique advantage in addition to their scalable channel number and kernel size.Our architecture provides a solution to build practical machine learning photonic devices.展开更多
With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Further...With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Furthermore,given the open environment and a multitude of devices,enhancing the security of ICPS is an urgent concern.To address these issues,this paper proposes a novel trusted virtual network embedding(T-VNE)approach for ICPS based combining blockchain and edge computing technologies.Additionally,the proposed algorithm leverages a deep reinforcement learning(DRL)model to optimize decision-making processes.It employs the policygradient-based agent to compute candidate embedding nodes and utilizes a breadth-first search(BFS)algorithm to determine the optimal embedding paths.Finally,through simulation experiments,the efficacy of the proposed method was validated,demonstrating outstanding performance in terms of security,revenue generation,and virtual network request(VNR)acceptance rate.展开更多
Objectives:Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice,affecting millions of postmenopausal women worldwide.Postmenopausal osteoporosis demands safe and effective therapies...Objectives:Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice,affecting millions of postmenopausal women worldwide.Postmenopausal osteoporosis demands safe and effective therapies.This study aimed to evaluate the potential of hederagenin(Hed)for treating osteoporosis and to elucidate its underlying mechanisms of action.Methods:The anti-osteoporotic potential of Hed was assessed by investigating its effects on ovariectomy(OVX)-induced bone loss in mice and on receptor activator of NF-kappaB ligand(RANKL)-induced osteoclast differentiation in RAW264.7 cells.Network pharmacology analysis and molecular docking were employed to identify key targets,which were subsequently validated experimentally.Results:In vitro,Hed suppressed osteoclastogenesis by inhibiting the formation of osteoclasts and F-actin rings and by down-regulating osteoclastspecific genes(Atp6v0d2 and Acp5).In vivo,Hed significantly amelioratedOVX-induced bone loss,restoring trabecular bone volume fraction(BV/TV)and trabecular number(Tb.N),while reducing trabecular separation(Tb.Sp).Network pharmacology analysis identified 142 overlapping targets linking Hed to osteoporosis,including tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),and IL-1β,with enrichment in innate immune signaling and osteoclast differentiation.Molecular docking analysis indicated strong binding affinities between Hed and targets such as TNF-α,IL-6,and IL-1β.Experimentally,Hed was found to decrease RANKL,elevate osteoprotegerin(OPG),and suppress intestinalmRNA levels of pro-inflammatory cytokines such as IL-1β,IL-6,IL-17A,and TNF-α.Conclusion:Hed exerts significant anti-osteoporotic effects inOVX-induced osteoporosis through a dualmechanism involving the suppression of both osteoclastogenesis and innate immune signaling pathways.These findings highlighted Hed’s novel role in modulating immune-bone crosstalk,offering a promising strategy for treating osteolytic diseases without estrogenic side effects.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
The regulation of signal transmission speed is one of the most important capabilities of the biological nervous system.This study explores the mechanisms and methods for regulating signal transmission speed among nonm...The regulation of signal transmission speed is one of the most important capabilities of the biological nervous system.This study explores the mechanisms and methods for regulating signal transmission speed among nonmyelinated neurons within the same brain region,starting from spike-timing-dependent plasticity(STDP)of synapses.Building upon the Hodgkin-Huxley model,the dynamic behavior of synapses is incorporated,and the adaptive growth neuron(AGN)model is proposed.Artificial synaptic structures and neuronal physical nodes are also designed.The artificial synaptic structure exhibits unidirectionality,memory capacity,and STDP,enabling it to connect neuronal physical nodes through branching and merging structures.Furthermore,the artificial synapse can adjust signal transmission speed,regulate functional competition between different regions of the neuromorphic network,and promote information interaction.The findings of this study endow neuromorphic networks with the ability to regulate signal transmission speed over the long term,providing new insights into the development of neuromorphic networks.展开更多
Population aging is one of the common challenges in the current world.As people age,the body’s tissues including cells,and molecules inevitably degrade,and their functions gradually decline,causing various age-relate...Population aging is one of the common challenges in the current world.As people age,the body’s tissues including cells,and molecules inevitably degrade,and their functions gradually decline,causing various age-related diseases like Alzheimer’s disease,osteoporosis,low immunity,glucose and lipid metabolism disorders,and cardiovascular diseases.With the continuous increase of the elderly population,the pressure on the medical industry is increasing.To lower the burden on the medical industry and increase the average age of the elderly,it is vital to explore effective anti-aging materials.Ginseng Radix et Rhizoma(Renshen),as a traditional and precious Chinese medicinal herb,is known as the“king of all herbs”.It is famous for its effects of“tonifying Qi,restoring pulse”(helping with the generation of Qi(the fundamental,vital energy that continuously flows within the body)and the circulation of blood)and strengthening the body,nourishing the spleen and lungs,generating fluids and nourishing blood,calming the mind and improving intelligence.Recently,its anti-aging effect has received increasing attention from modern scientific research.This study summarizes the pharmacological effects of the main active ingredients of Renshen(ginsenosides,polysaccharides,etc.)on resisting aging,including preventing neuroaging,suppressing skin aging,mitigating ovarian aging,inhibiting osteoporosis and arthritis,enhancing the immune system of the elderly,protecting the cardiovascular system,resisting aging-induced fatigue and exerting the anti-tumor effects.Through network pharmacology and molecular docking,the anti-aging active ingredients of Renshen were screened,and the key targets and pathways of anti-aging active ingredients in Renshen were determined.Using network pharmacology,totally 106 drug targets and 3,479 disease targets were screened,and 79 common targets between aging and Renshen were identified.Three core targets were identified in the PPI network,including TNF,AKT1,and IL-1β.Molecular docking was used to obtain further verification.This study emphasizes the potential of Renshen as a source of anti-aging activity,which can be developed into a novel drug for the treatment of age-related diseases.展开更多
The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a n...The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a necessary step before their practical application.As these investigations are time and resource-consuming undertakings,an effective prediction model can significantly improve the efficiency of research operations.In this work,an Artificial Neural Network(ANN)model is developed to predict the thermal conductivity of metal oxide water-based nanofluid.For this,a comprehensive set of 691 data points was collected from the literature.This dataset is split into training(70%),validation(15%),and testing(15%)and used to train the ANN model.The developed model is a backpropagation artificial neural network with a 4–12–1 architecture.The performance of the developed model shows high accuracy with R values above 0.90 and rapid convergence.It shows that the developed ANN model accurately predicts the thermal conductivity of nanofluids.展开更多
Community detection is one of the most fundamental applications in understanding the structure of complicated networks.Furthermore,it is an important approach to identifying closely linked clusters of nodes that may r...Community detection is one of the most fundamental applications in understanding the structure of complicated networks.Furthermore,it is an important approach to identifying closely linked clusters of nodes that may represent underlying patterns and relationships.Networking structures are highly sensitive in social networks,requiring advanced techniques to accurately identify the structure of these communities.Most conventional algorithms for detecting communities perform inadequately with complicated networks.In addition,they miss out on accurately identifying clusters.Since single-objective optimization cannot always generate accurate and comprehensive results,as multi-objective optimization can.Therefore,we utilized two objective functions that enable strong connections between communities and weak connections between them.In this study,we utilized the intra function,which has proven effective in state-of-the-art research studies.We proposed a new inter-function that has demonstrated its effectiveness by making the objective of detecting external connections between communities is to make them more distinct and sparse.Furthermore,we proposed a Multi-Objective community strength enhancement algorithm(MOCSE).The proposed algorithm is based on the framework of the Multi-Objective Evolutionary Algorithm with Decomposition(MOEA/D),integrated with a new heuristic mutation strategy,community strength enhancement(CSE).The results demonstrate that the model is effective in accurately identifying community structures while also being computationally efficient.The performance measures used to evaluate the MOEA/D algorithm in our work are normalized mutual information(NMI)and modularity(Q).It was tested using five state-of-the-art algorithms on social networks,comprising real datasets(Zachary,Dolphin,Football,Krebs,SFI,Jazz,and Netscience),as well as twenty synthetic datasets.These results provide the robustness and practical value of the proposed algorithm in multi-objective community identification.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
文摘Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.
基金National Natural Science Foundation of China(52175237)。
文摘The key parameters that characterize the morphological quality of multi-layer and multi-pass metal laser deposited parts are the surface roughness and the error between the actual printing height and the theoretical model height.The Taguchi method was employed to establish the correlations between process parameter combinations and multi-objective characterization of metal deposition morphology(height error and roughness).Results show that using the signal-to-noise ratio and grey relational analysis,the optimal parameter combination for multi-layer and multi-pass deposition is determined as follows:laser power of 800 W,powder feeding rate of 0.3 r/min,step distance of 1.6 mm,and scanning speed of 20 mm/s.Subsequently,a Genetic Bayesian-back propagation(GB-BP)network is constructed to predict multi-objective responses.Compared with the traditional back propagation network,the GB-back propagation network improves the prediction accuracy of height error and surface roughness by 43.14%and 71.43%,respectively.This network can accurately predict the multi-objective characterization of morphological quality of multi-layer and multi-pass metal deposited parts.
文摘In modern ZnO varistors,traditional aging mechanisms based on increased power consumption are no longer relevant due to reduced power consumption during DC aging.Prolonged exposure to both AC and DC voltages results in increased leakage current,decreased breakdown voltage,and lower nonlinearity,ultimately compromising their protective performance.To investigate the evolution in electrical properties during DC aging,this work developed a finite element model based on Voronoi networks and conducted accelerated aging tests on commercial varistors.Throughout the aging process,current-voltage characteristics and Schottky barrier parameters were measured and analyzed.The results indicate that when subjected to constant voltage,current flows through regions with larger grain sizes,forming discharge channels.As aging progresses,the current focus increases on these channels,leading to a decline in the varistor’s overall performance.Furthermore,analysis of the Schottky barrier parameters shows that the changes in electrical performance during aging are non-monotonic.These findings offer theoretical support for understanding the aging mechanisms and condition assessment of modern stable ZnO varistors.
文摘BACKGROUND:Breast hyperplasia is a common benign breast disease mainly caused by endocrine disorders,manifested as abnormal hyperplasia of breast tissue.In recent years,traditional Chinese medicine compounds and probiotics have shown good potential in regulating the endocrine system and improving the intestinal microecology,providing new ideas for the treatment of breast hyperplasia.OBJECTIVE:To explore the effects and mechanisms of traditional Chinese medicine compounds and fermented probiotic compounds on breast hyperplasia in mice,providing new theoretical and experimental bases for the clinical treatment and prevention of breast hyperplasia.METHODS:(1)Network pharmacology tools were used to predict the anti-breast-hyperplasia activity of Herba Gueldenstaedtiae(Euphorbia humifusa),as well as its potential targets and signaling pathways.The databases included:TCMSP,OMIM,GeneCards database,UniProt website,Venny2.1.0 website,Metascape,HERB website,and STRING database,all of which are open-access databases.Network pharmacology can predict and screen key information such as the targets corresponding to the active ingredients of traditional Chinese medicine,disease targets,and action pathways through network analysis and computer-system analysis.Therefore,it has been increasingly widely used in the research of traditional Chinese medicine.(2)A breast hyperplasia model was induced in mice by injecting estrogen and progesterone.Mice in the normal blank group were injected intraperitoneally with normal saline every day.Mice in the model group and drugadministration groups were injected intraperitoneally with estradiol benzoate injection at a concentration of 0.5 mg/kg every day for 25 days.From the 26th day,the injection of estradiol benzoate injection was stopped.Mice in the normal blank group were injected intramuscularly with normal saline every day,and mice in the model group and drug-administration groups were injected intramuscularly with progesterone injection at a concentration of 5 mg/kg for 5 days.After the model was established,each group was given drugs respectively.The normal blank group and the model group were gavaged with 0.2 mL/d of normal saline;the positive blank group(Xiaozheng Pill group)was gavaged with an aqueous solution of Xiaozheng Pill at 0.9 mg/g;the low-,medium-and high-dose groups of Compound Herba Gueldenstaedtiae were gavaged with an aqueous solution of the compound medicine at 0.75,1.5,and 3.0 mg/(g·d)respectively;the low-,medium-and high-dose groups of traditional Chinese medicine-bacteria fermentation were gavaged with an aqueous solution of the compound medicine at 0.75,1.5,and 3.0 mg/(g·d)respectively.The administration was continuous for 30 days.RESULTS AND CONCLUSION:(1)The results of network pharmacology research showed that the Compound Herba Gueldenstaedtiae(Euphorbia humifusa)contained 46 active ingredients,which were related to 1213 potential targets.After comparison with 588 known breast-hyperplasia targets,it was speculated that 50 of these targets might be related to the direct effect of the compound on breast hyperplasia.(2)After drug intervention,there was no significant change in the high-dose group of Compound Herba Gueldenstaedtiae compared with the normal blank group.The liver indicators of the other intervention groups all significantly decreased(P<0.05).(3)In terms of kidney and uterine indicators,the medium-dose group of Compound Herba Gueldenstaedtiae decreased significantly compared with the normal blank group(P<0.05).In terms of the uterine index,the model group increased significantly compared with the normal blank group(P<0.01).(4)After 1-month drug treatment,the number of lobules and acini in the breast tissue of the Xiaozheng Pill group,the low,medium,and high-dose group of Compound Herba Gueldenstaedtiae,the low,medium,and highdose groups of traditional Chinese medicine-bacteria fermentation decreased,and the duct openings narrowed.With the increase of drug dose,diffuse hyperplasia of breast tissue was significantly improved.(5)The ELISA results showed that compared with the model group,the estrogen level was lower in the medium-dose group of traditional Chinese medicine-bacteria fermentation after the intervention(P<0.05).In addition,the follicle-stimulating hormone level in the low-dose group of Compound Herba Gueldenstaedtiae was lower than that of the model group(P<0.05).(6)The intervention in the mouse model led to changes in the abundance of short chain fatty acids and intestinal flora in all groups.To conclude,the Compound Herba Gueldenstaedtiae and its probiotic fermentation products significantly improved mammary gland hyperplasia in mice by regulating hormone levels,improving the structure of the gut microbiota,and increasing the content of shortchain fatty acids,providing new ideas and potential sources of drugs for the treatment of breast hyperplasia.
基金supported by the MSIT(Ministry of Science and ICT),Republic of Korea,under the ICAN(ICT Challenge and Advanced Network of HRD)support program(IITP-2025-RS-2023-00259497)supervised by the IITP(Institute for Information&Communications Technology Planning&Evaluation)and was supported by Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by the Republic of Korea government(MSIT)(No.IITP-2025-RS-2023-00254129+1 种基金Graduate School of Metaverse Convergence(Sungkyunkwan University))was supported by the Basic Science Research Program of the National Research Foundation(NRF)funded by the Republic of Korean government(MSIT)(No.RS-2024-00346737).
文摘Network attacks have become a critical issue in the internet security domain.Artificial intelligence technology-based detection methodologies have attracted attention;however,recent studies have struggled to adapt to changing attack patterns and complex network environments.In addition,it is difficult to explain the detection results logically using artificial intelligence.We propose a method for classifying network attacks using graph models to explain the detection results.First,we reconstruct the network packet data into a graphical structure.We then use a graph model to predict network attacks using edge classification.To explain the prediction results,we observed numerical changes by randomly masking and calculating the importance of neighbors,allowing us to extract significant subgraphs.Our experiments on six public datasets demonstrate superior performance with an average F1-score of 0.960 and accuracy of 0.964,outperforming traditional machine learning and other graph models.The visual representation of the extracted subgraphs highlights the neighboring nodes that have the greatest impact on the results,thus explaining detection.In conclusion,this study demonstrates that graph-based models are suitable for network attack detection in complex environments,and the importance of graph neighbors can be calculated to efficiently analyze the results.This approach can contribute to real-world network security analyses and provide a new direction in the field.
基金supported in part by the Rosetrees Trust(#CF-2023-I-2_113)by the Israel Ministry of Innovation,Science,and Technology(#7393)(to ES).
文摘The organization of biological neuronal networks into functional modules has intrigued scientists and inspired engineers to develop artificial systems.These networks are characterized by two key properties.First,they exhibit dense interconnectivity(Braitenburg and Schüz,1998;Campagnola et al.,2022).The strength and probability of connectivity depend on cell type,inter-neuronal distance,and species.Still,every cortical neuron receives input from thousands of other neurons while transmitting output to a similar number of neurons.Second,communication between neurons occurs primarily via chemical or electrical synapses.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(RS-2025-00559546)supported by the IITP(Institute of Information&Coummunications Technology Planning&Evaluation)-ITRC(Information Technology Research Center)grant funded by the Korea government(Ministry of Science and ICT)(IITP-2025-RS-2023-00259004).
文摘The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment.
基金National Natural Science Foundation of China(Grant No.62103434)National Science Fund for Distinguished Young Scholars(Grant No.62176263).
文摘With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a promising Deep Learning(DL)approach,has proven to be highly effective in identifying intricate patterns in graph⁃structured data and has already found wide applications in the field of network security.In this paper,we propose a hybrid Graph Convolutional Network(GCN)⁃GraphSAGE model for Anomaly Traffic Detection,namely HGS⁃ATD,which aims to improve the accuracy of anomaly traffic detection by leveraging edge feature learning to better capture the relationships between network entities.We validate the HGS⁃ATD model on four publicly available datasets,including NF⁃UNSW⁃NB15⁃v2.The experimental results show that the enhanced hybrid model is 5.71%to 10.25%higher than the baseline model in terms of accuracy,and the F1⁃score is 5.53%to 11.63%higher than the baseline model,proving that the model can effectively distinguish normal traffic from attack traffic and accurately classify various types of attacks.
基金supported by the Chung-Ang University Research Grants in 2023.Alsothe work is supported by the ELLIIT Excellence Center at Linköping–Lund in Information Technology in Sweden.
文摘Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of user preferences.To address this,we propose a Conditional Generative Adversarial Network(CGAN)that generates diverse and highly relevant itineraries.Our approach begins by constructing a conditional vector that encapsulates a user’s profile.This vector uniquely fuses embeddings from a Heterogeneous Information Network(HIN)to model complex user-place-route relationships,a Recurrent Neural Network(RNN)to capture sequential path dynamics,and Neural Collaborative Filtering(NCF)to incorporate collaborative signals from the wider user base.This comprehensive condition,further enhanced with features representing user interaction confidence and uncertainty,steers a CGAN stabilized by spectral normalization to generate high-fidelity latent route representations,effectively mitigating the data sparsity problem.Recommendations are then formulated using an Anchor-and-Expand algorithm,which selects relevant starting Points of Interest(POI)based on user history,then expands routes through latent similarity matching and geographic coherence optimization,culminating in Traveling Salesman Problem(TSP)-based route optimization for practical travel distances.Experiments on a real-world check-in dataset validate our model’s unique generative capability,achieving F1 scores ranging from 0.163 to 0.305,and near-zero pairs−F1 scores between 0.002 and 0.022.These results confirm the model’s success in generating novel travel routes by recommending new locations and sequences rather than replicating users’past itineraries.This work provides a robust solution for personalized travel planning,capable of generating novel and compelling routes for both new and existing users by learning from collective travel intelligence.
基金supported by the National Natural Science Foundation of China (Grant Nos.12192251,12334014,62335019,12134001,1230441812474378)+1 种基金the Quantum Science and Technology National Science and Technology Major Project(Grant No.2021ZD0301403)the Shanghai Municipal Science and Technology Major Project (Grant No.2019SHZDZX01)。
文摘Photonic neural networks(PNNs)of sufficiently large physical dimensions and high operation accuracies are envisaged as ideal candidates for breaking the major bottlenecks in the current artificial intelligence architectures in terms of latency,energy efficiency,and computational power.To achieve this vision,it is of vital importance to scale up the PNNs while simultaneously reducing the high demand on the dimensions required by them.The underlying cause of this strategy is the enormous gap between the scales of photonic and electronic integrated circuits.Here,we demonstrate monolithically integrated optical convolutional processors on thin film lithium niobate(TFLN)that harness inherent parallelism in photonics to enable large-scale programmable convolution kernels and,in turn,greatly reduce the dimensions required by subsequent fully connected layers.Experimental validation achieves high classification accuracies of 96%(86%)on the MNIST(Fashion-MNIST)dataset and 84.6%on the AG News dataset while dramatically reducing the required subsequent fully connected layer dimensions to 196×10(from 784×10)and 175×4(from 800×4),respectively.Furthermore,our devices can be driven by commercial field-programmable gate array systems;a unique advantage in addition to their scalable channel number and kernel size.Our architecture provides a solution to build practical machine learning photonic devices.
基金supported by the National Natural Science Foundation of China under Grant 62471493supported by the Natural Science Foundation of Shandong Province under Grant ZR2023LZH017,ZR2024MF066。
文摘With the rapid development of intelligent cyber-physical systems(ICPS),diverse services with varying Quality of Service(QoS)requirements have brought great challenges to traditional network resource allocation.Furthermore,given the open environment and a multitude of devices,enhancing the security of ICPS is an urgent concern.To address these issues,this paper proposes a novel trusted virtual network embedding(T-VNE)approach for ICPS based combining blockchain and edge computing technologies.Additionally,the proposed algorithm leverages a deep reinforcement learning(DRL)model to optimize decision-making processes.It employs the policygradient-based agent to compute candidate embedding nodes and utilizes a breadth-first search(BFS)algorithm to determine the optimal embedding paths.Finally,through simulation experiments,the efficacy of the proposed method was validated,demonstrating outstanding performance in terms of security,revenue generation,and virtual network request(VNR)acceptance rate.
基金supported by the Scientific Research Project of Anhui ProvincialHealth Commission(Grant No.AHWJ2021b063)National Natural Scientific Foundation of China(Grant No.82160048)+1 种基金Natural Science Foundation Project of Anhui Province(Grant No.2308085MH265)Major Scientific Research Project of Anhui Provincial Department of Education(Grant No.2024AH040205).
文摘Objectives:Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice,affecting millions of postmenopausal women worldwide.Postmenopausal osteoporosis demands safe and effective therapies.This study aimed to evaluate the potential of hederagenin(Hed)for treating osteoporosis and to elucidate its underlying mechanisms of action.Methods:The anti-osteoporotic potential of Hed was assessed by investigating its effects on ovariectomy(OVX)-induced bone loss in mice and on receptor activator of NF-kappaB ligand(RANKL)-induced osteoclast differentiation in RAW264.7 cells.Network pharmacology analysis and molecular docking were employed to identify key targets,which were subsequently validated experimentally.Results:In vitro,Hed suppressed osteoclastogenesis by inhibiting the formation of osteoclasts and F-actin rings and by down-regulating osteoclastspecific genes(Atp6v0d2 and Acp5).In vivo,Hed significantly amelioratedOVX-induced bone loss,restoring trabecular bone volume fraction(BV/TV)and trabecular number(Tb.N),while reducing trabecular separation(Tb.Sp).Network pharmacology analysis identified 142 overlapping targets linking Hed to osteoporosis,including tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),and IL-1β,with enrichment in innate immune signaling and osteoclast differentiation.Molecular docking analysis indicated strong binding affinities between Hed and targets such as TNF-α,IL-6,and IL-1β.Experimentally,Hed was found to decrease RANKL,elevate osteoprotegerin(OPG),and suppress intestinalmRNA levels of pro-inflammatory cytokines such as IL-1β,IL-6,IL-17A,and TNF-α.Conclusion:Hed exerts significant anti-osteoporotic effects inOVX-induced osteoporosis through a dualmechanism involving the suppression of both osteoclastogenesis and innate immune signaling pathways.These findings highlighted Hed’s novel role in modulating immune-bone crosstalk,offering a promising strategy for treating osteolytic diseases without estrogenic side effects.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by the National Natural Science Foundation of China(Grant No.62171182)the Natural Scienceof Hunan Province(Grant No.2025JJ50345)the Postgraduate Scientific Research Innovation Project of Hunan Province(Grant No.CX20240452)。
文摘The regulation of signal transmission speed is one of the most important capabilities of the biological nervous system.This study explores the mechanisms and methods for regulating signal transmission speed among nonmyelinated neurons within the same brain region,starting from spike-timing-dependent plasticity(STDP)of synapses.Building upon the Hodgkin-Huxley model,the dynamic behavior of synapses is incorporated,and the adaptive growth neuron(AGN)model is proposed.Artificial synaptic structures and neuronal physical nodes are also designed.The artificial synaptic structure exhibits unidirectionality,memory capacity,and STDP,enabling it to connect neuronal physical nodes through branching and merging structures.Furthermore,the artificial synapse can adjust signal transmission speed,regulate functional competition between different regions of the neuromorphic network,and promote information interaction.The findings of this study endow neuromorphic networks with the ability to regulate signal transmission speed over the long term,providing new insights into the development of neuromorphic networks.
基金supported by the Jilin Science and Technology Development Talent Special Project,Nos.20240601086RC,23JQ08(all to ZH)YDZJ202502CXJD077+1 种基金JLARS-2025-0802-09YDZJ202501ZYTS706.
文摘Population aging is one of the common challenges in the current world.As people age,the body’s tissues including cells,and molecules inevitably degrade,and their functions gradually decline,causing various age-related diseases like Alzheimer’s disease,osteoporosis,low immunity,glucose and lipid metabolism disorders,and cardiovascular diseases.With the continuous increase of the elderly population,the pressure on the medical industry is increasing.To lower the burden on the medical industry and increase the average age of the elderly,it is vital to explore effective anti-aging materials.Ginseng Radix et Rhizoma(Renshen),as a traditional and precious Chinese medicinal herb,is known as the“king of all herbs”.It is famous for its effects of“tonifying Qi,restoring pulse”(helping with the generation of Qi(the fundamental,vital energy that continuously flows within the body)and the circulation of blood)and strengthening the body,nourishing the spleen and lungs,generating fluids and nourishing blood,calming the mind and improving intelligence.Recently,its anti-aging effect has received increasing attention from modern scientific research.This study summarizes the pharmacological effects of the main active ingredients of Renshen(ginsenosides,polysaccharides,etc.)on resisting aging,including preventing neuroaging,suppressing skin aging,mitigating ovarian aging,inhibiting osteoporosis and arthritis,enhancing the immune system of the elderly,protecting the cardiovascular system,resisting aging-induced fatigue and exerting the anti-tumor effects.Through network pharmacology and molecular docking,the anti-aging active ingredients of Renshen were screened,and the key targets and pathways of anti-aging active ingredients in Renshen were determined.Using network pharmacology,totally 106 drug targets and 3,479 disease targets were screened,and 79 common targets between aging and Renshen were identified.Three core targets were identified in the PPI network,including TNF,AKT1,and IL-1β.Molecular docking was used to obtain further verification.This study emphasizes the potential of Renshen as a source of anti-aging activity,which can be developed into a novel drug for the treatment of age-related diseases.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2021R1A6A1A10044950).
文摘The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids.Researchers rely on experimental investigations to explore nanofluid properties,as it is a necessary step before their practical application.As these investigations are time and resource-consuming undertakings,an effective prediction model can significantly improve the efficiency of research operations.In this work,an Artificial Neural Network(ANN)model is developed to predict the thermal conductivity of metal oxide water-based nanofluid.For this,a comprehensive set of 691 data points was collected from the literature.This dataset is split into training(70%),validation(15%),and testing(15%)and used to train the ANN model.The developed model is a backpropagation artificial neural network with a 4–12–1 architecture.The performance of the developed model shows high accuracy with R values above 0.90 and rapid convergence.It shows that the developed ANN model accurately predicts the thermal conductivity of nanofluids.
文摘Community detection is one of the most fundamental applications in understanding the structure of complicated networks.Furthermore,it is an important approach to identifying closely linked clusters of nodes that may represent underlying patterns and relationships.Networking structures are highly sensitive in social networks,requiring advanced techniques to accurately identify the structure of these communities.Most conventional algorithms for detecting communities perform inadequately with complicated networks.In addition,they miss out on accurately identifying clusters.Since single-objective optimization cannot always generate accurate and comprehensive results,as multi-objective optimization can.Therefore,we utilized two objective functions that enable strong connections between communities and weak connections between them.In this study,we utilized the intra function,which has proven effective in state-of-the-art research studies.We proposed a new inter-function that has demonstrated its effectiveness by making the objective of detecting external connections between communities is to make them more distinct and sparse.Furthermore,we proposed a Multi-Objective community strength enhancement algorithm(MOCSE).The proposed algorithm is based on the framework of the Multi-Objective Evolutionary Algorithm with Decomposition(MOEA/D),integrated with a new heuristic mutation strategy,community strength enhancement(CSE).The results demonstrate that the model is effective in accurately identifying community structures while also being computationally efficient.The performance measures used to evaluate the MOEA/D algorithm in our work are normalized mutual information(NMI)and modularity(Q).It was tested using five state-of-the-art algorithms on social networks,comprising real datasets(Zachary,Dolphin,Football,Krebs,SFI,Jazz,and Netscience),as well as twenty synthetic datasets.These results provide the robustness and practical value of the proposed algorithm in multi-objective community identification.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
